Article
Cell Biology
Qiang Fu, Qian Shen, Jin Tong, Liu Huang, Yi Cheng, Wei Zhong
Summary: Our study demonstrates that TNFR2 antagonist can inhibit Tregs function and suppress breast tumor cell proliferation, suggesting it as a potential therapeutic strategy for breast cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Hao Deng, Bin Xiao, Yinger Huang, Kongyan Weng, Jialing Chen, Kun Li, Hongfeng Wu, Shuhong Luo, Wenbo Hao
Summary: This study explores the oncolytic effects of the parapoxvirus Orf virus (ORFV) and demonstrates the potential therapeutic strategy for breast cancer via ORFV. The combination treatment of ORFV and PAK4 inhibitor effectively improves the oncolytic effect of ORFV by inhibiting cell viability, inducing apoptosis, and suppressing cell migration and invasion.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Fei Wang, Chong Yuan, Bo Liu, Yan-Fang Yang, He-Zhen Wu
Summary: This study isolated Syringin and demonstrated its anti-breast cancer effects. Bioinformatics analysis revealed the target genes and potential mechanisms of Syringin against breast cancer. In vitro experiments confirmed that Syringin inhibits proliferation and migration and promotes apoptosis in breast cancer cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Lisa Gherardini, Giovanni Inzalaco, Francesco Imperatore, Romina D'Aurizio, Lorenzo Franci, Vincenzo Miragliotta, Adele Boccuto, Pierpaolo Calandro, Matteo Andreini, Alessia Tarditi, Mario Chiariello
Summary: DDX3X has been shown to have pro-tumorigenic effects in breast cancer, making it a potential molecular target for novel personalized therapeutic approaches. The inhibitor FHP01 has demonstrated effective antiproliferative and tumor killing activity in vitro and in vivo against various breast cancer cells, with good bioavailability and no toxicity, highlighting its potential as a therapeutic strategy against breast cancer, including the triple-negative subtype.
Article
Biochemistry & Molecular Biology
Woo Dae Jang, Mi Young Lee, Jihye Mun, Gyutae Lim, Kwang-Seok Oh
Summary: FoxM1 is a transcription factor that is overexpressed in most human cancers and is involved in tumor development. We discovered a small molecule called CDI that inhibits the interaction between FoxM1 and DNA. CDI suppressed cell proliferation and induced cell death in breast cancer cells. It also reduced the expression of FoxM1 and its downstream targets. Additionally, CDI was shown to bind to the DNA interaction site of FoxM1 and inhibit its function.
Article
Biochemistry & Molecular Biology
Myeongjin Jeon, Sungpyo Hong, Hyoungmin Cho, Hanbyeol Park, Soo-Min Lee, Soonkil Ahn
Summary: This study investigates the therapeutic potential of a novel dual inhibitor of FAK and PYK2, named SJP1602, for TNBC. In vitro experiments demonstrate that SJP1602 effectively inhibits FAK and PYK2 activities, showing potent effects on both kinases. In vivo studies confirm significant dose-dependent inhibition of tumor growth by SJP1602 in TNBC xenograft models.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shinya Takahashi, Farhana Ferdousi, Seri Yamamoto, Atsushi Hirano, Sachiko Nukaga, Hiroyuki Nozaki, Hiroko Isoda
Summary: The present study investigated the anti-inflammatory effects of Botryococcus terribilis ethanol extract (BTEE) on LPS-induced inflammation in RAW264 cells. BTEE significantly inhibited the production of nitric oxide and inflammatory cytokines, while promoting the expression of anti-inflammatory mediators. Whole-genome microarray analysis revealed that BTEE downregulated genes related to stimulus response, locomotion, and immune system response, and upregulated genes associated with cell cycle. Pathway and protein-protein interaction analyses suggested the potential role of BTEE as an Axl inhibitor. These findings demonstrate the anti-inflammatory properties of BTEE and its potential therapeutic value as an Axl inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zhiyong Shi, Yang Gao, Lifeng Feng, Wencong Tian, Zhihua Dou, Chen Liu, Jie Liu, Yang Xu, Yachen Wang, Jie Yan, Qiang Wu, Jing Li, Liang Yang, Zhaocai Zhang, Jie Yang, Zhi Qi
