Article
Medicine, General & Internal
Mei Jiang, Yihang Cheng, Dan Wang, Yali Lu, Shaohua Gu, Chenji Wang, Yan Huang, Yao Li
Summary: By integrative analysis and experimental validation, a prognostic signature of 16 transcription factors in prostate cancer and their interactions with long noncoding RNAs have been identified, providing new insights into potential biomarkers and therapeutic targets for prostate cancer.
Article
Oncology
Kaili Wang, Shanshan Mei, Mengcheng Cai, Dongxia Zhai, Danying Zhang, Jin Yu, Zhexin Ni, Chaoqin Yu
Summary: This study explores the potential of ferroptosis-related genes as biomarkers and molecular targets for ovarian cancer (OC) diagnosis and intervention. Eight lncRNAs are identified as potential diagnostic markers and intervention targets. The risk scoring model based on ferroptosis-related lncRNAs shows good performance in predicting OC patient prognosis and may support the implementation of precise immunotherapy for OC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sara Terreri, Sara Mancinelli, Matteo Ferro, Maria Concetta Vitale, Sisto Perdona, Luigi Castaldo, Vincenzo Gigantino, Vincenzo Mercadante, Rossella De Cecio, Gabriella Aquino, Marco Montella, Claudia Angelini, Eugenio Del Prete, Marianna Aprile, Angelo Ciaramella, Giovanna L. Liguori, Valerio Costa, George A. Calin, Evelina La Civita, Daniela Terracciano, Ferdinando Febbraio, Amelia Cimmino
Summary: Ultra-conserved-transcript-8+ (uc.8+) levels correlate with the grading and staging of bladder cancer, showing localization in both cytoplasm and nucleus of bladder cells at early stages and prevalent cytoplasmic localization in advanced stages. The study suggests that uc.8+ localization can serve as a potential prognostic biomarker for bladder cancer.
Article
Cell Biology
Xiufang Wang, Chenyang Dai, Minqing Ye, Jingyun Wang, Weizhao Lin, Ruiman Li
Summary: This study identified 1297 lncRNAs related to autophagy genes and established a prognostic signature consisting of five autophagy-related lncRNAs for endometrial cancer. The signature showed potential as an independent prognostic indicator and may play a key role in the development of the disease.
Article
Biotechnology & Applied Microbiology
Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai, Ping Han
Summary: The study developed a hypoxia-related lncRNA signature to predict survival outcomes in bladder cancer patients, accurately predicting survival outcomes and showing associations with immune cell infiltration, tumor mutation burden, and gene set enrichment.
Review
Biochemistry & Molecular Biology
Bela Goyal, Shashi Ranjan Mani Yadav, Nikee Awasthee, Sweety Gupta, Ajaikumar B. Kunnumakkara, Subash Chandra Gupta
Summary: MALAT1 is a widely studied lncRNA in cancer, playing an important role in tumorigenesis and development, localized in the periphery of nuclear speckles. Molecular tools have shown its diagnostic, prognostic, and therapeutic potential in various cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Zi-Hao Feng, Yan-Ping Liang, Jun-Jie Cen, Hao-Hua Yao, Hai-Shan Lin, Jia-Ying Li, Hui Liang, Zhu Wang, Qiong Deng, Jia-Zheng Cao, Yong Huang, Jin-Huan Wei, Jun-Hang Luo, Wei Chen, Zhen-Hua Chen
Summary: In this study, an m6A-immune-related lncRNA risk model was established, which can be used to predict prognosis, immune landscape, and chemotherapeutic response in bladder cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Bin Zhang, Liming Yang, Yang He, Dali Han, Peng Qi, Panfeng Shang
Summary: Bladder cancer is the most common urothelial cancer, and metabolic reprogramming is gaining attention in its development. Recent studies have shown a strong correlation between noncoding RNAs and metabolic reprogramming in bladder cancer. Noncoding RNAs can directly or indirectly regulate the expression and function of metabolic enzymes in bladder cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Review
Oncology
Hao Wang, Yanfei Feng, Xiangyi Zheng, Xin Xu
Summary: Bladder cancer, a common urological malignancy, is closely associated with dysregulation of long noncoding RNAs, specifically small nucleolar RNAs (snoRNAs) and long intergenic noncoding RNAs (lincRNAs). This review focuses on the important role of snoRNAs and lincRNAs in the carcinogenesis and development of bladder cancer, providing valuable insights into their specific mechanisms and potential as diagnostic biomarkers and therapeutic targets.
