Article
Chemistry, Physical
Liuxin Yang, Cuixia Chen, Tiantian Liang, Liyun Hao, Qilong Gu, Hai Xu, Yurong Zhao, Lixia Jiang, Xinglong Fan
Summary: In this study, a series of lipopeptides were designed to investigate the relationship between their physicochemical properties, self-assembly behaviors, and antibacterial activity. It was found that the stability of lipopeptides played a crucial role in their antibacterial ability. The findings enhance our understanding of the antibacterial mechanisms of self-assembling lipopeptides and have implications for their biomedical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Chemical
Omar M. Khubiev, Victoria E. Esakova, Anton R. Egorov, Artsiom E. Bely, Roman A. Golubev, Maxim V. Tachaev, Anatoly A. Kirichuk, Nikolai N. Lobanov, Alexander G. Tskhovrebov, Andreii S. Kritchenkov
Summary: In this study, chitosan/Fe(III)/deferoxamine nanoparticles were prepared with a unimodal size distribution. These nanoparticles exhibited outstanding antibacterial activity in vitro and in vivo, surpassing that of commercial antibiotics ampicillin and gentamicin. Additionally, the nanoparticles were found to be non-toxic. The introduction of iron ions into the chitosan matrix increased the ability of the nanoparticles to disrupt the integrity of microorganism membranes, and the incorporation of deferoxamine greatly enhanced their membrane destruction effect.
Article
Biochemistry & Molecular Biology
Vivek Chauhan, Vivek Kumar Dhiman, Shamsher S. Kanwar
Summary: Lipopeptides (LPs) are biomolecules with lipid heads attached to peptide tails. They have shown various medicinal properties, with antimicrobial and anticancer effects being the most studied. In this study, LPs were extracted and purified from the Pseudomonas sp. OXDC12 strain, and their surfactant nature was characterized. The purified LPs exhibited antimicrobial and antifungal activity, as well as cytotoxic and antiproliferative effects on transformed cell lines.
PROCESS BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Juliana Cotabarren, Santiago Claver, Juan Abreu Payrol, Javier Garcia-Pardo, Walter David Obregon
Summary: In this study, the first phytocystatin MoPI isolated from Moringa oleifera was characterized for its potent inhibitory activity against cysteine proteases, antimicrobial activity against human pathogens, and anticoagulant activity. These findings highlight the pharmaceutical potential of this plant and its bioactive molecules.
Article
Fisheries
Penghui Zhang, Tom J. Carney, Karin Schroen, Remko M. Boom, Mary B. Chan-Park
Summary: Crosslinked beads prepared by diffusion-driven layer by layer process exhibit excellent antibacterial activity and biocompatibility, with high adsorption capacity for removing fish waste.
Article
Biochemistry & Molecular Biology
Lewis Rolband, Liam Yourston, Morgan Chandler, Damian Beasock, Leyla Danai, Seraphim Kozlov, Nolan Marshall, Oleg Shevchenko, Alexey Krasnoslobodtsev, Kirill A. Afonin
Summary: This study combines atomically precise metal nanoclusters with nucleic acid nanotechnology to create DNA-templated silver nanoclusters with reproducible fluorescent properties and antibacterial activity. Additionally, the use of cytosine-rich single-stranded DNA oligonucleotides improves stability, modulates antibacterial properties, and enhances the quality of observed fluorescent signals of the silver nanoclusters. The research characterizes the sequence-specific fluorescence and composition of four representative DNA-AgNCs, compares their antibacterial effectiveness at different pH levels, and evaluates cytotoxicity to various mammalian cell lines.
Article
Biochemistry & Molecular Biology
Rosiane Andrade da Costa, Isadora Emanoela Pereira Costa Andrade, Otavio Henrique Bezerra Pinto, Beatriz Blenda Pinheiro de Souza, Debora Luiza Albano Fulgencio, Marise Leite Mendonca, Adriane Silva Kurokawa, Daniel Barros Ortega, Lucas Silva Carvalho, Ricardo Henrique Kruger, Marcelo Henrique Soller Ramada, Cristine Chaves Barreto
Summary: A study identified a novel variant of antimicrobial peptides, tridecaptin G1 and G2, produced by Paenibacillus elgii AC13. These variants exhibited antimicrobial activity against various bacteria and fungi.
