Article
Chemistry, Multidisciplinary
Yang Xue, Lan Zhang, Jianhong Zhou, Jun Chen, Yuwei Ma, Yong Han
Summary: This study demonstrates that bacterial cuproptosis-like death can be induced by low-dose supplement of Cu ions and mild heat stimulus. The use of Cu-doped hydroxyapatite nanorods (PC) on polyetheretherketone (PEEK) improves antibacterial activity and tissue integration. The photothermal strategy of PC shows promising application in improving PEEK performance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Ray Ong, Jillian Cornish, Jingyuan Wen
Summary: Bone and joint infections are a rare but serious problem worldwide. Lactoferrin has antimicrobial and bone-regenerating effects, which may help improve the treatment of bone and joint infections. However, its oral bioavailability in humans is highly variable due to potential degradation in the stomach and small intestine. Encapsulating lactoferrin in nanocarriers can enhance its absorption, stability, and oral bioavailability.
Article
Chemistry, Multidisciplinary
Xianhui Wei, Xiakun Zhang, Zhan Yang, Liang Li, Haitao Sui
Summary: This study utilized nanotechnology to synthesize IONSs-HA-SR@C for bone repair, demonstrating its excellent physicochemical properties and bioactivity. The material showed advantages in promoting cell proliferation and differentiation, improving mechanical strength, and antibacterial activity, providing a potential solution for bone defect repair and infection prevention.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Ceramics
M. Afifi, M. K. Ahmed, Hala A. Ibrahium, Nasser S. Awwad, E. Abdel-Fattah, Mohammad Y. Alshahrani
Summary: This study investigated nanocomposites based on hydroxyapatite (HAP), which showed improved human osteoblast viability and excellent antibacterial activity when combined with CuO and GO. The results suggest that the biomaterials have great biocompatibility for biomedical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Huan-Ming Chen, Hao-Yu Huang, Yang Xue, Kai Li, Tie-Xin Ding, Xiao-Jun Cai, Jun Chen, Lan Zhang
Summary: The study demonstrated that immobilized HA nanorods with HHC36 showed antibacterial activity, and pegylation significantly enhanced the antibacterial activity of immobilized HHC36 against Staphylococcus aureus. PEG12's flexibility increased the mobility of HHC36, allowing lateral diffusion of peptide molecules into microbial membranes, resulting in highly effective antibacterial activity.
Article
Food Science & Technology
Angela Michela Immacolata Montone, Francesca Malvano, Roberta Taiano, Rosanna Capparelli, Federico Capuano, Donatella Albanese
Summary: This study evaluated the effect of an alginate-based coating loaded with hydroxyapatite/lactoferrin/quercetin (HA/LACTO-QUE) complexes on the storage of pork meat. The results showed that QUE and LACTO were successfully adsorbed into HA crystals, and the release of LACTO from the coating was faster than QUE in an aqueous medium. The activated alginate-based coating effectively inhibited the growth of bacteria and maintained the quality of the pork meat during storage, with positive sensory evaluation results.
Article
Materials Science, Composites
Ibrahim M. Alarifi
Summary: In this study, artificial bones made of HA/PAN and PLA were developed as potential replacements for natural bone. Composite filaments were fabricated using HA/PAN and PLA and applied to produce reentrant artificial bone materials. Scanning electron microscopy and energy-dispersive X-ray spectroscopy were used to analyze the scaffold morphology and elemental composition. Compressive tests were conducted to determine the optimal scaffolding prototype and assess the mechanical behavior of the cellular structure. The results showed that the auxetic cells influenced the bone macrostructure and PLA/HA scaffoldings exhibited excellent potential for bone deficiency restoration.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
Wenxi Yan, Shan Zhang, Yinchuan Wang, Guiyong Xiao, Yupeng Lu
Summary: In this study, bundles of hydroxyapatite (HA) with oriented nanofibers were successfully synthesized by controlling the amount of carbonate addition and using oleic acid as a template in a solvothermal reaction system. The resulting product has excellent flexibility, mechanical strength, and great application potential.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Biochemistry & Molecular Biology
Sung Hyun Noh, Kanghyon Sung, Hye Eun Byeon, Sung Eun Kim, Keung Nyun Kim
Summary: This study investigated the use of lactoferrin-anchored tannylated mesoporous silica nanomaterials as bone fusion materials in a rat model. The results showed that these materials effectively promoted bone fusion and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
K. Perez Zapata, J. A. Lenis, P. Rico, J. L. Gomez Ribelles, F. J. Bolivar
Summary: Ti alloys are widely used in biomedical field due to their good balance between mechanical properties, corrosion resistance and biocompatibility. However, their incorporation in the human body can lead to unfavorable reactions. This study evaluated the influence of surface modification with hydroxyapatite and silicon coating on the biological response of Ti6Al4V alloy. The coatings promoted cell adhesion and exhibited potential non-toxic characteristics.