Article
Medicine, Research & Experimental
Yumin Zhu, Siqi Wang, Xiaochen Xi, Minfeng Zhang, Xiaofan Liu, Weina Tang, Peng Cai, Shaozhen Xing, Pengfei Bao, Yunfan Jin, Weihao Zhao, Yinghui Chen, Huanan Zhao, Xiaodong Jia, Shanshan Lu, Yinying Lu, Lei Chen, Jianhua Yin, Zhi John Lu
Summary: The study utilized sequencing technologies to detect different types of cancer-related RNA variations in plasma, revealing pathways associated with tumorigenesis and metastasis, immune responses, and metabolism. A 3-RNA detection panel for liver cancer was identified, showing promise for detecting AFP-negative and early-stage patients.
Review
Medical Laboratory Technology
Mei Xue, Wei Chen, Xu Li
Summary: EV-transferred lncRNAs play crucial roles in cancer progression and show significant potential as noninvasive biomarkers or therapeutic targets for cancer diagnosis and treatment, particularly in bladder cancer (BC).
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Han-Jie Yang, Tian Liu, Yang Xiong
Summary: The study investigates the function of LINC00478 in bladder cancer and uncovers its inhibitory mechanism through the recruitment of histone demethylation transferase KDM1A to the MMP9 promoter region. The findings provide potential implications for novel therapeutic targets against bladder cancer.
CELL DEATH DISCOVERY
(2022)
Editorial Material
Oncology
Barbara Pardini, Mihnea P. Dragomir
Summary: The study by Zagorac et al. unveils a novel molecular mechanism in breast cancer involving SOX2, EZH2, and the long noncoding RNA SCIRT. Upregulation of SCIRT may lead to the dedifferentiation of TICs into a less tumorigenic phenotype and offer new therapeutic opportunities.
Article
Oncology
Yong Chen, Wanqin Xie, Feng Hu, Jia Chen, Hexin Zheng, Haiyan Zhou, Bin Ni, Wanmeng Li, Jianda Zhou
MOLECULAR MEDICINE REPORTS
(2017)
Article
Food Science & Technology
Hui Zou, Lei Xu, Zhenzhen Xu, Wanqin Xie, Yongtao Wang, Xiaojun Liao, Xiankui Kong
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
Review
Pediatrics
Wen Jiang, Bin Ni, Zhiyu Liu, Xuan Liu, Wanqin Xie, Irene X. Y. Wu, Xingli Li
Article
Genetics & Heredity
Hui Xi, Ying Peng, Wanqin Xie, Jialun Pang, Na Ma, Shuting Yang, Jinping Peng, Hua Wang
MOLECULAR CYTOGENETICS
(2020)
Article
Medicine, Research & Experimental
Wanqin Xie, Haiyan Zhou, Lin Zhou, Yun Gong, Jiwu Lin, Yong Chen
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Obstetrics & Gynecology
Wen Jiang, Zhiyu Liu, Bin Ni, Wanqin Xie, Haiyan Zhou, Xingli Li
Summary: Exposure to NO2 and SO2 during the first trimester of pregnancy is consistently associated with an increased risk of CLDs. Meteorological conditions such as low and high temperatures and high humidity act synergistically with these air pollutants to further increase the risk.
