Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammed Yusuf Zanna, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Suri Arshad, Abdul Razak Mariatulqabtiah, Saulol Hamid Nur-Fazila, Md Isa Nur Mahiza
Summary: Dendritic cells are crucial antigen-presenting cells in the immune system, playing a significant role in activating T cells and maintaining immune balance. Their distribution and dynamic perspectives in various animal species, as well as their roles in diseases, have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chengcheng Liu, Wenwen Qi, Zhenxiao Teng, Runtong Xu, Yue Xi, Yiming Qin, Fenglei Xu, Lei Shi, Miaoqing Zhao, Ming Xia
Summary: This study suggests that NGR-PM-SHI could be a novel strategy for targeted treatment of allergic rhinitis through the NF-kappa B pathway by targeting PARP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Nathifa A. Moyo, Dave Westcott, Rachel Simmonds, Falko Steinbach
Summary: This study investigates the interaction between EAV and host immune cells, specifically dendritic cells (DC), using an optimized eqMoDC system. The results show that EAV is able to replicate in monocytes and mature MoDC, and has an effect on cell morphology, phenotype, and function. EAV evades host anti-viral immunity through inhibition of antigen presentation early after infection and by killing infected DC during replication.
Article
Immunology
Sara Sadat Aghamiri, Bhanwar Lal Puniya, Rada Amin, Tomas Helikar
Summary: Dendritic cells (DCs) are professional antigen-presenting cells that play a critical role in shaping immunity. Researchers have developed a logical and predictive model of DC function, integrating the heterogeneity of DCs population, APC function, and cell-cell interaction, to study cell dynamics and disease environments, providing a platform for vaccine design, drug discovery, and immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Alessio Alesci, Gioele Capillo, Angelo Fumia, Emmanuele Messina, Marco Albano, Marialuisa Aragona, Patrizia Lo Cascio, Nunziacarla Spano, Simona Pergolizzi, Eugenia Rita Lauriano
Summary: This study aimed to characterize intestinal dendritic cells (DCs) from myxines to teleosts using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II. The findings reveal the presence of DCs and DC-like cells phylogenetically from myxines to teleosts, providing new insights into the evolution of the immune system and the role of sentinel cells in body defense.
Article
Urology & Nephrology
Junwen Qu, Dawei Li, Jingsi Jin, Nan Sun, Jiajin Wu, Chao Yang, Lingling Wu, Shaoyong Zhuang, Haoyu Wu, Ruoyang Chen, Yaofei Ren, Chen Zhong, Liang Ying, Yan Zhang, Xiaodong Yuan, Ming Zhang
Summary: This study reveals that the absence of HIF-2 alpha in dendritic cells (DCs) exacerbates renal ischemia-reperfusion injury (IRI) by hyperactivating natural killer T (NKT) cells. HIF-2 alpha deficiency in DCs leads to the upregulation of CD36, resulting in cellular lipid accumulation and activation of NKT cells. These findings suggest a potential therapeutic target for the treatment of this severe complication.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Manish Sharma, Mariana Marin, Hui Wu, David Prikryl, Gregory B. Melikyan
Summary: Despite extensive efforts, the exact sites of HIV-1 entry into cells, plasma membrane or endosomes, remain controversial. Through a triple labeling approach, it was discovered that HIV-1 primarily fuses with pH-neutral intracellular vesicles.
Review
Immunology
Paulo Arantes Laginha, Fernanda Vieira Lins Arcoverde, Luiza Gama Coelho Riccio, Marina Paula Andres, Mauricio Simoes Abrao
Summary: Research suggests that dendritic cells play a critical role in the development and progression of endometriosis, being susceptible to pro-endometriotic changes that inhibit maturation and induce a macrophage phenotype. Endometriosis growth and vascularization rely on the presence of endogenous dendritic cells, which promote endothelial cell migration and angiogenesis. Immature dendritic cells actively support angiogenesis and endometriosis progression, changing their immunologic role from antigen presentation to angiogenesis support.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Immunology
David M. Koelle, Lichun Dong, Lichen Jing, Kerry J. Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M. Posavad
Summary: HSV-2-specific T-RM cells are abundant in the female reproductive tract between episodes of recurrent genital herpes, provide protection, and maintain the ability to expand.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chae Won Kim, Kyun-Do Kim, Heung Kyu Lee
Summary: Dendritic cells play a crucial role in initiating antitumor immune responses through antigen presentation. Different subsets of DCs have distinct roles in the tumor microenvironment, and regulating DC functionality holds promise for improving cancer therapies.