Article
Food Science & Technology
Yangliu Liu, Yawei Ning, Zhou Chen, Panpan Han, Tongxin Zhi, Siting Li, Aijin Ma, Yingmin Jia
Summary: This study further explored the antibacterial mechanism of lipopeptide brevilaterin B against L. monocytogenes using transcriptomic analysis. The findings showed that brevilaterin B affects various pathways involved in bacterial growth, membrane transport, cellular metabolism, and stress response.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Engineering, Environmental
Wang Xi, Li Guo, Dingxin Liu, Renwu Zhou, Zifeng Wang, Wei Wang, Zhijie Liu, Xiaohua Wang, Kostya (Ken) Ostrikov, Mingzhe Rong
Summary: The study proposes a new approach to convert hazardous fluorides from plasma processing of PTFE into a potent antimicrobial disinfectant, utilizing cold plasma surface modification and plasma-activated water technology. By capturing gaseous fluorides into the PAW, the microbial disinfection efficiency is significantly enhanced, showcasing a sustainable valorization of toxic fluoride etching products.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
D. Sanchez-Campos, M. G. Pena-Juarez, D. Salado-Leza, D. Mendoza-Anaya, V. Rodriguez-Lugo, J. A. Gonzalez-Calderon, E. Perez
Summary: A composite material containing hydroxyapatite, graphene oxide and silver nanoparticles was synthesized using a microwave-assisted hydrothermal method. The addition of dietary quercetin was utilized for the formation and deposition of silver nanoparticles. The composite exhibited cytotoxicity in human keratinocytes dependent on the presence of graphene oxide, while samples containing hydroxyapatite showed superior cytocompatibility. The ternary system displayed increased inhibition zone against S. aureus and E. coli compared to silver nanoparticles alone, making it a potential bactericidal material for tissue replacement and surface coating.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Food Science & Technology
Yi Liu, Li Zhu, Yongliang Ma, Lu Liu, Hongsu Wang, Xiaodi Niu
Summary: This study focused on the modification of chitosan using TEMPO/laccase oxidation system and chitosanase. The experimental results showed that the modified chitosan had increased aldehyde group content and water solubility. Furthermore, the covalent binding with lysozyme improved its inhibition effect and extended the preservation time of strawberries at room temperature.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Kaori Ozaki, Yuka Asato, Noriyuki Natsume, Shunya Tojo, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from a marine cyanobacterium called Okeania. Their structures were determined using spectroscopic analyses and their absolute configurations were elucidated through a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) were found to dose-dependently promote the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Amisha Patel, Amita Shah
Summary: A novel thermostable GH5 family endoglucanase from a newly isolated brown rot fungi Fomitopsis meliae CFA 2 was purified, characterized and partially sequenced in this study. The enzyme exhibited high specificity, optimal temperature and pH conditions, and was stimulated by metal ions and DTT. Overall, the endoglucanase showed potential for applications in biomass hydrolysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Dorota Chelminiak-Dudkiewicz, Miloslav Machacek, Jolanta Dlugaszewska, Magdalena Wujak, Aleksander Smolarkiewicz-Wyczachowski, Szymon Bocian, Kinga Mylkie, T. Goslinski, Michal P. Marszall, Marta Ziegler-Borowska
Summary: In this study, porous bacterial levan-based sponges containing cannabis oil (Lev@CBDs) were prepared and characterized. The sponges exhibited desirable physical properties and showed good performance in terms of swelling ratio, water vapor transmission rate, thermal stability, mechanical properties, antioxidant and anti-inflammatory properties. These sponges also demonstrated antibacterial activity and biocompatibility. The results suggest that Lev@CBDs have the potential to be used as wound dressings in future in vivo applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Sunju Choi, Hittu Matta, Ramakrishnan Gopalakrishnan, Venkatesh Natarajan, Songjie Gong, Alberto Jeronimo, Wei-Ying Kuo, Bryant Bravo, Preet M. Chaudhary
