Article
Cardiac & Cardiovascular Systems
Shucai Xiao, Youzheng Dong, Bin Huang, Xinghua Jiang
Summary: This study aimed to identify risk factors for coronary heart disease in patients with type 2 diabetes mellitus and build a clinical prediction model. Through coronary angiography of 1808 diabetic patients, relevant features associated with coronary heart disease were selected and a prediction model was established using logistic regression and a nomogram. The results showed that the model had high accuracy and clinical utility.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Han Xiao, Yujia Ma, Zechen Zhou, Xiaoyi Li, Kexin Ding, Yiqun Wu, Tao Wu, Dafang Chen
Summary: We presented a genotypic-phenotypic framework for deciphering the genetic architecture underlying the disease patterns of coronary heart disease (CHD) and type 2 diabetes (T2D). Our study identified distinct genetic architectures for different disease patterns and revealed specific pathways related to lipid metabolism in fibrosis that may be activated by diabetes. These findings provide new insights for exploring biological pathways.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Masanori Iwase, Toshiaki Ohkuma, Hiroki Fujii, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Hitoshi Ide, Udai Nakamura, Takanari Kitazono
Summary: This study aimed to investigate the incidence, risk factors, and prognosis of coronary heart disease (CHD) and heart failure (HF) in Japanese patients with type 2 diabetes. The results showed that the incidence of heart disease was low and circulating adiponectin and sarcopenia may predict the development of heart disease in patients with type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Yilin Yoshida, Zhipeng Chen, Robin L. Baudier, Marie Krousel-Wood, Amanda H. Anderson, Vivian A. Fonseca, Franck Mauvais-Jarvis
Summary: Early menopause may increase cardiovascular disease risk in postmenopausal women, especially in those with type 2 diabetes, particularly in Black women.
Article
Endocrinology & Metabolism
Xinxin Zhang, Jinfeng Xiao, Tong Liu, Qing He, Jingqiu Cui, Shaofang Tang, Xin Li, Ming Liu
Summary: This study aimed to explore the associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with coronary heart disease (CHD) and stroke in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM). The study found that serum DHEA and DHEAS levels were significantly and negatively associated with CHD in men with T2DM, but not with stroke. These findings suggest potential roles of DHEA and DHEAS in the pathogenesis of CHD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Niina Sandholm, Per-Henrik Groop
Summary: This study explores the use of a genetic risk score (GRS) for coronary artery disease (CAD) risk prediction in individuals with type 1 diabetes. The GRS showed similar predictive performance to established clinical markers and was more effective in younger individuals.
Article
Genetics & Heredity
Yong Tian, Junhong Wang, Yanxiao Liu, Xiangguang Luo, Ziying Yao, Xinjun Wang, Yuanyuan Zhang, Cheng Xu, Xiaoyu Zhao
Summary: The study found that gene polymorphisms related to pharmacotherapy were common in Chinese patients with T2DM, and the expression of LDL-C and sdLDL-C was consistent with the progression of the disease. It is recommended to conduct multigene screening before therapy and monitor LDL-C and sdLDL-C levels during treatment to assist in T2DM treatment.
BMC MEDICAL GENOMICS
(2021)
Article
Medicine, General & Internal
Yongyan Song, Tariq Muhammad Raheel, Aimei Jia, Guowei Dai, Liang Liu, Xiaobin Long, Chuan He
Summary: The polymorphisms in PPARG gene, rs10865710 and rs3856806, are significantly associated with glucose levels in patients with T2DM. The rs10865710 polymorphism is significantly associated with the severity of CAD, possibly mediated by hyperlipidaemia and hyperglycaemia.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Francesco Piarulli, Cristina Banfi, Maura Brioschi, Alessandra Altomare, Eugenio Ragazzi, Chiara Cosma, Giovanni Sartore, Annunziata Lapolla
Summary: This study aimed to verify the burden of various forms of albumin and their relationship with diseases in patients with diabetes and coronary heart disease. The results showed that levels of AGE and pentosidine were significantly higher in diabetic patients compared to non-diabetic patients, and RAGE levels were higher in diabetic patients, especially those with coronary heart disease. Different forms of albumin could discriminate between different patient groups. Additionally, oxidized forms of albumin were found to increase the expression of the inflammatory cytokine TNF alpha.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Cardiac & Cardiovascular Systems
Peter P. Harms, Petra P. J. M. Elders, Femke Rutters, Birgit Lissenberg-Witte, Hanno L. Tan, Joline W. J. Beulens, Giel Nijpels, Amber A. Van der Heijden
Summary: This study aims to investigate the association between electrocardiogram abnormalities and major adverse cardiac events in individuals with Type 2 diabetes without pre-existing cardiovascular disease. It was found that ECG abnormalities were associated with an increased risk of heart failure, while only certain abnormalities were associated with coronary heart disease. Regular ECG examinations can help in early detection of heart disease in individuals with Type 2 diabetes without cardiovascular disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hertzel C. Gerstein, Sibylle Hess, Brian Claggett, Kenneth Dickstein, Lars Kober, Aldo P. Maggioni, John J. V. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Jean-Claude Tardif, Marc A. Pfeffer
Summary: This study used protein biomarkers to identify individuals with type 2 diabetes who are at high risk for cardiovascular outcomes and death. The results showed that NT-proBNP and other proteins can independently predict these outcomes in this population. Adding additional biomarkers only slightly improved the predictive value of NT-proBNP.
