Journal
PEERJ
Volume 6, Issue -, Pages -Publisher
PEERJ INC
DOI: 10.7717/peerj.5650
Keywords
Xeno-miRNA; Network analysis; miRNA; Cross-species communication; Exosome
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Genome Canada
- Canada Research Chairs (CRC) Program
- NSERC
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Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Based on computational predictions, many more miRNAs could be potentially transferred to human circulation system. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool-Xeno-miRNet-to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca.
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