Review
Cell Biology
Alexandre Balaphas, Jeremy Meyer, Raphael P. H. Meier, Emilie Liot, Nicolas C. Buchs, Bruno Roche, Christian Toso, Leo H. Buhler, Carmen Gonelle-Gispert, Frederic Ris
Summary: Anal sphincter incontinence is a chronic disease that significantly impacts quality of life, with surgery showing disappointing success rates. Stem/progenitor cell therapy is being considered as a promising alternative with higher efficacy, but further research and development is necessary to overcome challenges and establish optimal treatment protocols.
Article
Medicine, General & Internal
Minsung Kim, Bo-Young Oh, Ji-Seon Lee, Dogeon Yoon, You-Rin Kim, Wook Chun, Jong Wan Kim, Il Tae Son
Summary: This study demonstrated for the first time that implanted adipose-derived stem cells can restore impaired smooth muscle cells at the injury site, showing stem cell fate corresponding to the established IAS-specific AI model.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Nicola Adanna Okeahialam, Annika Taithongchai, Ranee Thakar, Abdul H. Sultan
Summary: This study systematically determined and compared the incidence of anal incontinence among different grades of obstetric anal sphincter injury. A network meta-analysis was conducted to compare the outcomes of different tear grades. The results showed that the severity of tear grade is associated with worse clinical outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cell & Tissue Engineering
Li Sun, Alanna Billups, Anna Rietsch, Margot S. Damaser, Massarat Zutshi
Summary: The aim of this study was to evaluate the regeneration of a chronic large anal sphincter defect in a pig model after treatment with a plasmid encoding Stromal Cell Derived Factor-1(SDF-1). The results showed that injection of SDF-1 improved anal resting pressures and regenerated muscle in the entire defect in the treated groups. This suggests that SDF-1 plasmid could be effective in treating chronic defects of the anal sphincter in large animals.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Review
Surgery
Chiara Eberspacher, Domenico Mascagni, Iulia Catalina Ferent, Enrico Coletta, Rossella Palma, Cristina Panetta, Anna Esposito, Stefano Arcieri, Stefano Pontone
Summary: Anal fistula is a common disease that requires surgical treatment. The application of mesenchymal stem cells derived from adipose tissue has shown promising results in treating fistulas, but further studies are needed to establish their efficacy and potential complications.
FRONTIERS IN SURGERY
(2022)
Review
Obstetrics & Gynecology
S. K. Doumouchtsis, J. Loganathan, V Pergialiotis
Summary: The global prevalence of obesity is on the rise, with complex and differing mechanisms related to urinary and anal incontinence. Weight loss can reduce urinary incontinence, but the effect on anal incontinence remains unclear.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Multidisciplinary Sciences
Troy M. Robinson, Robert L. Bowman, Sonali Persaud, Ying Liu, Rosemary Neigenfind, Qi Gao, Jingping Zhang, Xiaotian Sun, Linde A. Miles, Sheng F. Cai, Adam Sciambi, Aaron Llanso, Christopher Famulare, Aaron Goldberg, Ahmet Dogan, Mikhail Roshal, Ross L. Levine, Wenbin Xiao
Summary: A single-cell MRD assay was developed in this study, which can detect residual cancer cells with high sensitivity and provide clone-specific information on clonal architecture and immunophenotype.
Article
Biotechnology & Applied Microbiology
Satoshi Kainuma, Shigeru Miyagawa, Koichi Toda, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yoshito Ito, Hiroko Iseoka, Takayoshi Ueno, Toru Kuratani, Kei Nakamoto, Fusako Sera, Tomohito Ohtani, Tomomi Yamada, Yasushi Sakata, Yoshiki Sawa
Summary: This study evaluated the recovery of cardiac function in patients with ischemic cardiomyopathy following skeletal myoblast cell-sheet transplantation, with positive outcomes in long-term survival. Some patients showed good responses to the treatment, and preoperative renal and left ventricular function may predict the response to this therapy.
Article
Gastroenterology & Hepatology
Alexandre Balaphas, Jeremy Meyer, Nicolas C. Buchs, Ali Modarressi, Leo H. Buhler, Christian Toso, Carmen Gonelle-Gispert, Frederic Ris
Summary: This study reports the presence of mesenchymal stem cells in the anal canal transition zone in pigs for the first time, and demonstrates the feasibility of their isolation. These findings offer potential for isolating human anal canal transition zone mesenchymal stem cells, which could be used to study sphincters healing and treat anal incontinence.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Lingye Chen, Fatemeh Hassani Nia, Tobias Stauber
Summary: This review focuses on the critical role of ion channels and transporters in developmental processes of muscle tissues, discussing their influence on myoblast differentiation, cardiac differentiation, and vascular smooth muscle cell differentiation. It highlights examples of model organisms or patients with mutations in ion channels, and proposes a potential underlying molecular mechanism involving hyperpolarization of the resting membrane potential and calcium signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Olivier Boyer, Gillian Butler-Browne, Hector Chinoy, Giulio Cossu, Francesco Galli, James B. Lilleker, Alessandro Magli, Vincent Mouly, Rita C. R. Perlingeiro, Stefano C. Previtali, Maurilio Sampaolesi, Hubert Smeets, Verena Schoewel-Wolf, Simone Spuler, Yvan Torrente, Florence Van Tienen
Summary: This article reviews the use of myogenic cell transplantation for congenital and acquired diseases of skeletal muscle, highlighting the comparison of similarities and differences among different diseases to understand the limitations of clinical success in this area. The choice between autologous and heterologous cells is dictated by various criteria, and the potential of induced pluripotent stem cell derivatives in the future is also discussed.
FRONTIERS IN GENETICS
(2021)
Article
Gastroenterology & Hepatology
Francesco Litta, Angelo A. Marra, Nuria Ortega Torrecilla, Raffaele Orefice, Angelo Parello, Veronica De Simone, Paola Campenni, Marta Goglia, Carlo Ratto
Summary: This prospective clinical study evaluated changes in external anal sphincter contractility after implantation of a self-expandable hyexpan prostheses, showing improvements in clinical outcomes.
DISEASES OF THE COLON & RECTUM
(2021)
Review
Endocrinology & Metabolism
A. M. James Shapiro, Kevin Verhoeff
Summary: The year 2022 witnessed game-changing advancements in clinical trials with stem cell islets, durable and promising 20-year data in clinical islet transplantation, and the development of locally protective or gene-editing-based approaches to prevent long-term immunosuppression.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Quynh Pham, Noor El-Dassouki, Raima Lohani, Aravinth Jebanesan, Karen Young
Summary: The COVID-19 pandemic has led to fundamental changes in how Canadians access healthcare, with virtual care playing a critical role in reducing viral transmission. However, there is a persistent gap in equitable access to virtual care for Canada's aging and ethnocultural minority communities, who are often excluded from existing solutions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Medical Laboratory Technology
Ngoc Anh Thi Nguyen, Hoai Thi Bui, Quynh Thi-Huong Pham, Ly Thi Thao Hoang, Hung Xuan Ta, Timo Heikkinen, Duyet Van Le, Trang Dinh Van, Nam Quoc Ngo, Phuong Thi Hong Huynh, Trang Thi Huyen Tran, Hoan Quoc Phan, Luong Van Hoang, H. Rogier van Doorn, Diep Thi Ngoc Nguyen, Tam Thi Nguyen, Nam Sy Vo, Cuong Viet Vo, Sau Khac Trinh, Tai The Pham, Quang Duc Le, Phan Van Le, Son Thai Nguyen, Loan Thi Tran, Toan Dinh Vu, Quynh Anh Vu Nguyen, Nguyet Thi Trieu, Thuy Thi Le, Ung Dinh Nguyen, Jakob Steman, Tho Huu Ho
Summary: A novel semi-nested RT-PCR assay has been developed for highly multiplex detection of SARS-CoV-2 RNA, allowing for 96-sample pooled testing to increase testing capacity.
CLINICA CHIMICA ACTA
(2022)
Article
Integrative & Complementary Medicine
Hau D. Tran, Huy Q. Hoang, Tuan D. Pham, Quynh T. Pham, Dat T. Bui, Nga Thu Bui, Cuong Hoang, Bo Han, Ba X. Hoang
Summary: This study investigates and evaluates the effectiveness of phytotherapy on a severe and complicated ITP patient who had failed with conventional treatments. The results show that phytotherapy significantly improves clinical symptoms, platelet counts, and laboratory tests.
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2022)
Article
Chemistry, Organic
Quynh Nguyen Nhu Pham, Komthep Silpcharu, Viwat Vchirawongkwin, Mongkol Sukwattanasinitt, Paitoon Rashatasakhon
Summary: Two diaryl derivatives of 1,1,4,4-tetracyanobuta-1,3-diene were synthesized and used as colorimetric ion sensors in aqueous media. One of the compounds showed good selectivity towards hydrogen sulfide ion, with a detection limit of 15.5 μM.
Article
Multidisciplinary Sciences
Quynh Mai Pham, Thi Hoai Thu Ho
Summary: This study examines the factors affecting the business efficiency of seafood companies listed on the Vietnamese stock market. Using data from the financial statements of 20 listed seafood companies operating in Vietnam from 2016 to 2020, the study utilizes EViews software for quantitative analysis and builds a panel data regression model to determine the relationship and impact of internal factors on the business performance of seafood companies. The research findings indicate that capital structure, firm size, growth rate of assets, and solvency are factors that significantly influence the business efficiency of listed seafood companies.
