The role of sphingolipids in respiratory disease

The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Ceramide Is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease

(2010) Malcolm Brodlie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutral Sphingomyelinase 2

(2010) Simone Filosto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Obligate Role for Membrane-Associated Neutral Sphingomyelinase Activity in Orienting Chemotactic Migration of Human Neutrophils

(2010) Robert G. Sitrin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Membrane raft–lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin

(2010) Min Xia et al.   CARDIOVASCULAR RESEARCH

Ceramide in Pseudomonas aeruginosa Infections and Cystic Fibrosis

(2010) Katrin Anne Becker et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature

(2010) Wolfgang M. Kuebler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Regulated Secretion of Acid Sphingomyelinase

(2010) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-mediated Inhibition of Apoptotic Cell Clearance by Alveolar Macrophages

(2010) Daniela N. Petrusca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle

(2010) Agnieszka Blachnio-Zabielska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Critical Modifier Role of Membrane-Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Ceramide Signaling in Lung Injury and Emphysema

(2010) M. Bodas et al.   JOURNAL OF IMMUNOLOGY

Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection

(2010) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice

(2010) Yoshihiko Chiba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Modulation of Chemokines and Allergic Airway Inflammation by Selective Local Sphingosine-1-phosphate Receptor 1 Agonism in Lungs

(2010) D. Marsolais et al.   MOLECULAR PHARMACOLOGY

Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma

(2010) Yoshihiko Chiba et al.   PHARMACOLOGICAL RESEARCH

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

(2010) P. Puneet et al.   SCIENCE

SPHINGOSINE KINASE INHIBITION ALLEVIATES ENDOTHELIAL PERMEABILITY INDUCED BY THROMBIN AND ACTIVATED NEUTROPHILS

(2010) Kiyoshi Itagaki et al.   SHOCK

Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death

(2009) Michal Levy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ceramide-dependent PP2A regulation of TNFα-induced IL-8 production in respiratory epithelial cells

(2009) Timothy T. Cornell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Stimulation of Sphingosine 1-Phosphate Signaling as an Alveolar Cell Survival Strategy in Emphysema

(2009) Khalil J. Diab et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis

(2009) Katrin Anne Becker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Systemic Administration of Sphingosine-1-Phosphate Increases Bronchial Hyperresponsiveness in the Mouse

(2009) Fiorentina Roviezzo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential Effects of Sphingosine 1–Phosphate Receptors on Airway and Vascular Barrier Function in the Murine Lung

(2009) Saad Sammani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates

(2009) Anke G. Roth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis

(2009) Joachim Riethmüller et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat

(2009) Oliver Murch et al.   CRITICAL CARE MEDICINE

Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase

(2009) Y. Yang et al.   EUROPEAN RESPIRATORY JOURNAL

Peptidoglycan Induces Cyclooxygenase-2 Expression in Macrophages by Activating the Neutral Sphingomyelinase-Ceramide Pathway

(2009) Bing-Chang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent Regulation of Periarteriolar and Perivenular Nitric Oxide Mechanisms in theIn VivoHamster Cheek Pouch Microvasculature

(2009) David D. Kim et al.   MICROCIRCULATION

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

(2009) David Marsolais et al.   NATURE REVIEWS DRUG DISCOVERY

Sphingosine kinase 1 regulates mucin production via ERK phosphorylation

(2009) Yuko Kono et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide

(2008) Irina Petrache et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model

(2008) Teruaki Nishiuma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Improved Pulmonary Function by Acid Sphingomyelinase Inhibition in a Newborn Piglet Lavage Model

(2008) Philipp von Bismarck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sphingolipids in the Lungs

(2008) Stefan Uhlig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apoptotic Sphingolipid Signaling by Ceramides in Lung Endothelial Cells

(2008) Terry R. Medler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells

(2008) Si Jin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Allergy therapy: The therapeutic potential of targeting sphingosine kinase signalling in mast cells

(2008) Alirio J. Melendez   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse

(2008) Ricardo J. Giordano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-  Involves Protein Kinase C-  in Lung Epithelial Cells

(2008) C. J. Clarke et al.   MOLECULAR PHARMACOLOGY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

A Prospective, Cross-sectional Survey Study of the Natural History of Niemann-Pick Disease Type B

(2008) M. M. McGovern et al.   PEDIATRICS