Review
Biochemistry & Molecular Biology
Tasuku Tamai, Kenji Ihara
Summary: Celiac disease is an autoimmune disease caused by gluten ingestion that primarily affects the small intestine. It is prevalent worldwide, but often goes undiagnosed, especially in Asian countries like Japan. This paper provides an overview of the epidemiology, diagnosis, and treatment of celiac disease, as well as summarizing reported Japanese cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Andrea Costantino, Matilde Topa, Leda Roncoroni, Luisa Doneda, Vincenza Lombardo, Davide Stocco, Andrea Gramegna, Claudio Costantino, Maurizio Vecchi, Luca Elli
Summary: A study found that 25.2% of Italian CD patients had hesitancy towards COVID-19 vaccines, with a 4.8% refusal rate. The main reason for hesitancy was fear of adverse events related to vaccination. Determinants positively influencing willingness to be vaccinated included adherence to a GFD, good knowledge about COVID-19 and its vaccines, and a positive attitude towards previous vaccines.
Review
Pediatrics
Sumit K. Singh, Anshu Srivastava
Summary: Celiac disease is a gluten-related disorder that affects all age groups. The worldwide prevalence of CD is around 1% and is higher in certain at-risk groups. Diagnosis requires serology and duodenal histology, and treatment involves a strict gluten-free diet. However, many patients, especially those who were diagnosed in childhood, receive no medical or dietary supervision after transitioning to adulthood, leading to non-compliance and potential complications. It is crucial to educate patients about CD, the importance of a strict gluten-free diet, regular follow-up, and disease complications before the transition to ensure better long-term outcomes.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Marco Valvano, Stefano Fabiani, Sabrina Monaco, Mauro Calabro, Antonio Mancusi, Sara Frassino, Claudia Rolandi, Marta Mosca, Susanna Faenza, Emanuele Sgamma, Nicola Cesaro, Giovanni Latella
Summary: Celiac disease is a chronic enteropathy caused by gluten ingestion in genetically susceptible individuals. The only recommended treatment is a gluten-free diet, but unintentional gluten ingestion or refractory celiac disease with persistent villous atrophy poses a major challenge. This review analyzed data from randomized controlled trials and observational studies to evaluate adjunctive and novel therapies for CD and RCD. Although a gluten-free diet remains the only effective treatment, steroids, mesalamine, and biological therapies have shown promise in managing RCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Pediatrics
Shruti Sakhuja, Lori R. Holtz
Summary: A subset of patients initially with negative biopsy for celiac disease later develop histopathologic celiac disease, with slower progression in some cases. Regular reassessment is recommended for children with serological signs of celiac disease despite normal small bowel biopsy results.
Review
Biochemistry & Molecular Biology
Serena Scapaticci, Annamaria Venanzi, Francesco Chiarelli, Cosimo Giannini
Summary: Celiac disease is an immune-mediated disorder caused by the ingestion of gluten. It can present as asymptomatic or with multiple systemic symptoms. The rising obesity rates have led to an increased possibility of diagnosing celiac disease in obese patients, who may also have obesity-related disorders such as metabolic associated fatty liver disease (MAFLD). The exact mechanisms linking celiac disease and obesity-related disorders are not yet known, but a gluten-free diet and alterations in the gut-liver axis may play a role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Barbara Erthal Smeral Dutra, Dongguang Wei, Dongfeng Tan, Mazen Alasadi, Hao Chi Zhang, Austin Thomas, Anusha Shirwaikar Thomas, David Matthew Richards, Yinghong Wang
Summary: This study describes the clinical course and endoscopic features of patients with positive celiac serology post-cancer therapy exposure. The results suggest that patients with celiac disease after cancer therapy may experience diarrhea, malnutrition, and death, but a gluten-free diet could be effective in symptom management.
Article
Medicine, General & Internal
Rakel Nurmi, Camilla Pasternack, Teea Salmi, Kaisa Hervonen, Inka Koskinen, Jutta Jarvelin, Heini Huhtala, Pekka Collin, Jukka Mustonen, Katri Kaukinen, Satu Makela
Summary: Patients with celiac disease have an increased risk of kidney diseases, particularly IgA nephropathy. This risk is phenotype-dependent and is not observed in patients with dermatitis herpetiformis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Cara Dochat, Niloofar Afari, Danielle Arigo
Summary: Through analyzing data from 453 adults with self-reported Celiac disease, the study found that the English CD-QOL has good internal consistency reliability, convergent validity, and known groups validity. Compared to generic instruments, the CD-QOL appears to better capture specific cognitive and affective aspects of living with Celiac disease, making it a valuable tool for measuring disease-specific quality of life.
QUALITY OF LIFE RESEARCH
(2023)
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Chiara Monachesi, Anil K. Verma, Giulia N. Catassi, Tiziana Galeazzi, Elisa Franceschini, Valentina Perticaroli, Elena Lionetti, Carlo Catassi
Summary: This study investigated the level of gluten contamination in the daily diet of celiac children on a gluten-free diet. Results showed that in a country with high celiac disease awareness, the daily unintended exposure to gluten of treated celiac children on regular follow-up is very low, and did not exceed the tolerable threshold of gluten intake in the gluten-free diet.
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Article
Biochemistry & Molecular Biology
Jorma Isola, Markku Maeki, Martin Hils, Ralf Pasternack, Keijo Viiri, Valeriia Dotsenko, Toni Montonen, Timo Zimmermann, Ralf Mohrbacher, Roland Greinwald, Detlef Schuppan
Summary: In this study, the accumulation of ZED1227 after oral administration of the drug was studied. It was found that ZED1227 mainly accumulated in the villous enterocytes and had an inhibitory effect on TG2 activity. These findings are significant for the treatment of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)