Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Clement Bresteau, Aurelien Amiot, Julien Kirchgesner, Nicola De'Angelis, Jeremie H. Lefevre, Yoram Bouhnik, Yves Panis, Laurent Beaugerie, Matthieu Allez, Antoine Brouquet, Franck Carbonnel, Antoine Meyer
Summary: A retrospective study of 247 patients who underwent IPAA surgery between 2011 and 2019 found a 5-year cumulative incidence of CP or CDP of 35.3%. Risk factors included IBDU diagnosis, age less than 35 at surgery, articular manifestations, and other extra-intestinal manifestations.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Scott Friedberg, David Choi, Thomas Hunold, Natalie K. Choi, Nicole M. Garcia, Emma A. Picker, Nathaniel A. Cohen, Russell D. Cohen, Sushila R. Dalal, Joel Pekow, Atsushi Sakuraba, Noa Krugliak Cleveland, David T. Rubin
Summary: In this study, the authors reported a large real-world experience with the use of upadacitinib in patients with ulcerative colitis and Crohn's disease. They found that upadacitinib was rapidly effective and safe, even in patients who had prior exposure to tofacitinib.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Shahana Prakash, Tomohiro Tanaka, Divya Ashat
Summary: Indeterminate colitis (IC) is a subtype of inflammatory bowel disease (IBD) with features of both Crohn's disease (CD) and ulcerative colitis (UC). This study examines the characteristics of patients hospitalized with IC in the United States (US) and compares them with patients admitted with CD and UC. The study also analyzes trends in cost and length of stay.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
Summary: Maternal smoking during pregnancy has an impact on the risk of Crohn's disease in adult offspring. Personal smoking and genetic risk amplify this effect.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Frank Phillips, Bram Verstockt, Malgorzata Sladek, Nanne de Boer, Konstantinos Katsanos, Konstantinos Karmiris, Ahmad Albshesh, Carl Erikson, Daniel Bergemalm, Tamas Molnar, Pierre Ellul
Summary: There is a correlation between orofacial granulomatosis (OFG) and Crohn's disease (CD), which can occur before, concurrently with, or after CD diagnosis. Perianal and upper gastrointestinal diseases are common associations, with a significant symptom burden in many patients. Remission can be achieved with various immunosuppressive treatments, including several biologics approved for CD.
JOURNAL OF CROHNS & COLITIS
(2022)