Article
Agriculture, Dairy & Animal Science
Martina Karasova, Csilla Tothova, Simona Grelova, Maria Fialkovicova
Summary: Babesia gibsoni is a parasite that causes red blood cell rupture in dogs, and its incidence has been increasing in European countries. Fighting dog breeds are more susceptible to the disease and may serve as potential sources of infection. The disease is often asymptomatic and easily introduced into Europe through importation or travel of dogs from endemic areas. This highlights the need for attention and study of B. gibsoni infection and its treatment, which can be challenging.
Article
Agriculture, Dairy & Animal Science
Olga Gojska-Zygner, Justyna Karabowicz, Justyna Bartosik, Wojciech Zygner
Summary: This study investigates the association between increased serum AST activity and renal indices in dogs with renal azotaemia infected with Babesia canis. The results suggest that increased serum AST activity may have a renal origin and the AST/ALT ratio could be a convenient renal index for recognizing renal azotaemia in canine babesiosis.
Review
Agriculture, Dairy & Animal Science
Wojciech Zygner, Olga Gojska-Zygner, Justyna Bartosik, Pawel Gorski, Justyna Karabowicz, Grzegorz Kotomski, Luke J. Norbury
Summary: Canine babesiosis is a disease caused by protozoan pathogens of the genus Babesia. The disease is caused by four species of large Babesia, with each species having specific regions of occurrence. B. vogeli is the most prevalent and widely distributed species globally, likely due to its wide range of vector species and mild infections, as well as its long evolutionary association with dogs. The main risk factors for large Babesia infection include living in rural areas, kennels or animal shelters, being in endemic regions, the season of the year (increased tick activity), tick infestation, and lack of acaricidal treatment.
Review
Microbiology
Wojciech Zygner, Olga Gojska-Zygner, Luke J. J. Norbury
Summary: Canine babesiosis is a tick-borne parasitic disease that leads to anemia in infected dogs. The anemia is not caused directly by the pathogen, but rather by the immune response to the infection. Pro-inflammatory cytokines and chemokines play a role in the mechanisms leading to anemia in canine babesiosis, including antibody production, erythrophagocytosis, oxidative damage, and splenic sequestration of red blood cells.
Article
Microbiology
Stephen J. Goodswen, Paul J. Kennedy, John T. Ellis
Summary: Infections from Babesia in red blood cells can lead to severe diseases in susceptible hosts. Bovine babesiosis and canine babesiosis are significant issues in the beef and dairy cattle industries, as well as with dogs. Machine learning methods have been developed to predict exportome members, providing valuable insights for laboratory validation.
Article
Veterinary Sciences
Susana Remesar, Jose Luis Arnal, Andrea Gomez, Alberto Prieto, David Garcia-Dios, Alfredo Benito, Rosario Panadero, Patrocinio Morrondo, Pablo Diaz
Summary: This case report highlights the existence of feline babesiosis caused by Babesia canis in Europe and its association with symptoms such as anemia and thrombocytopenia, providing molecular and epidemiological evidence.
BMC VETERINARY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Rachel L. Smith, Amelia Goddard, Arun Boddapati, Steven Brooks, Johan P. Schoeman, Justin Lack, Andrew Leisewitz, Hans Ackerman
Summary: The study investigates the clinical and transcriptomic progression of B. rossi infection in canines through controlled inoculations. The research establishes a large mammalian model of severe hemoprotozoal disease, providing insights into host-parasite biology and potential anti-disease therapeutics. Insights gained from studying B. rossi in canines may improve understanding of this emerging infectious disease threat in domestic dogs and offer knowledge on human diseases caused by Babesia and Plasmodium species.
