Article
Medicine, General & Internal
Matvey M. Tsyganov, Marina K. Ibragimova, Evgeniy Yu. Garbukov, Irina A. Tsydenova, Kseniya A. Gaptulbarova, Daria S. Dolgasheva, Ekaterina A. Zdereva, Anastasia A. Frolova, Elena M. Slonimskaya, Nikolai V. Litviakov
Summary: Sensitivity of breast tumors to chemotherapy drugs has been a focus of research, and personalized approaches based on this sensitivity have been developed. This study investigates the predictive and prognostic significance of gene expression and chromosomal aberrations in breast cancer patients. The results suggest that specific gene expressions and aberrations are associated with treatment response and survival rate.
Article
Oncology
Juncheng Li, Peng Sun, Tao Huang, Shengdong He, Lingfan Li, Gang Xue
Summary: Individualized chemotherapy based on genetic detection can significantly prolong disease-free survival (DFS) and overall survival (OS) in breast cancer patients, while reducing the incidence of adverse reactions. The chemotherapy strategy guided by genetic detection is an independent protective factor for DFS, but not for OS.
Article
Health Care Sciences & Services
Matvey M. Tsyganov, Evgeny O. Rodionov, Marina K. Ibragimova, Sergey Miller, Olga Cheremisina, Irina G. Frolova, Sergey A. Tuzikov, Nikolai Litviakov
Summary: Personalized chemotherapy based on the assessment of chemosensitive gene expression can improve treatment efficacy and reduce unnecessary toxicity in patients with non-small-cell lung cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhifei Liu, Liyong Xing, Yanfeng Zhu, Peng Shi, Gang Deng
Summary: This study found that high expression of TOP2A or low expression of RRM1 could predict the sensitivity of NMIBC to pirarubicin or gemcitabine treatment. In addition, the expression of HER2 and ERCC1 may affect the functions of TOP2A and RRM1, thereby affecting the efficacy of chemotherapeutic drugs.
Article
Multidisciplinary Sciences
Tomotaka Kato, Hiroaki Ono, Mikiya Fujii, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
Summary: High RRM1 expression in pancreatic cancer patients is associated with poorer clinical outcomes, especially in those receiving adjuvant chemotherapy. Activation of cytoplasmic RRM1 is related to cancer cell viability and drug resistance, while inhibition of RRM1 enhances the cytotoxic effects of gemcitabine for pancreatic cancer cells.
Article
Mathematics, Applied
Michael Weba
Summary: A parameterized family of series representations for the numbers zeta(2m + 1) is presented, where m is a positive integer. By utilizing Clausen functions of higher order, several conventional results are improved and generalized, leading to a significant improvement in the convergence rate. The parameterized family is also applicable to represent the numbers beta(2m) and derive asymptotically finite representations for both zeta(2m + 1) and beta(2m).
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS
(2022)
Article
Oncology
Wendy Munoz-Montano, Sae Muniz-Hernandez, Alejandro Aviles-Salas, Rodrigo Catalan, Luis Lara-Mejia, Suraj Samtani-Bassarmal, Andres F. Cardona, Jorge Mendoza-Desion, Daniel Hernandez-Cueto, Altagracia Maldonado, Guillermina Baay-Guzman, Sara Huerta-Yepes, Oscar Arrieta
Summary: The study conducted immunohistochemistry semi-quantitative analysis on four biomarkers (ERCC1, RRM1, RRM2, and hENT-1) to predict treatment response in advanced MPM patients receiving continuous infusion gemcitabine plus cisplatin, showing that ERCC1 and RRM1 are useful biomarkers for predicting better survival outcomes.
Article
Environmental Sciences
Guilherm Pereira Schoeler, Thays Franca Afonso, Carolina Faccio Demarco, Victor Dos Santos Barboza, Tito Roberto Sant'anna Cadaval Jr, Andrei Valerao Igansi, Marcos Alexandre Gelesky, Janice Luehring Giongo, Rodrigo de Almeida Vaucher, Rafael de Avila Delucis, Robson Andreazza
Summary: The COVID-19 pandemic has had unprecedented impacts on health and the economy, emphasizing the importance of basic sanitation and social equality. This study developed a low-cost and efficient polyurethane biofoam material for the removal of SARS-CoV-2 from water, showing promising results.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pathology
Khushbu Khetan, RanjitK Sahoo, Vandana Baloda, Shalimar, Sreenivas Vishnubhatla, Anoop Saraya, NiharRanjan Dash, Atul Sharma, Siddhartha DattaGupta, Prasenjit Das
Summary: This study found that RRM1 and ERCC1 expression levels were higher in pancreatic and cholangiocarcinoma compared to controls, with statistically significant differences. However, no correlation was observed between low and high expression of RRM1 and ERCC1 with histological markers of prognosis and overall survival in these patients. This adds to the existing controversy regarding the prognostic significance of RRM1 and ERCC1 expression in pancreatic and biliary carcinomas, beyond their therapeutic benefits.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephen Bustin, Claire Bustin, Sara Kirvell, Tania Nolan, Reinhold Mueller, Gregory Shipley
Summary: The COVID-19 pandemic created a high demand for molecular diagnostic testing but resulted in a shortage of reagents and increased prices. Researchers have identified two strategies to conserve reagents and incorporate them into standard qPCR protocols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maddalena Benetton, Pietro Merli, Christiane Walter, Maria Hansen, Ambra Da Ros, Katia Polato, Claudia Tregnago, Jonas Abrahamsson, Luisa Strocchio, Edwin Sonneveld, Linda Fogelstrand, Nils Von Neuhoff, Dirk Reinhardt, Henrik Hasle, Martina Pigazzi, Franco Locatelli
Summary: This study investigates qPCR-MRD as a predictor of relapse in pretransplant bone marrow samples of AML patients. The study identifies a cutoff value and finds that patients with lower qPCR-MRD values have increased overall survival and relapse-free survival, independent of genetic markers, conditioning regimen, donor, and stem cell source. These findings suggest the clinical relevance of the PCR-based approach in AML transplant management.
Article
Virology
Yakup Artik, Alp B. Cosgun, Nevra P. Cesur, Nedret Hizel, Yavuz Uyar, Haydar Sur, Alp Ayan
Summary: The present study evaluates the effectiveness of LAMP method for rapid screening diagnostic test of COVID-19 and compares it with the gold standard q-RT-PCR. The results show that LAMP method performs similarly to q-RT-PCR in some cases and offers the advantages of speed and cost-effectiveness.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Guo, Xiuli Song, Rongxing Li, Qi Zhang, Shengwei Zheng, Qiucheng Li, Bo Tao
Summary: Glyphosate-resistant fungus Fusarium verticillioides was found and characterized in this study. It could grow in a medium containing glyphosate and its epsps gene was cloned, which showed low expression levels and belonged to class I genes naturally sensitive to glyphosate. Additionally, the strain C-2 was highly effective in degrading glyphosate and could be potentially used for bioremediation of contaminated soil.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Biology
Adrian Ruiz-Villalba, Jan M. Ruijter, Maurice J. B. van den Hoff
Summary: In the analysis of qPCR data, the C-q value indicates the position of the amplification curve relative to the cycle axis, but it can vary between runs and machines and is highly influenced by PCR efficiency. To avoid misinterpretations, efficiency-corrected starting concentrations should be calculated for reporting gene expression ratios and fold differences.
Article
Microbiology
Sofia Anastacio, Samuel Anjos, Suzi Neves, Tiago Neves, Pedro Esteves, Helder Craveiro, Bruno Madeira, Maria Dos Anjos Pires, Sergio Sousa, Gabriela da Silva, Hugo Vilhena
Summary: This study investigated the infection of C. burnetii in dogs, cats, and ticks in Portugal. The results showed a decrease in the exposure to C. burnetii in cats and dogs, with rural habitats favoring the infection. Additionally, no C. burnetii DNA was detected in ticks from the tested samples.