Review
Physiology
Simin Cai, Lihui Zheng, Yan Yao
Summary: Sinus node dysfunction is a complex disorder with variable symptoms that becomes more prevalent with age. Excessive vagal activity may be the sole cause in certain patients, who experience daytime symptoms related to bradyarrhythmia, with no organic sinus node lesions and cardiac vagal overactivation, and are non-elderly. Permanent pacemaker implantation is considered the ultimate solution for these patients, but cardioneuroablation shows promise in eliminating symptoms by denervating the cardiac vagal nerve. Guidelines for selecting suitable candidates for cardioneuroablation are currently lacking, but identifying patients with autonomic imbalance can maximize the benefits and success rate of the procedure.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Ethan G. Harrod, Ilan Shrira, Jared D. Martin, Paula M. Niedenthal
Summary: Despite the historically negative reactions towards strangers, contemporary migration patterns have increased interaction between different groups. This study suggests that cultural practices in ancestrally diverse societies promote emotion regulation and higher vagal tone, enabling individuals to effectively manage arousal and engage with outgroup members. The analysis of data from the MIDUS 2 Biomarker Project shows that the ancestral diversity of states in the United States significantly predicts the average vagal tone of its citizens, highlighting the impact of social context on human physiology.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Engineering, Biomedical
Thais Marques da Silva, Carlos Alberto Aguiar Silva, Helio Cesar Salgado, Rubens Fazan Jr, Luiz Eduardo Virgilio Silva
Summary: The study investigated the influence of the autonomic nervous system on heart rate fragmentation (HRF) in rats. Results showed that sympathetic and parasympathetic influences similarly decrease HRF, with parasympathetic control markedly affecting the type of inflection points. Further studies are needed to explore the role of the autonomic nervous system in diseases marked by autonomic imbalance.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Pediatrics
Rohit K. Kharbanda, Mathijs S. van Schie, Nawin Ramdat L. Misier, Fons J. Wesselius, Roxanne D. Zwijnenburg, Wouter J. van Leeuwen, Pieter C. van de Woestijne, Peter L. de Jong, Ad J. J. C. Bogers, Yannick J. H. J. Taverne, Natasja M. S. de Groot
Summary: Adult patients with uncorrected CHD exhibit more heterogeneous conduction and variations in preferential SAN exit site compared to pediatric patients, which may be related to aging-related remodeling.
FRONTIERS IN PEDIATRICS
(2022)
Article
Psychology, Biological
Valentin Magnon, Frederic Dutheil, Guillaume T. Vallet
Summary: This study examines the performance of self-regulation in decision-making under different contexts and finds that vagal reactivity and recovery in a specific decisional context is the best model to explain advantageous decision-making.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Cardiac & Cardiovascular Systems
Madalena D. Costa, Susan Redline, Elsayed Z. Soliman, Ary L. Goldberger, Susan R. Heckbert
Summary: Heart rate fragmentation (HRF), a marker of anomalous sinoatrial dynamics, is an independent predictor of atrial fibrillation (AF), adding value to existing predictive models and supporting the concept of electrodynamical remodeling in the prediction of AF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Masahiro Okada, Kosuke Okada, Masayuki Kakehashi
Summary: Based on the analysis of data from 53 young women, this study found that masticatory function is associated with nervous function and eating habit patterns. High occlusal force is related to an increased high-frequency component of heart rate variability, and eating habit patterns are also associated with occlusal force and heart rate variability. Therefore, eating habits may simultaneously affect masticatory function, nervous system development, and cardiovascular rhythm.
