Article
Polymer Science
Chung-Kai Sun, Cherng-Jyh Ke, Yi-Wen Lin, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: The study aims to establish an effective antibiotic slow-release system and evaluate its efficacy in preventing implant-related infections through an animal model experiment.
Article
Food Science & Technology
Moslem Sabaghi, Catherine Joly, Isabelle Adt, Keziban Ozturk, Amandine Cottaz, Pascal Degraeve
Summary: Enzymatic crosslinking by microbial transglutaminase can improve the physico-chemical properties of gelatin-based films and effectively control the release of lysozyme, a food preservative.
Article
Food Science & Technology
Yonggang Chen, Yuhang Wang, Ru Liu, Shanbai Xiong, Yan Xu, Yang Hu
Summary: In this study, microbial transglutaminase (MTG) was used to improve the gelling property of fish scale gelatin (FSG) from grass carp. The cross-linking of FSG by MTG increased its gel strength, textural property, and thermal property, with the effects varying with the concentration of MTG. In addition, the cross-linking of FSG by MTG also enhanced its digestion time and the release of unique peptides during gastric and intestinal digestion.
Article
Chemistry, Multidisciplinary
Jaehyung Jeon, Subin An, Jinseung Bae, Jaewon Kim, Jong-Sun Kang, Sungsu Park
Summary: This study developed a novel method for patterning structurally stable gelatin hydrogel gratings (GHG) on an elastic surface that can withstand high levels of cyclic stretching without detachment or tearing. The GHG on the PDMS surface withstood stretching at high ratios (15% and 20%) for several days. Myoblasts cultured on GHG differentiated into myotubes that were aligned along the grooves. When subjected to cyclic stretching at a ratio of 20%, these myotubes showed a significant increase in width, up to 57%. This method represents a significant advance in the field, providing a valuable platform for studying the effects of resistance exercise on muscle hypertrophy in vitro.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
G. M. Simsek, J. Barthes, C. Muller, G. B. McGuinness, N. E. Vrana, G. G. Yapici
Summary: Nickel-titanium shape memory alloys coated with polyvinyl alcohol/gelatin hydrogel were studied for their stability, corrosion resistance, and biocompatibility. The hydrogel coating did not affect the biocompatibility of the alloy, but significantly improved the corrosion resistance of the shape memory substrate and formed a cushion at the tissue-implant interfaces.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Materials Science, Biomaterials
Kamil Kopec, Michal Wojasinski, Michael Eichler, Hatice Genc, Ralf P. Friedrich, Rene Stein, Raminder Singh, Christoph Alexiou, Hanna Hlawaty, Tomasz Ciach, Iwona Cicha
Summary: Rapid endothelialization is crucial for overcoming the limitations of small-diameter vascular grafts. In this study, biomimetic coatings were developed using medical-grade polyurethane nanofibrous mats and tubular scaffolds. The coatings, consisting of polydopamine and gelatin, significantly enhanced endothelialization on both flat surfaces and small-diameter tubular scaffolds, as well as commercial vascular prostheses.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Applied
Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Karolynne Sousa Gomes, Raquel Aparecida Loss, Barbara Biduski, Christian Manera, Marcelo Godinho, Vandre Barbosa Briao, Aline Dettmer, Ionara Regina Pizzutti
Summary: This study aimed to extract gelatin from limed bovine hide wastes using steam explosion pretreatment and subsequent purification using ultrafiltration membranes. The results showed that temperature and extraction time had significant impacts on the gelatin yield and quality. Ultrafiltration membranes effectively reduced the ash content of gelatin solutions. Enzymatic treatment increased the molecular weight distribution of purified gelatins.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Alina Gabriela Rusu, Loredana Elena Nita, Natalia Simionescu, Alina Ghilan, Aurica P. Chiriac, Liliana Mititelu-Tartau
Summary: Development of a versatile hydrogel based on enzymatically-crosslinked gelatin and nanogels loaded with amoxicillin (Amox) is reported, demonstrating self-healing performance and tunable physical properties. The nanogels formed through self-assembly interactions contribute to the self-healing capacity and drug distribution within the hydrogel network. The physicochemical properties and drug release behavior of the hydrogels were studied, showing rapid release of amoxicillin in acidic conditions, indicating favorable characteristics for wound healing. In vitro and in vivo biocompatibility assays showed the potential of the optimized scaffolds as wound dressings.
Article
Polymer Science
Shouwei Zhao, Zhiwei Chen, Yaqi Dong, Wenhui Lu, Deyi Zhu
Summary: Mechanically enhanced gelatin-based composite hydrogels were developed using functionalized cellulose nanocrystals (CNCs) and microbial transglutaminase (mTG) as a binding agent, resulting in significantly improved mechanical properties and thermo-stability. The biocompatibility of the hydrogels was evaluated and showed no obvious inhibitory effect on cell proliferation, indicating great potential for biomedical applications.
Article
Chemistry, Applied
Hui Zheng, Meiyan Zhao, Qingfeng Dong, Min Fan, Li Wang, Li Li
Summary: In this study, melt extrusion was successfully applied to the preparation of gelatin composite films, improving their properties through non-covalent and covalent crosslinking. The resulting films exhibited reduced water solubility and increased tensile strength, making them potential candidates for commercial food packaging.
FOOD HYDROCOLLOIDS
(2022)
Article
Engineering, Biomedical
Yang Xue, Jun Chen, Tiexin Ding, Mengting Mao, Shengbo Zhu, Jianhong Zhou, Lan Zhang, Yong Han
Summary: A dual-layer coating, consisting of Fe2O3-FeOOH nanograins as the outer layer and Zn-doped microporous TiO2 as the inner layer, was fabricated using micro-arc oxidation, hydrothermal treatment, and annealing treatment. The coating showed excellent performance in killing bacteria, eliminating biofilm, and promoting soft tissue integration, which was attributed to the synergistic effect of photothermal response and released ions.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Buket Alkan Tas, Ekin Berksun, Cuneyt Erdinc Tas, Serkan Unal, Hayriye Unal
Summary: This study successfully immobilized lysostaphin (Lys), an important anti-staphylococcal agent, in a hybrid waterborne polyurethane/polydopamine (WPU/PDA) matrix to obtain highly effective antibacterial and antibiofilm surface coatings. These coatings exhibited strong anti-Staphylococcus aureus activity and maintained their antibacterial properties for at least 30 days.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Ting Ma, Chen-Xi Wang, Xi-Yuan Ge, Yu Zhang
Summary: This review summarizes the recent progress in research on dopamine and its derivatives as orthopedic and dental implant surface modification materials and analyzes the multiple functions of polydopamine.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Giovanna Rossi-Marquez, Maria Helguera, Manuel Briones, Cristian Aaron Davalos-Saucedo, Prospero Di Pierro
Summary: Edible coatings using mTG crosslinked whey protein-pectin are a promising alternative to enhance the shelf life of roasted peanut kernels, reducing peroxide value and water content while providing a better barrier effect to protect the kernels.
Article
Chemistry, Applied
Hongrui Chen, Di Wu, Wuchao Ma, Chao Wu, Jia Liu, Ming Du
Summary: In this study, strong fish gelatin hydrogels were successfully prepared by double crosslinking gelatin with transglutaminase (TGase) and kappa-carrageenan, resulting in significantly improved mechanical properties and thermal stability. The highest gel strength, compression fracture stress, and storage modulus were achieved when the concentration of TGase was 20 U/g gelatin. The thermal stability of the double crosslinked gelatin hydrogels was attributed to the presence of covalent crosslinks. The effect of TGase concentration on the physical properties and microstructure of the double crosslinked hydrogels was analyzed, and the differences between double crosslinked gelatin hydrogels and gelatin hydrogels single crosslinked by TGase or carrageenan were systematically compared.
