Article
Clinical Neurology
Marc Kermorgant, Pierre-Olivier Fernagut, Wassilios G. Meissner, Dina N. Arvanitis, Du N'Guyen, Jean-Michel Senard, Anne Pavy-Le Traon
Summary: Multiple system atrophy is a rare and progressive neurodegenerative disorder characterized by autonomic failure. This study found that baroreflex sensitivity was significantly changed in PLP-alpha-syn mice and varied with age. Additionally, impaired heart rate variability was observed in 12-month-old female PLP-alpha-syn mice, indicating cardiovascular autonomic failure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Anne Pavy-Le Traon, Alexandra Foubert-Samier, Fabienne Ory-Magne, Margherita Fabbri, Jean-Michel Senard, Wassilios G. Meissner, Olivier Rascol, Jacques Amar
Summary: This study investigated the association between mortality, 24-hour blood pressure level and variability, and drug treatments for orthostatic hypotension (OH) in patients with multiple system atrophy (MSA). The results showed that increased daytime blood pressure variability and OH treatment were independently predictive of mortality in MSA patients, regardless of disease severity.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sung Il Im, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, Su kyoung Kwon, Sung Pil Cho, Hun Shim, Jung Hwan Park, Hyun Su Kim, Chul Ho Oak
Summary: This study investigated the relationship between real-time heart rate variability (HRV) and ambulatory glucose levels in patients with diabetes. The findings suggest that poorly controlled glucose levels are associated with lower HRV, indicating cardiac autonomic dysfunction caused by elevated blood sugar levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Analytical
En-Fan Chou, Michelle Khine, Thurmon Lockhart, Rahul Soangra
Summary: The relationship between the robustness of HRV derived by linear and nonlinear methods to the required minimum data lengths has yet to be well understood. This study found that most HRV measures can be adequately computed by small data sizes, while some may require longer data lengths. Determining the optimal minimum data sizes can potentially improve efficiency and save time and effort for both patients and medical care providers.
Article
Cardiac & Cardiovascular Systems
Silav Zeid, Gregor Buch, David Velmeden, Jakob Soehne, Andreas Schulz, Alexander Schuch, Sven-Oliver Troebs, Marc William Heidorn, Felix Mueller, Konstantin Strauch, Katrin Coboeken, Karl J. Lackner, Tommaso Gori, Thomas Muenzel, Juergen H. Prochaska, Philipp S. Wild
Summary: This study aimed to establish reference values and clinically relevant determinants for heart rate variability (HRV) measures and assess their importance in predicting clinical outcomes in heart failure patients. The researchers found that HRV was closely associated with the clinical profile of heart failure and was a strong and independent predictor of prognosis in these patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Clinical Neurology
Lara Rosler, Glenn van der Lande, Jeanne Leerssen, Austin G. Vandegriffe, Oti Lakbila-Kamal, Jessica C. Foster-Dingley, Anne C. W. Albers, Eus J. W. van Someren
Summary: This study evaluates the objective quantification of insomnia by assessing state-related changes in cardiac measures. The researchers found that incorporating these changes in cardiac features in the ambulatory monitoring of sleep could provide a more sensitive biomarker for diagnosing and assessing the severity of insomnia.
Article
Chemistry, Analytical
Devdutta S. Warhadpande, Jiayan Huo, William A. Libling, Carol Stuehm, Bijan Najafi, Scott Sherman, Hong Lei, Janet Meiling Roveda, Phillip H. Kuo
Summary: This study investigated a measure for autonomic dysregulation in patients with Parkinson's disease and found that more imbalanced loss of neurons, particularly on the left side, resulted in greater autonomic dysregulation.
Article
Biochemistry & Molecular Biology
Jatinder Singh, Shashidhar Ameenpur, Ruksana Ahmed, Salah Basheer, Samiya Chishti, Rosie Lawrence, Federico Fiori, Paramala Santosh
Summary: This study evaluated heart rate variability (HRV) in Rett syndrome patients and found that heart rate decreases with age and is lower at night. The sympathetic and parasympathetic indices do not change with age but are higher during the day compared to the night. The findings suggest that Rett patients are less adaptable to autonomic changes during the night.
