Journal
ONCOIMMUNOLOGY
Volume 4, Issue 5, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/2162402X.2014.988476
Keywords
antigen presentation; anti-tumor immunity; plasmacytoid dendritic cells; Th17
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Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.
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