Review
Nutrition & Dietetics
Ozaifa Kareem, Sobia Nisar, Masood Tanvir, Umar Muzaffer, G. N. Bader
Summary: During pregnancy, there are physiological changes that require an increase in nutritional needs, particularly for thiamine (vitamin B1). Thiamine deficiency in pregnancy can have detrimental effects on both the mother and fetus, leading to various physical and neurological conditions. This review explores the physiological roles of thiamine, its prevalence and impact during pregnancy, and highlights the knowledge gaps in this area.
FRONTIERS IN NUTRITION
(2023)
Editorial Material
Multidisciplinary Sciences
Megan W. Bourassa, Gilles Bergeron, Kenneth H. Brown
Summary: Severe thiamine (vitamin B-1) deficiency, previously thought to mainly affect infants in low-income communities in Southeast Asia and adult alcoholics, may also impact other populations and result in long-lasting neurocognitive consequences. The scope of disorders associated with thiamine deficiency is broader than previously believed.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tim J. Green, Kyly C. Whitfield, Lisa Daniels, Rachel C. Brown, Lisa A. Houghton
Summary: In 2014, an outbreak of beriberi occurred on the remote atoll of Kuria in Kiribati due to a thiamine-poor diet. Research showed that the prevalence of inadequate thiamine intakes was over 30% in all groups, and food fortification with rice, sugar, or wheat flour was proposed as a solution to reduce this inadequacy. A regional approach to thiamine fortification is needed due to Kiribati's small size and limited resources.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Megan W. Bourassa, Filomena Gomes, Kerry S. Jones, Albert Koulman, Andrew M. Prentice, Carla Cerami
Summary: Thiamine deficiency disorders can affect the nervous and cardiovascular systems, and are not just limited to South Asia but also observed in free-living populations in West Africa. A study found that the risk of thiamine deficiency was significantly higher during the wet season compared to the dry season in West Africa.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Medicine, General & Internal
Marie S. H. Lim, Wutyee Win, Anna Von Essen, David Gannon, Mohamed Ramali
Summary: Shoshin beriberi is a fulminant variant of thiamine deficiency that can lead to severe lactic acidosis and cardiogenic shock, but rapid reversal of symptoms can be achieved through intravenous thiamine replacement. In this case, a 57-year-old woman presented with extreme malaise, breathlessness, and abdominal pain, with marked hypotension and tachycardia, but her hemodynamic instability was quickly reversed with intravenous thiamine administration.
Article
Multidisciplinary Sciences
Roshine Mary Koshy, Shajin Thankaraj, VijayAnand Ismavel, Carolin V. Solomi
Summary: This article reports the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, as well as the investigations, treatment, and recovery processes. Two detailed case studies are provided, and the authors share their experience and suggest ways forward to improve early diagnosis and treatment, and promote preventive public health strategies for at-risk populations in Northeast India.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Medicine, General & Internal
Elisabeth Mates, Deepti Alluri, Tailer Artis, Mark S. Riddle
Summary: Thiamine deficiency (TD) in non-alcoholic hospitalized patients is often underestimated, with symptoms including weakness, neuropsychiatric manifestations, gastrointestinal dysfunction, and ataxia. TD likely develops because of inflammatory stress from chronic inflammatory conditions, combined with decreased energy intake or increased nutrient losses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Madhusudan Samprathi, Faisal Mohammad, M. Sridhar, Prakash Ramachandra, Prakash Vemgal
Summary: Thiamine deficiency disorders are a serious public health issue in low- and middle-income countries. This study reports six infants with acute fulminant illness, with four of them showing dramatic recovery after empirical thiamine treatment, highlighting the importance of early recognition and treatment of infantile beriberi to save lives.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Kerry S. Jones, Damon A. Parkington, Lorna J. Cox, Albert Koulman
Summary: Vitamin B1, or thiamine, is an essential nutrient that plays a critical role in energy metabolism. Lack of thiamine can lead to conditions like beriberi, but clinical symptoms are not specific, making it difficult to diagnose. The ETK activity assay, measuring the activity of transketolase, has been used for over 50 years as a sensitive and specific biomarker for thiamine status.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Medicine, General & Internal
Ana-Maria Mateos-Diaz, Miguel Marcos, Antonio-Javier Chamorro
Summary: Wernicke-Korsakoff syndrome is a well-known consequence of thiamine deficiency, usually associated with chronic and excessive alcohol consumption, but can also be caused by other factors. Diagnosis relies mainly on clinical suspicion, while treatment is based on thiamine supplementation.
