Review
Cell Biology
Milena Tucic, Vera Stamenkovic, Pavle Andjus
Summary: TnC plays a crucial role in regulating cell proliferation and migration during adult neurogenesis, with implications for regenerative therapies. Understanding ECM signaling in the CNS niche is essential for potential therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Nan Yao, Yulin Li, Jinrui Han, Siting Wu, Xin Liu, Qiuyu Wang, Zhiguo Li, Fu-Dong Shi
Summary: This study reveals the detrimental role of microglia in neurogenesis and neurorepair after intraventricular hemorrhage (IVH), with CC chemokine ligand 20 (CCL20) playing a likely role in promoting pro-inflammatory responses and neural injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Ana C. Delgado, Angel R. Maldonado-Soto, Violeta Silva-Vargas, Dogukan Mizrak, Thomas von Kanel, Kelly R. Tan, Alex Paul, Aviv Madar, Henar Cuervo, Jan Kitajewski, Chyuan-Sheng Lin, Fiona Doetsch
Summary: Adult neural stem cells in the ventricular-subventricular zone of mice can generate glial cells in addition to neurons, with certain domains remaining quiescent under normal conditions. Our study also uncovers an intraventricular oligodendrocyte progenitor derived from NSCs that is recruited upon injury.
Review
Clinical Neurology
Yue Li, Weixiang Guo
Summary: Adult neurogenesis is a crucial process that generates new and functional neurons from neural stem cells throughout life. Maintaining the proper function of the neurogenic niche requires niche cells to respond to external cues and adapt their roles to influence NSC behavior. Understanding the interactive regulation of NSCs and neurogenesis by the neurogenic niche is important for maintaining the integrative process and functional integrity of the adult brain.
Article
Biochemistry & Molecular Biology
Luke L. Liu, Richard M. van Rijn, Wei Zheng
Summary: The subventricular zone in the adult brain contains high amounts of copper, which is linked to the stability of adult neurogenesis in this region. This study shows that chelating copper ions using a copper chelator can reduce copper levels in the subventricular zone and enhance the differentiation and migration of neural stem/progenitor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Toxicology
Bunichiro Ogawa, Yutaka Nakanishi, Masaki Wakamatsu, Yasunori Takahashi, Makoto Shibutani
Summary: Acrylamide (AA) is a neurotoxicant that inhibits synaptic function and neural cell differentiation in the hippocampus and olfactory bulb-subventricular zone (OB-SVZ) region. AA exposure decreased neuroblasts in the OB by suppressing neuronal migration and downregulating genes related to neuronal differentiation and migration. These findings indicate that AA has a similar detrimental effect on neurogenesis in the OB-SVZ as it does in the hippocampus.
TOXICOLOGY LETTERS
(2023)
Review
Neurosciences
Mihai Ceanga, Mahmoud Dahab, Otto W. Witte, Silke Keiner
Summary: In the aftermath of a stroke, the brain undergoes various signaling cascades that reshape both the perilesional zone and more distant regions. Stroke leads to a significant increase in adult neurogenesis, offering hope for neurological recovery. However, there are significant regional differences in the effects of neurogenesis in the SVZ and SGZ post-stroke on functional recovery.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yingxun Liu, Junrong Ren, Mengsi Kang, Chenyang Zhai, Qiangqiang Cheng, Jin Li, Yuzi Wu, Xiaofei Ruan, Jinlong Zhou, Juan Fan, Yingfang Tian
Summary: Research shows that PGRN treatment promotes acute functional recovery and stimulates neurogenesis in the subventricular zone after cerebral ischemia, which is beneficial for long-term recovery. The increase in neurogenesis may be associated with activation of the MAPK/ERK and PI3K/Akt pathways, suggesting a potential new strategy utilizing PGRN in ischemic stroke therapy.
Article
Biochemistry & Molecular Biology
Katja Baur, Yomn Abdullah, Claudia Mandl, Gabriele Hoelzl-Wenig, Yan Shi, Udo Edelkraut, Priti Khatri, Anna M. Hagenston, Martin Irmler, Johannes Beckers, Francesca Ciccolini
Summary: According to the current consensus, murine neural stem cells generate differentiated progenitors either through rare asymmetric divisions or by relocating to the basal side of the ventricular-subventricular zone. However, this study finds that adult-born olfactory bulb interneurons largely derive from a different type of neural stem cells residing in the basal V-SVZ. These basal neural stem cells differ from apical neural stem cells in terms of Nestin expression, primary cilia extension, cell division frequency, and activation of Notch-related genes.
