Understanding high endothelial venules: Lessons for cancer immunology

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression

(2015) Diana Costa Bento et al.   OncoImmunology

Occurrence of Tertiary Lymphoid Tissue Is Associated with T-Cell Infiltration and Predicts Better Prognosis in Early-Stage Colorectal Cancers

(2014) G. Di Caro et al.   CLINICAL CANCER RESEARCH

Fibroblast-Type Reticular Stromal Cells Regulate the Lymph Node Vasculature

(2014) S. Chyou et al.   JOURNAL OF IMMUNOLOGY

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing

(2014) Mike Lee et al.   NATURE IMMUNOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Characteristics of tertiary lymphoid structures in primary cancers

(2014) Jérémy Goc et al.   OncoImmunology

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

The density and type of MECA-79-positive high endothelial venules correlate with lymphocytic infiltration and tumour regression in primary cutaneous melanoma

(2013) Gabriela Avram et al.   HISTOPATHOLOGY

Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation

(2013) Lucas Onder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Endothelial Venule Blood Vessels for Tumor-Infiltrating Lymphocytes Are Associated with Lymphotoxin  -Producing Dendritic Cells in Human Breast Cancer

(2013) L. Martinet et al.   JOURNAL OF IMMUNOLOGY

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

(2012) J. P. Hindley et al.   CANCER RESEARCH

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels

(2012) Young-Min Hyun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling through L-Selectin Mediates Enhanced Chemotaxis of Lymphocyte Subsets to Secondary Lymphoid Tissue Chemokine

(2012) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Targeting TNF-  to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy

(2012) A. Calcinotto et al.   JOURNAL OF IMMUNOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

p100 Deficiency Is Insufficient for Full Activation of the Alternative NF-κB Pathway: TNF Cooperates with p52-RelB in Target Gene Transcription

(2012) Agnes Lovas et al.   PLoS One

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High endothelial venules (HEVs) in human melanoma lesions

(2012) Ludovic Martinet et al.   OncoImmunology

The split nature of tumor-infiltrating leukocytes

(2012) Telma Lança et al.   OncoImmunology

Functional Contributions of N- and O-Glycans to L-Selectin Ligands in Murine and Human Lymphoid Organs

(2011) Hanayo Arata-Kawai et al.   AMERICAN JOURNAL OF PATHOLOGY

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

(2011) Domenico Coppola et al.   AMERICAN JOURNAL OF PATHOLOGY

High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes

(2011) C. Mionnet et al.   BLOOD

Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates

(2011) W. H. Fridman et al.   CANCER RESEARCH

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells

(2011) Meike Wendland et al.   IMMUNITY

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

(2011) Daniel T. Fisher et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking

(2011) S. F. Soriano et al.   JOURNAL OF IMMUNOLOGY

CCR7 Essentially Contributes to the Homing of Plasmacytoid Dendritic Cells to Lymph Nodes under Steady-State As Well As Inflammatory Conditions

(2011) S. Seth et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

(2010) R. T. Boscacci et al.   BLOOD

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

Classical NF-κB Activation Negatively Regulates Noncanonical NF-κB-dependent CXCL12 Expression

(2010) Lisa A. Madge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Anti-carbohydrate Antibodies Reveal the Cooperative Function of SulfatedN- andO-Glycans in Lymphocyte Homing

(2010) Jotaro Hirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Regulation of Cancer

(2010) Mary L. Disis   JOURNAL OF CLINICAL ONCOLOGY

Ontogeny of Stromal Organizer Cells during Lymph Node Development

(2010) C. Benezech et al.   JOURNAL OF IMMUNOLOGY

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes

(2009) E. J. Park et al.   BLOOD

Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody

(2009) N Pullen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lymphocytic Reaction to Colorectal Cancer Is Associated with Longer Survival, Independent of Lymph Node Count, Microsatellite Instability, and CpG Island Methylator Phenotype

(2009) S. Ogino et al.   CLINICAL CANCER RESEARCH

Cyclical expression of L-selectin (CD62L) by recirculating T cells

(2009) A. Klinger et al.   INTERNATIONAL IMMUNOLOGY

Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

(2009) Takahiro Nagatake et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid and Accurate Large-Scale Coestimation of Sequence Alignments and Phylogenetic Trees

(2009) K. Liu et al.   SCIENCE

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node

(2008) Friederike Pfeiffer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY

CD40L+CD4+memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming

(2008) Alfonso Martín-Fontecha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

(2008) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

(2008) Monika Pruenster et al.   NATURE IMMUNOLOGY

Migration of Dendritic Cell Subsets and their Precursors

(2007) Gwendalyn J. Randolph et al.   Annual Review of Immunology

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE