Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Geriatrics & Gerontology
Alexandra Barbelivien, Laura Durieux, Eliabel Seys, Monique Majchrzak
Summary: Engagement in cognitive activity in adulthood is a key factor for successful cognitive aging. This study demonstrates that intermittent working memory training during adulthood can protect aged animals from the deleterious effects of aging on spatial reference memory.
Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Review
Behavioral Sciences
Filip Mazur, Jaroslaw Calka
Summary: Orexin-A and orexin-B are neuropeptides produced in the lateral hypothalamus that are involved in various functions, including memory. Changes in their levels have been linked to pathological states such as PTSD and memory deficits. Recent research suggests that modulating orexin levels through administration can improve memory, with different effects based on the specific orexin used and the route of drug administration. Blocking orexin receptors in different brain structures can either impair or enhance memory performance in specific paradigms. Thus, influencing the orexinergic balance in the brain has potential therapeutic implications for memory deficits and PTSD-induced recall.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Biological
Adnan M. Massadeh, Karem H. Alzoubi, Amal M. Milhem, Abeer M. Rababa'h, Omar F. Khabour
Summary: Chronic sleep deprivation impairs both short-term and long-term memory, while chronic selenium administration can prevent this impairment by normalizing antioxidant enzyme activities in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Anyla Konjusha, Shijing Yu, Moritz Mueckschel, Lorenza Colzato, Tjalf Ziemssen, Christian Beste
Summary: In a randomized crossover study, we found that auricular transcutaneous vagus nerve stimulation (atVNS) specifically modulates the closing of working memory (WM) gates through the modulation of EEG alpha band activity. This effect was seen in clusters of activity associated with stimulus and motor response information during WM gate closing. EEG-beamforming analysis showed that activity in fronto-polar, orbital, and inferior parietal regions was associated with these effects. These findings suggest that atVNS stabilizes information in neural circuits, possibly mediated by the GABAergic system.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Victoria E. Bernaud, Ryoko Hiroi, Mallori L. Poisson, Arthur J. Castaneda, Ziv Z. Kirshner, Robert B. Gibbs, Heather A. Bimonte-Nelson
Summary: Rodent aging research often uses spatial mazes to evaluate cognition, with evidence suggesting interference between reference and working memory especially at high working memory load. Young rats outperformed aged rats on tasks testing solely working memory, but their performances were similar when a reference memory component was added. The relationship between cholinergic activity and maze performance varied by age, demonstrating the complex role of the cholinergic system in memory and attention processes.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Jin Li, Dan Cao, Vasileios Dimakopoulos, Weiyang Shi, Shan Yu, Lingzhong Fan, Lennart Stieglitz, Lukas Imbach, Johannes Sarnthein, Tianzi Jiang
Summary: This study recorded intracranial EEG from the anterior and posterior hippocampi in humans to investigate the involvement and functional connections of these subregions in working memory (WM) processing. The results showed elevated low-frequency activity and increased theta/alpha band phase synchronization between anterior and posterior subregions during WM maintenance. Correct WM trials were associated with unidirectional influence from the posterior to the anterior hippocampus, while WM errors were associated with bidirectional interactions between the two subregions. These findings suggest that theta/alpha band synchrony within the hippocampus supports successful WM via a posterior to anterior influence.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Ying
Summary: The study found that ginsenosides can ameliorate memory impairment in rats caused by propofol anesthesia by increasing the expression levels of NGF and BDNF. Therefore, ginsenosides have the potential to serve as a novel therapeutic agent for postoperative cognitive dysfunction caused by propofol anesthesia.
Article
Neurosciences
David W. Sutterer, Sean M. Polyn, Geoffrey F. Woodman
Summary: Recent studies have shown that alpha-band activity can track the two-dimensional coordinates of remembered stimuli, indicating that it reflects a spotlight of attention focused on locations maintained in working memory.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Petra Hermann, Bela Weiss, Balazs Knakker, Petra Madurka, Annamaria Manga, Adam Narai, Zoltan Vidnyanszky
Summary: The study identified two top-down attentional control processes that have opposing effects on distractor resistance. An early selection negativity was found in EEG responses to matching distractors, and congruency effects were positively associated with distractor resistance.
Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Analytical
Jia-Hsun Lo, Han-Pang Huang, Su-Ching Sung
Summary: This research proposes an approach to evaluate working memory ability using electroencephalography (EEG) analysis. The study shows that there are certain characteristics in the EEG signals of subjects when performing working memory tasks, and a working memory model is developed to describe the changes in EEG signals within alpha, beta, and gamma waves. The study also predicts the working memory ability of subjects using multi-linear support vector regression (SVR) combined with fuzzy C-mean (FCM) clustering and knowledge-based fuzzy support vector regression (FSVR).
