Drug discovery based on genetic and metabolic findings in schizophrenia

The estrogen hypothesis of Schizophrenia implicates glucose metabolism: Association study in three independent samples

(2008) Line Olsen et al.   BMC Medical Genetics

AKT Signaling in Regulating Angiogenesis

(2008) Bing-Hua Jiang et al.   CURRENT CANCER DRUG TARGETS

Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies

(2008) Kyriaki Gerozissis   EUROPEAN JOURNAL OF PHARMACOLOGY

Antipsychotic drugs up-regulate tryptophan hydroxylase in ADF neurons ofCaenorhabditis elegans: Role of calcium-calmodulin-dependent protein kinase II and transient receptor potential vanilloid channel

(2008) Dallas R. Donohoe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glucose-Mediated Transactivation of Carbohydrate Response Element-Binding Protein Requires Cooperative Actions from Mondo Conserved Regions and EssentialTrans-Acting Factor 14-3-3

(2008) Ming V. Li et al.   MOLECULAR ENDOCRINOLOGY

Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway

(2008) R R Girgis et al.   MOLECULAR PSYCHIATRY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)

(2008) B. M. Emerling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are metabolic indices different between drug-naïve first-episode psychosis patients and healthy controls?

(2008) S SENGUPTA et al.   SCHIZOPHRENIA RESEARCH

Prolyl 4-hydroxylase activity-responsive transcription factors: From hydroxylation to gene expression and neuroprotection

(2007) Ambreena Siddiq   Frontiers in Bioscience-Landmark