Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic

Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease

(2014) S. Ying et al.   JOURNAL OF IMMUNOLOGY

Can anti-IgE therapy prevent airway remodeling in allergic asthma?

(2011) K. F. Rabe et al.   ALLERGY

Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma

(2011) Mario Castro et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells

(2011) F. Zhang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

(2011) R. E. Vandenbroucke et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling

(2011) Jae Youn Cho et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

(2011) Taylor A Doherty et al.   NATURE MEDICINE

Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention

(2011) Pierre-Olivier Girodet et al.   PHARMACOLOGY & THERAPEUTICS

T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma

(2011) C. J. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

(2011) Neil C Thomson et al.   BMC Pulmonary Medicine

Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma

(2010) Ke Wang et al.   ACTA PHARMACOLOGICA SINICA

Overexpression of Smad2 Drives House Dust Mite–mediated Airway Remodeling and Airway Hyperresponsiveness via Activin and IL-25

(2010) Lisa G. Gregory et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Persisting Remodeling and Less Airway Wall Eosinophil Activation in Complete Remission of Asthma

(2010) Martine Broekema et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Transforming Growth Factor–β in Airway Remodeling in Asthma

(2010) Rabih Halwani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vascular endothelial growth factor levels in induced sputum and emphysematous changes in smoking asthmatic patients

(2010) Yun-Jeong Bae et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Transforming growth factor-β1 in asthmatic airway smooth muscle enlargement: is fibroblast growth factor-2 required?

(2010) Y. Bossé et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interactions of airway epithelium with protease allergens in the allergic response

(2010) A. Jacquet   CLINICAL AND EXPERIMENTAL ALLERGY

A new look at the pathogenesis of asthma

(2010) Stephen T. Holgate et al.   CLINICAL SCIENCE

IL-33 family members and asthma – bridging innate and adaptive immune responses

(2010) Clare M. Lloyd   CURRENT OPINION IN IMMUNOLOGY

Cytokine inhibition in severe asthma: current knowledge and future directions

(2010) Jonathan Corren   CURRENT OPINION IN PULMONARY MEDICINE

Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial

(2010) S. T. Holgate et al.   EUROPEAN RESPIRATORY JOURNAL

Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction

(2010) I. H. Heijink et al.   EUROPEAN RESPIRATORY JOURNAL

Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice

(2010) Xiang Zhiguang et al.   IMMUNOLOGY LETTERS

Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro

(2010) Hye Young Yum et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Increased IL-33 expression by epithelial cells in bronchial asthma

(2010) David Préfontaine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibitory Effects of Anti-Immunoglobulin E Antibodies on Airway Remodeling in A Murine Model of Chronic Asthma

(2010) Ji Young Kang et al.   JOURNAL OF ASTHMA

Thymic Stromal Lymphopoietin Receptor-Mediated IL-6 and CC/CXC Chemokines Expression in Human Airway Smooth Muscle Cells: Role of MAPKs (ERK1/2, p38, and JNK) and STAT3 Pathways

(2010) L. Shan et al.   JOURNAL OF IMMUNOLOGY

Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI

(2010) Ravi Aysola et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

A Novel CC-Chemokine Receptor 3 Antagonist, Ki19003, Inhibits Airway Eosinophilia and Subepithelial/Peribronchial Fibrosis Induced by Repeated Antigen Challenge in Mice

(2010) Masato Komai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Increased levels of osteopontin in sputum supernatant in severe refractory asthma

(2010) V. Delimpoura et al.   THORAX

Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes

(2010) S. Gupta et al.   THORAX

Biomarkers Predicting Isocyanate-Induced Asthma

(2010) Nami Shrestha Palikhe et al.   Allergy Asthma & Immunology Research

Effects of omalizumab on markers of inflammation in patients with allergic asthma

(2009) S. Holgate et al.   ALLERGY

Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics

(2009) M. Humbert et al.   ALLERGY

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

(2009) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

House Dust Mite–Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium

(2009) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes

(2009) I. Stuart Wood et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma

(2009) Xiaojin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Use of Endobronchial Ultrasonography in Assessment of Bronchial Wall Remodeling in Patients With Asthma

(2009) Jerzy Soja et al.   CHEST

Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses

(2009) Y.-H. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma

(2009) D. E. Smith   CLINICAL AND EXPERIMENTAL ALLERGY

Biologic therapies for asthma

(2009) David Gruenberg et al.   CURRENT OPINION IN PULMONARY MEDICINE

Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling

(2009) D. J. Song et al.   JOURNAL OF IMMUNOLOGY

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

(2009) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation

(2009) Zhijun Jie et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI

(2008) Sean B. Fain et al.   ACADEMIC RADIOLOGY

Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment

(2008) E. L. J. van Rensen et al.   ALLERGY

Daclizumab Improves Asthma Control in Patients with Moderate to Severe Persistent Asthma

(2008) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

(2008) David H. Broide   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma

(2008) E J Hothersall et al.   THORAX

Mast cell-derived tumour necrosis factor is essential for allergic airway disease

(2007) S. Reuter et al.   EUROPEAN RESPIRATORY JOURNAL

FGF2 in asthmatic airway-smooth-muscle-cell hyperplasia

(2007) Ynuk Bossé et al.   TRENDS IN MOLECULAR MEDICINE