Summary: The active camel whey fraction TR35 has been shown to suppress the growth and promote apoptosis of NSCLC cells by affecting MAPK and Jak-STAT pathways. In a xenograft nude mouse model, TR35 demonstrated inhibition of tumor growth, indicating its potential as a therapeutic agent against lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yaping Chen, Hao Huang, Yuan Li, Wenlu Xiao, Yingting Liu, Rongzhang Chen, Yulan Zhu, Xiao Zheng, Changping Wu, Lujun Chen
Summary: Combination immunotherapy based on immune checkpoint inhibitors (ICIs) has shown great success in cancer treatment, and the combination of ablation and immunotherapy has potential for the treatment of liver metastasis of colorectal cancer (CRC). The expression of TIGIT was up-regulated after microwave ablation (MWA), and the combination of MWA and TIGIT blockade significantly promoted the expansion and functions of CD8(+) tumor-infiltrating lymphocytes (TILs) and reshaped myeloid cells in the tumor microenvironment (TME).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Miriam Bazan-Peregrino, Rocio Garcia-Carbonero, Berta Laquente, Rafael Alvarez, Ana Mato-Berciano, Marta Gimenez-Alejandre, Sara Morgado, Alba Rodriguez-Garcia, Maria Maliandi, M. Carmen Riesco, Rafael Moreno, Mireia M. Ginesta, Mercedes Perez-Carreras, Joan B. Gornals, Susana Prados, Sofia Perea, Gabriel Capella, Ramon Alemany, Ramon Salazar, Emma Blasi, Carmen Blasco, Manel Cascallo, Manuel Hidalgo
Summary: The study showed that VCN-01 can replicate in PDAC models and improve antitumor effects when combined with chemotherapy. The hyaluronidase produced by VCN-01 degrades tumor stroma and facilitates the delivery of various therapeutic agents. Clinically, VCN-01 treatment was well-tolerated and resulted in disease stabilization of injected lesions.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Nehad M. Ayoub, Sara K. Jaradat, Kamal M. Al-Shami, Amer E. Alkhalifa
Summary: Angiogenesis plays a vital role in the growth and spread of solid cancers, but breast cancer has shown poor response to anti-angiogenic drugs. Assessing the angiogenic signaling mechanisms in breast cancer, exploring new drug targets, and improving treatment outcomes through vascular normalization and nanotechnology are important areas of research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Ke, Hongbo Wang, Xiangxuan Zhao, Zaiming Lu
Summary: The Foeniculum vulgare extract has shown anti-cancer effects on HCC cells by reducing cell viability, inducing apoptosis, and inhibiting cell migration. Studies in nude mice also demonstrated significant inhibition of HCC growth. Mechanistic analyses suggest that the extract targets the oncoprotein survivin, sensitizing HCC cells to apoptosis while sparing normal liver cells.
Article
Biochemistry & Molecular Biology
Shuquan Zhang, Yu Liu, Ji Zhou, Jiaxin Wang, Guangyi Jin, Xiaodong Wang
Summary: A novel tumor vaccine containing MUC1 antigen and two adjuvants was developed by the research group, which effectively and safely prevented and treated tumors expressing MUC1 antigen by enhancing specific humoral and cellular immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Shan Wang, Rong-Hong Zhang, Hong Zhang, Yu-Chan Wang, Dan Yang, Yong-Long Zhao, Guo-Yi Yan, Guo-Bo Xu, Huan-Yu Guan, Yan-Hua Zhou, Dong-Bing Cui, Ting Liu, Yong-Jun Li, Shang-Gao Liao, Meng Zhou
Summary: A series of DAPY derivatives were designed, synthesized, and evaluated for their potential as FAK inhibitors with strong antitumor and anti-angiogenesis activities. Compounds 11b and 12f showed potent inhibition of FAK enzymatic activities, antiproliferative effects on cancer cells, and suppression of migration and invasion. Additionally, they induced apoptosis, arrested cell cycle, and inhibited the FAK/PI3K/Akt signal pathway in cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Qingfang Zeno, Cairong Luo, Junlae Cho, Donna Lai, Xiangchun Shen, Xiaoyan Zhang, Wei Zhou
Summary: Tryptanthrin inhibited proliferation, migration, and invasion of MCF-7 cells by modulating the inflammatory tumor microenvironment, and showed anti-tumor activity in a murine breast cancer model. The study suggests that Tryptanthrin may be an effective and safe anti-breast cancer agent.
