Journal
FEBS OPEN BIO
Volume 4, Issue -, Pages 829-833Publisher
WILEY
DOI: 10.1016/j.fob.2014.09.006
Keywords
Chronological lifespan; Fission yeast; Pma1
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [22580079, 25660290]
- Nagase Science and Technology Foundation
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [22580079, 25660290] Funding Source: KAKEN
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We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1(+) that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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