Article
Chemistry, Multidisciplinary
Sandra Cossul, Felipe Rettore Andreis, Mateus Andre Favretto, Jefferson Luiz Brum Marques
Summary: This study examined the use of EMD-based features from ECG RR interval signals to differentiate between different levels of cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). Six EMD features were extracted and compared between groups, revealing significant differences between individuals with noCAN and estCAN. However, only some EMD components showed significant differences between individuals with noCAN or estCAN and those with subCAN.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
D. Wehler, H. F. Jelinek, A. Gronau, N. Wessel, J. F. Kraemer, R. Krones, T. Penzel
Summary: This study aimed to provide methodologically strong evidence for the reliability of HRV analysis of ultra-short ECGs compared to the benchmark of 300 s. Results showed that RMSSD and HF were reliable and retained significant differences between control and dCAN from ECGs down to 10 s, while LF could be considered reliable in recordings of at least 30 s. The study also indicated that ultra-short HRV analysis has the potential to become a time-efficient and accurate diagnostic tool for dCAN in clinical practice.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Clinical Neurology
Benedetta Heimler, Or Koren, Rivka Inzelberg, Uri Rosenblum, Sharon Hassin-Baer, Gabi Zeilig, Ronny P. Bartsch, Meir Plotnik
Summary: This study aims to investigate the possibility of detecting a predisposition for freezing of gait (FoG) events from autonomic nervous system (ANS) activity measured at rest. The results show that FoG+ participants have imbalanced ANS activity and disrupted self-regulatory capacity. FoG- participants and elderly controls have similar ANS activity. These findings expand previous evidence of ANS involvement in FoG.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Biology
Gianfranco Piccirillo, Federica Moscucci, Ilaria Di Diego, Martina Mezzadri, Cristina Caltabiano, Myriam Carnovale, Andrea Corrao, Ilaria Lospinuso, Sara Stefano, Claudia Scinicariello, Marco Giuffre, Valerio De Santis, Susanna Sciomer, Pietro Rossi, Emiliano Fiori, Damiano Magri
Summary: The autonomic nervous system (ANS) can modulate the oscillation of electrocardiogram segments and their intervals, including the myocardial repolarization phase. This study investigates the influence of head-up/-down tilt on ECG segments, suggesting that cardiopulmonary postural reflexes can modulate ECG interval oscillations. T wave amplitude decreases during head-up tilt and correlates with left ventricular end-systolic volume. Head-up/-down tilt acutely modifies the autonomic nervous system balance through deactivation of cardiopulmonary reflexes.
Article
Medicine, General & Internal
Dominika Zalas, Waldemar Bobkowski, Jaroslaw Piskorski, Przemyslaw Guzik
Summary: Heart rate asymmetry (HRA) is a physiological phenomenon characterized by an unequal contribution of heart rate decelerations and accelerations to different heart rate variability (HRV) features. This study investigated the variance- and number-based HRA features in 96 healthy children using 24-h ECGs and found that heart rate decelerations contributed more to short-term HRV in boys. The majority of children had some form of HRA, providing reference data for future clinical studies on HRA in children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Yoshiyuki Kasahara, Chihiro Yoshida, Masatoshi Saito, Yoshitaka Kimura
Summary: This study measured ECG signals of mouse fetuses to evaluate the development of heart rate and autonomic nervous activity at different stages, finding that fetal heart rate significantly increased at E18.5, accompanied by reduced parasympathetic activity. It suggests that parasympathetic activity rather than sympathetic activity affects fetal heart rate, and the decrease in parasympathetic activity towards the end of pregnancy could lead to the observed increase in fetal heart rate.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David S. Goldstein, Patti Sullivan, Courtney Holmes, Guillaume Lamotte, Abhishek Lenka, Yehonatan Sharabi
Summary: Parkinson's disease, multiple system atrophy, and pure autonomic failure share evidence of central noradrenergic deficiency, but differ in the extent of central dopaminergic deficiency, with PD and MSA showing more prominent deficits compared to PAF.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Computer Science, Information Systems
Emi Yuda, Masaya Kisohara, Yutaka Yoshida, Junichiro Hayano
Summary: This study found that heart rate variability (HRV) indices are mainly constituted by two common factors related to cardiac vagal function and complexity of heart rate dynamics, respectively, and they differ in their relationships with age and physical activity.
Article
Cardiac & Cardiovascular Systems
Junichiro Hayano, Emi Yuda
Summary: The study found that long-term ECG monitoring is more accurate in detecting persistent and transient abnormalities in HRV and HR dynamics compared to 24-hour ECG monitoring, and can differentiate between the two types of abnormalities. Long-term ECG monitoring increases sensitivity and detects more abnormal indices.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Asami Koike, Yoshihiro Sobue, Mayumi Kawai, Masaru Yamamoto, Yukina Banno, Mashide Harada, Ken Kiyono, Eiichi Watanabe
Summary: The study indicates that remote monitoring-guided walking exercise for 3 months in patients with CRT significantly increased quality of life, active time, and exercise capacity without any adverse effects.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kenichi Hashimoto, Toshio Kinoshita, Yosuke Miwa, Mari Amino, Koichiro Yoshioka, Kenji Yodogawa, Mikiko Nakagawa, Kohki Nakamura, Eiichi Watanabe, Kentaro Nakamura, Tetsu Watanabe, Yuji Kasamaki, Takanori Ikeda
Summary: The combination of w-LPs and NSVT was identified as a significant risk factor for lethal ventricular tachyarrhythmias and cardiac death in patients with CKD and structural heart disease. NIEMs were found to be important tools for assessing the risk of cardiac events in these patients.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Junichiro Hayano, Emi Yuda
Summary: The study found that the frequency of cyclic variation of heart rate (Fcv) in sleep apnea patients showed considerable night-to-night variability, leading to missed diagnoses on 62% of nights in presumed moderate-to-severe cases and in at least one night in 88% of patients. This suggests that patients with mild sleep apnea exhibit greater night-to-night variability and would benefit from long-term assessment.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshihiro Nomura, Masahide Harada, Yuji Motoike, Asuka Nishimura, Masayuki Koshikawa, Takehiro Ito, Yoshihiro Sobue, Fumihiko Kitagawa, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa
Summary: This study evaluated the predictability of S-QRS score for the recovery of LVEF in PeAF patients with LVSD undergoing CA. The results showed that S-QRS score was an independent predictor of LVEF normalization, and patients with low S-QRS score had greater LVEF improvement.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Wakaya Fujiwara, Hideki Ishii, Yoshihiro Sobue, Shinya Shimizu, Tomoya Ishiguro, Ryo Yamada, Sayano Ueda, Hideto Nishimura, Yudai Niwa, Akane Miyazaki, Wataru Miyagi, Shuhei Takahara, Hiroyuki Naruse, Junichi Ishii, Ken Kiyono, Eiichi Watanabe, Hideo Izawa
Summary: This study assessed the role of proteinuria in predicting contrast-associated acute kidney injury (CA-AKI) in patients undergoing percutaneous coronary intervention (PCI). A risk score based on proteinuria, along with other variables, showed good predictive power and calibration for CA-AKI.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yukinobu Arata, Itsuki Shiga, Yusaku Ikeda, Peter Jurica, Hiroshi Kimura, Ken Kiyono, Yasushi Sako
Summary: Fractal scaling is a common feature in animal behavioral activity and is regulated by insulin signaling in C. elegans behavior. This study suggests that altered fractal scaling of human behavior may be associated with behavioral defects in patients with diabetes mellitus.