Article
Veterinary Sciences
Alida Avenant, Janice Y. Park, Ilse Vorster, Emily P. Mitchell, Angela M. Arenas-Gamboa
Summary: Babesiosis, caused by Babesia spp., is a tick-borne disease that affects livestock worldwide. Although less common in pigs, a case in a 12-year old pot-bellied pig from South Africa exhibited typical pathological features including hemoparasites, anemia, icterus, and organ damage. The 18SrRNA sequence analysis confirmed the identity of the Babesia strain, highlighting the clinical manifestations of porcine babesiosis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biology
Mariana Ionita, Laurentiu Leica, Marion Wassermann, Emanuel Mitrea, Isabela Madalina Nicorescu, Ioan Liviu Mitrea
Summary: This study aimed to investigate the genetic diversity of Babesia spp. strains in a tick-endemic area in southeastern Romania. It identified the presence of both Babesia canis and Babesia vogeli strains, with different genotypes of B. canis. It also revealed the first evidence of genetic variability in canine babesiosis in Romania, providing a basis for further studies on the disease.
Article
Parasitology
Masahiro Yamasaki, Yuka Nukada, Minori Ito, Naohiro Uchida, Aiko Iguchi, Hisashi Inokuma
Summary: Babesia odocoilei-like parasites were first reported in 2003, and their association with canine babesiosis cases in dogs from Iwate Prefecture, Japan was investigated using gene analysis. Results revealed that the HSP70 gene sequences of the parasites did not match B. odocoilei, indicating a different species. Two dogs were confirmed to be infected with B. odocoilei-like parasites, while one dog was suspected to be infected. Further research with additional cases is suggested to validate these findings.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Veterinary Sciences
Krzysztof Jasik, Anna Kleczka, Sandra Filipowska
Summary: This study investigated the effects of transplacental transmission of Babesia microti on the spleen and kidneys of rats. The results showed that congenital babesiosis can damage these organs and impair their functioning. Therefore, mandatory screening tests should be introduced for carriers of pathogenic species of Babesia, especially in young women, blood donors, and people exposed to tick bites for occupational reasons.The study demonstrated the negative effects of B. microti on cells and tissues in rats with congenital babesiosis.
VETERINARY SCIENCES
(2023)
Article
Microbiology
Olga Pawelczyk, Damian Kotela, Marek Asman, Joanna Witecka, Peter Wilhelmsson, Paulina Bubel, Krzysztof Solarz
Summary: Tick-borne microorganisms, including Babesia canis, are important agents causing infectious diseases in humans and animals. This study reports two cases of symptomatic canine babesiosis caused by Babesia canis in domestic dogs from Poland, as well as the presence of Dermacentor reticulatus ticks on one of the infected dogs. Molecular analysis confirmed the presence of Babesia canis in the dogs' blood, with the obtained sequence being identical to a known isolate.
Article
Immunology
Iqra Zafar, Tomoyo Taniguchi, Hanadi B. Baghdadi, Daisuke Kondoh, Mohamed Abdo Rizk, Eloiza May Galon, Shengwei Ji, Shimaa Abd El-Salam El-Sayed, Thom Do, Hang Li, Moaz M. Amer, Zhuowei Ma, Yihong Ma, Jinlin Zhou, Noboru Inoue, Xuenan Xuan
Summary: Malaria is a significant global health issue, and efforts to eliminate it continue. This study investigated the impact of co-infection with B. microti and P. berghei on the severity of malaria, and found that B. microti infection activated immunity and reduced the severity of malaria. TNF-α, IFN-γ, and IL-12p70 were identified as key cytokines associated with the severity of P. berghei infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Dulanjalee Neelawala, D. R. A. Dissanayake, D. V. P. Prasada, I. D. Silva
Summary: This study identified risk factors associated with recurrence of canine babesiosis, including Rottweiler breed, secondary IMHA, low RBC counts, and persistent anemia. Dogs with concurrent haemoparasitic infections were predicted to have a fatal outcome in the survival analysis.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Brigitta Margit Kallai, Judit Csondes, Gergely Kiss, Lilla Bodrogi, Zsolt Ronai, Tamas Meszaros
Summary: Glucocorticoids, through their receptor GR, play a central role in regulating inflammatory responses and alleviating symptoms in critically ill patients. Different splice variants of GR, including cGRα and cGR-P, are expressed in response to stress, with elevated levels associated with increased survival rates, underscoring the importance of total GR expression in disease outcomes.
SCIENTIFIC REPORTS
(2021)
