Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

Decision making inxia2

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Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

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Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls

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Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway

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Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells

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Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

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REFMAC5 for the refinement of macromolecular crystal structures

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ANODE: anomalous and heavy-atom density calculation

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New role for an established drug? Bisphosphonates as potential anticancer agents

(2011) H K Koul et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

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Features and development ofCoot

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Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

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Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth

(2009) Hannu Mönkkönen et al.   ANTI-CANCER DRUGS

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

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Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

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Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases

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