Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
Summary: The study revealed a significant association between higher serum ADMA levels and severe glaucoma, which remained significant after adjusting for potential confounders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda
Summary: The XO inhibitor febuxostat, as well as allopurinol, could reduce hypertension-related increase in AF perpetuation by restoring Ca2+ handling and gap junction.
Article
Endocrinology & Metabolism
Lei Zhao, Cheng-Lin Zhang, Lei He, Qinghua Chen, Limei Liu, Lijing Kang, Jian Liu, Jiang-Yun Luo, Lingshan Gou, Dan Qu, Wencong Song, Chi Wai Lau, Ho Ko, Vincent C. T. Mok, Xiao Yu Tian, Li Wang, Yu Huang
Summary: Monomerization and uncoupling of eNOS play crucial roles in mediating vascular dysfunction in diabetes. This study reveals that impaired autophagic flux leads to eNOS monomerization and reduced nitric oxide bioavailability in diabetic mice. Restoring autophagic flux improves endothelial cell oxidative stress, promotes eNOS dimerization, and enhances endothelium-dependent relaxations in diabetic mice.
Article
Plant Sciences
Neha Gupta, Arun Kumar Mishra
Summary: NOS-derived NO plays a critical role in protecting cyanobacteria from oxidative burst and maintaining their physiological balance. Addition of L-NAME inhibitor reduces NO accumulation, while addition of L-arginine increases NO synthesis. Inhibition of NOS leads to decreased growth and metabolic activity of cyanobacteria, as well as decline in photopigments, PSII efficiency, loss in membrane integrity and DNA damage, ultimately resulting in cell death.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Marios Sagris, Emmanouil P. Vardas, Panagiotis Theofilis, Alexios S. Antonopoulos, Evangelos Oikonomou, Dimitris Tousoulis
Summary: Atrial fibrillation is a common arrhythmia associated with increased risk of death, stroke, and peripheral embolism, leading to a high burden on healthcare systems. Identifying modifiable risk factors and implementing preventive measures are crucial for improving community health and reducing healthcare costs. Various mechanisms contributing to the development of AF, including electrical and structural remodeling of atrial tissue, have been proposed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luigi Falco, Viviana Tessitore, Giovanni Ciccarelli, Marco Malvezzi, Antonello D'Andrea, Egidio Imbalzano, Paolo Golino, Vincenzo Russo
Summary: Thrombosis-related diseases are a major cause of illness and death, despite advances in pharmacologic therapy. Oxidative stress plays a crucial role in thrombosis pathophysiology. Anticoagulant and antiplatelet drugs used in the management of these diseases have pleiotropic effects, including antioxidant effects. This review aims to summarize the current evidence on the antioxidant effects of oral antithrombotic therapies in patients with atherosclerotic disease and atrial fibrillation.
Article
Horticulture
Xiangli Sun, Zebin Yuan, Bo Wang, Liping Zheng, Jianzhong Tan
Summary: The study found that exogenous putrescine (Put) has positive effects on the chilling tolerance of Anthurium andraeanum. Pretreatment of anthurium seedlings with Put resulted in the accumulation of endogenous NO, with the NOS-dependent pathway playing a vital role in its generation. The NOS-dependent pathway was identified as the primary source of endogenous NO in Put-pretreated anthurium.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Analytical
Lei Wen, Xinyu Ma, Jing Yang, Minmin Jiang, Chao Peng, Zhongyun Ma, Huan Yu, Yinhui Li
Summary: This study proposed a new design strategy based on pi-conjugation modulation for fluorescent probes, which can generate different emission bands in the presence and absence of the target. The newly designed fluorescence probe, Rhod-DCM-B, exhibited outstanding sensitivity and excellent selectivity towards ONOO-. It was successfully employed to determine endogenous and exogenous ONOO- in living cells, and effectively monitored the ONOO- in vivo.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Megan Watts, Gopi K. Kolluru, Parinita Dherange, Sibile Pardue, Man Si, Xinggui Shen, Krystle Trosclair, John Glawe, Zaki Al-Yafeai, Mazen Iqbal, Brenna H. Pearson, Kathryn A. Hamilton, A. Wayne Orr, Edward Glasscock, Christopher G. Kevil, Paari Dominic
Summary: Oxidative stress is a driving factor in the pathogenesis of atrial fibrillation (AF), with hydrogen sulfide (H2S) playing an important role in regulating electrical remodeling and susceptibility to AF. Patients with AF had significantly lower plasma sulfide levels, and those with persistent AF had even lower levels compared to paroxysmal AF patients. Additionally, CSE knockout mice showed decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type mice.
