Article
Multidisciplinary Sciences
Patrik Sivco, Dominika Plancikova, Juliana Melichova, Martin Rusnak, Iva Hereitova, Vaclav Beranek, Roman Cibulka, Marek Majdan
Summary: This study analyzed the epidemiological patterns of traumatic brain injury-related deaths in 30 European countries in 2015 among residents and non-residents. It found that TBI-related deaths among non-residents were more common in young people and traffic accidents, while residents were more likely to die from TBI-related falls in older age groups. Different approaches are needed for prevention and safety promotion based on these findings.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Rupa Thapa, Cecilie Dahl, Wai Phyo Aung, Espen Bjertness
Summary: The study found that urban residents had higher rates of overweight and obesity, which increased with higher socioeconomic status. Urban residents, especially those with higher education levels and income, had higher BMIs. Additionally, urban residents had a higher waist-hip ratio. Urban-rural differences in BMI and waist-hip ratio were partially mediated by socioeconomic factors such as income, education, and employment.
Article
Environmental Sciences
Ester Cerin, Anthony Barnett, Jonathan E. Shaw, Erika Martino, Luke D. Knibbs, Rachel Tham, Amanda J. Wheeler, Kaarin J. Anstey
Summary: This study examines the impacts of urban environment features and air pollution on cognitive function in older adults using data from a national sample in Australia. The results show that interrelated built and natural environment features, as well as ambient air pollution, are directly and indirectly related to cognitive function, mediated by cardiometabolic risk factors. The findings suggest that dense, interconnected urban environments with access to parks, blue spaces, and low levels of air pollution may have positive effects on cognitive health through cardiometabolic risk factors.
Article
Medicine, General & Internal
Anna Bartoskova Polcrova, Ramfis Nieto-Martinez, Jeffrey Mechanick, Geraldo A. Maranhao Neto, Maria M. Infante-Garcia, Hynek Pikhart, Martin Bobak, Jose Medina-Inojosa, Juan P. Gonzalez-Rivas
Summary: This study compared the relationships of social determinants with cardiometabolic risk in Venezuela and Czechia. The results suggest that the associations between socioeconomic status indices and cardiometabolic risk differed between the two countries. Further research is needed to confirm and quantify these differences.
Article
Medicine, General & Internal
Mulugeta Molla Birhanu, Roger G. Evans, Ayse Zengin, Michaela Riddell, Kartik Kalyanram, Kamakshi Kartik, Oduru Suresh, Nihal Jacob Thomas, Velandai K. Srikanth, Amanda G. Thrift
Summary: This study compared the performance of laboratory-based cardiovascular risk prediction tools in a low-income and middle-income country setting and found disparities in their performance. The study also revealed that only a small percentage of high-risk individuals were receiving recommended lipid-lowering and antihypertensive medications.
Article
Food Science & Technology
Carl Johan Lagerkvist, Assem Abu Hatab, Swamikannu Nedumaran, Padmaja Ravula
Summary: In this study, researchers found that lack of access to refrigerators is a significant issue in households in Hyderabad, India. Among households with refrigerators, the majority set the temperature at medium levels. Smell and food appearance were the main criteria used to determine the edibility of food. The study also identified various subgroups of households based on their handling and hygiene practices, with only a small proportion exhibiting adequate and consistent practices. The findings suggest that education level, food expenditure, and refrigerator temperature are predictive factors for households with more adequate practices, while social class, age, income, and obesity are distinguishing factors for households without refrigerators. These latent trait-specific behaviors have important implications for interventions aimed at improving food safety practices in developing countries.
Article
Medicine, General & Internal
Akif Mustafa
Summary: This study examines the association between hysterectomy and hypertension among middle-aged and older women in India, and investigates if the association differs across different age groups. The nationally representative data of the Longitudinal Ageing Study in India (2017-2018) was used. The findings suggest a significant association between hysterectomy and hypertension in middle-aged and older women in India.
Article
Medicine, General & Internal
Akif Mustafa
Summary: This cross-sectional exploratory study using nationally representative data from India found a significant association between hysterectomy and hypertension in middle-aged and older women. The association varied across different age groups.
