Article
Immunology
Qiaxuan Li, Daipeng Xie, Lintong Yao, Hongrui Qiu, Peimeng You, Jialong Deng, Congsen Li, Weijie Zhan, Maotao Weng, Shaowei Wu, Fasheng Li, Yubo Zhou, Fanjun Zeng, Yong Zheng, Haiyu Zhou
Summary: The study investigated the potential of autophagy-immune-derived biomarkers in predicting prognosis and therapeutic response in lung adenocarcinoma patients. It identified a gene signature based on autophagy and immune factors that could stratify patients into high-risk and low-risk groups. The low-risk group showed greater immune infiltration, higher expression of immune checkpoint molecules, and a higher potential for responding to immunotherapy. The study also identified immune- and autophagy-related pathways that differed between the high-risk and low-risk groups. The findings suggest that this gene signature could be a useful tool for guiding personalized targeted therapy or immunotherapy in lung adenocarcinoma patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Adria Hasan, Suroor Fatima Rizvi, Sana Parveen, Neelam Pathak, Aamir Nazir, Snober S. Mir
Summary: Cancer formation is a complex process regulated by the microenvironment. Autophagy and ROS play important regulatory roles in cancer development, but their effects are multifaceted. This review explores the regulatory roles of autophagy and ROS from tumor induction to metastasis, as well as discussing therapeutic strategies and research gaps in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Cell Biology
Jorge Moscat, Ana Maria Cuervo, Maria T. Diaz-Meco
Summary: The mechanisms of immunosurveillance and immunoevasion are crucial in determining whether a tumor cell survives and the role of autophagy in promoting catabolism and detoxification for transformed cells is significant in the cancer microenvironment.
Article
Oncology
Ji In Kang, Dong Hyun Kim, Ki Woon Sung, Sang Mi Shim, Hyunjoo Cha-Molstad, Nak Kyun Soung, Kyung Ho Lee, Joonsung Hwang, Hee Gu Lee, Yong Tae Kwon, Bo Yeon Kim
Summary: Cancer-associated fibroblasts (CAFs) play an important role in tumor progression. The autophagy adaptor protein p62 is up-regulated in early stages of CAFs in lung adenocarcinoma. Inhibiting p62-induced autophagy can impair CAF activation and reduce TGFβ production, leading to inhibition of tumor growth.
Article
Cell Biology
Xiaona Xie, Xueding Cai, Yemeng Tang, Chunhui Jiang, Feng Zhou, Lehe Yang, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao, Xiaoying Huang
Summary: Flubendazole, a traditional anthelmintic drug, exhibits potent antitumor activity in non-small cell lung carcinoma (NSCLC) by suppressing STAT3 activity and activating autophagy. It has the potential to be a new therapeutic agent for NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Aaron G. Whitt, Aaron M. Neely, Omar Sadi Sarkar, Shuhan Meng, Sengodagounder Arumugam, Kavitha Yaddanapudi, Chi Li
Summary: Recent research has shown that PON2 is upregulated in various types of tumors, potentially playing a role in modulating lung cancer development by suppressing oxidative stress and apoptosis. However, the specific effects of PON2 on lung cancer cell proliferation and tumor initiation are still unknown.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Wenhua Xu, Jiajun Cui, Linqing Wu, Caigu He, Gang Chen
Summary: Chronic exposure to arsenic negatively affects T cell anti-tumor immunity, promoting lung cancer development. The up-regulation of PD-1/PD-L1 and increase in Tregs, along with decreased CD8/Treg ratio, hinder T cell anti-tumor function in the lungs, enhancing lung tumorigenesis. Inhibition of PD-1/PD-L1 shows potential as a preventive strategy to mitigate the tumorigenic effects of chronic arsenic exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Hariprasad Thangavel, Kezia Lizardo, Dhanya Dhanyalayam, Sonia De Assis, Jyothi F. Nagajyothi
Summary: Breast cancer is one of the most diagnosed cancer types, and the association between obesity and breast cancer risk varies by age. A short-term high-fat diet delays tumorigenesis, while a regular diet may increase tumor occurrence and metastasis in young mice. It suggests that the pathogenesis of breast cancer is regulated by diet composition, adipogenesis, and loss of body fat, which differs between young and post-menopausal subjects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang
Summary: Rab37 regulates IL-6 secretion in macrophages to induce M2 polarization, promoting PD-1 expression in CD8(+) T cells. Tumors with high stromal Rab37 and IL-6 levels are associated with immunotherapeutic resistance and poor prognosis in lung cancer patients.
Article
Immunology
Jingyan Gao, Fei Lu, Jiawen Yan, Run Wang, Yaoxiong Xia, Li Wang, Lan Li, Li Chang, Wenhui Li
Summary: This study investigated the prognostic role of radiotherapy-related autophagy genes (RRAGs) in lung adenocarcinoma (LUAD) and identified three biomarkers. The findings enhanced the understanding of the relationship between radiotherapy, autophagy, and prognosis in LUAD and provided potential therapeutic targets for LUAD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhi Nie, Dating Cheng, Chenglong Pan, Zhimin Wei, Chenyang Wang, Chunyan Wang
Summary: The study revealed that SH3BGRL3 is highly expressed in GBM and glioma stem cells, and its high expression is associated with poor survival in GBM patients. SH3BGRL3 is directly regulated by STAT3, forming a positive feedback loop that enhances the tumorigenic potential of GBM.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qun Zhao, Xinran Cheng, Jian Guo, Yun Bi, Li Kuang, Jianhua Ren, Jing Zhong, Longrui Pan, Xudong Zhang, Yang Guo, Yongqiang Liu, Shu Jin, Yan Tan, Xianjun Yu
Summary: MLKL plays a suppressive role in intestinal tumorigenesis by inhibiting the IL-6/JAK2/STAT3 signaling pathway, reducing the risk of intestinal tumor development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Milad Ashrafizadeh, Sepideh Mirzaei, Kiavash Hushmandi, Vahid Rahmanian, Amirhossein Zabolian, Mehdi Raei, Mahdi Vasheghani Farahani, Mohammad Ali Sheikh Beig Goharrizi, Haroon Khan, Ali Zarrabi, Saeed Samarghandian
Summary: Lung cancer is a major cause of death worldwide, with various risk factors such as genetics, epigenetics, and environmental factors playing a role in its development. The AMP-activated protein kinase (AMPK) signaling pathway is crucial in lung cancer progression, influencing metastasis, proliferation, and response to treatments like chemotherapy and radiotherapy. AMPK activation can both enhance and suppress lung cancer progression, indicating its complex and dual role in cancer cells.
Article
Biochemistry & Molecular Biology
Rania Faouzi Zaarour, Mohak Sharda, Bilal Azakir, Goutham Hassan Venkatesh, Raefa Abou Khouzam, Ayesha Rifath, Zohra Nausheen Nizami, Fatima Abdullah, Fatin Mohammad, Hajar Karaali, Husam Nawafleh, Yehya Elsayed, Salem Chouaib
Summary: This study revealed the activation of autophagy in lung cancer cells exposed to waterpipe smoke and investigated its relationship with smoking status in lung adenocarcinoma patients. Smokers exhibited a higher tumor mutational burden, higher CD8+ T-cell level, and lower dysfunction level compared to non-smokers. While there were no relative differences in the expression of immune checkpoint genes between smokers and non-smokers, other genes including B7-1, B7-2, IDO1, and CD200R1 showed higher expression in non-smokers. Therefore, targeting autophagy in smoker patients with lung adenocarcinoma, in combination with checkpoint inhibitor-targeted therapies or chemotherapy, should be considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