Article
Pharmacology & Pharmacy
Yousef Hannawi, Mohamed G. Ewees, Jordan T. Moore, Jay L. Zweier
Summary: The study found that CD38 expression and enzymatic activity were significantly increased in the brains of SHRSP rats, with a further increase in CD38 activity in 24-week-old SHRSP. SHRSP exhibited characteristics of oxidative stress, reduced NO levels, reduced NAD(P)H levels, and decreased endothelial NOS expression compared to WKY.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Wiecek, Zbigniew Szygula, Joanna Gradek, Justyna Kusmierczyk, Jadwiga Szymura
Summary: The study found that repeated whole-body exposure to cryogenic temperature can increase the concentration of inducible nitric oxide synthase (iNOS) in senior subjects, which is more pronounced in athletes. However, the whole-body cryotherapy did not have a significant effect on the concentration of other markers.
Article
Medicine, Research & Experimental
Victor P. Long, Ingrid M. Bonilla, Stephen Baine, Patric Glynn, Sanjay Kumar, Karsten Schober, Kent Mowrey, Raul Weiss, Nam Y. Lee, Peter J. Mohler, Sandor Gyorke, Thomas J. Hund, Vadim V. Fedorov, Cynthia A. Carnes
Article
Cardiac & Cardiovascular Systems
Mark A. Munger, Yusuf Olgar, Megan L. Koleske, Heather L. Struckman, Jessica Mandrioli, Qing Lou, Ingrid Bonila, Kibum Kim, Roberto Ramos Mondragon, Silvia G. Priori, Pompeo Volpe, Hector H. Valdivia, Joseph Biskupiak, Cynthia A. Carnes, Rengasayee Veeraraghavan, Sandor Gyorke, Przemyslaw B. Radwanski
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Stephen Baine, Justin Thomas, Ingrid Bonilla, Marina Ivanova, Andriy Belevych, Jiaoni Li, Rengasayee Veeraraghavan, Przemyslaw B. Radwanski, Cynthia Carnes, Sandor Gyorke
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Kaori Iimura, Nobuhiro Watanabe, Philip Milliken, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar, Harumi Hotta
Article
Multidisciplinary Sciences
Kevin M. Huang, Megan Zavorka Thomas, Tarek Magdy, Eric D. Eisenmann, Muhammad Erfan Uddin, Duncan F. DiGiacomo, Alexander Pan, Markus Keiser, Marcus Otter, Sherry H. Xia, Yang Li, Yan Jin, Qiang Fu, Alice A. Gibson, Ingrid M. Bonilla, Cynthia A. Carnes, Kara N. Corps, Vincenzo Coppola, Sakima A. Smith, Daniel Addison, Anne T. Nies, Ralf Bundschuh, Taosheng Chen, Maryam B. Lustberg, Joanne Wang, Stefan Oswald, Moray J. Campbell, Pearlly S. Yan, Sharyn D. Baker, Shuiying Hu, Paul W. Burridge, Alex Sparreboom
Summary: By studying the critical transporter OCT3 for doxorubicin accumulation in the heart, researchers have revealed the mechanism of doxorubicin-induced cardiotoxicity, providing a theoretical basis for a targeted intervention strategy to prevent this side effect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
James A. Hokanson, Christopher L. Langdale, Arun Sridhar, Phil Milliken, Warren M. Grill
Summary: State-dependent electrical stimulation can increase both bladder capacity and voiding efficiency by using different parameters during bladder filling and emptying, compared to continuous stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Stephen Baine, Ingrid Bonilla, Andriy Belevych, Andrei Stepanov, Lisa E. Dorn, Radmila Terentyeva, Dmitry Terentyev, Federica Accornero, Cynthia A. Carnes, Sandor Gyorke
Summary: Chronic treatment with the cholinesterase inhibitor, pyridostigmine (PYR), improves cardiac function in pressure overload heart failure by alleviating aberrant calcium handling and modulating pathological signaling pathways related to arrhythmogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Vladimir Bogdanov, Tae Yun Kim, Fruzsina Perger, Jiajie Yan, Xun Ai, Cynthia A. Carnes, Andriy E. Belevych, Christopher H. George, Jonathan P. Davis, Sandor Gyorke, Bum-Rak Choi, Dmitry Terentyev