Article
Materials Science, Ceramics
Shuai-Bin Hua, Xi Yuan, Jia-Min Wu, Jin Su, Li-Jin Cheng, Wen Zheng, Ming-Zhu Pan, Jun Xiao, Yu-Sheng Shi
Summary: Amorphous bioglass has been used to improve the bioactivity of HA, but the crystallization of bioglass during sintering has made it difficult to tailor the properties of HA bioceramics. In this study, TPMS structural HA ceramics doped with akermanite showed increased porosity, bioactivity, and mechanical strength. The substitution of Ca2+ ions by Mg2+ ions from akermanite led to the decomposition of HA into beta-TCP, increasing porosity and enhancing mechanical strength. By optimizing the content of akermanite, bioceramics exhibited high porosity, appropriate compressive strength, enhanced in vitro bioactivity, and good biocompatibility, suitable for repairing cancellous bone defects.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Atchara Khamkongkaeo, Thanachai Boonchuduang, Wantana Klysubun, Penphitcha Amonpattaratkit, H-thaichnok Chunate, Nutth Tuchinda, Adulphan Pimsawat, Sujittra Daengsakul, Pitphichaya Suksangrat, Wutthigrai Sailuam, Drusawin Vongpramate, Atipong Bootchanont, Boonrat Lohwongwatana
Summary: In this study, hydroxyapatite powder was prepared by calcining Nile tilapia bone, and its structure and properties were investigated. The addition of magnesium was found to stabilize the β-TCP phase and improve the mechanical properties of the material, but it could also lead to the partial decomposition of the HAp phase.
CERAMICS INTERNATIONAL
(2021)
Review
Engineering, Multidisciplinary
Joachim Enax, Bennett T. T. Amaechi, Erik Schulze zur Wiesche, Frederic Meyer
Summary: Hydroxyapatite is a commonly used active ingredient in oral care products, which has preventive effects on oral health. This review analyzes the efficacy of natural ingredients commonly combined with hydroxyapatite, and finds that these ingredients have beneficial effects on oral health.
Article
Chemistry, Multidisciplinary
Magnus Mahl, M. A. Niyas, Kazutaka Shoyama, Frank Wuerthner
Summary: This study demonstrates the assembly of C-64 nanographene derivative with smaller PAHs into multilayer stacks and identifies dispersion forces as the main stabilizing factor for these complexes.
Article
Chemistry, Multidisciplinary
Haoyue Song, Meng Cai, Zhengyi Fu, Zhaoyong Zou
Summary: In this study, the influence of fluoride on the formation and stability of amorphous calcium phosphate (ACP) nanospheres was investigated. It was found that fluoride had little effect on the formation and particle size of ACP nanospheres, but increased the stability of ACP. Aggregation of ACP nanospheres and nucleation of crystalline phases were important steps during ACP crystallization, which were retarded in the presence of fluoride. Fluoride also promoted the formation of rod-like crystals on the surface of ACP nanospheres.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Yulu Yang, Rui Chen, Ke Li, Pengfei Gao, Yi Gong, Weihu Yang, Kaiyong Cai
Summary: The study demonstrates the effectiveness of ferroptosis in treating refractory DLBCL and identifies two subtypes of DLBCL with different clinical characteristics. Researchers developed a novel ferroptosis nanocarrier PBPMn@PEG, which can induce ferroptosis and apoptosis in lymphoma cells and exhibit better anti-tumor effects in animal experiments.
Article
Engineering, Biomedical
Wenbo Geng, Xuezhe Liu, Bailong Tao, Ye He, Ke Li, Pengfei Gao, Qian Feng, Peng Zhao, Zhong Luo, Kaiyong Cai
Summary: This study reports a new block polymer that can scavenge NO and release H2S for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrate that the polymer can suppress reactive oxygen species and pro-inflammatory cytokines, regulate macrophage phenotype, and mitigate synovial inflammation. This work provides new insight into the synergistic treatment of rheumatoid arthritis and other endogenous gas-related diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dan Li, Danyang Wang, Yulu Yang, Pengfei Gao, Wuzhe Fan, Xianhui Zhang, Yu Tang, Weihu Yang, Kaiyong Cai
Summary: In this study, the genomic characteristics of osteonecrosis of the femoral head (ONFH) were analyzed, and differentially expressed genes (DEGs) related to autophagy were identified. A modified titanium substrate was designed to upregulate HIF-1 alpha expression in mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) through receptors of TGF-beta and TNFR. The upregulated HIF-1 alpha in MSCs promoted autophagy and regulated MSCs proliferation and osteogenic differentiation, while in HUVECs, it accelerated angiogenesis by increasing VEGF expression. The modified titanium substrate enhanced the integration effect of the implant and reta\rded the deterioration of ONFH.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhang Yuan, Jianshuang Wu, Yao Xiao, Huan Yang, Siyu Meng, Liangliang Dai, Peng Li, Kaiyong Cai
Summary: The use of non-antibiotic strategies to combat refractory drug-resistant bacterial infections, especially biofilms and inflammation, has attracted widespread interest. In this study, a photo-therapeutic nanocomposite, MI-MPDA NPs, was developed using manganese dioxide (MnO2) nanozymes and indocyanine green (ICG)-loaded mesoporous polydopamine nanoparticles (MPDA). This nanocomposite can generate oxygen (O-2) in the infection microenvironment, effectively alleviating biofilm hypoxia. Under near-infrared light irradiation, the continuous oxygen supply enhances the production of singlet oxygen (O-1(2)), leading to robust biofilm elimination through photodynamic/photothermal therapy. Additionally, the nanocomposite down-regulates inflammatory signaling pathways and prevents macrophage polarization, promoting pro-regenerative M2 phenotype and wound healing. This O-2-potentiated photo-therapeutic strategy shows promise in combating drug-resistant biofilm infections and inflammation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuai Wang, Jixi Huang, Hanyin Zhu, Jing Zhu, Zhenqiang Wang, Yuxin Xing, Xiyue Xie, Kaiyong Cai, Jixi Zhang
Summary: A 2D allomelanin nanomodulator was prepared by DNA guidance to scavenge reactive oxygen species (ROS) for inflammation and prognosis control following photothermal therapy (PTT). Compared with conventional photothermal agents, the nanodisks greatly reduce ROS accumulation during PTT, downregulate proinflammatory factors, and effectively prevent burn wound progression and promote tissue repair. The study provides useful inspiration for rationally modulating redox active nanostructures to address prognosis issues following PTT.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biophysics
Yuhua Chen, Yuxin Xing, Zhenqiang Wang, Lin Li, Hailing Wang, Shuqi Tang, Kaiyong Cai, Jixi Zhang
Summary: A dual-factor coactivation strategy was developed to enhance tumor imaging by increasing the accessibility of cytosolic biomarkers. Application of a lysosomotropic agent facilitated the release of nanosensors, leading to a significant increase in intracellular fluorescence in vitro. The coactivation strategy also improved the cancer-to-normal cell signal ratio and resulted in high tumor-to-normal tissue ratio values in the in vivo imaging results. This strategy establishes a new paradigm for selective and specific tumor imaging using fluorescent nanosensors.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Multidisciplinary
Jinxiu Yu, Pengfei Gao, Yulu Yang, Dan Peng, Xianhui Zhang, Danyang Wang, Weihu Yang, Yu Tang, Kaiyong Cai
Summary: In this study, a functionalized titanium implant was developed by incorporating H2S donors into Ti nanotubes and coating with chitosan/gelatin multilayers to enhance osteointegration. By optimizing the polarization regulation of M1 to M2 macrophages, the phagocytosis and neovascularization functions of M1 macrophages can be maintained, while the anti-inflammatory response can be improved by M2 macrophages polarization. The immunomodulation of macrophages leads to efficient osteogenic differentiation of MSCs, promoting neovascularization and osteogenesis around the implants.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Engineering, Biomedical
Yao Ding, Genhua Liu, Shaopeng Liu, Xuan Li, Kun Xu, Peng Liu, Kaiyong Cai
Summary: In this study, a functionalization strategy for doping Tannic acid-d-tyrosine nanoparticles with photothermal profile into the hydrogel coating composed of konjac gum and gelatin on the surface of titanium (Ti) substrate is accurately constructed. The modified Ti implant significantly eliminates the residual bacteria, relieves inflammation, mediates macrophage polarization, and accelerates osseointegration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Maohua Chen, Menghuan Li, Xijiao Ren, Fei Zhou, Yanan Li, Lu Tan, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: A nanoengineered composite coating was developed to improve the in situ osseointegration of a Ti implant for osteoporotic fracture repair. The coating inhibited STING in endothelial cells to stimulate the formation of Type H vessels. Galvanotaxis recruited endothelial cells and mesenchymal stem cells to the implant surface, where released narigenin upregulated eNOS in recruited endothelial cells under ROS stimulation, leading to enhanced local angiogenesis. Coordinately released DNFzns abolished STING expression in endothelial cells to transform the newly formed vessels into Type H vessels, thereby promoting the osseointegration of Ti implants.
