Review
Public, Environmental & Occupational Health
Shirin Jalili, Ramin Ghasemi Shayan
Summary: Health assessment data is crucial for developing care plans and understanding patient needs. The Quality of Life of cancer patients is significantly impacted by the disease, with symptoms such as pain having a negative effect.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Annelise Mortensen, Irene Wessel, Simon N. Rogers, Anders Tolver, Mary Jarden
Summary: This study investigated the effect and feasibility of integrating a head and neck cancer-specific needs assessment tool into nursing rehabilitation consultations early in the post-surgical period. The results showed that the intervention did not improve quality of life or symptom burden, but identified and addressed important needs.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Margherita Gobbo, Praveen R. Arany, Elisabetta Merigo, Rene-Jean Bensadoun, Alan Roger Santos-Silva, Luiz Alcino Gueiros, Giulia Ottaviani
Summary: The role of photobiomodulation (PBM) in head and neck cancer (HNC) treatment was investigated. PBM showed beneficial effects in improving quality of life (QoL), nutritional status, reducing pain and functional impairment. It may also reduce interruptions in radiotherapy (RT) and improve cancer treatment outcomes. However, it does not directly impact cancer survival/recurrences. PBM should be included in supportive cancer care for HNC patients due to its efficacy, safety, feasibility, and tolerability.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Oumar Billa, Franck Bonnetain, Jerome Chamois, Angeline Ligey, Valerie Ganansia, Georges Noel, Sophie Renard, Sophie Maillard, Magali Quivrin, Noemie Vulquin, Pierre Truntzer, Tienhan Sandrine Dabakuyo-Yonli, Philippe Maingon
Summary: Routine assessment of HRQoL can significantly improve quality of life and satisfaction with care for patients with head and neck cancer, with potential clinical benefits in terms of HRQoL and satisfaction outcomes.
Article
Oncology
Grace M. M. Spiro, Philip C. C. Doyle, Nedeljko Jovanovic, Melissa Nash, Kevin Fung, Danielle MacNeil, Anthony Nichols, John Yoo
Summary: This study investigated the degree of perceived fatigue in individuals treated for head and neck cancer (HNCa). Results showed that more than half of the participants reported clinically significant levels of fatigue. There was an inverse relationship between fatigue and overall health-related quality of life, suggesting that as fatigue increases, perceived HRQOL decreases.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Primoz Strojan, Ales Groselj, Gregor Sersa, Christina Caroline Plaschke, Jan B. Vermorken, Sandra Nuyts, Remco de Bree, Avraham Eisbruch, William M. Mendenhall, Robert Smee, Alfio Ferlito
Summary: Electrochemotherapy, based on reversible electroporation and intracellular accumulation of hydrophilic drug molecules, is considered an effective and safe treatment for tumors, including mucosal cancer of the head and neck. Limited experience with ECT in mucosal HNC due to poor accessibility of tumors highlights the need for further research to confirm its potential as a treatment option in selected patients.
Article
Oncology
Nan Jiang, Siqi Wei, Jan Martensson, Yue Zhao, Kristofer Arestedt
Summary: The study confirmed the validity and reliability of the XQ in Chinese patients with head and neck cancer undergoing radiotherapy. The XQ can be used as a valuable tool for assessing xerostomia, monitoring its severity, and evaluating treatment and intervention outcomes.
Article
Oncology
Ines Leao, Catarina Garcia, Pedro Antunes, Ana Campolargo, Isabel Dias, Edite Coimbra, Pedro Oliveira, Horacio Zenha, Horacio Costa, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Ana Joaquim
Summary: Head and neck cancer treatment can have negative impact on health-related quality of life and treatment efficacy. Exercise training may bring benefits to these patients. This study aimed to analyze the acute effects of treatment on patients and their preferences for exercise training. The findings suggest that an exercise training program can improve the physical fitness of patients and reduce toxicities.
