Review
Endocrinology & Metabolism
Marthe Isaksen Aukan, Silvia Coutinho, Sindre Andre Pedersen, Melanie Rae Simpson, Catia Martins
Summary: This systematic review and meta-analysis investigated the differences in gastrointestinal hormone response to food intake between individuals with and without obesity. The findings suggest that individuals with obesity have lower concentrations of total ghrelin and total peptide YY compared to controls, which may contribute to lower postprandial hunger ratings. However, there were no significant differences in other gastrointestinal hormones or appetite ratings. The study highlights the need for more comprehensive research to determine if these differences are a cause or consequence of obesity.
Article
Sport Sciences
Tanya M. Halliday, Mollie H. White, Allison K. Hild, Molly B. Conroy, Edward L. Melanson, Marc-Andre Cornier
Summary: This study compared the effects of resistance exercise (REx) and aerobic exercise (AEx) on energy intake and appetite regulation, finding that REx significantly decreases orexigenic (ghrelin) and anorectic (PYY and GLP-1) gut peptides, but does not increase ad libitum energy intake. Both exercise modalities have appetite and energy intake suppressing effects.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Nutrition & Dietetics
Dariush Sheikholeslami-Vatani, Naser Rostamzadeh
Summary: This study investigated the effects of 8 weeks of High Intensity Interval Training (HIIT) and vitamin D-3 supplementation on sedentary overweight men. The findings suggest that the combination of regular HIIT with vitamin D supplementation can improve appetite control and body composition.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Catia Martins, Jessica A. Roekenes, Jens F. Rehfeld, Gary R. Hunter, Barbara A. Gower
Summary: This study found that a larger metabolic adaptation during weight loss is accompanied by a greater drive to eat. This might help explain the interindividual differences in weight loss outcomes to dietary interventions.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Behavioral Sciences
Marthe Isaksen Aukan, Siren Nymo, Karoline Haagensli Ollestad, Guro Akersveen Boyesen, Julia Nicole DeBenedictis, Jens Frederik Rehfeld, Silvia Coutinho, Catia Martins
Summary: Obesity is characterized by impaired secretion of gastrointestinal hormones and reduced postprandial satiety, particularly in individuals with class III obesity.
Article
Nutrition & Dietetics
Tetsuro E. Okada, Tony Quan, Marc R. Bomhof
Summary: This study investigated the effects of ketone ester on appetite-related hormones and appetite perception after exercise, finding that although ketone ester altered homeostatic regulators of appetite, it did not acutely affect energy intake during the post-exercise period in healthy adults.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Svenja Meyhoefer, Rodrigo Chamorro, Manfred Hallschmid, Denisa Spyra, Nelli Klinsmann, Bernd Schultes, Hendrik Lehnert, Sebastian M. Meyhoefer, Britta Wilms
Summary: Evidence shows that reduced sleep duration can increase hunger, appetite, and food intake, leading to metabolic diseases like type 2 diabetes and obesity. However, the impact of sleep timing on hunger and appetite regulation is less clear independent of sleep duration. This study aimed to evaluate the effect of sleep loss during late night vs. early night on hunger, appetite, and desire for food. The results indicate that sleep loss during late night, but not early night, increases ghrelin levels and feelings of hunger and appetite, highlighting the metabolic relevance of chronobiological sleep timing.
Article
Nutrition & Dietetics
Mette Glavind Billow Pedersen, Esben Stistrup Lauritzen, Mads Vandsted Svart, Julie Stoy, Esben Sondergaard, Henrik Holm Thomsen, Ulla Kampmann, Mette Bjerre, Niels Jessen, Niels Moller, Nikolaj Rittig
Summary: LEAP2 concentration decreases after fasting and increases postprandially. Oral administration of glucose and lactate elevates LEAP2 concentration, while BHB reduces LEAP2 concentration.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Susanna Bianzano, Andrea Henrich, Lena Herich, Brigitte Kalsch, Donald Sarubbi, Friedeborg Seitz, Thomas Forst
Summary: Two Phase I studies showed that BI 1356225, a GOAT inhibitor, was well-tolerated in healthy males and subjects with overweight/obesity. However, treatment with BI 1356225 for 28 days did not lead to significant reduction in bodyweight or changes in appetite, eating control, or energy intake.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Nutrition & Dietetics
Katarina T. Borer, Po-Ju Lin, Elizabeth Wuorinen
Summary: This study investigated the effects of changing the timing of exercise on human appetite, finding that moderate-intensity exercise performed after meals can effectively reduce insulin resistance.
Review
Food Science & Technology
Mingkai Zhang, Ling Zhu, Gangcheng Wu, Hui Zhang, Xingguo Wang, Xiguang Qi
Summary: Glucose and energy metabolism disorders are the main causes of type 2 diabetes and obesity. Dietary nutrients can regulate glucose homeostasis and food intake through intestinal nutrient sensing. Protein sensing in the intestines plays a crucial role in secreting hormones and regulating glucose homeostasis and food intake. Various research models, such as co-culture cell models, intestinal organoids, and gut-on-a-chips, have been used to study intestinal protein sensing.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Chihiro Yamada
Summary: Stress plays a significant role in affecting appetite by modulating peptides involved in appetite regulation. The orexigenic peptide ghrelin is known to be crucial in appetite abnormalities in various diseases and psychological states. Studies have also shown the impact of sex differences and age on appetite under stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Junewoo Na, Byong Seo Park, Doohyeong Jang, Donggue Kim, Thai Hien Tu, Youngjae Ryu, Chang Man Ha, Marco Koch, Sungchil Yang, Jae Geun Kim, Sunggu Yang
Summary: This study extensively characterizes the AgRP, POMC, and dopaminergic neurons in the hypothalamic arcuate nucleus (Arc). The distinct anatomical and physiological properties of these neurons in response to appetite-regulating hormones are identified. This research highlights the importance of hypothalamic Arc neurons in appetite control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
David Blum, Susanne de Wolf-Linder, Rolf Oberholzer, Michael Brandle, Thomas Hundsberger, Florian Strasser
Summary: In this study, the use of ghrelin in improving nutritional intake in advanced cancer patients was investigated. The results showed that ghrelin had variable effects on appetite and eating-related symptoms, as well as a positive impact on patient narratives. The intervention was complex, and although the number of patients included was small, ghrelin was found to be safe and well tolerated in advanced cancer patients with cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Nutrition & Dietetics
Kara C. Anderson, Faten Hasan, Emily E. Grammer, Sibylle Kranz
Summary: This study conducted a systematic review and meta-analysis of the association between different forms of ghrelin and perceptions of hunger in healthy adults. It found that ghrelin concentrations are moderately correlated with perceptions of hunger in humans, and this relationship is strengthened when acylated ghrelin is isolated. Further research should focus on understanding the role of de-acylated ghrelin in hunger sensations.
ADVANCES IN NUTRITION
(2023)
Article
Cell Biology
Hiroto Sasaki, Aya Ishibashi, Yoshihumi Tsuchiya, Nobuhiro Shimura, Toshiyuki Kurihara, Kumiko Ebi, Kazushige Goto
GROWTH HORMONE & IGF RESEARCH
(2015)
Article
Endocrinology & Metabolism
Yoshifumi Tsuchiya, Daisuke Ando, Kaoru Takamatsu, Kazushige Goto
METABOLISM-CLINICAL AND EXPERIMENTAL
(2015)
Article
Sport Sciences
S. Mizuno, I. Morii, Y. Tsuchiya, K. Goto
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2016)
Article
Endocrinology & Metabolism
Yoshifumi Tsuchiya, Toshiaki Ijichi, Kazushige Goto
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Cell & Tissue Engineering
Shin Fujimaki, Daiki Seko, Yasuo Kitajima, Kiyoshi Yoshioka, Yoshifumi Tsuchiya, Shinya Masuda, Yusuke Ono
Article
Physiology
Kiyoshi Yoshioka, Yasuo Kitajima, Daiki Seko, Yoshifumi Tsuchiya, Yusuke Ono
Summary: The study showed that muscle regeneration and atrophy varied throughout the body in mouse models. Head muscles regenerated more slowly compared to limb muscles, which exhibited rapid regeneration and overgrowth. Different muscles were affected differently in muscle atrophy models caused by cancer cachexia, aging, and castration.
Article
Cell & Tissue Engineering
Yoshifumi Tsuchiya, Yasuo Kitajima, Hiroshi Masumoto, Yusuke Ono
Article
Biochemistry & Molecular Biology
Yoshifumi Tsuchiya, Kazushige Goto
Summary: The study aimed to investigate the effects of endurance exercise under different environmental temperatures on myokine responses. Findings revealed that exercise in hot environment positively influenced FGF21 and myostatin concentrations compared to thermoneutral conditions.
Article
Multidisciplinary Sciences
Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono
Summary: Mouse and human somite-derived satellite cells exhibit maintained expression of Hox-A cluster genes accompanied by DNA hypermethylation, replicating their embryonic origin. Inactivation of Hoxa10 in these cells leads to genomic instability and mitotic catastrophe. The decline in regenerative ability of somite-derived muscles in mice with satellite cell-specific Hoxa10 ablation suggests modulation of region-specific pathophysiology by Hox gene expression profiles.
Article
Oncology
Yoshifumi Tsuchiya, Monika Lucia Bayer, Peter Schjerling, Casper Soendenbroe, Michael Kjaer
Summary: This study found that tenocytes can influence myotube formation in human primary cells in vitro, but did not enhance the proliferation of myoblasts. These findings contribute to an understanding of the role of tendon-derived cells in skeletal muscle development and regeneration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Yoshifumi Tsuchiya, Rene B. Svensson, Ching-Yan Chloe Yeung, Peter Schjerling, Michael Kjaer
Summary: Skeletal muscle has adaptability and regenerative potential due to muscle stem cell activity. The interplay between skeletal muscle and adjacent tendon tissue has not been fully investigated. In this study, we found that factors released by mechanically loaded tendon constructs stimulated myotube formation in human-derived myoblasts. These results suggest the importance of mechanical loading in the signaling interplay between skeletal muscle and tendon tissue for musculoskeletal tissue development and regeneration in humans.
TISSUE ENGINEERING PART A
(2023)
Article
Biochemistry & Molecular Biology
Yoshifumi Tsuchiya, Hisashi Takakura, Seita Osawa, Tetsuya Izawa
Summary: Physical inactivity and aging can cause tendon deterioration, which is a significant public health concern. The effects of exercise training on tendon function are being studied, with a focus on high-intensity interval training (HIIT) in this research. The mRNA expression in rat Achilles tendons was used to evaluate the impact of HIIT on tendon progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biology
Yoshifumi Tsuchiya, Yusuke Ono
Summary: In this study, an in vitro mechanical damage model of myofibers was established to investigate the activation of satellite cells. The findings provide insights into the mechanism of satellite cell activation and the role of damaged myofiber-derived factors.
Article
Sport Sciences
Tomoyo Kageta, Yoshifumi Tsuchiya, Takuma Morishima, Yuta Hasegawa, Hiroto Sasaki, Kazushige Goto
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2016)