Article
Endocrinology & Metabolism
Gabriela Aguiar Mesquita Galdino, Luiz Eduardo Virgilio Silva, Silvia Cristina Garcia Moura-Tonello, Juliana Cristina Milan-Mattos, Stephanie Nogueira Linares, Alberto Porta, Thais Marques da Silva, Rubens Fazan Jr, Thomas Beltrame, Aparecida Maria Catai
Summary: This study evaluated the heart rate fragmentation (HRF) of type 2 diabetes mellitus (T2DM) patients and its relationship with heart rate variability (HRV) indices. The results showed that T2DM patients had higher HRF and stronger correlation with HRV indices.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Diego Candia-Rivera, Vincenzo Catrambone, Julian F. Thayer, Claudio Gentili, Gaetano Valenza
Summary: The century-long debate on bodily states and emotions continues, with this study investigating the brain-heart interplay during emotional experiences. Using a computational model, the researchers found that sympathetic-vagal activity plays a leading and causal role in initiating the emotional response, and the subsequent dynamic interplay between the central and autonomic nervous systems sustains the processing of emotional arousal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Simone Grassi, Oscar Campuzano, Monica Coll, Francesca Cazzato, Anna Iglesias, Francesco Ausania, Francesca Scarnicci, Georgia Sarquella-Brugada, Josep Brugada, Vincenzo Arena, Antonio Oliva, Ramon Brugada
Summary: This article describes a case of sudden death in a 21-year-old obese woman. Clinical autopsy and histopathological analysis revealed eosinophilic inflammatory focus and interstitial fibrosis in the sino-atrial node. Molecular autopsy identified a variant in the KCNQ1 gene, possibly associated with long QT syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Marta Zammuto, Cristina Ottaviani, Fiorenzo Laghi, Antonia Lonigro
Summary: Theory of mind (ToM) is the ability to infer the mental states of others in order to understand their behaviors, and is related to heart rate variability (HRV). A meta-analysis found a significant association between HRV and ToM, with studies using high frequency-HRV assessment at rest and the Reading the Mind in the Eyes Test showing the largest effect sizes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A. B. Burton
Summary: Atrial arrhythmias, such as atrial fibrillation, are a major risk for mortality and stroke. This study found that AC1 is involved in the response of atrial tissue and cells to alpha-adrenoceptor stimulation and IP3R calcium release.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Matilde Costa, Mariana Xavier, Ines Nunes, Teresa S. Henriques
Summary: Intrapartum fetal monitoring aims to avoid adverse outcomes related to hypoxia/acidosis, with the new biomarker HRF indices being used to evaluate fetal acidemia. The fragmentation indices correlate with Sisporto variability measures and can detect pathological patterns in FHR tracings, potentially enhancing real-time analysis capabilities.
FRONTIERS IN PEDIATRICS
(2021)
Article
Psychology, Biological
Kevin Dang, Megan A. Kirk, Georges Monette, Joel Katz, Paul Ritvo
Summary: The study found a quadratic relationship between higher meaning in life (MIL) and vagally-mediated heart rate variability (VmHRV), with higher MIL associated with greater stress reactivity. However, MIL did not enhance stress attenuation. Overall, the findings suggest that cardiac vagal tone and reactivity are linked to MIL, shedding light on the physiological processes underlying the relationship between MIL and health outcomes.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thassio Mesquita, Rui Zhang, Jae Hyung Cho, Rui Zhang, Yen-Nien Lin, Lizbeth Sanchez, Joshua Goldhaber, Joseph K. Yu, Jialiu A. Liang, Weixin Liu, Natalia A. Trayanova, Eugenio Cingolani
Summary: Chronotropic incompetence and sinoatrial node (SAN) dysfunction are common problems in patients with heart failure, but the underlying mechanisms are not yet fully understood. This study identified intrinsic abnormalities in SAN structure and function as the cause of chronotropic incompetence in heart failure patients with preserved ejection fraction (HFpEF).
