The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C

(2014) Kosuke Sako et al.   Nature Communications

Modulation of cell cycle control during oocyte-to-embryo transitions

(2013) Eva Hörmanseder et al.   EMBO JOURNAL

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

(2013) Weiping Wang et al.   NATURE CELL BIOLOGY

EMI1, a three-in-one ubiquitylation inhibitor

(2013) Hiroyuki Yamano   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C)

(2012) Ziguo Zhang et al.   BIOCHEMICAL JOURNAL

A Zinc-Dependent Mechanism Regulates Meiotic Progression in Mammalian Oocytes1

(2012) Miranda L. Bernhardt et al.   BIOLOGY OF REPRODUCTION

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

(2012) Daisuke Izawa et al.   JOURNAL OF CELL BIOLOGY

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

(2012) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The APC/C Inhibitor XErp1/Emi2 Is Essential for Xenopus Early Embryonic Divisions

(2012) T. Tischer et al.   SCIENCE

Dynamic Regulation of Emi2 by Emi2-Bound Cdk1/Plk1/CK1 and PP2A-B56 in Meiotic Arrest of Xenopus Eggs

(2011) Michitaka Isoda et al.   DEVELOPMENTAL CELL

Structural basis for the subunit assembly of the anaphase-promoting complex

(2011) Anne Schreiber et al.   NATURE

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase

(2010) T. Suzuki et al.   DEVELOPMENT

Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box–independent Mechanism

(2010) Wanli Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Emi2 Inhibition of the Anaphase-promoting Complex/Cyclosome Absolutely Requires Emi2 Binding via the C-Terminal RL Tail

(2010) Munemichi Ohe et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for the dual RNA-recognition modes of human Tra2-β RRM

(2010) Kengo Tsuda et al.   NUCLEIC ACIDS RESEARCH

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

(2009) Mathew J. Garnett et al.   NATURE CELL BIOLOGY

Cytostatic Factor Proteins Are Present in Male Meiotic Cells and β-Nerve Growth Factor Increases Mos Levels in Rat Late Spermatocytes

(2009) Marie-Hélène Perrard et al.   PLoS One

Regulation of APC/C Activators in Mitosis and Meiosis

(2008) Jillian A. Pesin et al.   Annual Review of Cell and Developmental Biology

Tracing the Silhouette of Individual Cells in S/G2/M Phases with Fluorescence

(2008) Asako Sakaue-Sawano et al.   CHEMISTRY & BIOLOGY

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC

(2008) Matthew K. Summers et al.   MOLECULAR CELL

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL