Article
Anatomy & Morphology
Chelsea A. Johnson, Yanni Liu, Noah Waller, Soo-Eun Chang
Summary: This study compared the white matter diffusivity characteristics of the cerebellar peduncles in children who stutter and control children using diffusion MRI. The results showed that children who stutter had lower FA values in the right inferior cerebellar peduncle compared to controls. This difference may impact error monitoring and sensory input processing, affecting motor adjustments.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Hiroshi Nagahama, Masahiko Wanibuchi, Toru Hirano, Mitsuhiro Nakanishi, Hiroyuki Takashima
Summary: The cerebellum communicates with the cerebral cortex via the superior, middle, and inferior cerebellar peduncles (CPs). Diffusion tensor tractography (DTT) is a technique capable of depicting the major fiber bundles in CPs, but routine use for brainstem visualization remains challenging. Visualizing CPs using high-resolution DTT may aid in surgical planning and intraoperative guidance, but challenges exist related to the smallness and complexity of the brainstem.
ACTA NEUROCHIRURGICA
(2021)
Article
Neuroimaging
Sebastian M. Toescu, Lisa Bruckert, Rashad Jabarkheel, Derek Yecies, Michael Zhang, Christopher A. Clark, Kshitij Mankad, Kristian Aquilina, Gerald A. Grant, Heidi M. Feldman, Katherine E. Travis, Kristen W. Yeom
Summary: Cerebellar mutism syndrome is a common complication following resection of medulloblastoma in children, and is associated with damage to the superior cerebellar peduncles. This study found that post-operative reductions in fractional anisotropy (FA) in the distal left superior cerebellar peduncle were highly specific to cerebellar mutism syndrome.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pediatrics
Yong-Ho Choi, Jong-Min Lee, Joo Young Lee, Ji Young Lee, Young-Jun Lee, Ja Hye Ahn, Hyun Ju Lee
Summary: The study found that the white matter maturation of VLBW infants is associated with neurodevelopmental outcomes at 18 months of corrected age, with particular significance in the MCP region. The FA values in the MCP region are significantly related to cognitive and motor scores, potentially predicting cognitive and motor impairments in infants.
Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Alexander Rau, Wolfgang H. Jost, Theo Demerath, Elias Kellner, Marco Reisert, Horst Urbach
Summary: This study analyzed diffusion microstructure imaging (DMI) in patients with suspected atypical Parkinson syndromes and healthy controls. The results showed widespread axonal loss in PSP patients, and the ROI-based approach had the highest accuracy in identifying PSP in the thalamus and frontal white matter.
Article
Sport Sciences
Xiaoao Xue, Rong Lu, Hong Li, Ziyi Chen, Dandan Sheng, Zhengbiao Jin, Shiyin Liu, Ailin Liu, Xu Yan, Weijun Tang, Shuang Chen, Yinghui Hua
Summary: Participants with chronic ankle instability (CAI) exhibit altered neural injuries in the middle and inferior cerebellar peduncles compared to healthy controls. These alterations are correlated with the duration and severity of ankle instability.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Review
Neurosciences
Parnian Shobeiri, Sedighe Hosseini Shabanan, Maryam Haghshomar, Shaghayegh Khanmohammadi, Soudabeh Fazeli, Houman Sotoudeh, Arash Kamali
Summary: This study aimed to investigate the microstructural abnormalities and cerebellar changes associated with OCD using DTI investigations. The results showed that alterations in cerebellar white matter integrity and diffusivity parameters were linked to different symptoms of OCD. Changes in connectivity between the cerebellum and other brain areas were also observed.
Article
Medicine, General & Internal
Sungeun Hwang, Chang-Hyun Park, Regina Eun-Young Kim, Hyeon Jin Kim, Yun Seo Choi, Sol-Ah Kim, Jeong Hyun Yoo, Ki Wha Chung, Byung-Ok Choi, Hyang Woon Lee
Summary: Structural changes were observed in cerebellar white matter in CMT patients with NEFL mutations, while abnormal diffusion tensor imaging findings were found in specific cerebellar regions associated with NEFL and GJB1 mutations. The presence of cerebellar ataxia was linked to cerebellar white matter abnormalities in the NEFL subgroup, highlighting the importance of neuroimaging in detecting these abnormalities in CMT patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Donnie Cameron, David A. Reiter, Fatemeh Adelnia, Ceereena Ubaida-Mohien, Christopher M. Bergeron, Seongjin Choi, Kenneth W. Fishbein, Richard G. Spencer, Luigi Ferrucci
Summary: Diffusion-tensor magnetic resonance imaging (DT-MRI) can objectively measure muscle characteristics and provide insights into age-related changes. In this study, DT-MRI was used to examine the microstructure and architecture of skeletal muscle in a large healthy aging cohort. The results showed age-related differences in muscle structure and differences in microstructure among different muscles.