ACTA PHARMACEUTICA
(2021)
Article
Pathology
Simon Haefliger, Alexandar Tzankov, Stephan Frank, Michel Bihl, Alfonso Vallejo, Juerg Stebler, Juergen Hench
Summary: NUT midline carcinoma is an aggressive neoplasm with chromosomal rearrangements of the NUT gene. The article presents a strategy to detect this rare tumor through DNA methylation array analysis, using molecular data and computational strategies. This combined approach can detect the unusual cell lineage of NUT midline carcinomas for diagnostic use.
Article
Pathology
Simon Haefliger, Spasenija Savice Prince, Julien Rebetez, Heinz Borer, Lukas Bubendorf
Summary: Malignant pleural mesothelioma (MPM) is a rare and deadly disease, and the distinction between reactive and malignant mesothelial cells, especially with the proposed precursor MPMIS, can be challenging. Fluorescence in situ hybridization (FISH) for detection of 9p21 deletion is a powerful diagnostic tool in this context.
Article
Pathology
Simon Haefliger, Muriel Genevay, Michel Bihl, Romina Marone, Daniel Baumhoer, Michael Papaloizos, Matthias S. Matter, Beata Bode-Lesniewska
Summary: Myoepithelial neoplasms of soft tissue are rare tumors with clinical, morphological, immunohistochemical, and genetic heterogeneity. The diagnosis often requires immunostaining to confirm myoepithelial differentiation. In some cases, tumors may have typical morphology but with immunophenotype that fails to confirm myoepithelial differentiation, termed as myoepithelioma-like tumors.
Article
Surgery
Romano Schneider, Marko Kraljevic, Ralph Peterli, Theresa Rohm, Angela J. T. Bosch, Andy J. Y. Low, Lena Keller, Shefaa AlAsfoor, Simon Haefliger, Bahtiyar Yilmaz, Caspar J. Peterson, Ioannis I. Lazaridis, Pascale Vonaesch, Tarik Delko, Claudia Cavelti-Weder
Summary: In obese mice, a longer biliopancreatic limb (BPL) is associated with enhanced weight loss and improved glucose tolerance. However, its effects on hepatic steatosis and adipose tissue inflammation are not significant. Additionally, bariatric surgery dramatically alters gut microbiota.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Review
Oncology
Simon Haefliger, Vanghelita Andrei, Daniel Baumhoer
Summary: The craniofacial skeleton is a complex anatomical region containing bone sarcomas that differ from peripheral counterparts. Involvement of a multidisciplinary team is necessary for optimal diagnosis and treatment planning. Advances in molecular characterization have increased diagnostic accuracy and hold promise for identifying therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Daniel Turek, Simon Haefliger, Baptiste Ameline, Ilaria Alborelli, Byron Calgua, Wolfgang Hartmann, Dorothee Harder, Adrienne M. Flanagan, Fernanda Amary, Daniel Baumhoer
Summary: Brown tumors are rare bone lesions associated with hyperparathyroidism. This study found that brown tumors may be true neoplasms driven by the activation of the RAS-MAPK signaling pathway. Regression of brown tumors after normalization of hyperparathyroidism suggests a second hit mediated by endocrine stimulation is required for tumor development. Brown tumors have a pathogenic relation to nonossifying fibroma and giant cell granuloma of the jaws.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Cell Biology
Simon Haefliger, Katharina Marston, Ilaria Alborelli, Edouard-Jean Stauffer, Mathias Gugger, Philip M. Jermann, Sylvia Hoeller, Luigi Tornillo, Luigi M. Terracciano, Michel Bihl, Matthias S. Matter
Summary: The molecular profile analysis of Swiss CRC patients reveals the frequent occurrence of mutations in genes such as TP53, KRAS, and PIK3CA. This study is the first to uncover the molecular landscape of CRC in Switzerland.
