Article
Biochemistry & Molecular Biology
Svetlana Spremovic Radenovic, Miljan Pupovac, Mladen Andjic, Jovan Bila, Svetlana Sreckovic, Aleksandra Gudovic, Biljana Dragas, Nebojsa Radunovic
Summary: This review presents the current knowledge in epidemiology, pathophysiology, diagnostics, and treatment of nonalcoholic fatty liver disease (NAFLD) in polycystic ovary syndrome (PCOS) women. It highlights the associations of insulin resistance, hyperandrogenemia, obesity, adipose tissue dysfunction, and inflammation with the development of NAFLD in PCOS women. Additionally, the possible roles of the gut microbiome, mitochondrial dysfunction, and endocannabinoid system in NAFLD maintenance in PCOS women are discussed.
Article
Biochemistry & Molecular Biology
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. A study investigated the levels of branch chain amino acids (BCAA) in women with PCOS and found significantly higher levels of BCAA compared to healthy controls. These elevated BCAA levels were associated with metabolic alterations and other disturbances in PCOS patients. The findings suggest that BCAA profiles could be used as a predictive factor for PCOS-related complications.
Review
Endocrinology & Metabolism
Hui Zhang, Claudette Butoyi, Guoyue Yuan, Jue Jia
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine gynecological disorder with unclear pathogenesis. Obesity, a significant public health problem, plays a vital role in PCOS by worsening symptoms through insulin resistance and hyperandrogenemia. Lifestyle interventions and weight loss are the first-line treatments for PCOS, which is closely associated with the gut microbiota, a current research hotspot, and obesity. This study aims to explore the role of the gut microbiota in obesity and PCOS to offer novel insights for PCOS treatment.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Immunology
Huan Xiao, Tailang Yin, Lianghui Diao, Yan Zhang, Chunyu Huang
Summary: Polycystic ovary syndrome (PCOS) is characterized by endocrine and metabolic disorders, including hyperandrogenemia, insulin resistance, and ovulation disorder. Recent studies have suggested that a chronic low-grade inflammatory state may contribute to the development of PCOS. This article reviews the role of immune factors in affecting these three symptoms, aiming to explore potential treatment strategies.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Salvatore Giovanni Vitale, Anna Maria Fulghesu, Mislav Mikus, Rafal Watrowski, Maurizio Nicola D'Alterio, Li-Te Lin, Mohsin Shah, Enrique Reyes-Munoz, Thozhukat Sathyapalan, Stefano Angioni
Summary: MicroRNAs (miRNAs) play crucial regulatory roles in tissue development, differentiation, and metabolic processes. In the context of PCOS, altered miRNA levels have been associated with hormonal changes, glucose and lipid metabolism, and fertility issues. This systematic review provides an overview of miRNA expression, hormonal changes, and metabolic correlations in PCOS, highlighting the potential of miRNAs as therapeutic targets and diagnostic markers.
Article
Obstetrics & Gynecology
Anthony Deangelis, Lisa Deangelis, William Catherino, Nanette L. Rollene
Summary: The exact etiology of the biochemical changes and symptoms in PCOS remains unknown, with genetics, lifestyle, and hormonal abnormalities all playing a role. This article delves into the dysregulation of multiple biochemical pathways in PCOS and their impact on female physiology.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Yu, Lina Wang, Wufan Tao, Wenxiang Zhang, Shuanghao Yang, Jian Wang, Jia Fei, Rui Peng, Yiming Wu, Xiumei Zhen, Hong Shao, Weiyue Gu, Rong Li, Bai-Lin Wu, Hongyan Wang
Summary: Activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology, while ALMS1 deficiency may promote anovulatory infertility via elevated androgens, suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes, characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Medicine, General & Internal
Enrico Carmina
Summary: The diagnosis of PCOS is based on the Rotterdam guidelines, but the current classification does not include obesity and metabolic changes. This makes it challenging to establish clear strategies for follow-up and treatment of high-risk patients and may hide genetic or environmental differences between PCOS patients. A new classification is suggested which divides each Rotterdam phenotype into obese or lean sub-phenotypes, aiming to improve our understanding and treatment of PCOS.
Article
Medicine, General & Internal
Enrico Carmina, Rogerio A. Lobo
Summary: This study investigated the influence of body weight on the various phenotypes of women with Polycystic Ovary Syndrome (PCOS). It revealed that the Rotterdam diagnostic criteria fail to differentiate between obese patients with altered metabolic patterns and lean patients with normal metabolic patterns. A new classification system is needed.