Summary: Cytotoxicity assays are crucial for testing novel immunotherapies for cancer treatment. The Matador-Glo assay utilizes a thermostable variant of Click Beetle Luciferase for luminescence detection and is simple, fast, specific, sensitive, cost-efficient, and not labor-intensive. This assay can also be combined with the marine luciferase-based Matador assay for dual luciferase detection of cell death, and the target cells expressing Luc146-1H2 can be used for in vivo bioluminescence imaging applications.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Trinath Chowdhury, Piyush Baindara, Santi M. Mandal
Summary: The recent outbreak of SARS-CoV-2 has caused a deadly atypical pneumonia, making COVID-19 an urgent public health issue. This study screened seven different lipopeptides and found that LPD-12 showed the most promising results in disrupting the binding of SARS-CoV-2 spike protein with ACE2 receptor, suggesting its potential as a therapeutic drug for COVID-19.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Biotechnology & Applied Microbiology
Sounik Manna, Trinath Chowdhury, Ranadhir Chakraborty, Santi M. Mandal
Summary: Probiotic-derived lipopeptides may play a significant role in inhibiting the spread of the SARS-CoV-2 virus.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biotechnology & Applied Microbiology
Shelley Sardul Singh, Md. Naushad Akhtar, Deepika Sharma, Santi M. Mandal, Suresh Korpole
Summary: This study identified a novel lipopeptide, iturin V, with antibacterial and immunomodulatory properties secreted by the LAB isolate strain M31. It showed activity against species of the genera Pseudomonas and Vibrio, indicating potential application for pathogen intervention treatments in processing of aquatic food products.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Biochemistry & Molecular Biology
Deepika Sharma, Krishan Kumar, Gopal Singh Bisht
Summary: Neuropeptides are small protein-like messenger molecules that play a role in regulating various activities in living organisms. They have diverse functions and can regulate cell signaling, growth, social behavior, and reproduction. Many neuropeptides have been identified and their association with various diseases has been discovered. Neuropeptides show promise as potential therapeutics, although research on them has only recently gained attention.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Sanjoy Pal, Trinath Chowdhury, Kishalay Paria, Sounik Manna, Sana Parveen, Manjeet Singh, Pralay Sharma, Sk Saruk Islam, Sk Md Abu Imam Saadi, Santi M. Mandal
Summary: The recent pandemic of COVID-19 poses a global threat to human health, with a focus on the rapid spread of the disease and the lack of proper therapeutic drugs. In the Indian subcontinent, herbal medicinal plants have gained attention as a potential treatment for COVID-19. The discussion includes the mechanism of action of phytochemicals in these plants against the virus and the potential for immune stimulation and inhibition of viral multiplication.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Bhupinder Kaur, Nitish Kumar, Sonam Chawla, Deepika Sharma, Suresh Korpole, Rajni Sharma, Manoj K. Patel, Kanwaljit Chopra, Om Prakash Chaurasia, Shweta Saxena
Summary: This study aimed to compare the volatile phytocomposition of snow mountain garlic (SMG) with normal garlic and investigate its anti-Candida efficacy against multi-drug resistant isolates of Candida species. The results showed that SMG has superior fungicidal power against C. albicans and C. glabrata compared to normal garlic. GC-MS profiling revealed unique volatile compounds and higher saponins content in SMG. In-silico analysis identified a potential inhibitor in SMG, suggesting a plausible anti-Candida mechanism. This study provides valuable insights into the potential use of SMG as a fungal phytotherapy agent.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Oncology
Deepika Sharma, Gopal Singh Bisht
Summary: This review article provides a brief overview of the advancements in cancer treatment through nanodelivery systems. The benefits of various nanocarriers and the targeted drug delivery approach are discussed, highlighting the selectivity and safety characteristics of nanodelivery systems compared to conventional drug delivery. The review also covers different targeting strategies, characteristics of ideal drug delivery systems, advantages of these systems, and future prospects.
CURRENT CANCER THERAPY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jiko Raut, Md Majharul Islam, Shrabani Saha, Santi M. Mandal, Sukhendu Mandal, Prithidipa Sahoo
Summary: In this study, blue luminous nitrogen-doped carbon quantum dots were developed for the differential detection of doxycycline. The suggested sensor exhibited high sensitivity and selectivity, making it ideal for measuring doxycycline in environmental applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Food Science & Technology
Piyush Baindara, Santi M. Mandal
Summary: Food spoilage caused by microbial growth is a global issue resulting in significant food waste daily. Plant-derived antimicrobial peptides (AMPs) offer potential as effective food preservatives due to their bioactivity against various pathogens. Developing synthetic AMPs from plants with higher bioactivity, better stability, and reduced cytotoxicity could benefit the food industry. However, challenges need to be addressed for the commercial use of AMPs in food preservation techniques.
Article
Chemistry, Multidisciplinary
Tamanna Roy, Surya Kanta Dey, Ananya Pradhan, Angsuman Das Chaudhuri, Malay Dolai, Santi M. Mandal, Sujata Maiti Choudhury
Summary: In this research, eco-friendly and cost-effective silver nanoparticles were synthesized and characterized. These nanoparticles showed significant antioxidant and antineoplastic effects both in vitro and in vivo. The nanoparticles induced cytotoxicity and oxidative stress in cancer cells, while enhancing the antioxidant status of the host. These findings suggest that these nanoparticles have potential applications in T-cell lymphoma therapy.
Article
Biochemistry & Molecular Biology
Santi M. Mandal
Summary: COVID-19 patients with happy hypoxia often have higher levels of nitric oxide (NO) compared to non-COVID-19 hypoxemics. Excessive production of reactive oxygen species (ROS) and oxidative stress decrease the level of NO, leading to mitochondrial dysfunction and hypoxia-mediated mortality in COVID-19. NO has a dual role of increasing oxygenation and inhibiting cytokine storm. Precise dosing of NO, along with NOS inhibitors, can help maintain optimal NO levels in patients. Monitoring NO levels is crucial in understanding the pathogenesis of COVID-19 and happy hypoxia.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Review
Medicine, General & Internal
Piyush Baindara, Sriradha Ganguli, Ranadhir Chakraborty, Santi M. Mandal
Summary: The vast surface area of the respiratory system is the initial contact site for microbes and foreign particles. Respiratory secretions contain host defense peptides (HDPs) that play a crucial role in the body's defense against respiratory infections. Understanding the regulation of HDPs during respiratory disorders can provide alternative methods for combating respiratory viral infections.
CLINICS AND PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Shrodha Mondal, Jiko Raut, Olivia Sarkar, Santi M. Mandal, Ansuman Chattopadhyay, Prithidipa Sahoo
Summary: In this research, carbon quantum dots were developed to trap 6-thioguanine (6TG) and disrupt the spreading of fire blight caused by the bacterium Erwinia amylovora. The effectiveness of this approach was validated in guava saplings, and the trapping mechanism was confirmed through confocal microscopic imaging. Various analytical tools were used to elucidate the quenching mechanism and establish the attributes of the nitrogen-doped carbon quantum dots. The research provides a novel and significant approach to prevent and manage fire blight.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jiko Raut, Md Majharul Islam, Rinchen D. Sherpa, Biraj Sarkar, Shanti M. Mandal, Subhra P. Hui, Sukhendu Mandal, Prithidipa Sahoo
Summary: Dichloroacetic acid (DCA), an organohalide found in environmental samples and biological systems, has therapeutic potential as a pyruvate dehydrogenase kinase (PDK) inhibitor. Researchers have developed cobalt conjugated carbon quantum dots (N-CQDs/Co) that selectively detect DCA using a fluorescence turn-on mechanism.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Piyush Baindara, Dinata Roy, Santi M. Mandal, Adam G. Schrum
Summary: The Omicron variant of SARS-CoV-2 exhibits altered peptide sequences in the spike protein, which may contribute to its higher infectivity compared to the original variant. Through analysis and in silico simulations, we predict that these alterations may affect the binding between the spike protein and the receptor Nrp1, potentially explaining the increased infectivity of the Omicron variant.
INFECTIOUS DISEASE REPORTS
(2022)