Article
Cell Biology
Simon Haefliger, Juergen Hench, Colm J. O'Rourke, Nathalie Meyer-Schaller, Sarp Uzun, Joan Saldarriaga, Achim Weber, Luca Mazzucchelli, Philip Jermann, Stephan Frank, Jesper B. Andersen, Luigi Terracciano, Christine Sempoux, Matthias S. Matter
Summary: This study analyzed the genetic and epigenetic alterations of hepatocellular adenomas (HCA) with atypical morphological features, and found differences with hepatocellular carcinoma (HCC) or HCA without atypical morphology. Therefore, targeted sequencing and/or combined methylation/copy number profiling should be performed to differentiate between HCC and HCA when diagnosis is difficult.
Article
Pathology
Simon Haefliger, Daniel Turek, Vanghelita Andrei, Ilaria Alborelli, Byron Calgua, Baptiste Ameline, Dorothee Harder, Daniel Baumhoer
Summary: Cemento-osseous dysplasia (COD) is a benign fibro-osseous lesion that occurs exclusively in the tooth-bearing areas of the jaws. It can be classified into periapical, focal, and florid subtypes based on the site and extent of involvement, which share the same histomorphology. Most cases are asymptomatic and self-limited, requiring no specific treatment. The molecular pathogenesis of COD, specifically the mechanism underlying the spontaneous growth arrest in most lesions, is still unknown.
Editorial Material
Hematology
Simon Haefliger, Alexandar Tzankov
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Infectious Diseases
Gaetan-Romain Joliat, Sebastiao N. Martins-Filho, Simon Haefliger, Nicolas Demartines, Nermin Halkic, Ismail Labgaa, Christine Sempoux
Summary: This study analyzed the prognostic value of PD-L1 expression in tissue samples of patients with AE undergoing surgery. It found that patients with lower PD-L1 expression had better disease-free survival. These findings highlight the potential importance of PD-L1 in AE and the role of immune checkpoint blockade as a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Simon Haefliger, Olga Chervova, Christopher Davies, Steven Nottley, Steven Hargreaves, Vaiyapuri P. Sumathi, Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephan Beck, Adrienne M. Flanagan, Iben Lyskjaer
Summary: Epithelioid sarcoma is a rare and aggressive tumor characterized by the loss of SMARCB1 expression. Limited research attention and therapeutic options exist for this disease. Methylation profiling helps distinguish epithelioid sarcoma from other tumors, and immunotherapy may be a promising treatment strategy.
JOURNAL OF PATHOLOGY
(2023)
Review
Medical Laboratory Technology
Vanghelita Andrei, Simon Haefliger, Daniel Baumhoer
Summary: The diagnosis of mesenchymal neoplasms in superficial soft tissue is challenging due to their rarity and overlapping features. The classification of these tumors has expanded to include potential new entities that were described after the publication of the 5th edition of WHO classification in 2020. Although non-mesenchymal tumors are more common in the skin and superficial soft tissue, specific entities in the mesenchymal category can express epithelial markers, highlighting the importance of being aware of diagnostic pitfalls. This article provides an overview on the differential diagnosis of these mesenchymal tumors in the skin.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2023)
Article
Orthopedics
Simon Haefliger, Judith Bubbear, Christropher Davies, Lucia Cottone, Fernanda Amary, Roberto Tirabosco, Isidro Cortes-Ciriano, Paul O'Donnell, Adrienne M. Flanagan
Summary: This study presents a case of a 60-year-old Italian patient with Paget disease of bone and an osteoclast-rich tumor. Through analysis of clinical, morphological, and genetic data, the authors suggest that osteoclast-rich lesions in Paget disease of bone are genetically distinct from classical giant cell tumor of bone. The importance of differentiating these lesions is discussed.
SKELETAL RADIOLOGY
(2023)
Article
Pathology
Daniel Baumhoer, Simon Haefliger, Baptiste Ameline, Wolfgang Hartmann, Fernanda Amary, Arjen Cleven, Michael J. Klein, Lester D. R. Thompson, Dorothee Harder, Paul O'Donnell
Summary: A study on 20 fibro-osseous lesions found that these tumors are distinct from existing classifications, making them difficult to categorize. Unlike fibrous dysplasia, ossifying fibroma and cemento-osseous dysplasia primarily develop in the cranio-facial region.
HEAD & NECK PATHOLOGY
(2022)