Review
Biochemistry & Molecular Biology
Perla Leal-Galicia, Maria Elena Chavez-Hernandez, Florencia Mata, Jesus Mata-Luevanos, Luis Miguel Rodriguez-Serrano, Alejandro Tapia-de-Jesus, Mario Humberto Buenrostro-Jauregui
Summary: The generation of new neurons in the adult brain is a well-accepted phenomenon that mainly occurs in the subventricular zone and the hippocampal dentate gyrus. These new neurons are generated through an asymmetric division process and contribute to the local circuitry with their unique properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Haoyang Li, Li Xu, Wei Jiang, Xiusheng Qiu, Huiming Xu, Fan Zhu, Yu Hu, Shuzhen Liang, Chengcheng Cai, Wei Qiu, Zhengqi Lu, Yaxiong Cui, Changyong Tang
Summary: This study reveals that cognitive impairment is associated with a decline in adult hippocampal neurogenesis (AHN). Pleiotrophin (PTN) expression decreases with aging, leading to impaired AHN and poor learning and memory. The study shows that PTN interacts with protein tyrosine phosphatase receptor type Z1 (PTPRZ1) to promote neural stem and progenitor cell (NSPC) proliferation and differentiation through AKT signaling. Overexpression of PTN or pharmacological activation of AKT signaling in aging mice restores AHN and improves memory deficits.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Gurvan Dissaux, Brieg Dissaux, David Bourhis, Ulrike Schick, Solene Querellou
Summary: Glioma stem cells may originate from neural stem cells in the adult subventricular zone, and a tumor-background ratio greater than 1.6 in SVZ on F-18-FET PET/CT could indicate glioblastoma recurrence, highlighting the need for attention to the SVZ due to the potential development of GSC.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Psychiatry
Jenny Nyberg, Sara Gustavsson, Maria A. I. aberg, H. Georg Kuhn, Margda Waern
BRITISH JOURNAL OF PSYCHIATRY
(2020)
Article
Clinical Neurology
Sara Vive, Jean-Luc af Geijerstam, H. Georg Kuhn, Lina Bunketorp-Kall
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
(2020)
Article
Behavioral Sciences
Simon Skau, Ingibjorg H. Jonsdottir, Anna Sjors Dahlman, Birgitta Johansson, H. Georg Kuhn
Summary: The study found that patients with Exhaustion Disorder (ED) have altered functional activity in the prefrontal cortex, indicating a difference in information processing in the prefrontal cortex compared to healthy individuals.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Multidisciplinary Sciences
Susanne Neumann, Michelle J. Porritt, Ahmed M. Osman, H. Georg Kuhn
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Yuki Ohkawa, Anna Wade, Olle R. Lindberg, Katharine Y. Chen, Vy M. Tran, Spencer J. Brown, Anupam Kumar, Mausam Kalita, C. David James, Joanna J. Phillips
Summary: Heparan sulfate plays a crucial role in promoting receptor tyrosine kinase signaling in glioblastoma, contributing to tumor growth and invasion. Cells deficient in heparan sulfate show decreased proliferation and activation of multiple RTKs, leading to impaired tumor establishment and growth in vivo. Furthermore, heparan sulfate regulates the ligand-receptor interaction of platelet-derived growth factor receptor alpha, affecting sensitivity to targeted RTK inhibition in human GBM tumorspheres and murine GBM models.
