Article
Neurosciences
Jonathan J. Chow, Rebecca S. Hofford, Joshua S. Beckmann
Summary: This study showed that neuronal activity measured as cFos expression in the brain regions OFC and NAc was not directly reflective of cocaine preference when cocaine intake was controlled for, but was related to overall cocaine intake in the OFC when cocaine intake varied. The results suggest that controlling for cocaine frequency and intake is important in isolating the neurobehavioral mechanisms underlying drug preference.
Article
Clinical Neurology
Kien Chai Ong, Khong Ying Ng, Chiu Wan Ng, Soon Hao Tan, Woon Li Teo, Norain Karim, Shalini Kumar, Kum Thong Wong
Summary: Neuronal infection appears to play a more important role than vasculopathy-induced microinfarction in acute NiV encephalitis.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Monica Regina de Matos, Aline Patricia Grzegozevski, Alessandra da Cruz, Arthur Colombari Cheng, Amanda Gerelli, Carla Fusco, Leonardo Gruchouskei, Aline de Marco Viott
Summary: This study aimed to identify Brachyspira spp. using histology, immunohistochemistry, and fluorescence in situ hybridization in tissue samples from the cecum of commercial poultry, demonstrating the effectiveness and accuracy of these techniques for diagnosis.
SEMINA-CIENCIAS AGRARIAS
(2021)
Editorial Material
Oncology
C. Simon Herrington, Richard Poulsom, Hartmut Koeppen, Philip J. Coates
Summary: The 2021 Annual Review Issue of The Journal of Pathology features 14 invited reviews on current research areas in pathology, covering topics like the impact of the COVID-19 pandemic, biomarkers for immune checkpoint inhibitors, and advances in nucleic acid detection. Authored by experts in academia and industry, the reviews offer comprehensive updates on these areas with recent progress.
JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Clifford M. Chapman
Summary: The CelLock procedure kit is used to collect and prepare cellular specimens into a paraffin cell-block, allowing for subsequent microtomy and staining. CelLock provides optimal preservation and processing of cell-blocks, ensuring availability of cellular protein and genetic information for histological and ancillary testing.
JOURNAL OF HISTOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jennifer Kersigo, Lintao Gu, Linjing Xu, Ning Pan, Sarath Vijayakuma, Timothy Jones, Seiji B. Shibata, Bernd Fritzsch, Marlan R. Hansen
Summary: The expression of Neurod1 reduces the progression of slow-growing MB and decreases cell proliferation in primary human SC cultures. In a genetic mouse model of schwannomas, the effects of Neurod1 expression are present but the high variability indicates a need for more tightly regulated expression levels to validate the effects on schwannoma progression.
Article
Neurosciences
Samyukta Karthik, Dake Huang, Yaritza Delgado, Justin J. Laing, Lila Peltekian, Gabrielle N. Iverson, Fillan Grady, Rebecca L. Miller, Corey M. McCann, Bernd Fritzsch, Igor Y. Iskusnykh, Victor V. Chizhikov, Joel C. Geerling
Summary: This article presents a developmental-genetic ontology that classifies neurons in the parabrachial nucleus (PB) based on their intrinsic, molecular features, and predicts their neural projections. This molecular framework could accelerate the translation of experimental findings from animal models to human patients.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Geriatrics & Gerontology
Karen L. Elliott, Bernd Fritzsch, Ebenezer N. Yamoah, Azel Zine
Summary: ARHL is a common issue for older adults, affecting various auditory structures. The gradual loss of cochlear hair cells and spiral ganglion neurons can lead to high-frequency hearing deficits, while reductions in auditory nuclei may impact the auditory process. Decreased neurons in the cochlear nuclei could affect interactions with the superior olivary complex.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Iva Filova, Romana Bohuslavova, Mitra Tavakoli, Ebenezer N. N. Yamoah, Bernd Fritzsch, Gabriela Pavlinkova
Summary: This study found that early elimination of Neurod1 significantly affects the development of inner ear neurons. It leads to a reduction and disorganization of sensory epithelia, formation of ectopic hair cells, and a shortened cochlea in the inner ear. Additionally, the central projections of inner ear neurons become reduced, unsegregated, disorganized, and interconnecting the vestibular and auditory systems. The volume of the cochlear nuclei is also decreased due to diminished afferent input from auditory neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Bernd Fritzsch, Paul R. Martin
Summary: During early vertebrate evolution, the expansion of the Hox gene clusters may have influenced the development of the visual system. Neurosensory cells split into photoreceptors and retinal ganglion cells, which possibly originated from early chordates. The neurosensory cells in lancelets correspond to eye fields in ascidians, which could be the basis of the vertebrate retina, pineal, and parapineal.
