Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 2, Issue 5, Pages 476-480Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5qo00034c
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Funding
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21272253, 21332009, 21361140373, 21421091]
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A sequential catalysis involving olefin cross-metathesis/asymmetric intramolecular Friedel-Crafts alkylation of pyrrole derivatives has been developed. A variety of enantioenriched 4,5,6,7-tetrahydroindoles were obtained in good yields and enantioselectivity by combining a Zhan-1B catalyst with a chiral phosphoric acid.
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