Article
Oncology
Hans Paul van der Laan, Arjen van der Schaaf, Lisa Van den Bosch, Erik W. Korevaar, Roel J. H. M. Steenbakkers, Stefan Both, Johannes A. Langendijk
Summary: The study evaluated the feasibility of semi-automatic QOL-weighted NTCP-guided VMAT treatment plan optimization in head and neck cancer patients and compared it to conventional treatment. Results showed that QOL-weighted NTCP-guided VMAT plans were clinically acceptable, prioritizing sparing of organs at risk related to high-impact toxicities, leading to an improvement in predicted QOL compared to conventional VMAT plans.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Paula Luiza Bejenaru, Bogdan Popescu, Alina Lavinia Antoaneta Oancea, Catrinel Beatrice Simion-Antonie, Gloria Simona Bertesteanu, Mihnea Condeescu-Cojocarita, Anca Ionela Cirstea, Irina Doinita Oasa, Teodora Elena Schipor-Diaconu, Dan Popescu, Raluca Grigore
Summary: Squamous cell carcinoma of the head and neck (HNSCC) is a common malignancy with a complex negative impact on the patient's quality of life. Our retrospective study involving 89 patients who survived 3 years after HNSCC surgery showed an overall improvement in quality of life compared to the pre-treatment period. These findings underscore the importance of considering patient characteristics in quality-of-life research and demonstrate how such data can support the multi-disciplinary team in patient follow-up care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Alexandria Harris, Jinhong Li, Karley Atchison, Christine Harrison, Daniel Hall, Tyler VanderWeele, Jonas T. Johnson, Marci L. Nilsen
Summary: This study evaluates the relationship between demographics, clinical characteristics, and posttreatment symptom burden with the subjective sense of flourishing among head and neck cancer survivors. The results suggest that late- and long-term side effects of treatment and financial hardship are associated with lower levels of flourishing.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Otorhinolaryngology
Michele Fiorella, Angela Alnemri, Sarah Sussman, Anusha Koka, Jennifer Johnson, David Cognetti, Joseph Curry, Leila Mady, Brooke Worster, Amy E. Leader, Adam Luginbuhl
Summary: This study aimed to investigate the impact of head and neck squamous cell carcinoma diagnosis and treatment on patient and partner perceived intimacy, as well as whether a diagnosis of HPV-related head and neck squamous cell carcinoma affects patient-partner intimacy. The results showed that patient and partner intimacy levels remained stable or improved throughout the study, and there was generally agreement between couples in their levels of perceived intimacy. A diagnosis of HPV did not significantly affect intimacy scores.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Chandrika Gibson, Moira O'Connor, Rohen White, Melanie Jackson, Siddhartha Baxi, Georgia K. B. Halkett
Summary: This qualitative study explores the experiences of head and neck cancer (HNC) patients in communicating with health professionals. The loss of speech capacity is found to be distressing and traumatic for survivors of HNC. Tensions arise in the communication between patients and health professionals, including abrupt, hurried communication versus slower, more mindful communication. Disparities in health literacy levels and a lack of empathy are also observed.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Oncology
Sarah R. Sutton, April N. Taniguchi, Shaun A. Nguyen, William G. Albergotti, John M. Kaczmar, Alexandra E. Kejner, Jason G. Newman
Summary: In patients with head and neck cancer undergoing treatment, there is a correlation between quality of life scores and treatment outcomes, with higher scores associated with improved survival. However, the assessment of quality of life varies in clinical trials. Only 10 studies included supplemental quality of life data. The inclusion of trials introduces a high risk of bias. There is currently no standardized method for reporting quality of life data in clinical trials for head and neck cancer patients receiving antiEGFR inhibitors. Future trials should standardize their approach to improve patient-centered care and treatment choices for better survival outcomes.
Article
Oncology
Virginie Prevost, Claire Delorme, Alexandra Leconte, Aline Le Chevalier, Lauriane Fourel, Maud Gicquere, Marie-Christine Grach, Franck Le Caer, Benedicte Clarisse
Summary: This article describes the establishment and implementation of a therapeutic patient education program focused on cancer pain, as well as the challenges and opportunities encountered. Ten nurse-doctor pairs were trained and developed educational, evaluation, and communication tools for patients to understand different types of pain, pain treatments, and daily pain management. The importance of communicating with oncologists and independent health professionals was emphasized. The program met patient needs and addressed difficulties, such as organization, structure, and communication issues.
