Editorial Material
Multidisciplinary Sciences
Inma Cobos, Jorge J. J. Palop
Summary: Abnormal protein aggregates in Alzheimer's disease lead to swellings in neuronal axons, which disrupt proper circuit function.
Article
Developmental Biology
Steffen Gonda, Christian Riedel, Andreas Reiner, Ina Koehler, Petra Wahle
Summary: Neuronal differentiation is regulated by neuronal activity. The dendrites and axons of BCs and non-BCs were analyzed, and it was found that AcDs were the most complex dendrites in both cell types. The configuration of AcDs influenced the development of BC axons, while non-BCs' axons did not respond to the AcD configuration. The results suggest that the formation of dense BC plexuses is regulated by spontaneous activity and the growth of AcDs and their axons mutually support each other.
Article
Genetics & Heredity
Zachary A. Schaaf, Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Ruelicke, Simon Hippenmeyer, Konstantinos S. Zarbalis
Summary: Research has shown that WDFY3 has cell autonomous requirements in neuronal development, as demonstrated by Wdfy3 mutant mice displaying the need for accurate laminar positioning of cortical projection neurons and elimination of mispositioned cells. Additionally, significant deviations in dendritic arborization, synaptic density, and morphology were identified in postnatal stages in Wdfy3 mutant mice.
Review
Behavioral Sciences
Benjamin L. Thompson, Marlene Oscar-Berman, Gary B. Kaplan
Summary: Opioid Use Disorder (OUD) is a chronic condition with significant morbidity and mortality even with treatment. Neuroplasticity plays a key role in OUD development, with alterations in dopaminergic and glutamatergic pathways potentially leading to behavioral symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Archana Sharma, Katherine E. Hill, Jean E. Schwarzbauer
Summary: The composition of the extracellular matrix (ECM) in nervous tissue has an important influence on neuronal outgrowth and synapse development. Alterations in fibronectin (FN), a major component of the ECM, lead to a reduction in dendrite outgrowth and decreased dendritic spines in cortical neurons. Tenascin-C (TN-C), an ECM protein that binds to FN, plays a crucial role in dendrite development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Agnes L. Nishimura, Natalia Arias
Summary: Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease caused by motor neuron degeneration. Loss of C9orf72 function and toxic effects of repeat expansions may contribute to the pathogenesis of ALS, leading to neurotransmission deficiencies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Ryosuke Kamei, Shinji Urata, Hisato Maruoka, Shigeo Okabe
Summary: Microglia, the only immune cells resident in the brain, play crucial roles in maintaining neural circuitry by modifying synapses and neuronal excitability, with functional heterogeneity observed in different brain regions. A new method enables chronic observation of microglia in the hippocampal CA1, allowing analysis of morphological changes over time.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Neurosciences
Macarena Tejos-Bravo, Robert H. Oakley, Shannon D. Whirledge, Wladimir A. Corrales, Juan P. Silva, Gonzalo Garcia-Rojo, Jorge Toledo, Wendy Sanchez, Luciano Roman-Albasini, Esteban Aliaga, Felipe Aguayo, Felipe Olave, Vinicius Maracaja-Coutinho, John A. Cidlowski, Jenny L. Fiedler
Summary: Sex differences in the brain, particularly in terms of miRNA expression and neuronal morphology, were investigated in this study by generating a neuron-specific GR knockout mouse model. The results showed a sex-biased effect of GR ablation, with differentially expressed miRNAs and changes in neuronal morphology observed mainly in female mice. The study also identified potential transcription factors involved in miRNA regulation and highlighted pathways related to neuronal arborization and spine morphology affected by GR deletion.
NEUROBIOLOGY OF STRESS
(2021)
Article
Cell Biology
Jeffrey B. Rosa, Khaled Y. Nassman, Alvaro Sagasti
Summary: Epithelial cell properties are determined by the polarized distribution of membrane lipids, the cytoskeleton, and adhesive junctions. Little research has been done on how neurites affect epithelial organization. This study found that axon endings in basal keratinocytes remodel cell membranes, cytoskeleton, and junctions, and regulate epidermal adhesion by organizing lipid microdomains.
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Multidisciplinary Sciences
Chelsea E. Matisz, Nadia Semenoff, Al-Shaimaa F. Ahmed, Lateece Griffin, Laurie E. Wallace, Parker McNabb, Robbin Gibb, Keith A. Sharkey, Aaron J. Gruber
Summary: Gut inflammation affects neural activity and leads to changes in fear-related neural circuits. Acute colitis does not affect overall dendritic spine density in the hippocampus, but increases the proportion of immature spines. In the basolateral amygdala, there are no changes in spine density or composition. The density of cFos immunoreactive neurons is not affected in the basolateral amygdala, but is decreased in CA1 region of the hippocampus in mice with colitis.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Courtney K. Walker, Kelsey M. Greathouse, Jennifer J. Tuscher, Eric B. Dammer, Audrey J. Weber, Evan Liu, Kendall A. Curtis, Benjamin D. Boros, Cameron D. Freeman, Jung Vin Seo, Raksha Ramdas, Cheyenne Hurst, Duc M. Duong, Marla Gearing, Charles F. Murchison, Jeremy J. Day, Nicholas T. Seyfried, Jeremy H. Herskowitz
Summary: Proteomic studies on postmortem human brain tissue samples have identified molecular alterations associated with aging and neurodegenerative diseases. To overcome the challenges of identifying individual proteins, researchers developed a blueprint to select and validate targets from proteomic datasets. Through network analysis, they identified TWF2 as a key protein correlated with thin spine length and experimentally validated the finding.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Developmental Biology
Sarah E. Latchney, Ania K. Majewska
Summary: The developing nervous system is sensitive to persistent organic pollutants (POPs) exposure, which may increase the risk for neurodevelopmental disorders in children. Research focuses on the cellular processes of synapse formation and plasticity during sensitive periods of rapid brain development, which may be affected by developmental neurotoxicants. Developmental POP exposure has long-lasting effects on dendritic morphology, spine formation, synaptic transmission, among other cellular processes.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Anatomy & Morphology
Hector De La Luz Torres, Paola Rojas Perez, Adriana Berenice Silva Gomez
Summary: Olfactory bulbectomy (OBX) is an experimental strategy widely used to study depression. This study investigated the effect of neonatal OBX on learning and memory, as well as dendritic spine density in the dorsal hippocampus, in male and female rats. Results showed that male rats with OBX exhibited more pronounced spatial learning deficit, while female rats showed a significant decrease in basilar dendritic spine density. These findings suggest sexual dimorphism in the effect of OBX on the dorsal hippocampus and its relation to spatial learning and memory processes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Multidisciplinary Sciences
Diana E. Mitchell, Soledad Miranda-Rottmann, Maxime Blanchard, Roberto Araya
Summary: Layer 5 pyramidal neurons in autism spectrum disorders (ASD) exhibit impaired integration of sensory inputs, contrary to the traditional belief of sensory hypersensitivity. Fragile X syndrome (FXS), the most common genetic cause of ASD, shows sublinear summation of subthreshold excitatory inputs. Knockdown of the regulatory beta 4 subunit of BK channels rescued this impairment, suggesting a differential dysfunction in the integration of feedforward sensory and feedback predictive inputs in FXS and potentially other forms of ASD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Mathematical & Computational Biology
W. Tecumseh Fitch
Summary: Contemporary neural network models often overlook the complexity and information processing abilities of single neurons, which store and compute information in a highly sophisticated manner. Recognizing the centrality of cellular computation in natural computation has important implications for the evolution and study of cognition, as well as providing insights into the unique features of human cognition.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Biophysics
Marco Canepari, Silvia Willadt, Dejan Zecevic, Kaspar E. Vogt
BIOPHYSICAL JOURNAL
(2010)
Article
Cell Biology
Marco Canepari, Kaspar Vogt, Dejan Zecevic
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2008)
Article
Neurosciences
Marko A. Popovic, Xin Gao, Nicholas T. Carnevale, Dejan Zecevic
Article
Neurosciences
Maja Djurisic, Marko Popovic, Nicholas Carnevale, Dejan Zecevic
JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Amanda Foust, Marko Popovic, Dejan Zecevic, David A. McCormick
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Amanda J. Foust, Yuguo Yu, Marko Popovic, Dejan Zecevic, David A. McCormick
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Knut Holthoff, Dejan Zecevic, Arthur Konnerth
JOURNAL OF PHYSIOLOGY-LONDON
(2010)
Article
Neurosciences
Marko A. Popovic, Amanda J. Foust, David A. McCormick, Dejan Zecevic
JOURNAL OF PHYSIOLOGY-LONDON
(2011)
Article
Biology
Ryota Homma, Bradley J. Baker, Lei Jin, Olga Garaschuk, Arthur Konnerth, Lawrence B. Cohen, Dejan Zecevic
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2009)
Review
Biophysics
Dejan Zecevic
Summary: Dendritic spines play a crucial role in signal integration and plasticity in the brain through biochemical compartmentalization. However, the debate on their electrical role remains unresolved due to conflicting evidence from different experimental methods.
BIOPHYSICAL JOURNAL
(2023)
Article
Neurosciences
Marco Canepari, Maja Djurisic, Dejan Zecevic
JOURNAL OF PHYSIOLOGY-LONDON
(2007)
Article
Cell Biology
BJ Baker, EK Kosmidis, D Vucinic, CX Falk, LB Cohen, M Djurisic, D Zecevic
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2005)
Article
Neurosciences
M Djurisic, S Antic, WR Chen, D Zecevic
JOURNAL OF NEUROSCIENCE
(2004)
Review
Biochemical Research Methods
M Djurisic, M Zochowski, M Wachowiak, CX Falk, LB Cohen, D Zecevic
BIOPHOTONICS, PT B
(2003)