Journal
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
Volume 7, Issue 10, Pages 959-974Publisher
Becaris Publishing
DOI: 10.2217/cer-2017-0106
Keywords
abatacept; joint erosion; rituximab; Sharp score; TNF inhibitors; tocilizumab
Categories
Funding
- AbbVie
Ask authors/readers for more resources
Aim: To evaluate the comparative effectiveness of biologics in inhibiting radiographic progression among rheumatoid arthritis (RA) patients. Materials & methods: Bayesian network meta-analysis of published trials investigating the USA FDA approved biologics treatment in RA patients, using methotrexate (MTX) as the reference comparator. Results: Nine trials met the inclusion criteria for base case analysis. Compared with MTX, most biologics (except golimumab) + MTX had significantly lower rates of radiographic progression at 1 year. Mean difference in radiographic progression rates between MTX monotherapy and biologics + MTX was highest for adalimumab + MTX (-3.8) and lowest for tocilizumab + MTX (-0.7). Inhibition of radiographic progression was sustained. Conclusion: Biologics inhibit radiographic progression in patients with RA at 1 year; however, published evidence beyond 1 year is limited.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available