HIV Reservoirs and Strategies for Eradication

An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency

(2014) A. Marini et al.   JOURNAL OF IMMUNOLOGY

CD4+ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis

(2011) Véronique Fabre-Mersseman et al.   AIDS

HIV cure and eradication: how will we get from the laboratory to effective clinical trials?

(2011) Sharon R Lewin et al.   AIDS

HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells

(2011) Christoph C. Carter et al.   Cell Host & Microbe

Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression

(2011) Ann Florence B. Victoriano et al.   FEBS LETTERS

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

(2011) Sofiya Micheva-Viteva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion Vaccine

(2011) Jacalyn Rosenblatt et al.   JOURNAL OF IMMUNOTHERAPY

A Randomized, Controlled Trial of Raltegravir Intensification in Antiretroviral-treated, HIV-infected Patients with a Suboptimal CD4+ T Cell Response

(2011) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy

(2011) Tae-Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Replication-Competent Simian Immunodeficiency Virus (SIV) Gag Escape Mutations Archived in Latent Reservoirs during Antiretroviral Treatment of SIV-Infected Macaques

(2011) S. E. Queen et al.   JOURNAL OF VIROLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells

(2011) J. A. Anderson et al.   JOURNAL OF VIROLOGY

The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy

(2011) P. Lerner et al.   JOURNAL OF VIROLOGY

Activation of Latent HIV Using Drug-Loaded Nanoparticles

(2011) Michael Kovochich et al.   PLoS One

The Emerging Race to Cure HIV Infections

(2011) J. Cohen   SCIENCE

Gene silencing in HIV-1 latency by polycomb repressive group

(2011) Hyeon Kim et al.   Virology Journal

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure

(2011) Mark Sharkey et al.   PLoS Pathogens

Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1

(2010) Byeong-Sun Choi et al.   AIDS

Genital tract HIV-1 RNA shedding among women with below detectable plasma viral load

(2010) Susan Cu-Uvin et al.   AIDS

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

Low Frequency of Intermittent HIV-1 Semen Excretion in Patients Treated with Darunavir-Ritonavir at 600/100 Milligrams Twice a Day plus Two Nucleoside Reverse Transcriptase Inhibitors or Monotherapy

(2010) S. Lambert-Niclot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

Short‐Course Raltegravir Intensification Does Not Reduce Persistent Low‐Level Viremia in Patients with HIV‐1 Suppression during Receipt of Combination Antiretroviral Therapy

(2010) D. McMahon et al.   CLINICAL INFECTIOUS DISEASES

The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

(2010) Shay Matalon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minocycline Attenuates HIV Infection and Reactivation by Suppressing Cellular Activation in Human CD4+T Cells

(2010) Gregory L. Szeto et al.   JOURNAL OF INFECTIOUS DISEASES

Differences in HIV Burden and Immune Activation within the Gut of HIV‐Positive Patients Receiving Suppressive Antiretroviral Therapy

(2010) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

HIV‐1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

(2010) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

Both CD31+and CD31−Naive CD4+T Cells Are Persistent HIV Type 1–Infected Reservoirs in Individuals Receiving Antiretroviral Therapy

(2010) Fiona Wightman et al.   JOURNAL OF INFECTIOUS DISEASES

Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques despite Antiretroviral Therapy

(2010) M. Kearney et al.   JOURNAL OF VIROLOGY

Hit-and-Run Stimulation: a Novel Concept To Reactivate Latent HIV-1 Infection without Cytokine Gene Induction

(2010) F. Wolschendorf et al.   JOURNAL OF VIROLOGY

Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants

(2010) J. C. Burnett et al.   JOURNAL OF VIROLOGY

R5 HIV env and Vesicular Stomatitis Virus G Protein Cooperate To Mediate Fusion to Naive CD4+ T Cells

(2010) M. J. Pace et al.   JOURNAL OF VIROLOGY

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton

(2010) P. U. Cameron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell line-dependent variability in HIV activation employing DNMT inhibitors

(2010) Guerau Fernandez et al.   Virology Journal

A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system

(2010) Janice E Clements et al.   Current Opinion in HIV and AIDS

HIV integration site distributions in resting and activated CD4+ T cells infected in culture

(2009) Troy Brady et al.   AIDS

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

(2009) Miranda Shehu-Xhilaga et al.   AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No Evidence for Decay of the Latent Reservoir in HIV‐1–Infected Patients Receiving Intensive Enfuvirtide‐Containing Antiretroviral Therapy

(2009) Rajesh T. Gandhi et al.   JOURNAL OF INFECTIOUS DISEASES

Human Immunodeficiency Virus Integration Efficiency and Site Selection in Quiescent CD4+ T Cells

(2009) D. N. Vatakis et al.   JOURNAL OF VIROLOGY

Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS

(2009) T. W. North et al.   JOURNAL OF VIROLOGY

A Simian Immunodeficiency Virus-Infected Macaque Model To Study Viral Reservoirs That Persist during Highly Active Antiretroviral Therapy

(2009) J. B. Dinoso et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV-1 Residual Viremia Correlates with Persistent T-Cell Activation in Poor Immunological Responders to Combination Antiretroviral Therapy

(2009) Maud Mavigner et al.   PLoS One

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

(2009) J. B. Dinoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Follicular Dendritic Cells and Human Immunodeficiency Virus Type 1 Transcription in CD4+ T Cells

(2008) T. C. Thacker et al.   JOURNAL OF VIROLOGY

Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer

(2008) R. Contreras-Galindo et al.   JOURNAL OF VIROLOGY

Immune reconstitution in the sigmoid colon after long-term HIV therapy

(2008) P M Sheth et al.   Mucosal Immunology

Infection of Semen-Producing Organs by SIV during the Acute and Chronic Stages of the Disease

(2008) Anna Le Tortorec et al.   PLoS One

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA