Article
Automation & Control Systems
Mohammad Farshad
Summary: A novel fault-location scheme for HVdc grids transmission lines is proposed, utilizing machine learning and soft computing strategy to train locators for accurate fault location, demonstrating good generalization ability and robustness in various fault scenarios.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2021)
Article
Chemistry, Medicinal
Yin-Ying Mak, Bi-Juin Loong, Paul Millns, Claudia C. Bauer, Robin S. Bon, Yvonne Mbaki, Fong-Kai Lee, Kuan-Hon Lim, Cin Kong, Sue-Mian Then, Kang-Nee Ting
Summary: This study investigated the vasorelaxant effects of schwarzinicine A, a newly reported alkaloid from Ficus schwarzii Koord. The results showed that schwarzinicine A exerts its significant vasorelaxant effect by blocking multiple TRPC channels and L-type VGCC.
PHYTOTHERAPY RESEARCH
(2022)
Article
Neurosciences
Yuichi Utsumi, Makiko Taketoshi, Michiko Miwa, Yoko Tominaga, Takashi Tominaga
Summary: Non-clinical toxicology is a major cause of drug candidate attrition during development. This paper presents an in vitro seizure liability assay using voltage-sensitive dye (VSD) imaging techniques in hippocampal brain slices, offering a powerful alternative to traditional electrophysiological methods. By employing this approach, the authors investigated the in vitro drug-induced seizure liability of representative pro-convulsant compounds.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Perla C. Reyes C. Fernandez, Christian S. Wright, Mary C. Farach-Carson, William R. Thompson
Summary: In addition to their role in cell excitability, voltage-sensitive calcium channels (VSCCs) are critical for the secretion of paracrine and endocrine factors, including those produced in bone. Activation of VSCCs modulates cellular processes such as cell proliferation, differentiation, and bone adaptation. The role of VSCCs in the control of bone and calcium homeostasis through secreted factors is not well understood. Understanding the multiple functions of VSCCs in the skeleton can lead to the development of new therapies for bone enhancement and improving systemic health.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Neurosciences
Rebecca W. Pak, Jeeun Kang, Emad Boctor, Jin U. Kang
Summary: In this study, a series of optimal tissue concentrations of VSD were established, maximizing the detection of membrane potential responses to external stimuli by varying the concentration of IR-780 perchlorate VSD in the brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Aleksandra Bartkowiak, Oleksandr Korolevych, Blazej Gierczyk, Daniel Pelczarski, Alberto Bossi, Maciej Klein, Lukasz Popenda, Waldemar Stampor, Malgorzata Makowska-Janusik, Maciej Zalas
Summary: The low photon-to-current conversion efficiency is a major limitation of dye-sensitized solar cells. In this study, two new bi-ruthenium sensitizers with extended anchoring ligands were synthesized to investigate the underlying processes determining photovoltaic action mechanisms. Experimental characterization and quantum-chemical calculations were performed to gain insight into the properties of the synthesized molecules. The study highlights the significance of the anchoring group architecture in the molecular design of sensitizers for dye-sensitized solar cell applications.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Ori Carmi, Adi Gross, Nadav Ivzan, Lamberto La Franca, Nairouz Farah, Zeev Zalevsky, Yossi Mandel
Summary: Neuronal activity magnitude localization and measurement are crucial for mapping and understanding neuronal systems. In this study, seven different methods for localizing cortical responses were evaluated, with Temporally Structured Component Analysis (TSCA) found to outperform others in generating high-resolution retinotopic maps.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson
Summary: Our study identified a novel mechanosensory complex within osteocytes composed of PLN and alpha(2)delta(1), which is crucial for bone force transmission. This complex is associated with the commonly used pain drug GBP and chronic use of GBP may result in impaired bone mechanosensation.
Article
Engineering, Electrical & Electronic
Xu Kong, Yan-zhao Xie, Wen-qi Xing, Zhen-dong Sun, Shao-yin He, Li Liu, Peng Qiu, Xiao-jun Ni, Kun Zhang
Summary: This article introduces the measurement and analysis of the transient electric field generated by the switching operation of the modular multilevel converter and the high voltage direct current circuit breaker in a converter station. It is revealed that the switching transient electric field is a quasi-static field, which can be used to accurately monitor the action moment of the devices and is more accurate than the traditional voltage recording system.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Neurosciences
Katsushige Sato, Yoko Momose-Sato
Summary: This study utilized NK2761 absorption dye to perform multiple-site optical recordings in the embryonic chick olfactory system, and investigated the functional development of olfactory nerve-related circuits. It was found that NMDA receptor function played a significant role in sensory information transfer in these circuits. Additionally, the ventral circuit developed earlier than the dorsal circuit, and the neural circuits projecting from the periphery to the subpallium matured earlier compared to those projecting to the pallium.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Physiology
Jamie S. S. Lindner, Salil R. R. Rajayer, Briana J. J. Martiszus, Stephen M. M. Smith
Summary: The calcium-sensing receptor agonist, cinacalcet, regulates neuronal excitability by modulating the voltage-dependence of voltage-gated sodium channel (VGSC) currents. This regulation is achieved by shifting the voltage-dependence of VGSC currents and involves an unidentified inhibitory molecule that is G-protein dependent.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Balazs Horvath, Zsigmond Kovacs, Csaba Dienes, Jozsef Ovari, Norbert Szentandrassy, Janos Magyar, Tamas Banyasz, Andras Varro, Peter P. Nanasi
Summary: The characteristics of late sodium current (I-Na,I-late) and its conductance changes (G(Na,late)) were studied in rabbit, canine, and guinea pig ventricular myocytes. The gating kinetics of I-Na,I-late showed notable interspecies differences, which cannot be explained by differences in action potential morphology. Intracellular Ca2+ concentration and Anemonia sulcata (ATX-II) toxin also influenced the I-Na,I-late and G(Na,late) profiles differently in canine and guinea pig myocytes.
Article
Pharmacology & Pharmacy
Talat Roome, Maha Qasim, Ahsana Dar Farooq, Qibtiya Ilyas, Sabahat Aziz, Syed Farooq Ali
Summary: Digas colic drops is a polyherbal formulation that exhibits spasmolytic effects on intestinal contractions by affecting various contractile agonists. Its mechanism of action may involve the modulation of neurotransmitter receptors and calcium channels.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Curtis L. Neveu, Yu Huan, Yuto Momohara, Paras R. Patel, Hillel J. Chiel, Cynthia A. Chestek, John H. Byrne
Summary: By combining carbon fiber electrode (CFE) arrays with voltage-sensitive dyes (VSD) and utilizing 3D printing technology, a laboratory equipment was developed for simultaneous VSD imaging, CFE array recording, and extracellular recording. This method enables stimulation and recording of multiple neurons simultaneously, and the 3D printed recording chamber and manipulators can be customized as needed.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Energy & Fuels
Gaohui Feng, Pengsheng Bu, Liqiang Yuan
Summary: The energy balance control (EBC) strategy for power electronic transformer utilizes energy relationships to reduce fluctuations and transient time of the two DC bus voltages, enhancing stability and reliability.
Article
Biochemistry & Molecular Biology
Istvan Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamas Arpadffy-Lovas, Tibor Magyar, Noemi Toth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov
Summary: The study found that ACh can influence the repolarization in human ventricular cardiomyocytes by affecting I-Kr, leading to prolonged action potential duration.
Article
Cardiac & Cardiovascular Systems
Kedar Aras, Anna Gams, Ndeye Rokhaya Faye, Jaclyn Brennan, Katherine Goldrick, Jinghua Li, Yishan Zhong, Chia-Han Chiang, Elizabeth H. Smith, Megan D. Poston, Jacqueline Chivers, Peter Hanna, Shumpei Mori, Olujimi A. Ajijola, Kalyanam Shivkumar, Donald B. Hoover, Jonathan Viventi, John A. Rogers, Olivier Bernus, Igor R. Efimov
Summary: The electrophysiology of human right ventricular outflow tract (RVOT) is characterized by shorter action potential duration and the arrhythmogenic effects of adrenergic stimulation can be attenuated by cholinergic stimulation. Additionally, arrhythmia wave fronts and rotors in RVOT are relatively more organized in the endocardium compared to the epicardium.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Arie O. Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montanes-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde R. Rivaud, Rosan de Winter, Makiri Kawasaki, Shirley C. M. van Amersfoorth, Eva R. Meulendijks, Antoine H. G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
Summary: The accumulation of epicardial adipose tissue (EAT) is associated with cardiac arrhythmias, and the secretome of EATs has effects on cardiac electrophysiology. In this study, it was found that incubation with EATs decreases the expression of the potassium channel subunit Kcnj2 and the inward rectifier K+ current I-K1 in cardiomyocytes, leading to depolarization of the resting membrane potential. EATs also decrease the expression of connexin43 and alter electrical cell-cell coupling.
Article
Multidisciplinary Sciences
Dmitry Rybashlykov, Jaclyn Brennan, Zexu Lin, Igor R. Efimov, Roman Syunyaev
Summary: Fluorescent imaging, an important technique to study cardiac or neural electrophysiology, is usually expensive. This study presents a complete solution, priced below $1,000, with an open-source software. The results show that the camera used in this study is capable of recording action potential with sufficient signal-to-noise ratio for accurate measurements and research.
Article
Multidisciplinary Sciences
Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak-Young Ahn, Grace Wickerson, Abraham Vazquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers
Summary: This study presents a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden.