Article
Endocrinology & Metabolism
Sanjoy K. Paul, Jonathan E. Shaw, Peter Fenici, Olga Montvida
Summary: This study aimed to explore the risks and mediation effects of developing chronic kidney disease (CKD) and heart failure (HF) in young- and usual-onset type 2 diabetes (T2D) among White Americans (WAs) and African Americans (AAs). The study found that AAs had a higher risk of developing CKD and HF compared to WAs, and CKD had a greater mediation effect on the HF risk difference between ethnicities compared to HF on CKD risk difference.
Article
Endocrinology & Metabolism
Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo
Summary: In menopausal women, the study found a negative correlation between TBA levels and CAD and MI in patients with T2DM, while low TBA levels were positively associated with the occurrence of CAD combined with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Carmelo Tiberio Curro, Giulia Nicocia, Vanessa Ziccone, Antonio Ciacciarelli, Giuseppina Russo, Antonio Toscano, Carmen Terranova, Paolo Girlanda
Summary: This case report describes a 70-year-old female patient with diabetic chorea, who benefitted from pimozide treatment but later died of pancreatic cancer. The patient initially presented with symptoms of choreic movements and high blood sugar, and despite various treatments, only pimozide proved effective in managing her symptoms. The diagnosis of pancreatic cancer several months after the onset of chorea suggests a potential causal link between the two conditions.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Raffaella Buzzetti, Riccardo C. Bonadonna, Andrea Giaccari, Gianluca Perseghin, Domenico Cucinotta, Carmine Fanelli, Angelo Avogaro, Gianluca Aimaretti, Monica Larosa, Ilaria Pacchetti, Geremia B. Bolli
DIABETES OBESITY & METABOLISM
(2022)
Article
Clinical Neurology
Carmelo Tiberio Curro, Giulia Fiume, Masina Cotroneo, Giuseppina Russo, Carmela Casella, Cristina Dell'Aera, Maria Carolina Fazio, Francesco Grillo, Angelina Lagana, Giuseppe Trimarchi, Antonio Toscano, Sergio Lucio Vinci, Rosa Fortunata Musolino, Paolino La Spina
Summary: This study aimed to explore the main prognostic factors in diabetic patients undergoing reperfusion therapies for ischemic stroke. The results showed that glycemia and neurological severity were associated with prognosis in intravenous thrombolysis, while age, glycemia, and systolic pressure were associated with prognosis in mechanical thrombectomy. Additionally, the study found that metformin had a protective effect in intravenous thrombolysis, and weight and treatment duration were associated with prognosis in mechanical thrombectomy.
NEUROLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Giuseppina T. Russo, Gerardo Corigliano, Franco Arturi, Maria Gisella Cavallo, Cristiano Bette, Edoardo Mannucci
Summary: This study investigated the prevalence and treatment of cardiovascular diseases in Italian patients with type 2 diabetes. The results showed that more than one-third of patients had cardiovascular diseases, but the majority of them were not receiving the recommended medications according to national and international guidelines.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Egidio Imbalzano, Giuseppina T. Russo, Annalisa Giandalia, Angela Sciacqua, Luana Orlando, Vincenzo Russo, Maria Perticone, Arrigo F. G. Cicero, Antonio Giovanni Versace, Pierpaolo Di Micco, Vincenzo Antonio Ciconte, Giuseppe Dattilo, Giovanni Squadrito, Marco Vatrano
Summary: This study evaluated the long-term cardiovascular risk in acute coronary syndrome patients based on different obesity/metabolic phenotypes and sex. The results showed that the impact of obesity phenotypes on cardiovascular risk varies between men and women.
Article
Medicine, General & Internal
Valeria Raparelli, Francesca Santilli, Alberto Maria Marra, Giulio Francesco Romiti, Elena Succurro, Anna Licata, Elena Buzzetti, Salvatore Piano, Maristella Masala, Patrizia Suppressa, Cecilia Becattini, Maria Lorenza Muiesan, Giuseppina Russo, Chiara Cogliati, Marco Proietti, Stefania Basili
Summary: Biological sex and sociocultural gender are important factors in health and diseases, and should be considered in clinical studies. The Gender Working Group of the Italian Society of Internal Medicine (SIMI) has provided a practical framework for internal medicine specialists to integrate gender considerations into their research and clinical practice. This framework, known as the SIMI Gender '5 Ws' Rule, provides guidelines for who, what, where, when, and why gender-related variables should be included in clinical studies.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Endocrinology & Metabolism
G. T. Russo, A. Giandalia, A. Ceriello, P. Di Bartolo, G. Di Cianni, P. Fioretto, C. B. Giorda, V. Manicardi, R. Pontremoli, F. Viazzi, G. Lucisano, A. Nicolucci, S. De Cosmo
Summary: In this study, a predictive model for eGFR loss in type 2 diabetes patients was developed and validated. The model showed good performance in identifying patients at risk of developing clinically significant renal complications within a 5-year timeframe.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Cardiac & Cardiovascular Systems
G. T. Russo, V. Manicardi, M. C. Rossi, E. Orsi, A. Solini
Summary: This review summarizes the contributions of Italian diabetologists to studying the complex relationship between sex/gender and long-term complications of type 1 and type 2 diabetes over the last fifteen years. It highlights the impact of sex- and gender-related differences on diabetes complications and the lack of consideration of such differences in current clinical guidelines.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Environmental Sciences
Annalisa Giandalia, Marta Ragonese, Eugenio Alessi, Maria C. Ruffo, Alberto Sardella, Alessandro Cuttone, Maria A. Aragona, Antonio G. Versace, Giorgio Basile, Domenico Cucinotta, Giovanni Squadrito, Giuseppina T. Russo
Summary: This study aimed to evaluate the predictive role of LOC and QoL scores on metabolic control in elderly T2D outpatients and found potential gender differences. The results showed that LOC scores may influence long-term glycemic control in elderly T2D patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Urology & Nephrology
Henry Sundqvist, Eveliina Heikkala, Jari Jokelainen, Giuseppina Russo, Ilona Mikkola, Maria Hagnas
Summary: This study examines the association between the screening frequency of estimated glomerular filtration rate (eGFR) and the substantial reduction in eGFR among type 2 diabetes patients. The study emphasizes the importance of regular eGFR screening in the prevention of kidney function decline.
Article
Endocrinology & Metabolism
Annalisa Giandalia, Giuseppina Tiziana Russo, Patrizia Ruggeri, Annalisa Giancaterini, Elisabetta Brun, Mariarosaria Cristofaro, Anna Bogazzi, Maria Chiara Rossi, Giuseppe Lucisano, Alberto Rocca, Valeria Manicardi, Paolo Di Bartolo, Graziano Di Cianni, Chiara Giuliani, Angela Napoli
Summary: This study investigated the prevalence of obesity and severe obesity, clinical correlates, and potential sex differences in a large cohort of T1D subjects in Italy. The results showed that obesity was similar between men and women, but severe obesity was more prevalent among women. Obesity was associated with a higher burden of cardiovascular disease risk factors and complications, and a lower quality of care, with no major sex differences.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Clelia Asero, Annalisa Giandalia, Irene Cacciola, Carmela Morace, Giuseppe Lorello, Amalia Rita Caspanello, Angela Alibrandi, Giovanni Squadrito, Giuseppina T. Russo
Summary: This study aimed to evaluate the occurrence and severity of liver fibrosis in type 2 diabetes outpatients without a known history of liver disease, and to identify predictive factors. The results showed that obesity, high triglycerides, worse glycemic control, and high creatinine levels were independent predictors of liver fibrosis in type 2 diabetes patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Anna Licata, Giuseppina T. Russo, Annalisa Giandalia, Marcella Cammilleri, Clelia Asero, Irene Cacciola
Summary: In recent years, there has been increasing reports on gender differences in the epidemiology, pathophysiological mechanisms and clinical features of chronic liver diseases associated with type 2 diabetes (T2D). This sexual dimorphism is influenced by a complex interaction between sex- and gender-related factors. However, the impact of sex and gender on the management of T2D subjects with liver disease is still unclear. Therefore, it is important to consider sex-related differences in pharmacology in order to improve drug safety and optimize medical therapy in both men and women with T2D.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Gian Paolo Fadini, Raffaella Buzzetti, Antonio Nicolucci, Monica Larosa, Maria Chiara Rossi, Domenico Cucinotta
Summary: This study assessed the comparative effectiveness of Gla-300 and Deg-100 in insulin-naive patients with T2D. The results showed similar improvements in glycemic control, no weight gain, and low hypoglycemia rates without severe episodes for both treatments.
ACTA DIABETOLOGICA
(2022)