Article
Neurosciences
Yeseul Lee, Zuner A. Bortolotto, Clarrisa A. Bradley, Thomas M. Sanderson, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Inhibition of GSK-3 improves learning speed in behavioral tasks and enhances the accuracy of long-term spatial memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Faiyaz Rahman, Roshan Nanu, Nathan A. Schneider, Donald Katz, John Lisman, Hyun-Jae Pi
Summary: The study found that disruptions in the RE-HPC circuit specifically impair the retrieval phase of working memory, supporting the hypothesis that abnormal delta frequency bursting in the thalamus could causally contribute to the working memory deficits seen in schizophrenia.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Clinical Neurology
Alexia M. Thomas, Michael D. Schwartz, Michael D. Saxe, Thomas S. Kilduff
Article
Neurosciences
Rhiannan H. Williams, Sarah W. Black, Alexia M. Thomas, Juliette Piquet, Bruno Cauli, Thomas S. Kilduff
Article
Pharmacology & Pharmacy
Michael D. Schwartz, Jeremiah B. Palmerston, Diana L. Lee, Marius C. Hoener, Thomas S. Kilduff
FRONTIERS IN PHARMACOLOGY
(2018)
Review
Clinical Neurology
Steven T. Szabo, Michael J. Thorpy, Geert Mayer, John H. Peever, Thomas S. Kilduff
SLEEP MEDICINE REVIEWS
(2019)
Article
Neurosciences
Anushka V. Goonawardena, Stephen R. Morairty, Ryan Dell, Gabriel A. Orellana, Marius C. Hoener, Tanya L. Wallace, Thomas S. Kilduff
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Shuntaro Izawa, Srikanta Chowdhury, Toh Miyazaki, Yasutaka Mukai, Daisuke Ono, Ryo Inoue, Yu Ohmura, Hiroyuki Mizoguchi, Kazuhiro Kimura, Mitsuhiro Yoshioka, Akira Terao, Thomas S. Kilduff, Akihiro Yamanaka
Article
Neurosciences
Rhiannan H. Williams, Tomomi Tsunematsu, Alexia M. Thomas, Kelsie Bogyo, Akihiro Yamanaka, Thomas S. Kilduff
JOURNAL OF NEUROSCIENCE
(2019)
Review
Physiology
Matthew D. Regan, Erin E. Flynn-Evans, Yuri V. Griko, Thomas S. Kilduff, Jon C. Rittenberger, Keith J. Ruskin, C. Loren Buck
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Clinical Neurology
Thomas C. Neylan, Anne Richards, Thomas J. Metzler, Leslie M. Ruoff, Jonathan Varbel, Aoife O'Donovan, Melinda Sivasubramanian, Terri Motraghi, Jennifer Hlavin, Steven L. Batki, Sabra S. Inslicht, Kristin Samuelson, Stephen R. Morairty, Thomas S. Kilduff
Article
Biology
Chi Jung Hung, Daisuke Ono, Thomas S. Kilduff, Akihiro Yamanaka
Article
Clinical Neurology
Lucie Barateau, Isabelle Jaussent, Julien Roeser, Claudio Ciardiello, Thomas S. Kilduff, Yves Dauvilliers
Summary: This study found no significant differences in levels of monoamines, their metabolites, and trace amines in the cerebrospinal fluid among patients with NT1, NT2/IH, and those without objective sleepiness. While most biomarkers were not associated with key clinical or neurophysiological parameters, a few were correlated with daytime sleepiness and high REM sleep propensity. These findings contribute to the understanding of the neurobiology of hypersomnolence in these disorders and suggest the need for further exploration.
Review
Clinical Neurology
Ryan K. Tisdale, Akihiro Yamanaka, Thomas S. Kilduff
Summary: Animal models have played a crucial role in investigating the etiology and phenotype of narcolepsy, revealing the relationship between the hypocretin/orexin system and narcolepsy. Additionally, these models have helped us understand the mechanisms of sleep/wake regulation.
Article
Clinical Neurology
Yu Sun, Ryan Tisdale, Sunmee Park, Shun-Chieh Ma, Jasmine Heu, Meghan Haire, Giancarlo Allocca, Akihiro Yamanaka, Stephen R. Morairty, Thomas S. Kilduff
Summary: This study compared the development of narcoleptic symptomatology in male and female mice with narcolepsy type 1. The study found that female mice showed characteristic symptoms of NT1 as early as the first week after the removal of doxycycline (DOX), while male mice did not consistently show these symptoms until the second week. By the second week, both sexes exhibited impaired ability to sustain wakefulness, lower subcutaneous temperature regulation, and the appearance of the Delta State.
Article
Neurosciences
Jaime E. Heiss, Akihiro Yamanaka, Thomas S. Kilduff
Article
Neurosciences
Rhiannan H. Williams, Jacqueline Vazquez-DeRose, Alexia M. Thomas, Juliette Piquet, Bruno Cauli, Thomas S. Kilduff
