Article
Clinical Neurology
Daniel Ontaneda, Praneeta C. Raza, Kedar R. Mahajan, Douglas L. Arnold, Michael G. Dwyer, Susan A. Gauthier, Douglas N. Greve, Daniel M. Harrison, Roland G. Henry, David K. B. Li, Caterina Mainero, Wayne Moore, Sridar Narayanan, Jiwon Oh, Raihaan Patel, Daniel Pelletier, Alexander Rauscher, William D. Rooney, Nancy L. Sicotte, Roger Tam, Daniel S. Reich, Christina J. Azevedo
Summary: Multiple sclerosis is not only a white matter disease, but also involves grey matter injury, especially in deep grey matter regions. The deep grey matter is uniquely suited for studying the mechanisms and clinical relevance of tissue injury in multiple sclerosis using magnetic resonance techniques. MRI characterization of deep grey matter properties has potential as clinical trial end points for neurodegenerative aspects of multiple sclerosis.
Review
Clinical Neurology
Christopher Martin Allen, Ellen Mowry, Mar Tintore, Nikos Evangelou
Summary: Clinically isolated syndrome (CIS) is a single attack of inflammatory demyelination of the central nervous system, which can predict the development of multiple sclerosis. MRI scanning remains the most influential prognostic investigation during diagnosis, while multiple testing methods and medical history information also contribute to the diagnosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Behavioral Sciences
Juichi Fujimori, Kazuo Fujihara, Mike Wattjes, Ichiro Nakashima
Summary: The study found that cortical gray matter thickness reduction patterns in multiple sclerosis (MS) patients are mainly characterized by the degree of temporal lobe cortical atrophy, which may start in the relapsing-remitting phase. As the disease progresses, neurodegenerative changes in the temporal pole region may accelerate in the progressive phase.
BRAIN AND BEHAVIOR
(2021)
Article
Neuroimaging
Alexandra de Sitter, Jessica Burggraaff, Fabian Bartel, Miklos Palotai, Yaou Liu, Jorge Simoes, Serena Ruggieri, Katharina Schregel, Stefan Ropele, Maria A. Rocca, Claudio Gasperini, Antonio Gallo, Menno M. Schoonheim, Michael Amann, Marios Yiannakas, Deborah Pareto, Mike P. Wattjes, Jaume Sastre-Garriga, Ludwig Kappos, Massimo Filippi, Christian Enzinger, Jette Frederiksen, Bernard Uitdehaag, Charles R. G. Guttmann, Frederik Barkhof, Hugo Vrenken
Summary: This study successfully established a standardized protocol for manual delineations of deep grey matter structures, demonstrating good reliability among different raters. The fast-semi-automated segmentation approach FASTSURF showed high accuracy in reproducing complete segmentations of deep grey matter based on sparse delineations.
NEUROIMAGE-CLINICAL
(2021)
Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ingrid Anne Lie, Sezgi Kacar, Kristin Wesnes, Iman Brouwer, Silje S. Kvistad, Stig Wergeland, Trygve Holmoy, Rune Midgard, Alla Bru, Astrid Edland, Randi Eikeland, Sonia Gosal, Hanne F. Harbo, Grethe Kleveland, Yvonne S. Sorenes, Nina Oksendal, Kristin N. Varhaug, Christian A. Vedeler, Frederik Barkhof, Charlotte E. Teunissen, Lars Bo, Oivind Torkildsen, Kjell-Morten Myhr, Hugo Vrenken
Summary: This study investigated the relationship between serum neurofilament light chain (sNfL) levels over a 2-year period in patients with relapsing-remitting multiple sclerosis (MS) and clinical disability and grey matter (GM) atrophy after 10 years. The findings showed that higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. It suggests that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Marco Pisa, Tommaso Croese, Gloria Dalla Costa, Simone Guerrieri, Su-Chun Huang, Annamaria Finardi, Lorena Fabbella, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roberto Furlan, Letizia Leocani
Summary: Optical coherence tomography (OCT) is increasingly important in evaluating patients with multiple sclerosis, showing neuro-retinal changes indicative of inflammatory and disease burden. Subclinical optic nerve involvement and thinning of ganglion cell layer in eyes without acute optic neuritis are associated with greater disease burden, reflecting early disease phases.