Article
Immunology
Chunying Xiao, Zhenlai Zhu, Chen Zhang, Jixin Gao, Yixin Luo, Hui Fang, Hongjiang Qiao, Wei Li, Gang Wang, Meng Fu
Summary: This study revealed that newly infiltrated inflammatory dermal Langerin(+) DCs play an essential role in the development of atopic dermatitis (AD) and the local production of TSLP, while TSLP further promotes the production of BM-derived i-Langerin(+) dDCs, which may contribute to the maintenance of AD inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Jiaxin Li, Jun Zhou, Huanhuan Huang, Jiahuan Jiang, Ting Zhang, Chao Ni
Summary: This article summarizes the important role of mature dendritic cells (mregDCs) in regulating the immune response and their potential impact on tumor immunotherapy. Recent research has shown that these regulatory cells are associated with a positive response to immunotherapy and a favorable prognosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ping Xiao, Jue Wang, Zitong Zhao, Xiaochen Liu, Xiangshi Sun, Dangge Wang, Yaping Li
Summary: Metabolic labeling of DCs is utilized to design nanoscale aAPCs that exhibit enhanced distribution in lymph nodes, activation of T cells and resident APCs, significant inhibition of tumor inoculation and growth, and improved efficacy when combined with PD1 therapy.
Article
Nanoscience & Nanotechnology
Marina Bekic, Milos Vasiljevic, Dusica Stojanovic, Vanja Kokol, Dusan Mihajlovic, Dragana Vucevic, Petar Uskokovic, Miodrag Colic, Sergej Tomic
Summary: The purpose of this study was to investigate the immunomodulatory effects of phosphonates conjugated with cellulose nanocrystals (CNCs) in human cells. The results showed that the delivery of 3-AminoPropylphosphonic Acid (ApA) via CNCs induced potent dendritic cell-mediated Th1 polarization, which could have potential application in tumor therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cell Biology
Venktesh S. Shirure, Tiantian Liu, Luis F. Delgadillo, Chaz M. Cuckler, David F. J. Tees, Fabian Benencia, Douglas J. Goetz, Monica M. Burdick
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Article
Endocrinology & Metabolism
Fabian Benencia, Stephanie Harshman, Silvana Duran-Ortiz, Ellen R. Lubbers, Edward O. List, Lara Householder, Mawadda Al-Naeeli, Xiaoyu Liang, Lonnie Welch, John J. Kopchick, Darlene E. Berryman
Article
Immunology
Alex Woody, Wilson. S. Figueroa, Fabian Benencia, Peggy M. Zoccola
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Meeting Abstract
Oncology
Grady Earl Carlson, Venktesh Shirure, Alexander O. Ostermann, Emily A. Blaha, Louis F. Delgadillo, David F. J. Tees, Fabian Benencia, Monica Burdick
Review
Immunology
Manindra Singh, Tiffany Loftus, Erin Webb, Fabian Benencia
IMMUNOLOGICAL INVESTIGATIONS
(2016)
Article
Psychiatry
Alex Woody, Wilson S. Figueroa, Fabian Benencia, Peggy M. Zoccola
PSYCHOSOMATIC MEDICINE
(2017)
Article
Immunology
Amritha Venkatesh, Harika Nandigam, Maria Muccioli, Manindra Singh, Tiffany Loftus, Deana Lewis, Michelle Pate, Fabian Benencia
Review
Virology
Leslee Sprague, Lynne Braidwood, Joe Conner, Kevin A. Cassady, Fabian Benencia, Timothy P. Cripe
Article
Oncology
Denarda Dangaj, Marine Bruand, Alizee J. Grimm, Catherine Ronet, David Barras, Priyanka A. Duttagupta, Evripidis Lanitis, Jaikumar Duraiswamy, Janos L. Tanyi, Fabian Benencia, Jose Conejo-Garcia, Hena R. Ramay, Kathleen T. Montone, Daniel J. Powell, Phyllis A. Gimotty, Andrea Facciabene, Donald G. Jackson, Jeffrey S. Weber, Scott J. Rodig, Stephen F. Hodi, Lana E. Kandalaft, Melita Irving, Lin Zhang, Periklis Foukas, Sylvie Rusakiewicz, Mauro Delorenzi, George Coukos
Review
Immunology
Manindra Singh, Fabian Benencia
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2019)
Article
Immunology
Ben Phillippi, Manindra Singh, Tiffany Loftus, Hannah Smith, Maria Muccioli, Julia Wright, Michelle Pate, Fabian Benencia
Article
Endocrinology & Metabolism
Jonathan A. Young, Brooke E. Henry, Fabian Benencia, Stephen Bell, Edward O. List, John J. Kopchick, Darlene E. Berryman
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Gastroenterology & Hepatology
Hilda E. Ghadieh, Raghd Abu Helal, Harrison T. Muturi, Daniella D. Issa, Lucia Russo, Simon L. Abdallah, John A. Najjar, Fabian Benencia, Guillermo Vazquez, Wei Li, Sonia M. Najjar
HEPATOLOGY COMMUNICATIONS
(2020)
Meeting Abstract
Immunology
Manindra Singh, Fabian Benencia
JOURNAL OF IMMUNOLOGY
(2017)
Meeting Abstract
Oncology
Grady E. Carlson, Alexander O. Ostermann, Venktesh S. Shirure, Fabian Benencia, Monica M. Burdick