Article
Cardiac & Cardiovascular Systems
Chendong Peng, Yuang Jiang, Xianhong Ou, Lei Liao, Chengying Yang, Qiao Zhou, Yan Wei, Lijia Chang, Xinrong Fan
Summary: A novel XIAP mutation (c.1259_1262 delACAG) was found to be potentially involved in the development of Crohn's disease and progression of heart failure. Thiamine deficiency may trigger a vicious cycle.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Ana-Maria Mateos-Diaz, Miguel Marcos, Antonio-Javier Chamorro
Summary: Wernicke-Korsakoff syndrome is the most well-known consequence of thiamine deficiency, commonly associated with chronic alcohol consumption but can be caused by any factor that leads to thiamine deficiency. The disease is often underdiagnosed, highlighting the importance of maintaining a high level of clinical suspicion, especially in patients without alcohol consumption as a risk factor. Diagnosis primarily relies on clinical assessment, which can be challenging due to significant clinical variability. Complementary tests, particularly magnetic resonance imaging, are used to support the diagnosis and exclude other potential causes with similar symptoms. Treatment involves early administration of thiamine, parenterally and at appropriate doses, in all patients presenting with compatible symptoms, without waiting for confirmation of the diagnosis.
Review
Cell Biology
Chandler Marrs, Derrick Lonsdale
Summary: Thiamine, also known as vitamin B1, is essential for mitochondrial energetics and energy production, but deficiency is common in modern life and poses significant health risks.
Article
Obstetrics & Gynecology
Sobia Nisar, Ozaifa Kareem, Umar Muzaffer, Masood Tanvir, Mohd. Ashraf Ganaie, Rabia Nazir Ahmed
Summary: This study aimed to understand the various manifestations and outcomes of acute thiamine deficiency in pregnant and postpartum women, emphasizing the significance of early recognition and thiamine therapy to prevent serious complications. The study found that thiamine deficiency can lead to serious symptoms such as gastric beriberi, paraparesis, high-output heart failure, and acute pulmonary hypertension. The results also highlight the importance of timely recognition and treatment with thiamine.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Food Science & Technology
Anne Karine Martins Assuncao, Maria dos Remedios Freitas Carvalho Branco, Thiago de Sousa Santos, Silmery da Silva Brito Costa, Jose de Jesus Dias Junior, Vanessa Moreira da Silva Soeiro, Adriana Soraya Araujo, Rejane Christine de Sousa Queiroz, Maria Tereza Borges Araujo Frota, Arlene de Jesus Mendes Caldas, Bruno Luciano Carneiro Alves de Oliveira, Alcione Miranda dos Santos
Summary: The study conducted a spatial analysis of reported beriberi cases among indigenous people in Brazil, finding that all cases occurred in states located in the Legal Amazon region, with high-density areas identified in Tocantins and Roraima through Kernel density estimation.
FOOD AND NUTRITION BULLETIN
(2021)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Sang Chol Lee, Jihoon Kim, Jun-Bean Park, In-Chang Hwang, You-Jung Choi, Seung-Pyo Lee, Sung-A Chang, Whal Lee, Eun-Ah Park, Goo-Yeong Cho, Yong-Jin Kim
Summary: This study investigated the prognostic role of LV-GLS and its incremental value in predicting SCD in patients with HCM. The results showed that lower LV-GLS values were associated with higher rates of SCD events. LV-GLS provided additional information to established risk models and improved their predictive performance for SCD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Endocrinology & Metabolism
Chan Soon Park, You-Jung Choi, Tae-Min Rhee, Hyun Jung Lee, Hee-Sun Lee, Jun-Bean Park, Yong-Jin Kim, Kyung-Do Han, Hyung-Kwan Kim
Summary: Weight loss or gain greater than 5% is associated with an increased risk of major cardiovascular events in patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Hyun-Jung Lee, Hyung-Kwan Kim, Bong-Seong Kim, Kyung-Do Han, Tae-Min Rhee, Jun-Bean Park, Heesun Lee, Seung-Pyo Lee, Yong-Jin Kim
Summary: DM HCM patients have higher risks of ESRD progression and HF. Active surveillance and management of DM-related outcomes should be highlighted, considering the extended life expectancy of HCM and increasing number of elderly HCM patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Multidisciplinary Sciences
Hyun-Jung Lee, Hyung-Kwan Kim, Sang Chol Lee, Steve R. Ommen, Jihoon Kim, Jun-Bean Park, You-Jung Choi, Seung-Pyo Lee, Sung-A Chang, Yong-Jin Kim
Summary: Women with hypertrophic cardiomyopathy have a worse cardiovascular prognosis than men, especially in the age group of 60 years and older. Female sex is associated with poorer cardiac function and cardiovascular outcomes, which become more prominent at the age of 60 years and older.
Article
Cardiac & Cardiovascular Systems
Hyun Jung Lee, Hyung Kwan Kim, Kyung Do Han, Kyu Na Lee, Jun Bean Park, Heesun Lee, Seung Pyo Lee, Yong Jin Kim
Summary: This study found that the associations between BMI and cardiovascular outcomes are influenced by age, with different patterns observed in young, middle-aged, and elderly individuals.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Soongu Kwak, Seung-Ah Lee, Jaehyun Lim, Seokhun Yang, Hong-Mi Choi, In-Chang Hwang, Sahmin Lee, Yeonyee Elizabeth Yoon, Jun-Bean Park, Hyung-Kwan Kim, Yong-Jin Kim, Jong-Min Song, Goo-Yeong Cho, Kyung-Hwan Kim, Duk-Hyun Kang, Dae-Hee Kim, Seung-Pyo Lee
Summary: This study identified five distinct phenogroups of patients with severe primary mitral regurgitation (MR) and different risk profiles. The findings suggest that this phenogrouping strategy may improve risk stratification and optimize interventions for severe MR.
