Article
Mathematics, Applied
Katsuhisa Mimachi
Summary: In this article, a simple proof of Ramanujan's 101 sum is provided. The proof relies solely on the residue theorem and the q-binomial theorem, without any manipulation of the series. Additionally, a proof of Bailey's 606 sum is also given in the same manner.
PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Matthijs Meijers, Kanika Vanshylla, Henning Gruell, Florian Klein, Michael Laessig
Summary: Broadly neutralizing antibodies show promise in treating and preventing HIV-1 infections, but the virus often evolves resistance. A fitness model based on in vivo data accurately predicts the dynamics of HIV-1 escape during antibody treatment, highlighting an evolutionary trade-off between antibody resistance and its collateral cost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Aurelie Drouin, Julie Migraine, Marie-Alice Durand, Alain Moreau, Julien Burlaud-Gaillard, Maxime Beretta, Philippe Roingeard, Melanie Bouvin-Pley, Martine Braibant
Summary: The cellular factor IFITM3 reduces HIV-1 infectivity through an unclear mechanism. IFITM3 interacts with Env of sensitive viruses, inducing conformational changes that decrease viral infectivity, but this antiviral action is modulated by the nature of Env, particularly the V1V2 and V3 loops, which may escape this interaction after processing in the Golgi apparatus.
JOURNAL OF VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Ksenia Glumakova, Georgy Ivanov, Valeria Vedernikova, Lena Shyrokova, Timofey Lebedev, Andrei Stomakhin, Anastasia Zenchenko, Vladimir Oslovsky, Mikhail Drenichev, Vladimir Prassolov, Pavel Spirin
Summary: This study identified 2',3'-isopropylidene-5-iodouridine as a novel compound with anti-HIV-1 activity and no toxic effects on T-cells. It was found to be significantly more effective than Azidothymidine (AZT) at high non-toxic concentrations and showed synergistic inhibition of HIV-1 when combined with the CDK4/6 inhibitor Palbociclib at low non-toxic concentration. AZT did not show any synergistic antiviral activity when combined with Palbociclib.
Article
Biochemistry & Molecular Biology
Nametso Kelentse, Sikhulile Moyo, Kesaobaka Molebatsi, Olorato Morerinyane, Shatho Bitsang, Ontlametse T. Bareng, Kwana Lechiile, Tshepo B. Leeme, David S. Lawrence, Ishmael Kasvosve, Rosemary Musonda, Mosepele Mosepele, Thomas S. Harrison, Joseph N. Jarvis, Simani Gaseitsiwe
Summary: This study investigated CSF viral escape and HIV-1 viral load in individuals treated for HIV-associated cryptococcal meningitis. The results showed a decreasing trend of CSF viral escape during antifungal treatment, indicating the potential of antifungal therapy in reversing CSF viral escape.
Article
Biochemistry & Molecular Biology
Yue Zheng, Xian-Wen Yang, Dominique Schols, Mattia Mori, Bruno Botta, Andy Chevigne, Martin Mulinge, Andre Steinmetz, Jean-Claude Schmit, Carole Seguin-Devaux
Summary: The study demonstrates that compounds from Cassia abbreviata block HIV-1 entry into cells and may have potential antiviral properties, with piceatannol showing promise in inhibiting HIV-1 infection in a model of the female genital tract. The structure-activity relationships (SAR) highlight the importance of pharmacophoric groups in piceatannol for inhibiting HIV-1 entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Aparajitha Vaidyanathan, Harry E. Taylor, Thomas J. Hope, Richard T. D'Aquila, Elizabeth T. Bartom, Judd F. Hultquist, Marcus E. Peter
Summary: HIV infection leads to depletion of CD4(+) T cells, but some cells can survive and become part of the latent reservoir. Understanding the mechanisms of HIV-mediated cell death could potentially help clear the latent reservoir.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Phillip Pymm, Stefan Tenzer, Edmund Wee, Mirjana Weimershaus, Anne Burgevin, Simon Kollnberger, Jan Gerstoft, Tracy M. Josephs, Kristin Ladell, James E. McLaren, Victor Appay, David A. Price, Lars Fugger, John I. Bell, Hansjoerg Schild, Peter van Endert, Maria Harkiolaki, Astrid K. N. Iversen
Summary: This study discovers that the cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a specific epitope in the human immunodeficiency virus are associated with enhanced immune control. The length and mutations of the epitope influence the CTL and NK cell responses, leading to viral escape.