Article
Biology
Sharon A. George, Zexu Lin, Igor R. Efimov
Summary: In this study, triple-parametric optical mapping was used to simultaneously assess multiple parameters in cardiac physiology and pathophysiology. The technique was applied to study the effects of drugs on cardiac function and to investigate metabolic and electrical changes during ischemia and reperfusion.
COMMUNICATIONS BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Sofian N. Obaid, Zhiyuan Chen, Micah Madrid, Zexu Lin, Jinbi Tian, Camille Humphreys, Jillian Adams, Nicolas Daza, Jade Balansag, Igor R. Efimov, Luyao Lu
Summary: Researchers have designed a soft implantable electro-optical cardiac device that allows simultaneous high-precision electrical mapping and optogenetics, providing real-time spatiotemporal mapping and control of cardiac rhythm and function. This technology has broad applications in basic and clinical cardiology.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jokubas Ausra, Micah Madrid, Rose T. Yin, Jessica Hanna, Suzanne Arnott, Jaclyn A. Brennan, Roberto Peralta, David Clausen, Jakob A. Bakall, Igor R. Efimov, Philipp Gutruf
Summary: Monitoring and control of cardiac function are crucial for studying cardiovascular pathophysiology and developing treatments. However, it is currently challenging to control the heart in freely moving small animal subjects. This study introduces a wireless battery-free device that enables real-time cardiac control and multisite stimulation, allowing optogenetic modulation of the entire rodent heart.
Meeting Abstract
Cardiac & Cardiovascular Systems
Auriane Ernault, Arie Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montanes-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde Rivaud, Makiri Kawasaki, Shirley C. M. van Amersfoorth, Eva R. Meulendijks, Antoine H. G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemical Research Methods
Rose T. Yin, Sheena W. Chen, K. Benjamin Lee, Yeon Sik Choi, Jahyun Koo, Quansan Yang, Michael A. Napolitano, Jokubas Ausra, Timothy J. Holleran, Jessica B. Lapiano, E. Alex Waters, Anlil Brikha, Grant Kowalik, Alana N. Miniovich, Helen S. Knight, Bender A. Russo, Alexi Kiss, Alejandro Murillo-Berlioz, Tatiana Efimova, Chad R. Haney, Philipp Gutruf, John A. Rogers, Gregory D. Trachiotis, Igor R. Efimov
Summary: Genetic engineering and implantable bioelectronics have revolutionized the study of cardiovascular physiology and diseases. However, combining these two approaches in the same species has been challenging. Researchers have recently developed miniature cardiac bioelectronic devices suitable for mice and rats, enabling the integration of molecular tools and implantable devices. The successful implementation of these devices requires reliable microsurgery techniques that minimize disruption to native physiology.
Article
Physiology
Girish S. Ramlugun, Kanchan Kulkarni, Nestor Pallares-Lupon, Bastiaan J. Boukens, Igor R. Efimov, Edward J. Vigmond, Olivier Bernus, Richard D. Walton
Summary: This study establishes an automated activation time-based analytical framework for optical mapping images of complex electrical behavior. The framework is able to accurately process high pacing frequency or irregular activity signals and provide detailed quantitative assessment and visualization.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Anna Gams, Alejandro Nevarez, Stephanie Perkail, Aileen Venegas, Sharon A. George, Tatiana Efimova, Igor R. Efimov
Summary: Abnormal heart rate variability (HRV) is commonly observed in cancer patients, but the sex-specific effects of cancer on cardiac function remain underexplored. This study investigated the sex-specific effects of pancreatic and liver cancers on cardiac function in transgenic mouse models. The results showed that female cancer mice had higher HRV, while male cancer mice showed increased HRV only in the liver cancer group. Female cancer mice also had lower median HR and higher HRV. These findings highlight the importance of considering sex when using HRV as a cancer biomarker.
PHYSIOLOGICAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Sharon A. George, Alexi Kiss, Katy Anne Trampel, Sofian N. Obaid, Lichao Tang, Igor R. Efimov, Tatiana Efimova
Summary: This study reveals the sex- and isoform-specific roles of p38 MAPKs in DOX-induced cardiac injury. Global p38 beta deletion aggravated DIC and worsened cardiac function deterioration, while cardiomyocyte-specific p38 alpha deletion improved survival of male mice. These findings have important implications for understanding and treating DIC.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sharon A. George, Jaclyn A. Brennan-McLean, Katy A. Trampel, Eric Rytkin, N. Rokhaya Faye, Bjorn C. Knollmann, Igor R. Efimov
Summary: The study investigated the antiarrhythmic potential of dantrolene, a RyR inhibitor, in human hearts. Results showed that dantrolene treatment reduced premature ventricular contractions (PVC) and reversed arrhythmogenic substrates in the heart, suggesting it could be a novel therapy for patients with structural heart diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sharon Ann George, Katy Trampel, Kelsey Brunner, Igor R. Efimov