Article
Endocrinology & Metabolism
Ruixue Cao, Jinrong Liu, Pinguo Fu, Yonghai Zhou, Zhe Li, Peining Liu
Summary: Basal LH levels and LH/FSH ratios were significantly different between girls with idiopathic CPP and those without at various timepoints after GnRH analogue stimulation testing. The peak LH and LH levels at 60 minutes after GnRH agonist stimulation showed the strongest correlation. The 60-minute LH/FSH ratio had the highest consistency in diagnosing CPP.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Jacob Christ, Christopher N. Herndon, Bo Yu
Summary: This study reported three cases of severe OHSS among oncofertility patients. Despite measures such as freezing embryos, patients still developed severe symptoms of OHSS. Therefore, caution should be exercised when deciding on treatment strategies for such patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Endocrinology & Metabolism
Erkan Kalafat, Engin Turkgeldi, Sule Yildiz, Merve Dizdar, Ipek Keles, Baris Ata
Summary: This study compared the use of GnRH agonist trigger after PPOS and GnRH antagonist ovarian stimulation cycles. The results showed that PPOS cycles had higher yields of mature oocytes and remaining blastocysts, but the cumulative ongoing pregnancy or live birth rates were similar between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Depeng Zhao, Rui Xie, Xuemei Li
Summary: This study aimed to compare the pregnancy outcomes after fresh embryo transfer in patients with thin endometrium using GnRH antagonist and GnRH agonist regimens. The results showed that in patients with thin endometrium, the rates of clinical pregnancy and live birth were significantly lower in the GnRH antagonist group compared to the GnRH agonist group. Multivariable regression analysis demonstrated that the GnRH agonist regimen was associated with a higher live birth rate compared to the GnRH antagonist protocol.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li
Summary: A retrospective cohort study on 110 patients with deep ovarian suppression found that a modified GnRH antagonist protocol based on LH levels during the second ovarian stimulation cycle resulted in significantly better reproductive outcomes compared to continuing with GnRH agonist long protocol. The use of modified protocol led to higher ongoing pregnancy and live birth rates, and lower cancellation rate, suggesting that patients may benefit from adjusting their treatment based on LH levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Endocrinology & Metabolism
Bum Chae Choi, Canquan Zhou, Hong Ye, Yun Sun, Ying Zhong, Fei Gong, Ivan Sini, Nadezda Abramova, Salvatore Longobardi, Miranda Hickey, Thomas D'Hooghe
Summary: The study found that using the redesigned r-hFSH pen injector resulted in significantly lower r-hFSH dose per oocyte retrieved and lower incidence of OHSS in patients at risk when compared to other injection devices. Additionally, overall implantation rate, clinical pregnancy rate, and live birth rates were higher in the study group than in the control group.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Yaxin Guo, Huahua Jiang, Shiqiao Hu, Shuai Liu, Fei Li, Lei Jin
Summary: This study aimed to investigate the efficacy of different COS protocols when AFC and AMH levels are discordant. The results showed that in patients with low AMH and normal AFC, the GnRH-a ultra-long protocol was associated with higher oocyte numbers and better clinical outcomes compared to the GnRH antagonist protocol. Conversely, for patients with normal AMH and low AFC, the long GnRH-a protocol appeared to have better clinical outcomes although the difference was not statistically significant.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Obstetrics & Gynecology
Ginevra Mills, Michael H. Dahan
Summary: In the study, the use of GnRH antagonists in GnRH agonist cycles was found to reduce the risk of developing moderate and severe OHSS by promoting luteolysis and downregulating VEGF production and receptor response, thereby decreasing vascular permeability.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Mu Lv, Juanjuan Yu, Peiqin Chen, Qimeng Xiao, Liqun Lou, Yifan Luo, Mu Yuan, Yuan Xu, Youji Feng, Mingzhu Bai, Zhenbo Zhang, Linxia Li
Summary: This study compares the efficacy of GnRH-ant protocol and GnRH-a protocol in IVF therapy for patients with severe male infertility factors. The results show that the GnRH-a protocol has a higher live birth rate and ongoing pregnancy rate, especially in single embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaojun Kuang, Yongzhe Tang, Hong Xu, Min Ji, Dongmei Lai
Summary: This review assesses the effectiveness of various therapies in recovering ovarian function in patients with primary ovarian insufficiency (POI) and explores a comprehensive evaluation method. The results indicate a lack of scientific evidence supporting any therapy in effectively restoring ovarian function in patients with POI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Hoon Kim, Soo Jin Han, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim
Summary: The optimal number of oocytes for maximizing the rate of clinical pregnancy varies depending on the method of pituitary suppression. Too many oocytes may not lead to better clinical outcomes.
REPRODUCTIVE SCIENCES
(2021)
Review
Endocrinology & Metabolism
Jamie Merkison, Carrie Malcom, Alan Decherney
Summary: Stem cell transplantation has shown significant improvement and potentially a cure in patients with various hematologic disorders and genetic immune deficiencies. However, it often leads to primary ovarian insufficiency, highlighting the importance of optimizing fertility preservation protocols.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
George A. Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R. Thompson, Rona S. Carroll, Min Chen, Lee S. Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J. Bernard, Ursula B. Kaiser
Summary: GnRH regulates gonadal function by stimulating gonadotropin production. The pulse frequency of GnRH differentially regulates FSH and LH synthesis and secretion. The GnRHR activates G alpha (q/11) signaling, but can also couple with G alpha (s).