Journal
FRONTIERS IN PHYSIOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2012.00270
Keywords
mast cells; myeloid-derived suppressor cells; neutrophils; regulatory T cells; T helper cells; macrophages; inflammation; stroma
Categories
Funding
- Pancreatic Cancer UK
- Pancreatic Cancer Research Fund
- National Institute for Health Research Pancreas Biomedical Research Unit, Liverpool, UK
Ask authors/readers for more resources
The pancreatic ductal adenocarcinoma (PDAC) microenv ronment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available