JOURNAL OF CANCER EDUCATION
(2022)
Article
Medicine, General & Internal
Marie Lange, Sarah Joo, Pierre-Andre Couette, Francois Le Bas, Xavier Humbert
Summary: This study assessed the mental health impact of COVID-19 on French General Practitioners, finding that up to 42% reported psychological disturbances including burnout and post-traumatic stress symptoms. Women were more likely to experience stress and burnout symptoms compared to men.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Brent J. Small, Marie Lange, Wanting Zhai, Jaeil Ahn, Tim A. Ahles, Judith E. Carroll, Harvey J. Cohen, Deena Graham, Martine Extermann, Natacha Heutte, Heather S. L. Jim, Brenna C. McDonald, Sunita K. Patel, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Xingtao Zhou, Jeanne Mandelblatt, Florence Joly
Summary: Pooled individual-level data from two large prospective studies of older breast cancer survivors showed that older women who received taxane-based chemotherapy did not experience greater declines in cognitive performance or well-being compared to women receiving other chemotherapy regimens. Despite being at greater risk for negative outcomes, treatment with taxane-based chemotherapies did not exacerbate these health consequences for older cancer survivors.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Pharmacology & Pharmacy
Marie Lange, Idlir Licaj, Michel Boulouard, David Garon, Estelle Richard, Jeanne Le Bas, Remi Salmon, Rheda Stroiazzo, Francois Le Bas, Xavier Humbert
Summary: This longitudinal study assesses the psychological impact of the COVID-19 outbreak on French owner community pharmacists. The results indicate that stress, posttraumatic stress, and burnout symptoms decreased during the follow-up period.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Aurelien Francois, Nadine Dermit-Richard, Daniel Plumley, Rob Wilson, Natacha Heutte
Summary: The study analyzes the effectiveness of UEFA's Financial Fair Play under the break-even requirement using data from English and French football clubs from 2008-2018. Results show an increase in clubs' profitability in the EPL, while in Ligue 1, the improvement is only significant for certain clubs.
SPORT BUSINESS AND MANAGEMENT-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Florence Joly, David Pasquier, Christelle Levy, Mireille Mousseau, Marie-Christine D'almeida, Sabine Noal, Florence Le Tinier, Julien Geffrelot, Catherine Ciais, Viviane Szymczak, Catherine Leon, Marie Pierre Rousselot, Stephanie Darbas, Chantal Hanzen, Natacha Heutte
Summary: Art therapy has a positive impact on social well-being and may improve mental fatigue and motivation among breast cancer patients undergoing radiation therapy. However, it does not significantly improve severe global fatigue.
Article
Oncology
Marie Lange, Benedicte Clarisse, Alexandra Leconte, Kleouforo-Paul Dembele, Justine Lequesne, Celeste Nicola, Martine Dubois, Laurence Derues, Yori Gidron, Helene Castel, Florence Joly
Summary: This study aims to evaluate the impact of immunotherapy on cognitive function in cancer patients without simultaneous anti-cancer treatment and to explore its effects on quality of life. The study will assess the incidence of cognitive decline and investigate secondary endpoints such as anxiety, depression, fatigue, clinical characteristics, biological data, and neurophysiological measures.
