Article
Biochemical Research Methods
Marcelo Duarte Azevedo, Sibilla Sander, Cheryl Jeanneret, Soophie Olfat, Liliane Tenenbaum
Summary: Efficient and specific targeting of PV+ interneurons in the striatum was achieved by combining AAV-FLEX vectors with PVCre mice. However, diffusion of viral particles to the globus pallidus led to transduction of PV+ projection neurons, impacting the overall targeting strategy. Different AAV serotypes and promoters were evaluated to optimize the process and avoid unintended transduction.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Francois Cinotti, Mark D. Humphries
Summary: This study presents a Bayesian approach to mapping neuron connectivity in the striatum. By applying it to the mouse striatum, two asymmetries in the circuit were discovered: a selective asymmetry of projection neuron connections and a length-scale asymmetry. The Bayesian approach can also evaluate evidence for wiring changes, making it significant for understanding the function and dysfunction of the striatum.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Physics, Fluids & Plasmas
D. Chalkiadakis, J. Hizanidis
Summary: This paper revisits the dynamical mechanisms of Josephson Junction-based neurons, revealing complex behaviors relevant for neurocomputation and the design of superconducting neuromorphic devices.
Article
Cell Biology
Perry W. E. Spratt, Ryan P. D. Alexander, Roy Ben-Shalom, Atehsa Sahagun, Henry Kyoung, Caroline M. Keeshen, Stephan J. Sanders, Kevin J. Bender
Summary: The loss of Na(V)1.2 channels in pyramidal neurons leads to intrinsically hyperexcitable neurons, firing high-frequency bursts of action potentials despite reductions in AP size and speed. This cell-intrinsic mechanism may explain why loss-of-function variants in SCN2A gene paradoxically promote seizure.
Article
Optics
M. Dillane, E. A. Viktorov, B. Kelleher
Summary: Neuromorphic computing has gained attention for its potential in ultrafast, controllable spike processing. This study demonstrates that optically injected dual-state quantum dot lasers can exhibit both leaky integrate-and-fire and integrate-and-inhibit mechanisms, resembling the behavior of biological neurons. This discovery contributes to the field of neuromorphic photonics.
Article
Cell Biology
Anna Tokarska, Gilad Silberberg
Summary: The interactions between striatal cholinergic and GABAergic systems play a crucial role in reward-related behavior and reinforcement learning. By studying Chrna2-Cre mice, we discovered that striatal Chrna2-INs have different electrophysiological, morphological, and synaptic properties compared to other brain regions. These INs form inhibitory synaptic connections with striatal projection neurons and other INs and receive excitatory inputs from the primary motor cortex. Some Chrna2-INs respond to nicotinic input, suggesting reciprocal interactions with striatal cholinergic synapses.
Review
Neurosciences
Lisa Z. Fang, Meaghan C. Creed
Summary: This article provides an overview of the neurochemical and molecular diversity of striatal and pallidal neurons, as well as recent studies on circuit connectivity in rodents. The authors highlight the anatomical organizational principles of the dorsal and ventral basal ganglia pathways. Future research integrating the molecular and anatomical properties of specific subpopulations may help resolve controversies related to the function of basal ganglia networks.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Thanh Tan Vo, Geun Ho Im, Kayoung Han, Minah Suh, Patrick J. Drew, Seong-Gi Kim
Summary: In this study, the hemodynamic responses elicited by optogenetic stimulation of PV interneurons were investigated using electrophysiology, fMRI, OIS, and pharmacological applications. The findings showed that activation of PV neurons induced an early vasoconstrictive response and a later ultraslow vasodilation response. The ultraslow response was mediated by neuropeptide substance P released from PV neurons and was dependent on the brain state.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Diana Rodrigues, Luis Jacinto, Margarida Falcao, Ana Carolina Castro, Alexandra Cruz, Catia Santa, Bruno Manadas, Fernanda Marques, Nuno Sousa, Patricia Monteiro
Summary: Chronic stress can trigger or worsen motor symptoms in neuropsychiatric disorders, and SOM interneurons in the striatum are involved in stress-induced motor behaviors.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Paige N. McKeon, Garrett W. Bunce, Mary H. Patton, Rong Chen, Brian N. Mathur
Summary: Fast-spiking interneurons in the dorsal striatum regulate actions and action strategies, with synchronization arising from electrical synapses or convergent cortical input. In adult mice, the primary source of functional coordination of fast-spiking interneuron activity is the convergence of corticostriatal input, with electrical synapses providing only minor enhancement of synchronization.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Bo Liang, Lifeng Zhang, Yan Zhang, Craig T. Werner, Nicholas J. Beacher, Alex J. Denman, Yun Li, Rong Chen, Charles R. Gerfen, Giovanni Barbera, Da-Ting Lin
Summary: The dorsal striatum plays a crucial role in movement control and motor skill learning. This study explores how the medium spiny neurons (MSNs) in the direct and indirect pathways of the striatum encode motor skill learning. By combining miniature fluorescence microscopy and an accelerating rotarod procedure, the researchers identified two distinct subpopulations of MSNs involved in accelerating rotarod learning. They found that early-stage neurons in both the D1 and D2 MSNs displayed activity tuned to acceleration during early stages of trials and movement speed during late stages of trials. The evolution of D1 MSNs correlated strongly with performance improvement, and inhibiting early-stage neural activity in D1 MSNs impaired accelerating rotarod learning.
Article
Cell Biology
Samet Kocaturk, Elif Beyza Guven, Fulva Shah, James M. Tepper, Maxime Assous
Summary: Cholinergic interneurons play crucial roles in striatal circuits and functions. The activation of acetylcholine signal via muscarinic receptors is well studied, but recent data suggest that nicotinic receptors located on GABAergic interneurons are equally important. Stimulation of cholinergic interneurons activates these receptors and leads to inhibitory effects on striatal projection neurons.
Article
Neurosciences
Gabrielle Devienne, Sandrine Picaud, Ivan Cohen, Juliette Piquet, Ludovic Tricoire, Damien Testa, Ariel A. Di Nardo, Jean Rossier, Bruno Cauli, Bertrand Lambolez
Summary: Inhibition of parvalbumin-expressing (PV) interneurons in adult mice can induce perineuronal net (PNN) regression, while activation of these neurons does not reduce PNN density. The density of PNN in the adult cortex is regulated by local changes in network activity, which can be triggered through modulation of PV interneurons.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jessica A. Burket, Jason D. Webb, Stephen Deutsch
Summary: The free concentrations of redox reactive metals iron and copper are highly regulated due to their ability to catalyze the generation of toxic free radicals. The perineuronal net, a specialized component of brain extracellular matrix, not only binds metal cations for protective function but also supports fast-spiking electrophysiological properties of surrounding neurons.
Article
Multidisciplinary Sciences
Elie M. Adam, Emery N. Brown, Nancy Kopell, Michelle M. McCarthy
Summary: A biophysical networked model was developed to investigate the therapeutic mechanism of deep brain stimulation (DBS) in Parkinson's disease (PD). The study found that DBS can restore normal beta, gamma, and theta striatal rhythms by recruiting certain neurons and regulating dopamine levels. This research highlights the potential of leveraging gamma and theta oscillations to enhance the effectiveness of DBS treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Anatomy & Morphology
Yi-Qun Wang, Rui Li, Dian-Ru Wang, Yoan Cherasse, Ze Zhang, Meng-Qi Zhang, Oriana Lavielle, Kristopher McEown, Serge N. Schiffmann, Alban de Kerchove d'Exaerde, Wei-Min Qu, Michael Lazarus, Zhi-Li Huang
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Laurie Lambot, Elena Chaves Rodriguez, Delphine Houtteman, Yuquing Li, Serge N. Schiffmann, David Gall, Alban de Kerchove d'Exaerde
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Ira Espuny-Camacho, Amaia M. Arranz, Mark Fiers, An Snellinx, Kunie Ando, Sebastian Munck, Jerome Bonnefont, Laurie Lambot, Nikky Corthout, Lorna Omodho, Elke Vanden Eynden, Enrico Radaelli, Ina Tesseur, Selina Wray, Andreas Ebneth, John Hardy, Karelle Leroy, Jean-Pierre Brion, Pierre Vanderhaeghen, Bart De Strooper
Article
Multidisciplinary Sciences
Yo Oishi, Qi Xu, Lu Wang, Bin-Jia Zhang, Koji Takahashi, Yohko Takata, Yan-Jia Luo, Yoan Cherasse, Serge N. Schiffmann, Alban de Kerchove d'Exaerde, Yoshihiro Urade, Wei-Min Qu, Zhi-Li Huang, Michael Lazarus
NATURE COMMUNICATIONS
(2017)
Article
Biology
Xiang-Shan Yuan, Lu Wang, Hui Dong, Wei-Min Qu, Su-Rong Yang, Yoan Cherasse, Michael Lazarus, Serge N. Schiffmann, Alban de Kerchove d'Exaerde, Rui-Xi Li, Zhi-Li Huang
Article
Biochemistry & Molecular Biology
Jean-Francois De Backer, Stephanie Monlezun, Berangere Detraux, Adeline Gazan, Laura Vanopdenbosch, Julian Cheron, Giuseppe Cannazza, Sebastien Valverde, Lidia Cantacorps, Merie Nassar, Laurent Venance, Olga Valverde, Philippe Faure, Michele Zoli, Olivier De Backer, David Gall, Serge N. Schiffmann, Alban de Kerchove d'Exaerde
Article
Neurosciences
Svetlana M. Molchanova, Joris Comhair, Deniz Karadurmus, Elisabeth Piccart, Robert J. Harvey, Jean-Michel Rigo, Serge N. Schiffmann, Bert Brone, David Gall
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Joris Comhair, Jens Devoght, Giovanni Morelli, Robert J. Harvey, Victor Briz, Sarah C. Borrie, Claudia Bagni, Jean-Michel Rigo, Serge N. Schiffmann, David Gall, Bert Brone, Svetlana M. Molchanova
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Naoki Yamawaki, Xiaojian Li, Laurie Lambot, Lynn Y. Ren, Jelena Radulovic, Gordon M. G. Shepherd
NATURE NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Anna B. Toth, Kotaro Hori, Michaela M. Novakovic, Natalie G. Bernstein, Laurie Lambot, Murali Prakriya
Article
Neurosciences
Deniz Karadurmus, Daniel Rial, Jean-Francois De Backer, David Communi, Alban de Kerchove d'Exaerde, Erge N. Schiffmann
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Adeline Gazan, Daniel Rial, Serge N. Schiffmann
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Daniel Rial, Emma Puighermanal, Marine Chazalon, Emmanuel Valjent, Serge N. Schiffmann, Alban de Kerchove d'Exaerde
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Stefan Pommer, Yumiko Akamine, Serge N. Schiffmann, Alban de Kerchove D'Exaerde, Jeffery R. Wickens
Summary: Research shows that serotonin modulates lateral inhibition among neurons in the striatum by acting on 5-HT1B receptors, while the activation of 5-HT1B receptors does not have a significant impact on the inhibitory effects caused by fast-spiking interneurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Muriel Laurent, Jean-Francois De Backer, Danie Rial, Serge N. Schiffmann, Alban de Kerchove d'Exaerde
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2017)