Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/2162402X.2014.988463
Keywords
c-di-GMP; IL-12; Listeria-Mage-b; metastatic breast cancer; STING ligand
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Funding
- NIA NIH HHS [R01 AG023096, T32 AG023475] Funding Source: Medline
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Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
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