Review
Oncology
Charlotte Sleurs, Ali Amidi, Lisa M. Wu, David Kiesl, Philipp Zimmer, Marie Lange, Anne Rogiers, Benedicte Giffard, Giulia Binarelli, Cindy Borghgraef, Sabine Deprez, Mylene Duivon, Michiel De Ruiter, Sanne Schagen, Djihane Ahmed-Lecheheb, Helene Castel, Cecilie R. Buskbjerg, Melanie Dos Santos, Florence Joly, Joy Perrier
Summary: Cancer-related cognitive impairment (CRCI) has been increasingly identified in non-CNS system cancer patients over the last two decades in Europe. Researchers in Europe have contributed to the field by developing preclinical models and exploring underlying mechanisms. New challenges need to be addressed, including data sharing, standardization of assessments, and assessing additional biomarkers and neuroimaging investigations. This consensus paper summarizes the current state of CRCI research in Europe and proposes specific actions for future intervention programs based on shared scientific expert opinion.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Otorhinolaryngology
Mathieu Cesaire, Audrey Rambeau, Florian Clatot, Alisson Johnson, Natacha Heutte, Juliette Thariat
Summary: This study evaluated the impact of lymphopenia on the efficacy of nivolumab immunotherapy in patients with head and neck cancer. The results showed that lymphopenia upon initiation of nivolumab did not affect patients' survival, but persistent lymphopenia during immunotherapy might be a prognostic marker of patient survival.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Marie Lange, Sophie Lefevre Arbogast, Isabelle Hardy-Leger, Olivier Rigal, Johan Le Fel, Barbara Pistilli, Jean Petrucci, Christelle Levy, Aurelie Capel, Charles Coutant, Laure Medeau, Florence Lerebours, Laurence Vanlemmens, Marine Brion, Emmanuelle Bourbouloux, Maxime Blain, Giulia Binarelli, Ines Vaz-Luis, Benedicte Giffard, Ophelie Querel, Sibille Everhard, Fabrice Andre, Cecile Charles, Sarah Dauchy, Florence Joly
Summary: Using the CANTO cohort, this study assessed cognitive functioning change after cancer treatments in a subgroup of breast cancer patients. The results showed that breast cancer patients had lower cognitive abilities before treatment and chemotherapy could lead to a decline in executive function and an increase in cognitive difficulties.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Gwenn Le Gall, Sabine Noal, Natacha Heutte, Benedicte Clarisse, Alexandra Leconte, Francois Cherifi, Corinne Delcambre, Florence Joly, Benedicte Clin
Summary: The study aimed to analyze the impact of adjuvant trastuzumab on fatigue, emotional status, and quality of personal and work life in patients with localized breast cancer. The results showed that trastuzumab did not affect fatigue and return to work, but patients treated with trastuzumab may experience a stronger feeling of helplessness in terms of emotional well-being. Therefore, emotional support should be provided for patients receiving trastuzumab.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Environmental Sciences
I. Benjelloun, N. Merlet-Machour, F. Portet-Koltalo, N. Heutte, D. Garon, F. Baraud, L. Leleyter
Summary: Soil contamination is a significant issue due to urbanization and industrialization. This paper introduces the bioaugmentation effect of fungal strain Absidia cylindrospora on co-contaminated industrial soil for the first time. The study investigates the evolution of metals and PAHs content in the soil over time, as well as the adsorption and/or accumulation of metals within the mycelium of Absidia cylindrospora. The results show that the fungal strain can simultaneously accumulate Cd, Co, Cu, Ni, and Zn, even in the presence of high levels of PAHs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Otorhinolaryngology
E. Babin, N. Heutte, M. Humbert, O. Laccourreye
Summary: This study analyzed the impact of total laryngectomy on the quality of sexual life for cancer patients and the methods used to assess it. The results showed that the quality of sexual life was severely affected, including issues like erectile dysfunction, decreased ejaculatory function, and low libido. Lack of postoperative support was also reported. Therefore, these factors should be taken into account before performing total laryngectomy, and there is a need for a common information tool to improve the management of sexuality based on patient demand.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Oncology
Virginie Prevost, Titi Tran, Benedicte Clarisse, Alexandra Leconte, Nathalie Duchange, Gregoire Moutel, Mylene Gouriot
Summary: People with cancer and health professionals often face psychological distress in the field of oncology. Mindfulness meditation has been used to relieve stress-related symptoms. A pilot study was conducted to evaluate the feasibility of a mindfulness intervention involving cancer patients, health professionals, and others. The qualitative findings from focus groups showed that meditating together was appreciated and seen as motivating and relieving feelings of loneliness. Participants reported better stress management and discussed the benefits and challenges of meditation practice. The study supports the need for a fully powered randomized trial to demonstrate the potential added value of shared meditation in improving well-being among cancer patients, health professionals, and others.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Engineering, Biomedical
Emilie Hummel, Melanie Cogne, Marie Lange, Anatole Lecuyer, Florence Joly, Valerie Gouranton
Summary: This study provides an overview of sixteen vocational or ecological VR-based clinical studies among patients with cognitive impairment. The results highlight the importance of higher immersion in promoting participant engagement and transferability, which are rarely assessed in current literature. However, there is a lack of adaptivity in studies involving patients with cognitive impairments.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
