Journal
ONCOIMMUNOLOGY
Volume 5, Issue 5, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1115943
Keywords
Adoptive cell transfer; colorectal cancer; frameshift mutation; immunotherapy; microsatellite instablility; neoantigen; neopeptide; tumor-specific CD8(+) T cell
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Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
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