INTERNATIONAL JOURNAL OF ADVANCED AND APPLIED SCIENCES
(2022)
Article
Engineering, Biomedical
Dan The Pham, Linh Phuong Nguyen, Quynh Thi Huong Pham, Chi Khanh Pham, Dung Thuy Nguyen Pham, Nguyen Thanh Viet, Hong Van Thi Nguyen, Toan Quoc Tran, Duong Thanh Nguyen
Summary: Liposomal encapsulation is a drug delivery strategy that offers advantages such as improved bioavailability, large drug carrying capacity, and specificity towards targeted tissues. In this study, a low-cost liposome extruder was designed and used to synthesize liposome suspensions with defined particle size and high homogeneity for loading and release of Murrayafoline A (Mu-A). The MuA-loaded liposomes showed biphasic drug release and remained stable under low temperature storage conditions. Additionally, they significantly reduced the viability of HepG2 cells in cancer spheroids.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Health Care Sciences & Services
Noor El-Dassouki, Kaylen Pfisterer, Camila Benmessaoud, Karen Young, Kelly Ge, Raima Lohani, Ashish Saragadam, Quynh Pham
Summary: This study aims to explore the value of technology in supporting caregiving for individuals living with heart failure. Through interviews with informal caregivers (ICs), three opportunities to add value to technological design were identified: increasing psychological bandwidth, serving as a member of the support system, and mitigating clinical knowledge requirements and learning curve. The findings suggest that incorporating IC functionality into digital health self-management interventions can improve outcomes for both heart failure patients and their ICs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Thi Hanh Nguyen Vu, Ngoc Son Pham, Phuong Chi Le, Quynh Anh Pham, Ngoc Tung Quach, Van The Nguyen, Thi Thao Do, Hoang Ha Chu, Quyet Tien Phi
Summary: This study identified and evaluated fungal endophytes from Tsuga chinensis for their potential to produce bioactive compounds, including the anticancer drug paclitaxel. The endophytic fungi demonstrated antimicrobial and antioxidant activities, making them a promising source for new drug candidates.
ANNALS OF MICROBIOLOGY
(2022)
Article
Microbiology
Ngoc Tung Quach, Tran Thi Loan, Thi Thu An Nguyen, Thi Hanh Nguyen Vu, Quynh Anh Pham, Hoang Ha Chu, Quyet-Tien Phi, Doan Van Thuoc
Summary: Alcaligenes faecalis D334 is a salt-tolerant bacterium isolated from mangrove sediment that produces high levels of ectoines and has adaptive features to the mangrove environment. Its genome contains salt-responsive genes, a complete pathway for ectoine synthesis, and genetic determinants for oxidative stress response. Moreover, D334 has the potential for polyhydroxyalkanoate production and possesses a flagellar biosynthesis operon for swimming motility. These findings highlight the versatility of A. faecalis D334 as an industrial platform for PHA and 5-hydroxyectoine production.
RESEARCH IN MICROBIOLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
V. Dao Truong, David W. Knight, Quynh Pham, Thuong T. Nguyen, Tuan D. Nguyen, Stephen G. Saunders
Summary: This article emphasizes the importance of reflexivity and metacognition in studying pro-poor tourism (PPT) and provides a reflexive and metacognitive account of the challenges faced during ethnographic fieldwork. It contributes to the conceptual recognition of the importance of reflexivity and metacognition in tourism studies and provides insights into the difficulties associated with researching poor people in the tourism industry.
TOURISM RECREATION RESEARCH
(2022)
Article
Cultural Studies
Quynh N. Pham
Summary: This essay examines the connections among anticolonial struggles, with a focus on the political work of ba Nguyen Thi Binh and her relations with people from other countries. The article emphasizes the need to shift research perspectives and learn from the submerged to gain a re-conceptualization of global relations.
POSTCOLONIAL STUDIES
(2023)
Article
Public, Environmental & Occupational Health
Thi Hoang Lan Vu, Quynh Long Khuong, Quynh Nga Pham, Tuan Lam Nguyen, Quoc Bao Tran, Van Minh Hoang
Summary: The aim of this study was to estimate the prevalence of non-communicable disease risk factors among people aged 30-69 years old and investigate the pathways from behavioral risk factors to metabolic risk factors. The results showed that a higher proportion of males had two or more behavioral risk factors compared to females. Additionally, the pathways from behavioral risk factors to metabolic risk factors differed between males and females.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Health Care Sciences & Services
Brian Lo, Quynh Pham, Sanjeev Sockalingam, David Wiljer, Gillian Strudwick
Summary: Improving user engagement with digital mental health tools is crucial for the value of digital health. This study aims to identify essential factors that influence user engagement by using a Delphi approach and consolidating perspectives from relevant stakeholders and academic literature.
Article
Medicine, Research & Experimental
Frank D. Buono, Chitra Lalloo, Kaitlyn Larkin, William T. Zempsky, Samuel Ball, Lauretta E. Grau, Quynh Pham, Jennifer Stinson
Summary: Neurofibromatosis Type 1 (NF1) is a genetic disorder characterized by chronic pain. The utilization of the iCanCope mobile application provides a scalable and accessible self-management treatment option for NF1 patients. This study aims to customize the iCanCope mobile application for NF1 patients and evaluate its acceptability and impact on pain-related activities through a pilot randomized control study.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Article
Business, Finance
Quynh Thi Thuy Pham
Summary: This study finds that value weighted stock returns can be predicted in the US stock market, with predictability varying across industries and being related to firm size. The research also suggests that differences in dividend smoothness may drive cross-industry predictive patterns. For some small industries, dividend yields are not good indicators for predicting returns.
FINANCE RESEARCH LETTERS
(2021)