MOLECULAR CANCER RESEARCH
(2021)
Article
Neurosciences
Lars Karlsson, Maria Nazareth Gonzalez-Alvarado, Reza Motalleb, Yafeng Wang, Yong Wang, Mats Borjesson, Changlian Zhu, Hans-Georg Kuhn
Summary: Physical exercise can improve age-dependent cognitive decline by restoring neurogenesis, with myokines serving as a link between muscle and brain communication. However, chronic muscular overexpression of PGC-1 alpha does not translate into exercise-induced effects on hippocampal neurogenesis, despite differences in serum composition. This suggests that activation of PGC-1 alpha in skeletal muscle alone is not enough to mimic exercise-induced effects or prevent neurogenesis decline with aging.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Marion Walser, Johan Svensson, Lars Karlsson, Reza Motalleb, Maria Aberg, H. Georg Kuhn, Jorgen Isgaard, N. David Aberg
Summary: In recent years, evidence has been accumulating on hemoglobin synthesis in both animal and human brains. The neuroprotective activities of growth hormone and insulin-like growth factor-I against ischemia and neurodegenerative diseases appear to be influenced by systemic and local brain hemoglobin concentrations, with further exploration needed in specific experiments.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
N. D. Aberg, M. Adiels, M. Lindgren, J. Nyberg, H. Georg Kuhn, J. Robertson, M. Schaufelberger, N. Sattar, M. Aberg, A. Rosengren
Summary: The study revealed a significant shift in early-onset cardiovascular disease events among young individuals over time, showing a transition from acute myocardial infarction and cardiovascular disease mortality to heart failure and stroke incidence. These trends were found to be moderately impacted by changes in baseline Body Mass Index and cardiorespiratory fitness.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Neurosciences
Sravani Devarakonda, Dilip Kumar Malipatlolla, Piyush Patel, Rita Grander, H. Georg Kuhn, Gunnar Steineck, Fei Sjoberg, Ana Rascon, Margareta Nyman, Yohanna Eriksson, Jolie Danial, Ella Ittner, Rukaya Naama Walid, Olena Prykhodko, Spandana Masuram, Marie Kalm, Cecilia Bull
Summary: The study aimed to investigate the impact of radiation to the colorectum on hippocampal neurogenesis in mice, and whether a fiber-rich diet could modulate this impact. Results showed that pelvic radiotherapy may have a long-lasting effect on hippocampal neurogenesis, and dietary interventions, such as a fiber-rich diet, could potentially mitigate this impact. Analysis of serum cytokines revealed a negative correlation between MIP1-a levels and the number of immature neurons one week after irradiation.
Article
Psychiatry
Jenny Nyberg, Malin Henriksson, Alexander Wall, Torbjorn Vestberg, Maria Westerlund, Marion Walser, Robert Eggertsen, Louise Danielsson, H. Georg Kuhn, N. David Aberg, Margda Waern, Maria Aberg
Summary: Anxiety severity in patients with anxiety disorders was found to be associated with executive functions, particularly working memory, independently of comorbid major depression, but not with lower fluid intelligence. Compared to a normed population, anxiety patients performed significantly worse on tests related to working memory, suggesting cognitive impairment in this population.
Article
Clinical Neurology
Malin Henriksson, Alexander Wall, Jenny Nyberg, Martin Adiels, Karin Lundin, Ylva Bergh, Robert Eggertsen, Louise Danielsson, H. Georg Kuhn, Maria Westerlund, N. David Aberg, Margda Waern, Maria Aberg
Summary: A 12-week exercise intervention with different intensities was found to effectively reduce anxiety symptoms in patients with anxiety disorders. Both exercise groups showed significant improvements compared to the control group, without differences in effect sizes, indicating a trend for intensity and symptom improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Simon Skau, Kristoffer Sundberg, Hans-Georg Kuhn
Summary: This paper proposes a set of unifying definitions that are useful in all areas of fatigue research while remaining neutral to various theories about fatigue. By establishing 13 distinct definitions of fatigue and fatigue-related phenomena, it helps facilitate communication between different researchers, link phenomena from divergent research fields together, facilitate application and knowledge production.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Aberg, Josefina Robertson, Demir Djekic, Annika Rosengren, Maria Schaufelberger, Georg Kuhn, N. David Aberg, Linus Schioler, Martin Lindgren
Summary: A Swedish study found that body mass index at 18 years old can predict the risk of early acute coronary events, especially in the highest weight category at 40 years old.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Sport Sciences
Aron Onerup, Kirsten Mehlig, Agnes af Geijerstam, Elin Eblom-Bak, Hans Georg Kuhn, Lauren Lissner, Maria Aberg, Mats Borjesson
Summary: This study found that in healthy young men, there is an association between cardiorespiratory fitness and the incidence of specific site cancers. Higher cardiorespiratory fitness is associated with a lower risk of cancers in the head and neck, esophagus, stomach, pancreas, liver, colon, rectum, kidney, and lung. However, higher cardiorespiratory fitness is associated with a higher risk of prostate cancer and malignant skin cancer.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Neurosciences
Simon Skau, Ola Helenius, Kristoffer Sundberg, Lina Bunketorp-Kall, Hans -Georg Kuhn
Summary: This study examines the relationships between mathematical cognition, general cognition, and neural foundation in 8 to 9-year-old children. The findings suggest that proactive control plays a more significant role in mathematical performance compared to other cognitive abilities, such as processing speed and attention. Functional near-infrared spectroscopy (fNIRS) imaging reveals differences in brain activity between proactive and reactive control, with increased activation in the left lateral prefrontal cortex during reactive beneficiary situations. Additionally, the dorsal medial prefrontal cortex shows increased activity in a text-based task involving additive reasoning compared to a task with spatial-geometric information.
TRENDS IN NEUROSCIENCE AND EDUCATION
(2022)