IBRO NEUROSCIENCE REPORTS
(2022)
Editorial Material
Neurosciences
Mary Ann Cheatham, Bernd Fritzsch, David Z. He, Bradley J. Walters
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Bernd Fritzsch, Karen L. Elliott, Ebenezer N. Yamoah
Summary: Different sensory information is processed in the brainstem and relayed to specific regions within the cortex for further integration with other sensory systems, providing a comprehensive sensory experience. The trigeminal system projects contralaterally, the taste system primarily ipsilaterally, and the vestibular and auditory systems develop bilateral connections.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Multidisciplinary Sciences
Young Rae Ji, Yosuke Tona, Talah Wafa, Matthew E. Christman, Edward D. Tourney, Tao Jiang, Sho Ohta, Hui Cheng, Tracy Fitzgerald, Bernd Fritzsch, Sherri M. Jones, Kathleen E. Cullen, Doris K. Wu
Summary: The otolith organs of the inner ear are connected to the brainstem and cerebellum through two parallel nerve projections. These projections segregate across the line of polarity reversal (LPR) within each otolith organ, forming two regions with opposite stereociliary orientation. Emx2 plays a role in establishing LPR, mediating neuronal segregation, and determining bidirectional sensitivity in the otolith organs.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Irene Y. Y. Szeto, Daniel K. H. Chu, Peikai Chen, Ka Chi Chu, Tiffany Y. K. Au, Keith K. H. Leung, Yong-Heng Huang, Sarah L. Wynn, Angel C. Y. Mak, Ying-Shing Chan, Wood Yee Chan, Ralf Jauch, Bernd Fritzsch, Mai Har Sham, Robin Lovell-Badge, Kathryn S. E. Cheah
Summary: This study investigates the in vivo mechanisms of dominant syndromes caused by mutations in SOX9 and SOX10 transcription factors. The results show that SOX9(Y440X) mutation causes deafness through distinct mechanisms in the endolymphatic sac/duct and cochlea, while conditional heterozygous Sox9-null mice are normal. Additionally, the study reveals the role of SOX9 in regulating Sox10 and the cooperation between these factors in the normal functioning of the endolymphatic system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Joel C. Glover, Bernd Fritzsch
Summary: His' studies in the late 19th and early 20th centuries revealed the crucial roles of the dorsal roof plate and rhombic lips in the development of the hindbrain choroid plexus and hindbrain auditory centers, respectively. Modern molecular studies have confirmed these findings and provided mechanistic insights, showing the importance of the transcription factor Lmx1a/b in regulating the formation of these structures.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Karen L. Elliott, Igor Y. Iskusnykh, Victor V. Chizhikov, Bernd Fritzsch
Summary: The transcription factors Atoh1 and Ptf1a play crucial roles in cochlear nuclei development. Atoh1 is necessary for the development of glutamatergic neurons, while Ptf1a is required for the generation of glycinergic and GABAergic neurons that migrate to the cochlear nucleus. Loss of Ptf1a leads to abnormal tonotopic projections and excessive neuronal branching in the cochlear nuclei of mutant mice.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Bernd Fritzsch, Hans-Peter Schultze, Karen L. Elliott
Summary: Sarcopterygians evolved around 415 Ma and developed unique features such as the basilar papilla, cochlear aqueduct, and tympanic membrane for hearing. These features, along with lungs and tympanic membranes, are morphologically integrated to improve sound reception in bony fish and tetrapods. The basilar papilla is lost in certain lungfish, caecilians, and salamanders, but transformed into the cochlea in mammals. The tympanic membrane, associated with spiracles in some fish, is displaced by pressure changes and enables tetrapods to perceive airborne sound waves.
IBRO NEUROSCIENCE REPORTS
(2023)
Review
Neurosciences
Ebenezer N. Yamoah, Gabriela Pavlinkova, Bernd Fritzsch
Summary: The development of the central auditory system is influenced by genetic and environmental factors, allowing infants to learn how to speak. Environmental factors, such as sound and language exposure, can impact the development and function of the auditory system, including speech perception, singing, and language processing. Sound exposure before birth shapes the structure and function of the developing auditory system in infants, and exposure to singing and speaking supports their auditory and language development. Neurodegenerative diseases like Alzheimer's can affect the hippocampus and auditory nucleus in aging individuals, leading to memory and auditory processing difficulties. As the disease progresses, auditory processing problems become more severe, significantly impacting communication abilities.
Review
Biochemistry & Molecular Biology
Azel Zine, Bernd Fritzsch
Summary: Sensorineural hearing loss is a common sensory deficit in humans, mainly caused by the degeneration of key structures in the cochlea. Cell-based strategies are being extensively researched to replace damaged inner ear tissue and restore hearing function. Experimental in vitro models that mimic the early development of the inner ear are crucial for these treatment approaches. This review highlights the developmental events and cellular transformations involved in the formation of the inner ear and its sensory cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Acoustics
Bernd Fritzsch, Karen L. Elliott
Summary: The hearing range of lampreys is similar to that of elasmobranchs, non-teleosts, and lungfish. Different organs are used for sound reception and gravistatic sensing in different species, with lungfish relying on the saccule for hearing. The basilar papilla is important for hearing in coelacanths and most tetrapods, and it generates pressure with the intracranial joint.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)