Summary: This study demonstrates that oxidative stress in cardiac disease impairs the regulation of Ca2+ release channel RyR2, leading to proarrhythmic disturbances. The researchers discovered a new intraluminal interaction axis involving RyR2, ERp44, and Ero1 alpha. Inhibition of Ero1 alpha has the potential to stabilize the RyR2-ERp44 complex and reduce spontaneous Ca2+ release and tachyarrhythmias.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemyslaw B. Radwanski, Douglas H. Sweet, Joerg Koenig, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Summary: Dofetilide, a potassium current inhibitor used to prevent atrial fibrillation recurrence, can cause QTc interval prolongation and increase the risk of ventricular arrhythmias. This study identified MATE1 as a transporter for Dofetilide and showed that inhibiting or knocking out MATE1 resulted in increased retention of Dofetilide in cardiomyocytes and prolonged QTc interval in mice. The findings also explained the drug-drug interactions between Dofetilide and contraindicated drugs and were validated using a pharmacokinetic model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ibrahim M. Salman, Omar Z. Ameer, Sheridan McMurray, Sarah F. Hassan, Arun Sridhar, Stephen J. Lewis, Yee-Hsee Hsieh
Summary: This study investigated the effects of low charge nerve stimulation on hypertensive rats and identified optimal stimulation parameters. Low-intensity intermittent electrical stimulation was found to be an effective method for neuromodulation of the aortic baroreceptor afferents, reducing blood pressure and minimizing hemodynamic disturbances.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Charlotte M. Forshay, John Mellett, Marcia M. Worley, Cynthia A. Carnes, Andre Fernandes, Trisha A. Jordan
Summary: This study developed an identification tool and documentation process to identify and complete prior authorizations for medications before patient discharge during the inpatient setting. The results showed that most medications did not require prior authorization, some had prior authorization started, and a few medications were discontinued or transferred to other facilities. The implementation of this method helps improve the workflow of prior authorizations and discharge care coordination.
Review
Oncology
Jennifer P. Booth, Julie M. Kennerly-Shah, Lindsey R. Kelley, Donna Capozzi, Hillary A. Prescott, Scott A. Soefje, Makala B. Pace, Sally Y. Barbour, Ricky F. Tizon, Sarah DeVincenzo, Cynthia A. Carnes, Marjorie Neidecker
Summary: The National Comprehensive Cancer Network's Pharmacy Directors Forum conducted a survey to establish consensus on acuity factors associated with hematology/oncology patients that are high priority for ambulatory clinical pharmacist review. A final consensus was achieved for 18 acuity factors, which can be incorporated into a pharmacy-specific electronic scoring tool.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Meeting Abstract
Biophysics
Benjamin Hernandez Orengo, Ingrid M. Bonilla, Galina Sakuta, Dennison Min, Stephen Baine, Andriy E. Belevych, Cynthia A. Carnes, Przemyslaw Radwanski, Sandor Gyorke
BIOPHYSICAL JOURNAL
(2022)
Article
Physiology
James A. Hokanson, Christopher L. Langdale, Philip H. Milliken, Arun Sridhar, Warren M. Grill
Summary: PGE(2) instilled into the bladder causes urinary urgency symptoms, and this effect is not dependent on capsaicin-sensitive pathways. Urethral relaxation/weakness and decreased compliance may contribute to urinary urgency, suggesting potential targets for new therapies for overactive bladder.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Muhammad Erfan Uddin, Yan Jin, Alice A. Gibson, Ingrid M. Bonilla, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom