Article
Dentistry, Oral Surgery & Medicine
Juliana Silva Ribeiro, Ester Alves Ferreira Bordini, Gabriel Kalil Rocha Pereira, Rohitha Rao Polasani, Cristiane Helena Squarize, Karla Zanini Kantorski, Luiz Felipe Valandro, Marco Cicero Bottino
Summary: Coating denture base material with cinnamon-laden nanofibers effectively reduces Candida albicans adhesion and proliferation, inhibiting fungal growth. Applying 20 wt.% cinnamon-laden nanofibers leads to a significant reduction in the growth of C. albicans while maintaining the viability of epithelial cells.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Polymer Science
Salwa Omar Bajunaid, Bashayer H. Baras, Michael D. Weir, Hockin H. K. Xu
Summary: This study investigated the incorporation of MPC and DMAHDM into a denture base material for the treatment of denture stomatitis. The results demonstrated that the dual incorporation of MPC and DMAHDM significantly reduced the adherence of C. albicans and could potentially reduce the prevalence of denture stomatitis. However, the addition of these bioactive agents reduced the flexural strength of the material and had some impact on surface roughness.
Article
Engineering, Biomedical
Carolina Montoya, Julia Kurylec, Alex Ossa, Santiago Orrego
Summary: This study investigated the effect of cyclic strain on the virulence of Candida albicans. The results showed that surfaces subjected to cyclic strain had significantly higher biofilm biomass and metabolic activity. Genes and transcription factors associated with adhesion, biofilm formation, secretion of extracellular matrix, virulence, and secretion of extracellular enzymes were significantly upregulated on cyclically strained surfaces compared to static surfaces. This study reveals a biomaterial surface factor triggering the pathogenesis of Candida albicans, which is important for understanding and preventing oral infections.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Doaa M. AlEraky, Hatem M. Abuohashish, Mohammed M. Gad, Muneer H. Alshuyukh, Amr S. Bugshan, Khalid S. Almulhim, Maha M. Mahmoud
Summary: This study demonstrated the antifungal and antibiofilm properties of caffeine against Candida albicans. It suggested caffeine as a potential disinfectant or alternative solution for fungal biofilms on denture surfaces.
Review
Polymer Science
Yousif A. A. Al-Dulaijan, Abdulrahman A. A. Balhaddad
Summary: DBR materials used in dentistry for constructing dentures and prostheses pose a high risk of denture stomatitis, causing inflammation of soft oral tissues. Fungal attachment, mainly by Candida albicans, to DBRs is a major cause of the disease. Attempts have been made to incorporate antimicrobial compounds and particles into DBRs to prevent microbial attachment. This review explores advanced approaches to designing bioactive and antimicrobial DBR materials, emphasizing the importance of mechanical and physical sustainability.
Article
Biotechnology & Applied Microbiology
Joel Oliveira Barreto, Francisca Bruna Stefany Aires do Nascimento, Said Goncalves da Cruz Fonseca, Leticia Serpa Sampaio, Cecilia Rocha da Silva, Joao Batista de Andrade Neto, Helio Vitoriano Nobre JUnior, Romulo Rocha Regis
Summary: The experimental solution containing Lippia sidoides essential oil showed antimicrobial activity against different pathogens, reduced the metabolic activity of C. albicans biofilm significantly, and caused cell wall damage at low concentrations, making it a potential alternative for the prevention and treatment of denture-induced infections.
Review
Chemistry, Medicinal
Yusen Shui, Jingya Li, Xiaoying Lyu, Yan Wang
Summary: This study aimed to compare the efficacy of phytotherapy for denture stomatitis with conventional therapies and placebo, showing that herbal medicines had fewer side effects and higher patient satisfaction compared to antifungal or disinfectant agents based on most of the studies included. Further randomized controlled trials with more standardized herbal formulations are needed to verify the clinical efficacy of phytotherapy for denture stomatitis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mike Herdman, Ilona Johnson, Stephen Mason, Christopher R. Vernazza, Roshan Varghese
Summary: This study aimed to develop a cost-effectiveness model to evaluate the feasibility of denture cleaning strategies for preventing denture stomatitis from the perspective of denture wearers in the United Kingdom. The model identified and estimated the costs and effects associated with three denture cleaning strategies. Results showed the total costs and incremental cost-effectiveness ratios, highlighting the lack of evidence on the relative effectiveness of different cleaning strategies and the need for further research.
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Chemistry, Physical
Helena Sandrini Venante, Ana Paula Chappuis-Chocano, Oscar Oswaldo Marcillo-Toala, Rafaela Alves da Silva, Rodrigo Moreira Bringel da Costa, Mariana Domingues Pordeus, Benedito Barraviera, Rui Seabra Ferreira Junior, Vanessa Soares Lara, Karin Hermana Neppelenbroek, Heitor Marques Honorio, Vinicius Carvalho Porto
Summary: This study evaluated the effectiveness of fibrin biopolymer with digluconate chlorhexidine or Punica granatum alcoholic extract in preventing Candida albicans biofilm. The results showed that the FBCh group performed better in inhibiting the growth of C. albicans biofilm in both PMMA materials analyzed.
Article
Dentistry, Oral Surgery & Medicine
Claudia Viviane Guimaraes Pellissari, Janaina Habib Jorge, Lina Maria Marin, Robinson Sabino-Silva, Walter Luiz Siqueira
Summary: The study evaluated the effect of statherin and its naturally occurring peptides on Candida albicans metabolism and biofilm development. The peptides were found to decrease the viability and proliferation of Candida albicans, with IT-32 showing the most significant reduction in cell proliferation and biomass. These results suggest that statherin peptides have potential in reducing Candida albicans colonization and biofilm proliferation.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Oncology
Abdul Rahman Saeed Al-Ghamdi, H. M. Khuthija Khanam, Zeeshan Qamar, Nishath Sayed Abdul, Naveen Reddy, Swetha Vempalli, Mohammed Noushad, Waleed M. S. Alqahtani
Summary: The efficacy of curcumin-mediated photodynamic therapy (CUR-PDT) as an adjunct to antifungal gel treatment in denture stomatitis (DS) patients was assessed by evaluating the levels of interleukin-6 (IL-6) and matrix metalloproteinases-8 (MMP-8) in saliva, as well as Candida species counts. The results showed that CUR-PDT can effectively reduce Candida species counts and improve the levels of IL-6 and MMP-8 in DS patients' saliva.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Helena Salgado, Ana T. P. C. Gomes, Ana S. Duarte, Jose M. F. Ferreira, Carlos Fernandes, Maria Helena Figueiral, Pedro Mesquita
Summary: This study tested the antimicrobial activity and surface roughness of a graphene-enhanced dental resin against Candida albicans and Streptococcus mutans. The increase in graphene concentration resulted in increased surface roughness. Graphene was effective in inhibiting the growth and adhesion of C. albicans and S. mutans.
Article
Chemistry, Physical
Salwa O. Bajunaid, Bashayer H. Baras, Abdulrahman A. Balhaddad, Michael D. Weir, Hockin H. K. Xu
Summary: This study aimed to investigate the effects of incorporating MPC into a new HIPA resin on the surface roughness, solution pH, and C. albicans biofilm adhesion to denture base. The results showed that incorporating 4.5% MPC led to a significant reduction in colony-forming units compared to the control group.
Article
Infectious Diseases
Andrew R. Dentino, DongHwa Lee, Kelley Dentino, Arndt Guentsch, Mohammadreza Tahriri
Summary: The study showed that as the density of phosphate in polymers increased, the metabolism of biofilms decreased. Loading CPC on phosphate disks significantly reduced biofilm metabolism, while a salivary pellicle only enhanced the antimicrobial activity of CPC on uncharged PMMA surfaces.
Review
Chemistry, Physical
Razia Z. Adam, Saadika B. Khan
Summary: This systematic review aimed to determine if silver nanoparticles inhibit the growth of Candida albicans in acrylic dentures and denture liners. Analysis of 18 studies showed that increasing the concentration of silver nanoparticles can reduce the growth of Candida albicans.