Review
Neurosciences
Maryam Haghshomar, Parnian Shobeiri, Seyed Arsalan Seyedi, Fatemeh Abbasi-Feijani, Amirhossein Poopak, Houman Sotoudeh, Arash Kamali
Summary: Diffusion tensor imaging (DTI) is a valuable research tool for evaluating neural fibers in Parkinson's disease (PD) and can provide insights into the microstructural changes in white matter. This study utilized the PRISMA 2020 framework to identify relevant articles and selected 68 papers for synthesis. The results suggest that reductions in cerebellar white matter integrity, as measured by DTI, are associated with PD symptoms and stages. PD patients with postural instability and gait difficulty show different DTI changes in the cerebellum compared to those with tremor dominant PD. Freezing of gait is strongly related to cerebellar involvement depicted by DTI. Other symptoms such as cognitive decline, visual disturbances, and sleep disorders are not related to cerebellar microstructural changes on DTI, while impulsive-compulsive behavior can be linked to cerebellar white matter alteration. Furthermore, higher PD stages and longer disease duration are associated with cerebellum white matter alteration depicted by DTI.
Article
Medicine, General & Internal
Jeong-Pyo Seo, Heun Jae Ryu
Summary: Using diffusion tensor tractography (DTT), this study explored the aging of the mesolibic tract (MLT) in normal human participants and found a significant negative correlation between age and the voxel number (VN) of MLT, as well as a positive correlation between age and the apparent diffusion coefficient (ADC). Aging of MLT was observed to begin in the 20s or 30s and steadily progress throughout life until significant degeneration occurred in the 60s. This may play a role in the decline of memory and social interaction with aging in normal participants.
Article
Neurosciences
Shannon Kelley, John Plass, Andrew R. Bender, Thad A. Polk
Summary: This study investigated age-related white matter differences using fixel-based analysis (FBA). The results revealed that age-related differences in FA were strongly associated with differences in multi-fiber complexity, indicating differences in crossing fibers and individual fiber segments. FBA also provided insights into distinct microstructural changes underlying age-related effects in specific brain regions.
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Clinical Neurology
Roxana Ameli, Charles R. G. Guttmann, Juan Carlos Prieto, Fabien Rollot, Miklos Palotai, Sandra Vukusic, Romain Marignier, Francois Cotton
Summary: This study retrospectively analyzed MRI scans of 54 NMOSD patients and found that patients with lesions in hAQP4 and lesions evocative of NMOSD exhibited significantly more extensive myelitis.
JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Miklos Palotai, Michele Cavallari, Brian C. Healy, Charles R. G. Guttmann
MULTIPLE SCLEROSIS JOURNAL
(2020)
Review
Anatomy & Morphology
Fernanda Troili, Virginia Cipollini, Marco Moci, Emanuele Morena, Miklos Palotai, Virginia Rinaldi, Carmela Romano, Giovanni Ristori, Franco Giubilei, Marco Salvetti, Francesco Orzi, Charles R. G. Guttmann, Michele Cavallari
FRONTIERS IN NEUROANATOMY
(2020)
Article
Clinical Neurology
Mattia Rosso, Cindy T. Gonzalez, Brian C. Healy, Shrishti Saxena, Anu Paul, Kjetil Bjornevik, Jens Kuhle, Pascal Benkert, David Leppert, Charles Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2020)
Article
Clinical Neurology
Alexandra de Sitter, Tom Verhoeven, Jessica Burggraaff, Yaou Liu, Jorge Simoes, Serena Ruggieri, Miklos Palotai, Iman Brouwer, Adriaan Versteeg, Viktor Wottschel, Stefan Ropele, Mara A. Rocca, Claudio Gasperini, Antonio Gallo, Marios C. Yiannakas, Alex Rovira, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Ludwig Kappos, Jette L. Frederiksen, Bernard M. J. Uitdehaag, Frederik Barkhof, Charles R. G. Guttmann, Hugo Vrenken
JOURNAL OF NEUROLOGY
(2020)
Article
Clinical Neurology
Mattia Rosso, Brian C. Healy, Shrishti Saxena, Anu Paul, Kjetil Bjornevik, Jens Kuhle, Pascal Benkert, David Leppert, Charles Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: This study investigated the relationship between serum neurofilament light levels and age in multiple sclerosis patients, revealing a more significant increase in sNfL levels after Gad+ lesions in younger patients. This insight provides new understanding of the effects of neuroinflammation on aging in MS.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Madhvi Deol, Miklos Palotai, Alfredo Morales Pinzon, Andrzej Marciniak, Gregory Bliault, Etta Covert, Ayal Aizer, Jeffrey P. Guenette, Matthew N. Desalvo, Xiao Tian Li, Aaron Thomas, Ngoc-Anh Tran, Alex Jacobson, Raymond Huang, Charles R. G. Guttmann
Summary: This study evaluated the impact of education level on the reproducibility of LM scoring, finding that structured education using the SPINE platform may improve consistency in LM reporting. In general, agreement on LM characteristics was higher between attending neuroradiologists than fellows or residents.
