Article
Rehabilitation
Kelly J. Negley, Alysha Rasool, Patrick J. Byrne
Summary: Facial paralysis is a clinical condition with significant functional and psychosocial impact. Management of the condition is evolving, with surgical techniques like hypoglossal-facial nerve anastomosis being used to restore facial muscle reinnervation through tongue movement.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
GwangWon Cho, Changjong Moon, Nagarajan Maharajan, Mary Jasmin Ang, Minseong Kim, Chul Ho Jang
Summary: The effect of a pre-induced MSC-coated cellulose/collagen nanofibrous nerve conduit on facial nerve regeneration was evaluated in a rat model both in vitro and in vivo. The results showed that group II, treated with the pre-induced MSC-coated conduit, exhibited the highest degree of recovery based on functional and histological evaluations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Inhyeok Kim, Yonjae Kim, Daewoong Kang, Junyang Jung, Sungsoo Kim, Hwasung Rim, Sanghoon Kim, Seung-Geun Yeo
Summary: Neuropeptides and neurotransmitters play important roles in transmitting nerve impulses and regulating nerve degeneration and regeneration. Three neuropeptides, CGRP, galanin, and PACAP, are associated with neural regeneration in facial nerve damage, with each having different effects and potential as markers for nerve regeneration.
Article
Materials Science, Multidisciplinary
Yuxiao Zhou, Warren Grayson
Summary: This article summarizes the application of 3D printing technology in craniofacial bone reconstruction. Through layer-by-layer manufacturing techniques, patient-specific craniofacial structures can be produced for esthetic purposes and functional restoration. The article also discusses the remaining hurdles and opportunities for growth in this technology.
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jae-Min Lee, Seung Geun Yeo, Su Young Jung, Junyang Jung, Sung Soo Kim, Myung Chul Yoo, Hwa Sung Rim, Hye Kyu Min, Sang Hoon Kim, Dong Choon Park
Summary: Facial nerve palsy greatly affects the quality of life, leading to increased rates of depression and limitations in social activities. Improving the prognosis of patients with this condition is crucial as it can devastate their emotional and social lives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Soo Young Choi, Jung Min Kim, Junyang Jung, Dong Choon Park, Myung Chul Yoo, Sung Soo Kim, Sang Hoon Kim, Seung Geun Yeo
Summary: Facial nerve palsy has significant impact on individuals' lives and has high costs for treatment and rehabilitation. Complete recovery remains challenging regardless of the cause of the paralysis.
Review
Medicine, General & Internal
Myung Chul Yoo, Jeong Hee Kim, Yong Jun Kim, Junyang Jung, Sung Soo Kim, Sang Hoon Kim, Seung Geun Yeo
Summary: Electrical stimulation therapy is frequently used to treat facial paralysis but its effectiveness varies and no clear standards have been developed. This review presents evidence from preclinical and clinical studies supporting the efficacy of electrical stimulation in promoting nerve regeneration after peripheral nerve injuries. However, the outcomes depend on various factors and potential negative outcomes need to be considered.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Developmental Biology
Ryo Fujita, Solene Jamet, Graham Lean, Harry Chun Man Cheng, Steven Hebert, Claudia L. Kleinman, Colin Crist
Summary: Translation control of gene expression through P-eIF2α enables the expansion of satellite cells. Certain genes are upregulated at the protein level without corresponding changes at the mRNA level. Deficiency of Tacc3 results in defects in the expansion, self-renewal, and regeneration of skeletal muscle in satellite cells.
Article
Neurosciences
Sofia Meyer Zu Reckendorf, Diana Moser, Anna Blechschmidt, Venkata Neeha Joga, Daniela Sinske, Jutta Hegler, Stefanie Deininger, Alberto Catanese, Sabine Vettorazzi, Gregor Antoniadis, Tobias Boeckers, Bernd Knoell
Summary: In postmitotic neurons, PTEN inhibition is crucial for successful axon regeneration in the central nervous system, but its influence in peripheral neurons is less understood. This study demonstrates that conditional PTEN deletion in mouse facial motoneurons not only induces morphological and physiological changes, but also promotes facial nerve regeneration and recovery after injury, highlighting the dual function of PTEN in neuronal function impairment and axon regeneration.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell & Tissue Engineering
Alvin Wong, Steven M. Garcia, Stanley Tamaki, Katharine Striedinger, Emilie Barruet, Scott L. Hansen, David M. Young, Jason H. Pomerantz
Summary: The study found that even after prolonged denervation, MuSCs retain intrinsic regenerative potential and can form new muscle fibers. This suggests that treating denervation atrophy will require elucidating non-MuSC environmental changes in muscle that prevent functional regeneration.
Article
Behavioral Sciences
Jing Fei, Xirui Guan, Lin Gao, Ping Ni, Hongdi Zheng, Kunling Duan, Na Liao, Leiji Li
Summary: To investigate facial nerve regeneration mechanisms, a reliable and standardized facial nerve crush injury model is necessary. This study examined the changes in facial nerve injury models with different pressing times through behavior analysis, electrophysiological tests, and histomorphometry analysis. The results showed a capacity for self-healing, but this capacity diminished with longer pressing times.
BRAIN AND BEHAVIOR
(2023)
Article
Materials Science, Biomaterials
Goeun Choe, Ul Gyu Han, Seongryeol Ye, Sujee Kang, Jin Yoo, Young Sang Cho, Youngmee Jung
Summary: This study examined the effects of electrical stimulation (ES) on nerve guidance conduits (NGCs) made of poly(D,L-lactide-co-epsilon-caprolactone) in promoting the recovery of facial function and nerve regeneration after facial nerve (FN) injury in rats. The experimental group received both NGC and transcutaneous ES, while the control group only received NGCs. The ES groups showed significant improvement in whisker movement, with a higher number of myelinated neurons, thicker and more uniform myelin sheaths, and increased expression of neurostructural proteins compared to the NGC-only group.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Myung Chul Yoo, Jinmann Chon, Junyang Jung, Sung Su Kim, Seonhwan Bae, Sang Hoon Kim, Seung Geun Yeo
Summary: This article reviewed experimental studies on facial nerve regeneration, highlighting recent bioengineering strategies for supporting facial nerve regeneration. The research found that neurotrophic factors from injured nerves play a crucial role in functional recovery and promote axon regeneration. This analysis provides important insights for future therapeutic strategies for facial nerve injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ema Onode, Takuya Uemura, Kiyohito Takamatsu, Takuya Yokoi, Kosuke Shintani, Shunpei Hama, Yusuke Miyashima, Mitsuhiro Okada, Hiroaki Nakamura
Summary: This study found that nerve conduits coated with human induced pluripotent stem cell (hiPSC)-derived neurospheres can promote nerve regeneration and functional recovery in repairing rat sciatic nerve defects. This nerve regeneration approach shows promise as a new clinical therapy for treating peripheral nerve defects.
SCIENTIFIC REPORTS
(2021)