Article
Obstetrics & Gynecology
Karen E. Elkind-Hirsch, Neil Chappell, Donna Shaler, John Storment, Drake Bellanger
Summary: This study aimed to evaluate the efficacy and safety of the GLP-1 analog liraglutide 3 mg (LIRA 3 mg) in reducing body weight and hyperandrogenism in women with obesity and polycystic ovary syndrome (PCOS). The results showed that LIRA 3 mg was superior to placebo in reducing body weight, lowering androgen levels, and improving cardiometabolic parameters.
FERTILITY AND STERILITY
(2022)
Review
Endocrinology & Metabolism
Anju E. Joham, Robert J. Norman, Elisabet Stener-Victorin, Richard S. Legro, Stephen Franks, Lisa J. Moran, Jacqueline Boyle, Helena J. Teede
Summary: Polycystic ovary syndrome (PCOS) affects 5-18% of women and is a reproductive, metabolic, and psychological condition. Its complex cause includes genetic and epigenetic susceptibility, hypothalamic and ovarian dysfunction, excess androgen exposure, insulin resistance, and adiposity-related mechanisms. The diagnostic criteria generate four phenotypes and treatment involves a combination of lifestyle alterations and medical management.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Merve Zeytinli Aksit, Fatma Demet Arslan, Inanc Karakoyun, Cengiz Aydin, Emre Turgut, Hulya Parildar, Umut Gokbalci, Banu Isbilen Basok, Can Duman, Mustafa Emiroglu
Summary: Gal-3 levels are higher in obese individuals and have a certain relationship with insulin resistance and inflammatory markers. After obesity surgery, leptin and hsCRP levels decreased significantly, but the decrease in Gal-3 levels was not significant. Postoperative adiponectin and IL-10 levels increased significantly.
Article
Endocrinology & Metabolism
Sweta Ravisankar, Melinda J. Murphy, Nash Redmayne-Titley, Brett Davis, Fangzhou Luo, Diana Takahashi, Jon D. Hennebold, Shawn L. Chavez
Summary: This study investigates the individual and combined effects of hyperandrogenemia and an obesogenic diet on ovarian function in female rhesus macaques. The results show that long-term consumption of an obesogenic diet reduces the development of fertilized oocytes into blastocysts, and the addition of testosterone further impacts gene expression and embryogenesis.
Article
Biochemistry & Molecular Biology
Mohita Maurya, Anant Jaiswal, Sanchita Gupta, Wahid Ali, Anil Nilkanth Gaikwad, Madhu Dikshit, Manoj Kumar Barthwal
Summary: Protein-S-glutathionylation promotes redox signaling in physiological and oxidative distress conditions. Gal-3 S-glutathionylation plays a protective role by enhancing insulin signaling and glucose uptake in adipocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Belma Ozlem Tural Balsak, Sevgul Faki, Sefika Burcak Polat, Kevser Orhan, Salih Suha Koparal, Muge Keskin, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
Summary: This study investigated the frequency of fibromyalgia and its predictors in women with polycystic ovary syndrome (PCOS), and explored the relationship between fibromyalgia and insulin resistance, as well as the impact on anxiety, depression, and quality of life in PCOS patients. The results showed a higher prevalence of fibromyalgia in PCOS patients with insulin resistance.
REPRODUCTIVE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Muserref Hosaf, Sedat Abusoglu, Ahmet Avci, Kenan Demir, Ali Unlu, Duygu Eryavuz, Gulsum Abusoglu
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2020)
Article
Biochemistry & Molecular Biology
Mehmet Yildirimel, Mehmet Nuri Atalar, Sedat Abusoglu, Duygu Eryavuz Onmaz, Abdullah Sivrikaya, Gulsum Abusoglu, Ali Unlu
Summary: The study validated a mass spectrometric creatinine method and compared it with Jaffe and enzymatic serum creatinine methods. Results showed that mass spectrometric creatinine method had higher accuracy and specificity, making it suitable for verifying discordant clinical results and specific populations.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2021)
Article
Neurosciences
Ayhan Bilgic, Sedat Abusoglu, Cagla Sadic celikkol, Mehmet Burhan Oflaz, Omer Faruk Akca, Abdullah Sivrikaya, Tamer Baysal, Ali Unlu
Summary: This study aimed to investigate kynurenine pathway metabolite levels, enzyme activities, and neuroprotective index in toddlers and preschool children with ASD. The results showed significantly higher serum 3-hydroxykynurenine and kynurenic acid concentrations in the ASD group compared to controls, indicating a potential role of the kynurenine pathway in the etiopathogenesis of ASD in early childhood.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ali Unlu, Duygu Eryavuz Onmaz, Sedat Abusoglu, Gulsum Abusoglu
Summary: This article discusses the HPLC and LC-MS/MS methods for measuring methylarginine derivatives, pointing out the problems and solutions in the process from solid phase extraction to reverse phase chromatography separation. Tandem mass spectrometry methods are considered as the gold standard for accurate, selective, sensitive, and rapid measurement of these analytes.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2021)
Article
Oncology
Oktay Ucer, Funda Kosova, Gokhan Temeltas, Sedat Abusoglu, Ali Unlu, Aylin Sepici Dincel, Zeki Ari
Summary: This study evaluated the levels of methylated arginine in patients with BC, finding that ADMA and arginine/total methylated arginine levels were significantly lower in non-muscle invasive BC patients. These markers may be promising for monitoring the diagnosis and treatment of patients.
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mehmet Sozen, Suleyman Baldane, Sedat Abusoglu, Levent Kebapcilar, Aysegul Kebapcilar, Fatma Tuncez Akyurek, Ali Unlu, Suleyman Hilmi Ipekci
Summary: The study aimed to evaluate cardiovascular and metabolic effects in men with male pattern alopecia beginning before 30 years of age. Results showed that AGA patients are similar to the normal population in terms of insulin resistance or metabolic syndrome components, but hsCRP and galectin-3 may be associated with cardiovascular disease risk factors in individuals with AGA.
Article
Biochemical Research Methods
Havva Yaglioglu, Duygu Eryavuz Onmaz, Sedat Abusoglu, Kenan Erdem, Abdullah Sivrikaya, Gulsum Abusoglu, Ali Unlu
Summary: The study developed a validated LC-MS/MS method for measuring statins and their metabolites, and investigated patient adherence and the effects of statin therapy on biochemical and hematological parameters. Results showed poor patient compliance with statin therapy and minor changes in biochemical and hematological parameters after 6 months of treatment.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Obstetrics & Gynecology
Belma G. Ozdemir, Halis Ozdemir, Cemal R. Atalay
Summary: This study aimed to investigate the predictive value of fetal adrenal gland volume (FAGV) measurement in the success of labor induction with oxytocin. The results showed that higher total volumes of fetal adrenal glands and fetal zone volumes were associated with successful labor induction. By setting specific cut-off values, the probability of induction success could be predicted.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Sema Yilmaz, Menekse Kuzu, Gulsum Abusoglu, Fatma H. Yerlikaya, Ali Unlu
Summary: This study found that serum levels of methylarginine derivatives and related metabolites were higher in patients with gout compared to the control group, while serum levels of arginine and homoarginine were lower. There may be an association between gout, methylarginine levels, hyperuricemia, and increased risk of cardiovascular disease.
BIOMARKERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ayse Elverdi Ozbek, Huseyin Korkmaz, Mehmet Sozen, Suleyman Hilmi Ipekci, Sedat Abusoglu, Cem Onur Kirac, Ali Unlu, Levent Kebapcilar
Summary: In this study, the effects of subclinical hyperthyroidism (SH) on bone metabolism were assessed. The results showed that patients with SH had significantly lower levels of serum osteoprotegerin (OPG), and OPG seemed to be associated with the risk of osteoporotic fracture.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Saadet Kader, Turan Akdag, Busra Ecer, Sedat Abusoglu, Ali Unlu
Summary: The study compared the performance of four methods for determining 25(OH)D levels, with the Roche Cobas assay showing better performance compared to LC-MS/MS.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Biochemistry & Molecular Biology
Ahmet Ercan Hataysal, Ali Unlu, Esra Paydas Hataysal, Sedat Abusoglu, Nimet Unlu
Summary: Salivary levels of total antioxidant capacity (TAC), total oxidant status (TOS), and visfatin were found to be significantly higher in patients with dental caries compared to caries-free individuals. There was a positive correlation between the number of caries and salivary TOS and visfatin levels. This study suggests that oxidative stress may play a role in the pathogenesis of dental caries, and salivary visfatin, TAC, and TOS could be novel markers for evaluating dental caries.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Review
Biochemistry & Molecular Biology
Ali Unlu, Sedat Abusoglu
Summary: Mass spectrometric methods are widely used in clinical laboratories, particularly in the fields of metabolic analysis and protein studies, playing a crucial role in various applications.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Obstetrics & Gynecology
Ozhan Ozdemir, Cemal Resat Atalay
Summary: Transmediastinal gunshot wounds can cause life-threatening injuries to vital organs in pregnant women, requiring additional caution. Diagnosis and treatment modalities for hemodynamically stable patients with TGWs can be controversial, with resuscitation playing a crucial role due to physiological changes during pregnancy. A conservative approach in managing such cases can lead to successful outcomes, as seen in the case of a 26-week pregnant woman with uncomplicated pregnancy and a healthy baby at term.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2021)
Article
Medicine, General & Internal
Cem Onur Kirac, Sedat Abusoglu, Esra Paydas Hataysal, Aysegul Kebapcilar, Suleyman Hilmi Ipekci, Ali Unlu, Levent Kebapcilar