JOURNAL OF NEUROIMAGING
(2021)
Article
Clinical Neurology
Miklos Palotai, Catherine Small, Nikolaos Makris, Nathaniel G. Somes, Alfredo Morales Pinzon, Yogesh Rathi, Aldo Marzullo, James J. Levitt, Rohit Bakshi, Tanuja Chitnis, Charles R. G. Guttmann
Summary: The study found that in patients with multiple sclerosis (MS), fatigue and depression were associated with microstructural changes in the left mesocorticolimbic reward pathway (slMFB), which may contribute to the comorbid development of fatigue and depression.
JOURNAL OF NEUROIMAGING
(2021)
Article
Multidisciplinary Sciences
Arman Eshaghi, Alexandra L. Young, Peter A. Wijeratne, Ferran Prados, Douglas L. Arnold, Sridar Narayanan, Charles R. G. Guttmann, Frederik Barkhof, Daniel C. Alexander, Alan J. Thompson, Declan Chard, Olga Ciccarelli
Summary: The study utilized an unsupervised machine learning algorithm to determine multiple sclerosis subtypes, progression, and response to potential therapeutic treatments based on neuroimaging data.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Katharina Schregel, Caroline Baufeld, Miklos Palotai, Roberta Meroni, Paolo Fiorina, Jens Wuerfel, Ralph Sinkus, Yong-Zhi Zhang, Nathan McDannold, P. Jason White, Charles R. G. Guttmann
Summary: EAE is a model of multiple sclerosis with moderate reproducibility, but lacks focal lesions observed in MS, making it difficult to assess the pathogenesis of lesion evolution. Using focused ultrasound to induce blood brain barrier disruption in EAE mice, we observed focal brain lesions with increased inflammatory activity reflected in changes of biomechanical parameters.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Miklos Palotai, Max Wallack, Gergo Kujbus, Adam Dalnoki, Charles Guttmann
Summary: This study introduced a novel mobile app designed to differentiate fatigue phenotypes and investigate brain MRI correlates of MS-related fatigue. The majority of patients showed reasonable compliance when using the app in a prospective study.
JMIR MHEALTH AND UHEALTH
(2021)
Correction
Multidisciplinary Sciences
Arman Eshaghi, Alexandra L. Young, Peter A. Wijeratne, Ferran Prados, Douglas L. Arnold, Sridar Narayanan, Charles R. G. Guttmann, Frederik Barkhof, Daniel C. Alexander, Alan J. Thompson, Declan Chard, Olga Ciccarelli
NATURE COMMUNICATIONS
(2021)
Review
Clinical Neurology
Hugo Vrenken, Mark Jenkinson, Dzung L. Pham, Charles R. G. Guttmann, Deborah Pareto, Michel Paardekooper, Alexandra de Sitter, Maria A. Rocca, Viktor Wottschel, M. Jorge Cardoso, Frederik Barkhof
Summary: Patients with multiple sclerosis have diverse clinical presentations and symptoms, making it difficult to assess and understand the disease. Utilizing large-scale data sharing and artificial intelligence can enhance image analysis and provide insights into disease processes. This includes training AI algorithms on validated reference data and detecting relevant patterns in large MS cohorts, ultimately improving the understanding of MS.
Article
Neuroimaging
Alexandra de Sitter, Jessica Burggraaff, Fabian Bartel, Miklos Palotai, Yaou Liu, Jorge Simoes, Serena Ruggieri, Katharina Schregel, Stefan Ropele, Maria A. Rocca, Claudio Gasperini, Antonio Gallo, Menno M. Schoonheim, Michael Amann, Marios Yiannakas, Deborah Pareto, Mike P. Wattjes, Jaume Sastre-Garriga, Ludwig Kappos, Massimo Filippi, Christian Enzinger, Jette Frederiksen, Bernard Uitdehaag, Charles R. G. Guttmann, Frederik Barkhof, Hugo Vrenken
Summary: This study successfully established a standardized protocol for manual delineations of deep grey matter structures, demonstrating good reliability among different raters. The fast-semi-automated segmentation approach FASTSURF showed high accuracy in reproducing complete segmentations of deep grey matter based on sparse delineations.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Jessica Burggraaff, Yao Liu, Juan C. Prieto, Jorge Simoes, Alexandra de Sitter, Serena Ruggieri, Iman Brouwer, Birgit Lissenberg-Witte, Mara A. Rocca, Paola Valsasina, Stefan Ropele, Claudio Gasperini, Antonio Gallo, Deborah Pareto, Jaume Sastre-Garriga, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Olga Ciccarelli, Hanneke E. Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard M. J. Uitdehaag, Hugo Vrenken, Charles R. G. Guttmann
Summary: Thalamus atrophy has been consistently associated with cognitive decline in multiple sclerosis (MS), and both manual and automated segmentation methods demonstrate this correlation. However, there may be a proportional bias in smaller thalami, and the choice of MRI vendor can also impact the findings.
NEUROIMAGE-CLINICAL
(2021)