Article
Public, Environmental & Occupational Health
Natsuko Nakagoshi, Sachimi Kubo, Yoko Nishida, Kazuyo Kuwabara, Aya Hirata, Mizuki Sata, Aya Higashiyama, Yoshimi Kubota, Takumi Hirata, Yukako Tatsumi, Kuniko Kawamura, Junji Miyazaki, Naomi Miyamatsu, Daisuke Sugiyama, Yoshihiro Miyamoto, Tomonori Okamura
Summary: This study examines the determinants of high double product (DP) by evaluating the association between resting DP and blood test results and lifestyle factors. The results show that age, hematocrit, and gamma-glutamyl transferase levels are positively associated with high DP in both men and women. Additionally, insulin resistance is positively associated with high DP in women, while exercise is negatively associated with high DP in men. The study concludes that high DP at rest is associated with insulin resistance, gamma-glutamyl transferase, and exercise in participants without underlying disease.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Xiaolin Peng, Qin Gao, Juan Zhou, Jianping Ma, Dan Zhao, Liping Hao
Summary: In Chinese middle-aged and older adults with hypertension, a linear inverse association was found between dietary vitamin C intake and the prevalence of high homocysteine levels, while an L-shaped association was observed between dietary retinol intake and high homocysteine prevalence. No significant associations were found between dietary vitamin E, carotenes, and lutein intake with high homocysteine levels.
Article
Medicine, General & Internal
Boitumelo Prescilla Letswalo, Karin Schmid-Zalaudek, Bianca Brix, Edna Ngoakoana Matjuda, Fabian Klosz, Natalie Obernhumer, Michael Gaisl, Godwill Azeh Engwa, Constance Sewani-Rusike, Per Morten Fredriksen, Benedicta Nkeh-Chungag, Nandu Goswami
Summary: The study found a high prevalence of overweight/obesity and hypertension in rural South African youth, with over half of the adolescents at risk of developing cardiovascular disease. There is a significant association between cardiometabolic risk factors and pulse wave velocity. Early detection and preventive strategies are urgently needed to prevent the progression of vascular damage and manifestation of cardiovascular disease in underprivileged young people in rural Africa.
Article
Endocrinology & Metabolism
Afif Nakhleh, Rizan Sakhnini, Eyal Furman, Naim Shehadeh
Summary: This study aimed to determine the prevalence and clustering of cardiometabolic risk factors (CMRFs) among children and adolescents with overweight or Class 1 obesity. The study found that Class 1 obesity with BMI 110%-119% of the 95th percentile was associated with a higher prevalence and clustering of CMRFs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Rainer Mueller, Peter Zangger, Dominik Straumann, Stefan Y. Boegli
Summary: This study aimed to determine the point prevalence of dizziness and BPPV among retirement home residents, as well as evaluate the efficacy of a 2-axis turntable for BPPV treatment. The results showed that approximately 11.3% of participants tested on the turntable had BPPV.
Article
Microbiology
Pilar Alfageme-Garcia, Victor Manuel Jimenez-Cano, Maria del Valle Ramirez-Duran, Adela Gomez-Luque, Sonia Hidalgo-Ruiz, Belinda Basilio-Fernandez
Summary: Onychomycosis is a common foot condition, and the infecting agent differs between the homeless population and the population with homes.
Article
Medicine, General & Internal
Rebecca Cai, Paul Novosad, Vaidehi Tandel, Sam Asher, Anup Malani
Summary: The study aimed to estimate age-specific and sex-specific mortality risk among all SARS-CoV-2 infections in India and compare age trends in mortality with high-income countries. Results showed significant variations in estimated age-specific IFRs across different regions in India during the first wave, with Mumbai, Karnataka, and Tamil Nadu having considerably lower IFRs compared to high-income countries.