Article
Cardiac & Cardiovascular Systems
Margie J. Bailey, Elsayed Z. Soliman, Leslie A. McClure, George Howard, Virginia J. Howard, Suzanne E. Judd, Frederick W. Unverzagt, Virginia Wadley, Bonnie C. Sachs, Timothy M. Hughes
Summary: This study of 25,980 black and white adults found that atrial fibrillation (AF) was associated with poorer baseline cognitive performance and incident cognitive impairment. Factors such as race, sex, and incident stroke were also found to modify the relationship between AF and cognitive decline. Adjustment for cardiovascular risk factors weakened the associations, except in the domain of learning.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dominique Drager, Elsayed Z. Soliman, Michelle L. Meyer, Zhu-Ming Zhang, Alvaro Alonso, Gerardo Heiss, Eric A. Whitsel
Summary: The Peguero-Lo Presti ECG-LVH criteria demonstrate excellent repeatability and agreement, supporting their utility in clinical and epidemiological studies.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Stephen T. Broughton, Muhammad Ahmad, Elsayed Z. Soliman, Jared W. Magnani
Summary: SCMI prevalence and its association with cardiovascular mortality differ by race, with Mexican Americans having a lower prevalence but increased risk of cardiovascular mortality. Screening for SCMI may help identify individuals at higher risk.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Ankit Maheshwari, Faye L. Norby, Elsayed Z. Soliman, Alvaro Alonso, Nona Sotoodehnia, Lin Y. Chen
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Sareh Keshavarzi, Barbara H. Braffett, Rodica Pop-Busui, Trevor J. Orchard, Elsayed Z. Soliman, Gayle M. Lorenzi, Annette Barnie, Amy B. Karger, Rose A. Gubitosi-Klug, Samuel Dagogo-Jack, Andrew D. Paterson
Summary: Individuals with diabetes have higher resting heart rate compared with those without, which may be predictive of long-term cardiovascular disease (CVD) risk. Using data from the DCCT/EDIC) study, the study evaluated the effect of intensive versus conventional diabetes therapy on heart rate, and the predictive value of heart rate on future CVD risk. The research found that intensive therapy can lower heart rate among diabetic patients and that heart rate can independently predict the risk of CVD.
Article
Cardiac & Cardiovascular Systems
Matthew J. Singleton, Ya Yuan, Farah Z. Dawood, George Howard, Suzanne E. Judd, Neil A. Zakai, Virginia J. Howard, David M. Herrington, Elsayed Z. Soliman, Mary Cushman
Summary: This study found that circulating stroke risk biomarkers such as cystatin C, factor VIII antigen, interleukin-6, and NT-proBNP were associated with stroke risk in atrial fibrillation patients. A multimarker risk score incorporating these biomarkers was developed, showing improved predictive accuracy for stroke risk in atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Bianco, Raffaele De Caterina, Alvin Chandra, Iolanda Aquila, Brian Claggett, Michelle C. Johansen, Alexandra Goncalves, Faye L. Norby, Rebecca Cogswell, Elsayed Z. Soliman, Rebecca Gottesman, Thomas Mosley, Alvaro Alonso, Amil Shah, Scott D. Solomon, Lin Yee Chen
Summary: The study found that age-related left atrial structural and functional abnormalities are associated with subclinical cerebral infarcts (SCIs) and stroke in elderly patients. The deterioration of LA global longitudinal strain and E/e' divided by LA global longitudinal strain is related to age increment and increased odds of SCIs and stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neurosciences
Naga Venkata K. Pothineni, Elsayed Z. Soliman, Mary Cushman, George Howard, Virginia J. Howard, Scott E. Kasner, Suzanne Judd, J. David Rhodes, Francis E. Marchlinski, Rajat Deo
Summary: This study examined the feasibility of telephone guided, mail-in ambulatory long-term cardiac rhythm monitoring in Black and White stroke survivors, and found a high prevalence of arrhythmias among those who completed monitoring.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Mai Z. Soliman, Elsayed Z. Soliman
Summary: The presence of premature ventricular complexes (PVCs) is associated with an increased risk of stroke mortality, particularly in individuals with coronary heart disease (CHD). Prospective studies are needed to investigate whether improved hospital care or modification of PVCs could improve outcomes.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Meeting Abstract
Cardiac & Cardiovascular Systems
Matthew J. Singleton, Elsayed Soliman, Timothy Hughes, Ghanshyam Shantha, Prashant Bhave, Elijah Beaty, Sean Whalen, Joseph Yeboah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jelena Kornej, Jared Magnani, Sarah R. Preis, Elsayed Soliman, Ludovic Trinquart, Darae Ko, Emelia Benjamin, Honghuang Lin
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Oguz Akbilgic, Liam Butler, Ibrahim Karabayir, Patricia Chang, Dalane Kitzman, Alvaro Alonso, Lin Chen, Elsayed Soliman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Travis Skipina, Bharathi Upadhya, Elsayed Soliman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)