Article
Neuroimaging
Jessica Burggraaff, Yao Liu, Juan C. Prieto, Jorge Simoes, Alexandra de Sitter, Serena Ruggieri, Iman Brouwer, Birgit Lissenberg-Witte, Mara A. Rocca, Paola Valsasina, Stefan Ropele, Claudio Gasperini, Antonio Gallo, Deborah Pareto, Jaume Sastre-Garriga, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Olga Ciccarelli, Hanneke E. Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard M. J. Uitdehaag, Hugo Vrenken, Charles R. G. Guttmann
Summary: Thalamus atrophy has been consistently associated with cognitive decline in multiple sclerosis (MS), and both manual and automated segmentation methods demonstrate this correlation. However, there may be a proportional bias in smaller thalami, and the choice of MRI vendor can also impact the findings.
NEUROIMAGE-CLINICAL
(2021)
Article
Medicine, General & Internal
Siddhesh P. Thakur, Matthew K. Schindler, Michel Bilello, Spyridon Bakas
Summary: This article introduces a computational approach that utilizes computer-aided detection (CAD) software to play a vital role in the diagnosis and treatment monitoring of Multiple Sclerosis (MS). The software can accurately detect disease activity and determine the necessity for injecting Gadolinium Based Contract Agents (GBCAs), providing reproducible and accurate clinical assessments, reducing adverse effects, and decreasing healthcare costs.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Amjad I. AlTokhis, Abrar AlAmrani, Abdulmajeed Alotaibi, Anna Podlasek, Cris S. Constantinescu
Summary: Definite imaging predictors for long-term disability in multiple sclerosis (MS) are currently lacking. However, recent findings suggest that white matter lesion (WML) counts and volumes may be able to predict long-term disability in MS. A meta-analysis of studies found that T2 brain lesion counts and volumes were associated with disability progression after 10 years, with a significant association between the presence of four or more lesions at baseline and EDSS 3 and EDSS 6. These findings suggest that lesion counts and volumes could provide additional guidance in treatment decision making.
Article
Clinical Neurology
Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Deborah Pareto, Alex Rovira, Jaume Sastre-Garriga, Piotr Sowa, Einar A. Hogestol, Hanne F. Harbo, Barbara Bellenberg, Carsten Lukas, Serena Ruggieri, Claudio Gasperini, Tomas Uher, Manuela Vaneckova, Stefan Bittner, Ahmed E. Othman, Sara Collorone, Ahmed T. Toosy, Sven G. Meuth, Frauke Zipp, Frederik Barkhof, Olga Ciccarelli, Sergiu Groppa
Summary: This study investigated the prognostic value of longitudinal structural networks in predicting 5-year Expanded Disability Status Scale (EDSS) progression in relapsing-remitting multiple sclerosis (RRMS) patients. The study found that changes in network degree and global efficiency can predict disability accumulation independent of disease activity, and these network measures outperform conventional MRI predictors in predicting EDSS worsening.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Al-Radaideh, Imad Athamneh, Hadeel Alabadi, Majed Hbahbih
Summary: In patients with relapsing-remitting multiple sclerosis, deep gray matter (dGM) volumetric metrics and MTR values are significantly lower than in healthy controls, and have moderate associations with lesion load and iron concentration. T1 changes in dGM regions weakly correlate with T2 lesions, while iron concentration does not show any association with lesion metrics. Most dGM metrics do not correlate with disease severity, while most lesion metrics show weak associations with disease severity.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Maria A. Rocca, Paola Valsasina, Alessandro Meani, Claudio Gobbi, Chiara Zecca, Frederik Barkhof, Menno M. Schoonheim, Eva M. Strijbis, Hugo Vrenken, Antonio Gallo, Alvino Bisecco, Olga Ciccarelli, Marios Yiannakas, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Lucy Matthews, Achim Gass, Philipp Eisele, Carsten Lukas, Barbara Bellenberg, Monica Margoni, Paolo Preziosa, Massimo Filippi
Summary: Spinal cord damage and, to a lesser extent, cortical volume loss are associated with worse 5-year clinical outcomes in multiple sclerosis patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Dimitrios Tzanetakos, Andreas Kyrozis, Efstratios Karavasilis, Georgios Velonakis, John S. Tzartos, Panagiotis Toulas, Stefania Alexia Sotirli, Ioannis Evdokimidis, Georgios Tsivgoulis, Constantin Potagas, Costantinos Kilidireas, Elisabeth Andreadou
Summary: The present study used proton magnetic resonance spectroscopy (H-1-MRS) to analyze the metabolic profiles in patients with clinically isolated syndrome (CIS) and found abnormalities in the metabolites in their grey and white matter. The results suggested that early indirect treatment could improve the brain metabolism in these patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Clinical Neurology
Elisabetta Sarasso, Federica Agosta, Noemi Piramide, Massimo Filippi
Summary: This review summarizes the current knowledge on longitudinal cortical and subcortical grey and white matter MRI findings in Parkinson's disease patients, with a focus on disease duration, severity, and cognitive impairment. Cortical atrophy accumulation in specific brain regions appears to progress with disease duration, while microstructural damage of motor and associative white matter tracts seems to rapidly progress even in early PD stages. The role of structural MRI metrics as biomarkers for disease progression in PD patients remains debated.
JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Varela-Mattatall, Corey A. Baron, Ravi S. Menon
Summary: The study presents an automatic, fast, and non-iterative method for determining regularization weighting in wavelet-based compressed sensing reconstructions. Through comparisons with experimental and simulation results, the method is shown to provide improved reconstructed image quality, prospectively determining regularization weighting with negligible computational time.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Ron Levy, Douglas J. Cook, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
Summary: Studies have found that under general anesthesia, the apparent fragmentation of whole-brain network structure is actually a result of a global reduction in functional connectivity rather than an actual change in network structure. This observation constrains current interpretations of how anesthesia-induced functional connectivity changes map onto existing neurobiological theories of consciousness.
Article
Neurosciences
Ramina Adam, David J. Schaeffer, Kevin Johnston, Ravi S. Menon, Stefan Everling
Summary: In a study involving monkeys, it was found that recovery after small prefrontal cortex lesions was associated with improvements in white matter microstructure in both cortical and thalamocortical areas, while larger lesions may have led to widespread structural damage and hindered compensatory remodeling in the cortical frontoparietal network.
Letter
Clinical Neurology
Kathryn Y. Manning, Ravi S. Menon
Article
Biology
Justine C. Clery, Yuki Hori, David J. Schaeffer, Ravi S. Menon, Stefan Everling
Summary: The study found that marmosets activate a network of brain areas, predominantly in the anterior lateral frontal and medial frontal cortex, when observing social interactions. This network is similar to that found in Old World macaque monkeys, suggesting a conservation of the network between New and Old World primates.
Article
Nutrition & Dietetics
Baraa K. Al-Khazraji, Sagar Buch, Mason Kadem, Brad J. Matushewski, Kambiz Norozi, Ravi S. Menon, J. Kevin Shoemaker
Summary: The study found that cerebral vascular reactivity protocols have a significant impact on vascular cross-sectional area, affecting blood velocity reactivity. Measuring blood flow velocity CVR through steady-state and ramp models can provide more accurate results, with steady-state hypercapnia showing greater blood flow CVR due to changes in vascular CSA.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Neurosciences
Yuki Hori, Justine C. Clery, David J. Schaeffer, Ravi S. Menon, Stefan Everling
Summary: The study utilized hierarchical clustering of interareal blood oxygen level-dependent signals in New World common marmoset monkeys to investigate their frontoparietal network organization, revealing similarities with macaque monkeys and supporting the presence of parallel frontoparietal processing streams in marmosets. These findings highlight the importance of the frontoparietal network in cognitive functions and validate the common marmoset as a valuable experimental animal model.
Article
Neurosciences
Geoffrey N. Ngo, Koen Haak, Christian F. Beckmann, Ravi S. Menon
Summary: The study utilized resting-state functional connectivity to investigate topographical principles of the human S1, revealing a topographic organization along the hierarchical axis strongly related to microstructure. The findings characterize the anatomical hierarchy of S1 as a 'continuous spectrum' with a functional boundary between areas 3b and 1.
Article
Neurosciences
Joonas A. Autio, Qi Zhu, Xiaolian Li, Matthew F. Glasser, Caspar M. Schwiedrzik, Damien A. Fair, Jan Zimmermann, Essa Yacoub, Ravi S. Menon, David C. Van Essen, Takuya Hayashi, Brian Russ, Wim Vanduffel
Summary: Recent methodological advances in MRI have facilitated increased neuroimaging studies in non-human primates, with open data-sharing initiatives enhancing availability of NHP MRI data. Establishment of minimal standards for data acquisition protocols and analysis pipelines is crucial for multi-center studies to accelerate research progress.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyle M. Gilbert, Paul Dubovan, Joseph S. Gati, Ravi S. Menon, Corey A. Baron
Summary: The study aimed to develop an RF coil integrated with a commercial field camera for ultrahigh field neuroimaging, allowing for field monitoring and k-space trajectory correction within a gradient coil. Results showed that the field probes had minimal impact on the RF coil performance, and the field monitoring system was able to correct higher-order field perturbations in single-shot spiral imaging.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
David J. Schaeffer, L. Martyn Klassen, Yuki Hori, Xiaoguang Tian, Diego Szczupak, Cecil Chern-Chyi Yen, Justine C. Clery, Kyle M. Gilbert, Joseph S. Gati, Ravi S. Menon, CiRong Liu, Stefan Everling, Afonso C. Silva
Summary: The Marmoset Functional Brain Connectivity Resource is an important tool for studying the functional and structural organization of the marmoset brain. It provides a large dataset of resting-state fMRI data, allowing users to view, manipulate, and download the data, as well as test hypotheses about functional connectivity.