Article
Cardiac & Cardiovascular Systems
You-Jung Choi, Hyung-Kwan Kim, In-Chang Hwang, Chan Soon Park, Tae-Min Rhee, Hyun-Jung Lee, Jun-Bean Park, Yeonyee Elizabeth Yoon, Seung-Pyo Lee, Goo-Yeong Cho, Yong-Jin Kim
Summary: The study aimed to investigate the association between low-normal left ventricular ejection fraction (LVEF) and adverse outcomes in hypertrophic cardiomyopathy (HCM), as well as evaluate the predictive power of LVEF in the conventional HCM sudden cardiac death (SCD)-risk model. The results showed that low-normal LVEF was an independent predictor of heart failure hospitalization and cardiovascular death in patients with HCM.
Article
Cardiac & Cardiovascular Systems
Jun-Bean Park, Je-Yeon Yun, Bongsung Kim, Tae-Min Rhee, Hyun-Jung Lee, Heesun Lee, In-Chang Hwang, Yeonyee E. Yoon, Hyo Eun Park, Seung-Pyo Lee, Su-Yeon Choi, Yong-Jin Kim, Goo-Yeong Cho, Kyungdo Han, Hyung-Kwan Kim
Summary: This study found that patients with hypertrophic cardiomyopathy (HCM) have a higher risk of mental disorders compared to those without HCM. The risk is particularly high within the first year after HCM diagnosis, highlighting the importance of screening for mood and anxiety disorders in HCM patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyue Mee Kim, In-Chang Hwang, Yeonyee Elizabeth Yoon, Jun-Bean Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Yaeji Lim, Goo-Yeong Cho
Summary: This study found that 2D global longitudinal strain (GLS) is associated with cardiovascular outcomes in patients with left bundle-branch block, but the predictive value of 3D speckle-tracking echocardiography has not been investigated in these patients. The study retrospectively analyzed the association between 2D and 3D strains and left ventricular ejection fraction (LVEF) in patients with preserved or reduced LVEF. The results showed that 2D-GLS is predictive of maintaining LVEF in patients with preserved LVEF, while a lower 3D-global circumferential strain is associated with persistently reduced LVEF in patients with reduced LVEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Bongseong Kim, Tae-Min Rhee, Hyun Jung Lee, Hee-Sun Lee, Jun-Bean Park, Yong-Jin Kim, Kyung-Do Han, Hyung-Kwan Kim
Summary: This study investigated the association between the use of ACEi, ARB, or non-RASi and incident cardiovascular events in a nationwide hypertension cohort. The results showed that patients on ACEi and ARB had lower risks of myocardial infarction, ischemic stroke, atrial fibrillation, heart failure, and all-cause deaths compared to those on non-RASi. Sensitivity analysis and propensity score matching results supported these findings.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Bong-Seong Kim, Kyung-Do Han, Soongu Kwak, Chan Soon Park, Tae-Min Rhee, Jun-Bean Park, Heesun Lee, Yong-Jin Kim
Summary: This study found that sacubitril/valsartan is not associated with an increased risk of incident dementia compared to ARBs in heart failure patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kina Jeon, Sang-Bae Yoo, Yoonhee Lee, Eun-Bin Lee, Hyung-Kwan Kim, Hyuk-Jae Chang, Sung-A Chang
Summary: This regulatory post-marketing surveillance aimed to evaluate the safety and effectiveness of ambrisentan in the Korean population. The study found that ambrisentan demonstrated tolerable safety and favorable effectiveness in Korean patients with pulmonary arterial hypertension (PAH). Age and concomitant drug use may affect the occurrence of adverse events.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
You-Jung Choi, Hyun-Jung Lee, Ji-Suck Park, Chan Soon Park, Tae-Min Rhee, Jah Yeon Choi, Hong-Mi Choi, Jun-Bean Park, Yeonyee E. Yoon, Seung-Pyo Lee, Jin Oh Na, Goo-Yeong Cho, Yong-Jin Kim, In-Chang Hwang, Hyung-Kwan Kim
Summary: The aim of this study was to investigate the prognostic utility of left ventricular global longitudinal strain (LV-GLS) in patients with hypertrophic cardiomyopathy (HCM) and a left ventricular ejection fraction (LVEF) of 50-60%. The study included 349 HCM patients with an LVEF of 50-60%, and the results showed that LV-GLS was an independent predictor of a composite outcome including cardiovascular death in these patients. Therefore, LV-GLS can aid in risk stratification in HCM patients with an LVEF of 50-60%.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Tae-Min Rhee, Hyung-Kwan Kim, You-Jung Choi, Hyun-Jung Lee, In-Chang Hwang, Yeonyee E. Yoon, Hack-Lyoung Kim, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: GE recently developed the new version of EchoPAC platform to provide 'vendor-independent' full-myocardial-layer left ventricular (LV) global longitudinal strain (LV-GLS). The study found that there was excellent agreement between LV-GLS measured by GE-Full and TomTec-Endo, regardless of various cardiac conditions.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