Article
Peripheral Vascular Disease
Thomas Beaney, Aletta E. Schutte, George S. Stergiou, Claudio Borghi, Dylan Burger, Fadi Charchar, Suzie Cro, Alejandro Diaz, Albertino Damasceno, Walter Espeche, Arun Pulikkottil Jose, Nadia Khan, Yoshihiro Kokubo, Anuj Maheshwari, Marcos J. Marin, Arun More, Dinesh Neupane, Peter Nilsson, Mansi Patil, Dorairaj Prabhakaran, Agustin Ramirez, Pablo Rodriguez, Markus Schlaich, Ulrike M. Steckelings, Maciej Tomaszewski, Thomas Unger, Richard Wainford, Jiguang Wang, Bryan Williams, Neil R. Poulter
Article
Pharmacology & Pharmacy
Ram B. Singh, Ghizal Fatima, Puneet Kumar, Jan Fedacko, Viliam Mojto, Adrian Isaza, Nar SinghVerma, Anuj Maheshwari, Shashank Joshi, Banshi Saboo, Manoj Saxena
Summary: This real-world observation study shows that treatment with EMPA in patients with diabetes can significantly reduce markers of inflammation, blood sugar, oxidative stress, uric acid, and blood pressure, while increasing levels of antioxidant vitamins and nitrite. Further randomized controlled intervention trials are needed to confirm these findings.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Arjun Krishnakumar, Ritika Verma, Rajeev Chawla, Aravind Sosale, Banshi Saboo, Shilpa Joshi, Maaz Shaikh, Abhishek Shah, Siddhesh Kolwankar, Vinod Mattoo
Summary: This study investigated the effectiveness of the Wellthy CARE digital therapeutic in improving glycemic control in a group of 102 patients with type 2 diabetes from India over a 16-week period. The results showed a significant reduction in HbA(1c), FBG, and PPBG levels, with higher program engagement leading to better outcomes in glycemic control.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Endocrinology & Metabolism
Aravind Sosale, Bhavana Sosale, Jothydev Kesavadev, Manoj Chawla, Sanjay Reddy, Banshi Saboo, Anoop Misra
Summary: This review aims to raise awareness among physicians on the challenges of steroid use and hyperglycemia during the COVID-19 pandemic. It provides guidance for managing hyperglycemia and highlights the importance of effective management during the current health crisis.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Endocrinology & Metabolism
Banshi Saboo, Sujoy Ghosh, Mangesh Tiwaskar, Rajeev Chawla
Summary: Teneligliptin did not cause QTc interval prolongation and was significantly effective in improving glycemic control in Indian Type 2 Diabetes Mellitus patients.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Endocrinology & Metabolism
Mohan Deepa, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Rajendra Pradeepa, Ashok Kumar Das, Sri Venkata Madhu, Paturi Vishnupriya Rao, Shashank Joshi, Banshi Saboo, Ajay Kumar, Anil Bhansali, Arvind Gupta, Sarita Bajaj, Nirmal Elangovan, Ulagamathesan Venkatesan, Radhakrishnan Subashini, Tanvir Kaur, R. S. Dhaliwal, Nikhil Tandon, Viswanathan Mohan
Summary: The study showed that HbA1c levels increase gradually with age, from 5.16±0.71% (33 mmol/mol) in the 20-29 age group to 5.49±0.69% (37 mmol/mol) in the 70+ age group. For every decadal increase in age, there was a 0.08% increase in HbA1c, with a more significant increase in females (0.10% vs. males: 0.06%) and urban population (urban: 0.10% vs. rural: 0.08%).
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Viswanathan Mohan, Coimbatore Subramanian Shanthi Rani, Banshi Saboo, Satinath Mukhopadhyay, Sudip Chatterjee, Panneerselvam Dharmarajan, Sunil Gupta, Sharad Pendsey, Jha Chandrakanta, Ganesan Umasankari, Anandakumar Amutha, Sheryl Salis, Supriya Datta, Prasanna Kumar Gupta, Philips Routray, Saravanan Jebarani, Nadiminty Ganapathi Sastry, Ulagamathesan Venkatesan, Ranjit Mohan Anjana, Ranjit Unnikrishnan
Summary: In this study comparing long-term survivors and nonsurvivors with type 1 diabetes in India, it was found that survivors had better glycemic control, blood pressure control, lipid profiles, and lower prevalence of complications. Non-survivors had higher rates of diabetic retinopathy, CKD, neuropathy, PVD, and CAD, with CAD and renal failure being the most common causes of death.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Review
Endocrinology & Metabolism
Banshi Saboo, Suhas Erande, A. G. Unnikrishnan
Summary: This study assessed the effect of Teneligliptin on glycemic control and variability. The results showed that Teneligliptin significantly reduced glycemic variability and improved control over hyperglycemic state in patients.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Endocrinology & Metabolism
Awadhesh Kumar Singh, Sanjeev Ratnakar Phatak, Ritu Singh, Kingshuk Bhattacharjee, Nagendra Kumar Singh, Arvind Gupta, Arvind Sharma
Summary: According to this study, there is a decline in humoral antibody levels after six months of receiving either Covishield or Covaxin vaccines against SARS-CoV-2 in India. Covishield recipients had higher antibody levels compared to Covaxin recipients, but there was a significant decrease in antibody titers with Covishield at six months, while there was no decline with Covaxin.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Review
Endocrinology & Metabolism
Jothydev Kesavadev, Anoop Misra, Banshi Saboo, Sanjay Agarwal, Aravind Sosale, Shashank R. Joshi, Akhtar Hussain, Noel Somasundaram, Abdul Basit, Pratik Choudhary, Sidartawan Soegondo
Summary: The prevalence of diabetes is high in South Asia, posing multiple treatment challenges. Despite advances, glycemic control remains suboptimal, necessitating the development of treatment guidelines and metrics tailored to the South Asian population.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Endocrinology & Metabolism
Ranjit Mohan Anjana, Seshadhri Srinivasan, Vasudevan Sudha, Shashank R. Joshi, Banshi Saboo, Nikhil Tandon, Ashok Kumar Das, Puthiyaveettil Kottayam Jabbar, Sri Venkata Madhu, Arvind Gupta, Sarita Bajaj, Subhankar Chowdhury, Sanjay Kalra, Rajagopal Gayathri, Kuzhandaivelu Abirami, Valangaiman Sriram Manasa, Thamotharan Padmapritha, Nagarajan Lakshmipriya, Gunasekaran Geetha, Mohan Deepa, Rajendra Pradeepa, Ranjit Unnikrishnan, Anura Viswanath Kurpad, Kamala Krishnaswamy, Tanvir Kaur, Rupinder Singh Dhaliwal, Viswanathan Mohan
Summary: A data-driven optimization approach was used to derive macronutrient recommendations for remission and prevention of type 2 diabetes in Asian Indians. Reduction in carbohydrates and an increase in protein intake were recommended for both T2D remission and for prevention of progression to T2D in prediabetes and normal glucose tolerance groups. These results highlight the importance of new dietary guidelines to address the burden of diabetes in South Asia.
Review
Multidisciplinary Sciences
Arvind Gupta, Rajeev Gupta
Summary: Diabetes is a chronic disease associated with metabolic abnormalities and it is the principal cause of disability and deaths, especially cardiovascular diseases, which are mainly caused by lipid abnormalities. Diabetic dyslipidemia is characterized by elevated levels of small-dense LDL cholesterol and triglycerides and low levels of HDL cholesterol. High LDL cholesterol has been proven to be causative for cardiovascular disease. Treatment with statins is the main therapy, but combination therapies might be needed for high-risk individuals. Recent research has also confirmed the role of elevated triglycerides as a cardiovascular risk factor. However, currently there are limited options for drug therapy. Low HDL cholesterol seems to be less significant as a contributor to cardiovascular risk compared to its previous consideration as a risk marker. Primary prevention strategies for cardiovascular disease in diabetes should focus on risk assessment, lifestyle interventions and statin treatment.
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2023)
Article
Endocrinology & Metabolism
Anuj Maheshwari, Dhruvi Hasnani, Meenakshi Bhattacharya, M. Mukhyaprana Prabhu, Divya Saxena, Bidita Khandelwal, C. L. Nawal, Brij Mohan Makkar, Sajid Ansari, Prahlad Chawla, Prabhat Agrawal, Ashish Saxena, Narsingh Verma, Banshi Saboo, Vipul Chavda, Uday Pratap Singh, Vanshika Arora
Summary: The study estimates the prevalence of newly detected diabetes patients who recovered from COVID-19 in India and compares them with patients without diabetes and those with known diabetes in terms of glycemic status and disease severity. The results show that diabetic patients had higher average blood glucose levels and a higher proportion of them required hospitalization. They also received higher doses of steroids for treatment. Further research is needed to understand the etiology, prognosis, and treatment opportunities of post-acute COVID-19 metabolism.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2023)
Review
Endocrinology & Metabolism
Sanjay Kalra, Jubbin Jacob, A. G. Unnikrishnan, Ganapathi Bantwal, Abhay Sahoo, Rakesh Sahay, Sushil Jindal, Madhu Sudan Agrawal, Nitin Kapoor, Banshi Saboo, Mangesh Tiwaskar, Kapil Kochhar
Summary: Male hypogonadism is a clinical and biochemical syndrome characterized by inadequate testosterone synthesis, which can lead to long-term effects on various aspects. The prevalence of male hypogonadism is high among Indian men above 40 and those with type 2 diabetes mellitus. However, underdiagnosis is common due to poor patient-physician communication. Testosterone replacement therapy is recommended for confirmed hypogonadism, but optimal treatment strategies are still a challenge.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Viswanathan Mohan, Banshi Saboo, Jabbar Khader, Kirtikumar D. Modi, Sushil Jindal, Subhash Kumar Wangnoo, Sugumaran Amarnath
Summary: This article evaluates national and international guidelines for diabetes management, with a focus on the role and recommendations of sulfonylureas (SUs) in the management of type 2 diabetes mellitus (T2DM). The guidelines suggest the use of certain second-generation SUs in select populations and specific scenarios. Effective management of T2DM requires identifying appropriate populations, classifying based on underlying risk, thorough assessment of comorbid conditions, and a step-wise approach for selecting appropriate SUs. Cost-to-benefit ratio should be considered, particularly in low- and middle-income countries (LMICs), where SUs can continue to play an important role.
CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES
(2022)