Article
Fisheries
Kamonwan Maruekawong, Orathai Namlamoon, Pongsopee Attasart
Summary: The study reveals the involvement of clathrin-mediated endocytosis and LvSID-1 in systemic gene silencing after oral intake of dsRNA in shrimp, which could enhance the potency of antiviral strategies in shrimp through fed RNAi in the future.
Article
Immunology
Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti
Summary: The kinetics of autologous and heterologous neutralizing antibody responses, as well as antibody-dependent cellular cytotoxicity, varied in HIV-1 infected children based on disease progression rates. Immune responses to viral and vaccine antigens were sustained and independent of disease progression.
Article
Infectious Diseases
Nametso Kelentse, Sikhulile Moyo, Wonderful T. Choga, Kwana Lechiile, Tshepo B. Leeme, David S. Lawrence, Ishmael Kasvosve, Rosemary Musonda, Mosepele Mosepele, Thomas S. Harrison, Joseph N. Jarvis, Simani Gaseitsiwe
Summary: This study compared the patterns of HIV-1 drug resistance mutations between the cerebrospinal fluid (CSF) and plasma of individuals with HIV-associated cryptococcal meningitis. The results showed high concordance in HIV-1 drug resistance mutations between the CSF and plasma, suggesting intercompartmental mixing and possibly a lack of compartmentalization. Some individuals also harbored minority HIV-1 drug resistance mutations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Kristina Kovacikova, Marina Gorostiola Gonzalez, Rhian Jones, Juan Reguera, Alba Gigante, Maria-Jesus Perez-Perez, Gerhard Puerstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric J. Snijder, Gerard J. P. van Westen, Martijn J. van Hemert
Summary: This study compared the antiviral efficacy of nsP1 inhibitors and found that CHVB and MADTP series had similar modes of action while differing from the FHNA series. Molecular-docking studies revealed the binding sites and potential actions of different series of inhibitors within the nsP1 structure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Hamadoun Toure, Nicolas Durand, Isabelle Guenal, Jean-Louis Herrmann, Fabienne Girard-Misguich, Sebastien Szuplewski
Summary: Mycobacterium abscessus is a highly pathogenic species among fast-growing mycobacteria that infects cystic fibrosis patients. It is able to resist the host innate response by being rapidly internalized by Drosophila phagocytes and thus escaping the antimicrobial peptides.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Baitshepi Mokaleng, Wonderful Tatenda Choga, Ontlametse Thato Bareng, Dorcas Maruapula, Doreen Ditshwanelo, Nametso Kelentse, Patrick Mokgethi, Natasha Onalenna Moraka, Modisa Sekhamo Motswaledi, Leabaneng Tawe, Catherine Kegakilwe Koofhethile, Sikhulile Moyo, Matshediso Zachariah, Simani Gaseitsiwe
Summary: HIV accumulates escape mutations in response to immune response, and the prevalence of CTL escape mutations in Botswana remains similar between two time points. The P17 protein has the most mutations, and unique mutations are found in both early and late time point sequences.
Article
Biochemistry & Molecular Biology
Markus Hoffmann, Prerna Arora, Rudiger Gross, Alina Seidel, Bojan F. Hornich, Alexander S. Hahn, Nadine Kruger, Luise Graichen, Heike Hofmann-Winkler, Amy Kempf, Martin S. Winkler, Sebastian Schulz, Hans-Martin Jack, Bernd Jahrsdorfer, Hubert Schrezenmeier, Martin Muller, Alexander Kleger, Jan Munch, Stefan Pohlmann
Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.
Article
Virology
Nancy Mueller, Alexander O. Pasternak, Bep Klaver, Marion Cornelissen, Ben Berkhout, Atze T. Das
JOURNAL OF VIROLOGY
(2018)
Review
Virology
Gang Wang, Na Zhao, Ben Berkhout, Atze T. Das
Article
Virology
Gilles Darcis, Caroline S. Binda, Bep Klaver, Elena Herrera-Carrillo, Ben Berkhout, Atze T. Das
Article
Virology
Filippo Turrini, Fabio Saliu, Greta Forlani, Atze T. Das, Carine Van Lint, Roberto S. Accolla, Ben Berkhout, Guido Poli, Elisa Vicenzi
Article
Microbiology
Dominik Hotter, Matteo Bosso, Kasper L. Jonsson, Christian Krapp, Christina M. Stuerzel, Atze Das, Elisabeth Littwitz-Salomon, Ben Berkhout, Alina Russ, Sabine Wittmann, Thomas Gramberg, Yue Zheng, Laura J. Martins, Vicente Planelles, Martin R. Jakobsen, Beatrice H. Hahn, Ulf Dittmer, Daniel Sauter, Frank Kirchhoff
CELL HOST & MICROBE
(2019)
Article
Virology
Atze T. Das, Alexander O. Pasternak, Ben Berkhout
Article
Virology
Atze T. Das, Caroline S. Binda, Ben Berkhout
CURRENT OPINION IN VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Zongliang Gao, Minghui Fan, Atze T. Das, Elena Herrera-Carrillo, Ben Berkhout
NUCLEIC ACIDS RESEARCH
(2020)
Article
Microbiology
Melissa Stunnenberg, John L. van Hamme, Atze T. Das, Ben Berkhout, Teunis B. H. Geijtenbeek
Summary: The study reveals that mutations in the TAR hairpin structure and sequence of HIV-1 RNA genome can impact viral sensing, leading to increased antiviral immune responses. These findings highlight the robustness of HIV-1 RNA sensing mechanisms.
Letter
Microbiology
Jose G. Dekker, Bep Klaver, Ben Berkhout, Atze T. Das
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Virology
Ye Liu, Rienk E. Jeeninga, Bep Klaver, Ben Berkhout, Atze T. Das
Summary: Novel therapeutic strategies for permanently inactivating the HIV-1 reservoir are being explored, including the use of CRISPR-Cas gene editing. In a study, transient CRISPR-Cas treatment led to complete inactivation of HIV replication in latently infected T-cell cultures through mutational inactivation of the proviral DNA. This suggests that transient CRISPR-Cas delivery methods may have potential for in vivo application.
Article
Virology
Jose G. Dekker, Bep Klaver, Ben Berkhout, Atze T. Das
Summary: Recent studies have shown that mutations in the HIV-1 3' polypurine tract (3' PPT) motif can reduce sensitivity to the integrase inhibitor dolutegravir (DTG). Multiple mutations in this viral RNA element confer DTG resistance by inactivating a critical reverse transcription element. These mutant viruses replicate without integration into the host cell genome, suggesting a novel escape mechanism from DTG.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lise Sarah Namer, Alex Harwig, Stephan P. P. Heynen, Atze T. T. Das, Ben Berkhout, Raymond Kaempfer
Summary: Activation of PKR and phosphorylation of eIF2 alpha play a crucial role in regulating splicing of HIV rev/tat mRNA by viral RNA. This study provides the first evidence that viruses may use the activation of host kinase PKR through RNA elements to promote splicing of their mRNA.
CELL AND BIOSCIENCE
(2023)
Article
Virology
Ye Liu, Caroline S. Binda, Ben Berkhout, Atze T. Das
Summary: Studies have shown that the CRISPR-Cas gene-editing system can be used to inactivate the HIV-1 proviral DNA in infected cells. However, this gene editing can also cause unintended large deletions, which may lead to oncogenic cell transformation.
JOURNAL OF VIROLOGY
(2023)
Article
Microbiology
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu
