Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Immunology
Muhong Wei, Can Li, Yu Dai, Haolong Zhou, Yuan Cui, Yun Zeng, Qin Huang, Qi Wang
Summary: Collective research indicates that gut microbiota play a significant role in bone remodeling and maintaining bone health. This study found that specific bacterial genera in the gut microbiota of osteoporosis patients may be associated with decreased bone density. After controlling for potential confounders, the associations of certain bacterial genera with the risk of osteoporosis were not significant.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Guangbin Ye, Yandong Huang, Lianfei Yin, Jianchu Wang, Xiufeng Huang, Xiaoyun Bin
Summary: The study found an association between certain single nucleotide polymorphisms of the leptin receptor gene and osteoporosis among Chinese Mulao people, with some genotypes potentially increasing or decreasing the risk of developing osteoporosis.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiaqiang Zhang, Qinlei Cai, Wangxue Chen, Maoxue Huang, Renyang Guan, Tianbo Jin
Summary: This study evaluated the relationship between the polymorphism of rs7586085, CCDC170, GALNT3 genes and the risk of osteoporosis in the Chinese Han population. The results showed that these gene variations were associated with the risk of osteoporosis in certain genetic models, particularly in specific populations.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Yangyang Wang, Xiaoguang Gao, Jing Lv, Yuhong Zeng, Qingmei Li, Liping Wang, Yuanyuan Zhang, Wenjie Gao, Jihan Wang
Summary: This study clarifies the composition and gene functional profile of the gut microbiome (GM) in older individuals with normal and low bone mineral density (BMD). It provides evidence regarding the mechanisms by which GM affects bone health and identifies potential diagnostic and therapeutic targets for osteoporosis (OP) and postmenopausal osteoporosis (PMOP). Furthermore, it highlights the importance of addressing and improving vitamin D deficiency or insufficiency in the Chinese population.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Miaomiao Wang, Hao Zhou, Wenjing Cui, Zhongqiu Wang, Guoying Zhu, Xiao Chen, Taiyi Jin
Summary: Cadmium exposure may increase the risk of osteoporosis and fractures, with age and cadmium exposure being independent risk factors. Nomograms were developed to predict these risks, showing age as a main determinant. Receiver operating curve demonstrated acceptable performance in predicting osteoporosis and fracture. Linear discriminant analysis showed a high percentage of correct classification for osteoporosis and fractures.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Yichen Liu, Yue Zeng, Jun Lu, Xiaoya Zhang, Zikai Zhang, Huijuan Li, Peipei Liu, Bin Ma, Yiqun Gu, Lige Song
Summary: This study aimed to evaluate the correlation between hemoglobin (Hb) and osteoporosis (OP) in the Chinese elderly population. The results showed that Hb level was positively correlated with bone mineral density (BMD) at the lumbar spine, femur neck, and total hip. After adjusting for confounding variables, the relationship remained significant. Additionally, lower Hb levels were associated with a higher risk of OP.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Zhikun Zhuang, Changyu Huang, Xianyi Chen, Qiushi Wei, Jinhua Guo, Zhiqing Xu, Rongkai Wu, Zhaoke Wu, Fudong Xu
Summary: This study aims to report the prevalence of osteoporosis and rate of anti-osteoporosis treatment in people awaiting UKA, as well as explore factors associated with osteoporosis prevalence in this population. The results show that osteoporosis is common in people waiting for UKA, but screening and treatment rates are low.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ya Zhang, Jian Pu
Summary: This study found a positive relationship between obesity and bone mineral density (BMD) in individuals over the age of 50. It also identified a saturation value for BMI and BMD, suggesting that maintaining a moderate BMI level (around 24.3 kg/m(2)) would result in optimal BMD in older adults.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bijuan Qing, Nan Wang, Lingling Wang, Peng Li, Lishan Li, Hong Chen
Summary: This study evaluated the relationship between geriatric nutrition risk index (GNRI) and bone mineral density (BMD) in elderly Chinese individuals. Results showed that higher GNRI values were associated with higher total hip and lumbar spine T-scores, especially in women. GNRI may be a valuable indicator for identifying older individuals in need of further bone health nutritional support.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Henrik Falhammar, Louise Frisen, Angelica Linden Hirschberg, Agneta Nordenskjold, Catarina Almqvist, Anna Nordenstrom
Summary: Patients with congenital adrenal hyperplasia (CAH) have an increased prevalence of fractures, especially those associated with osteoporosis. This highlights the need for regular assessment of fracture risk and optimization of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ling Wang, Kaiping Zhao, Xiaojuan Zha, Limei Ran, Heng Su, Yingying Yang, Qing Shuang, Yandong Liu, Li Xu, Glen M. Blake, Xiaoguang Cheng, Klaus Engelke, Annegreet Vlug
Summary: We found no association between fasting plasma glucose or diabetes and volumetric BMD measured with QCT after adjustment for age. Therefore, vBMD measured with QCT may be a more reliable measurement for diagnosing osteoporosis and assessing fracture risk than aBMD measured with DXA in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