HUMAN REPRODUCTION
(2021)
Article
Reproductive Biology
Wen Jiang, Zhiyu Liu, Bin Ni, Wanqin Xie, Haiyan Zhou, Xingli Li
Summary: Studies have found that maternal exposure to sulfur dioxide, carbon monoxide, nitrogen dioxide, PM2.5, and ozone during early pregnancy increases the risk of congenital heart defects, and ambient heat exposure may enhance these effects. Air pollutants showed more apparent synergistic effects under less and moderately intense heat exposure.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Genetics & Heredity
Duo Yang, Haiyan Zhou, Jiwu Lin, Shuangxi Zhao, Hao Zhou, Zhaochu Yin, Bin Ni, Yong Chen, Wanqin Xie
Summary: A novel heterozygous variation c.1871A>G (p.Lys624Arg) has been identified in the SIPA1L3 gene in a three-generation Chinese family with isolated juvenile-onset cataracts. The Lys 624 residue of SIPA1L3 is conserved across species and may have an impact on the regulatory function of SIPA1L3 on Rap signaling. Further investigations are needed to validate the functional alteration of this variant.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Ying Peng, Changbiao Liang, Hui Xi, Shuting Yang, Jiancheng Hu, Jialun Pang, Jing Liu, Yingchun Luo, Chengyuan Tang, Wanqin Xie, Hua Wang
Summary: Cornelia de Lange syndrome (CdLS) is a genetic disorder characterized by multisystemic malformations. This study presented clinical and genetic findings of three CdLS cases from separate Chinese families, showing associations between mutations in the NIPBL gene and CdLS.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Hui Xi, Wanqin Xie, Jing Chen, Wanglan Tang, Xiuli Deng, Hua Li, Ying Peng, Dan Wang, Shuting Yang, Yanan Zhang, Ranhui Duan, Junqun Fang, Hua Wang
Summary: The study found that implementing FXS carrier screening during prenatal diagnosis is feasible and may help increase the screening rate for FXS. Different types of FXS mutations were identified in pregnant women who participated in the screening, but none of the premutation alleles were inherited by the fetuses.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wen Jiang, Wanqin Xie, Bin Ni, Haiyan Zhou, Zhiyu Liu, Xingli Li
Summary: This study found that maternal exposure to CO, NO2, and SO2 during the first trimester of pregnancy may increase the risk of orofacial clefts, and these associations may be independent of particulate matter. Additionally, increasing exposure levels of NO2 may lead to an increased risk of cleft palate only (CPO), while O-3 did not show a significant effect.
Article
Genetics & Heredity
Mojiang Li, Yingshu Li, Huixing Liu, Haiyan Zhou, Wanqin Xie, Qinghua Peng
Summary: This study describes a patient with a homozygous ADAMTSL2 p.Gly656Ser variant, further increasing our understanding of the genotype-phenotype correlation in acromelic dysplasias.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Haiyan Zhou, Zhongmin Zhou, Zhaochu Yin, Jiwu Lin, Bin Ni, Xin Wang, Ying Peng, Wanqin Xie
Summary: This study used small RNA sequencing to detect the expression profile of cell-free miRNAs in amniotic fluid of Down syndrome (DS) and normal karyotype. The findings revealed 33 differentially expressed miRNAs in DS, including 9 upregulated and 24 downregulated miRNAs. These differentially expressed miRNAs were predicted to target genes involved in various pathways such as cancer, Cushing's syndrome, P13K-Akt, MAPK and AMPK signaling pathways, longevity regulating pathway, and cellular senescence. Furthermore, validation assays confirmed the significant downregulation of miR-22-3p in the DS group. These results provide new insights into the differential expression of cell-free miRNAs in amniotic fluid of DS fetuses.
Article
Medicine, Research & Experimental
Hong-Ying Shu, Hong-Chao Li, Wan-Qin Xie, Bin Ni, Hai-Yan Zhou
BIOMEDICAL REPORTS
(2019)
Article
Medicine, General & Internal
Gang-Hua Zhu, Hong-Ying Shu, Hai-Yan Zhou, Yong Chen, Fei Zhou, Bin Ni, Wanqin Xie
CLINICAL CASE REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