Article
Chemistry, Multidisciplinary
Kangkang Zha, Yuan Xiong, Wenqian Zhang, Meijun Tan, Weixian Hu, Ze Lin, Peng Cheng, Li Lu, Kaiyong Cai, Bobin Mi, Qian Feng, Yanli Zhao, Guohui Liu
Summary: This study explores the ability of humic acids (HAs) to modulate the inflammatory response, particularly macrophage polarization, and the potential underlying mechanism. A near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded with SEW2871 (SEW), a macrophage recruitment agent, was developed to treat bacteria-infected cutaneous wounds. The results show that HAs could promote M2 macrophage polarization in a dose-dependent manner. The Cu-HAs NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.
Article
Chemistry, Multidisciplinary
Ke Li, Kun Xu, Shaopeng Liu, Ye He, Meijun Tan, Yulan Mao, Yulu Yang, Jing Wu, Qian Feng, Zhong Luo, Kaiyong Cai
Summary: Researchers have developed an engineered multifunctional nanoplatform that combines low-temperature photothermal therapy (PTT) with ferroptosis and chemotherapy to effectively induce tumor cell death and eradicate tumor cells in vivo, prolonging the survival time of mice.
Article
Engineering, Biomedical
Jiawu Yu, Yuchen Zhang, Liqi Li, Yang Xiang, Xuemei Yao, Youbo Zhao, Kaiyong Cai, Menghuan Li, Zhongjun Li, Zhong Luo
Summary: By constructing a cooperative radio-ferroptosis-stimulatory nanomedicine, breast cancer cells can be selectively targeted and their sensitivity to radiotherapy can be enhanced.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Kangkang Zha, Wenqian Zhang, Weixian Hu, Meijun Tan, Shengming Zhang, Yongsheng Yu, Shuangquan Gou, Pengzhen Bu, Bikun Zhou, Yanan Zou, Yuan Xiong, Bobin Mi, Guohui Liu, Qian Feng, Kaiyong Cai
Summary: A bilayered gelatin/acryloyl & beta;-cyclodextrin hydrogel loaded with humic acids and astragaloside IV in the lower layer and verteporfin in the upper layer was developed to treat bacteria-infected cutaneous wounds. The hydrogel alleviates oxidative stress, promotes M2 macrophage polarization and angiogenesis during the inflammation and early proliferation phases, and inhibits excessive vessel growth during the late proliferation and remodeling phases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Yingqi Liu, Xuemei Yao, Youbo Zhao, De Fang, Lei Shi, Li Yang, Guanbin Song, Kaiyong Cai, Liqi Li, Qin Deng, Menghuan Li, Zhong Luo
Summary: This study reveals the important role of extracellular matrix stiffness in regulating tumor immunogenicity through the activation of the ROCK-myosin IIA-F-actin signaling pathway. Inhibiting this pathway can restore cGAMP production and enhance antitumor immunity, suggesting its potential as an immunotherapeutic target for solid tumor treatment.
Article
Chemistry, Physical
Genhua Liu, Ruichen Ma, Peng Liu, Kui Wang, Kaiyong Cai
Summary: This study developed a multifunctional nanocomposite hydrogel system that can prevent tumor recurrence, limit bacterial infections, and promote wound healing. The system demonstrated superior photothermal effects and antioxidant properties, resulting in synergistic therapeutic effects against bacteria and tumor cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