Article
Ophthalmology
Matthew P. Quinn, Vladimir Kratky, Marlo Whitehead, Sudeep S. Gill, Michael A. McIsaac, Robert J. Campbell
Summary: The use of topical glaucoma medications (TGMs) is associated with an increased risk of surgery for lacrimal drainage obstruction (LDO), entropion, and trichiasis, but not with ptosis risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Varela-Mattatall, Paul I. I. Dubovan, Tales Santini, Kyle M. M. Gilbert, Ravi S. S. Menon, Corey A. A. Baron
Summary: This study investigates the use of l1-wavelet regularization and expanded encoding in single-shot spiral DWI at 7T, and finds that this approach improves trade-offs between spatial resolution, readout time, and SNR.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Ophthalmology
Anastasiya Vinokurtseva, Matthew P. Quinn, Mandy Wai, Victoria Leung, Monali Malvankar-Mehta, Cindy M. L. Hutnik
Summary: The purpose of this study was to evaluate existing patient-reported outcome measures (PROMs) for clinical glaucoma practice. The study found three most commonly used questionnaires, but their routine use in clinical settings remains low, despite their recognized importance in patient-centered care.
OPHTHALMOLOGY GLAUCOMA
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Alycia M. Crooks, Kate M. Onuska, Aja Hogan-Cann, Cecilia P. Kramar, Paul A. S. Sheppard, Taylor W. Schmitz, Lisa Saksida, Ravi S. Menon, Timothy Bussey, Marco A. M. Prado, Vania F. Prado
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Clinical Neurology
Zahra Ghadimi Korka, Shohreh Noorizadeh Dehkordi, Soheil Mansour Sohani, Marzieh Yassin
Summary: The Trunk Impairment Scale (TIS) in Persian has been found to be a relevant and reliable tool for assessing trunk abnormalities in Persian-speaking people with multiple sclerosis (PWMS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Maddalena Sparaco, Elisabetta Maida, Floriana Bile, Renato Vele, Luigi Lavorgna, Giuseppina Miele, Simona Bonavita
Summary: The SDQ was translated into Italian and validated for use in pwMS to detect swallowing disturbances. The 14-item SDQ demonstrated high internal consistency, good accuracy, and reliability in pwMS, making it a readily applicable tool for investigating dysphagia in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Leticia Rodrigues Gomes, Benito Pereira Damasceno, Brunno Machado de Campos, Alfredo Damasceno
Summary: This study found that patients with multiple sclerosis (MS) have more frequent work restrictions and impairment in money management and driving abilities compared to controls. Cognitive function, physical disability, and MS lesion burden are strongly associated with work restrictions, and social cognition can influence financial capacity. Cognitive and brain reserve can help retain some of these daily occupations.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Kaitlin E. Riegler, John Beauvais, Lindsay O. Neto, Elizabeth S. Gromisch
Summary: This study examined the differences in resilience levels among individuals with multiple sclerosis (PwMS) who had sleep disorders, sleep problems, and no sleep disorders/problems. The results showed that PwMS with sleep disorders had significantly lower resilience, with the difference being driven by the support from family and friends. These findings highlight the connection between sleep and resilience in PwMS, emphasizing the importance of social support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
A. Maunula, S. Atula, Sm Laakso, Pj Tienari
Summary: This study aimed to investigate the frequency and risk factors of FTY rebound in a hospital district in Southern Finland. The results showed that 10.5% of patients experienced a rebound, and 28% of patients had relapses of any severity after discontinuing FTY. Younger age at diagnosis, longer exposure to FTY, lower lymphocyte count, and higher neutrophil to lymphocyte ratio after discontinuation were identified as risk factors for a rebound.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)