SCIENTIFIC REPORTS
(2022)
Article
Computer Science, Information Systems
Samar Helou, Elie El Helou, Naoko Evans, Taiki Shigematsu, Jeanine El Helou, Miki Kaneko, Ken Kiyono
Summary: Physicians gazing at the camera during video consultations are perceived as making eye contact, leading to higher communication and interpersonal skills ratings. The impact of camera gaze varies by country and consultation content, with potential positive effects on patient and physician perception.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2022)
Article
Environmental Sciences
Hitomi Ogata, Tomohiro Nishikawa, Momoko Kayaba, Miki Kaneko, Keiko Ogawa, Ken Kiyono
Summary: The number of times people stay in a car overnight during disasters is increasing, but the effects on sleep and daytime functioning are not well understood. This study investigated the effect of seat angle on sleep and calculation performance the following day. The results showed that a near-vertical seat angle (60 degrees) led to increased wake after sleep onset and decreased slow-wave sleep compared to other angles. Subjective sleep quality and calculation performance were also poorer in the trials with seat angles of 45 degrees and 60 degrees compared to sleeping at home. These findings suggest that a large seat angle may impair sleep.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Mariia Chernykh, Bohdan Vodianyk, Ivan Seleznov, Dmytro Harmatiuk, Ihor Zyma, Anton Popov, Ken Kiyono
Summary: Understanding brain reactions to facial expressions can help explain emotion-processing and memory mechanisms. This research examines the dynamics of electrical brain activity caused by visual emotional stimuli and focuses on changes in cognitive mechanisms produced by negative, positive, and neutral expressions on human faces.
APPLIED SCIENCES-BASEL
(2022)
Article
Cardiac & Cardiovascular Systems
Taro Makino, Tomohide Ichikawa, Mari Amino, Mari Nakamura, Masayuki Koshikawa, Yuji Motoike, Yoshihiro Nomura, Masahide Harada, Yoshihiro Sobue, Eiichi Watanabe, Ken Kiyono, Koichiro Yoshioka, Yuji Ikari, Yukio Ozaki, Hideo Izawa
Summary: This study aimed to investigate the association between ventricular repolarization instability and acute-phase ventricular tachycardia and ventricular fibrillation (VT/VF) after acute coronary syndrome (ACS), as well as the prognostic role of repolarization instability and heart rate variability (HRV) post-discharge. The study found that acute-phase VT/VF occurred in 7.5% of ACS patients, but T-wave amplitude variability was not predictive of survival post-discharge. However, DC, ?25s, and emergency coronary intervention were independent predictors.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2023)
Article
Engineering, Biomedical
Terumasa Kondo, Atsushi Teramoto, Eiichi Watanabe, Yoshihiro Sobue, Hideo Izawa, Kuniaki Saito, Hiroshi Fujita
Summary: In this study, a two-dimensional convolutional neural network (CNN) was used to predict the short-term prognosis of CCU patients by converting their ECG data into image data. The prediction accuracy was 77.3%. The results suggest that this method could be used to predict the short-term prognosis of CCU patients using ECG waveforms, which has clinical significance in determining treatment strategies and treatment intensity.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Bohdan Vodianyk, Ivan Seleznov, Mariia Chernykh, Igor Zyma, Anton Popov, Ken Kiyono
Summary: This study investigated the changes in brain activity induced by emotions, focusing on how neutral face stimuli affect cognitive mechanisms. The research found significant differences in female participants when processing neutral images under the influence of negative stimuli, and an increased synchronization of oscillations in the left frontal-temporal zones following positive stimuli.
2021 SIGNAL PROCESSING SYMPOSIUM (SPSYMPO)
(2021)