Article
Medicine, General & Internal
Toshihide Izumida, Teruhiko Imamura, Nikhil Narang, Koichiro Kinugawa
Summary: Pemafibrate effectively lowers serum triglyceride levels and reduces the risk of adverse cardiovascular events. Factors such as comorbidities and pemafibrate dosage are associated with the occurrence of cardiovascular events, suggesting that a higher dose of pemafibrate should be considered for patients with chronic heart failure or coronary disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Hwan-Hee Jang, In-Guk Hwang, Young-Min Lee
Summary: This study evaluated the effects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials. The results showed that anthocyanin supplementation significantly reduced triglyceride and low-density lipoprotein-cholesterol levels, and increased high-density lipoprotein-cholesterol levels. However, larger, well-designed clinical trials are needed to further investigate the effects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Leonie Schoch, Lina Badimon, Gemma Vilahur
Summary: Increasing doubt has been raised over the HDL-cholesterol hypothesis, with evidence pointing towards the complexity and molecular changes in HDL particles. Chemical modifications, compositional changes, and miRNA cargo have been identified as factors contributing to the ineffectiveness of HDL particles. Overcoming challenges is crucial to bringing hope to HDL-targeted approaches.
Article
Medicine, General & Internal
Gabriela P. Arrifano, Jacqueline Alvarez-Leite, Barbarella M. Macchi, Nubia F. S. S. Campos, Marcus Augusto-Oliveira, Leticia Santos-Sacramento, Amanda Lopes-Araujo, Jose Rogerio Souza-Monteiro, Raquel Alburquerque-Santos, Jose Luiz M. do Nascimento, Sidney Santos, Andrea Ribeiro-dos-Santos, Reinaldo B. Oria, Maria Elena Crespo-Lopez
Summary: The MetS epidemic is a global challenge, with significant prevalence in Amazonian riverine populations and other vulnerable populations in the Southern Hemisphere. Genetic influences and environmental factors such as mercury may play a role in the development of MetS in these populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Zahra Heidari, Zahra Kiani, Masoumeh Atefi, Azadeh Zareie, Mehrnaz Shojaei, Gholamreza Askari, Prashant Kesharwani, Mohammad Bagherniya
Summary: This meta-analysis evaluated the effects of the DASH diet on lipid profiles based on clinical controlled trials. The results showed that following the DASH diet significantly reduced serum triglycerides and low-density lipoprotein cholesterol levels, but had no significant effect on serum total cholesterol and high-density lipoprotein cholesterol levels. Therefore, the DASH diet can be considered as a strategy for the prevention and complementary management of dyslipidemia.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Hematology
Cheng-Chieh Hsu, Jenny E. Kanter, Vishal Kothari, Karin E. . Bornfeldt
Summary: APOA1 and APOB are structural proteins of different types of lipoproteins, regulating the levels of triglyceride and cholesterol. Among the smaller APOCs, APOC3 has been studied extensively and is associated with cardiovascular and kidney diseases in type 1 diabetes. Insulin deficiency and resistance are related to elevated APOC3 levels. APOC3 slows down the clearance of triglyceride-rich lipoproteins, leading to the accumulation of atherogenic remnants in atherosclerosis lesions. Little is known about the roles of APOC1, APOC2, and APOC4 in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Gang Huang, Junbo Xu, Zhen Zhang, Lin Cai, Hanxiong Liu, Xiuqiong Yu
Summary: This study investigated the potential association between total cholesterol and high density lipoprotein cholesterol ratio (THR) and metabolic syndrome (MetS) in a very elderly population in Chengdu. The study found a significant association between THR and MetS in this community of very elderly individuals.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Aicha Laouani, Hana Nasrallah, Awatef Sassi, Farhana Ferdousi, Feten Zar Kalai, Yosra Hasni, Khalifa Limem, Hiroko Isoda, Saad Saguem
Summary: In this study, the feasibility, compliance, and potential benefits of Nitraria retusa extract (NRE) intervention were explored in both healthy and overweight/obese adults. Participants were randomly assigned to either a low-dose or a high-dose NRE intervention group. Results showed that the high-dose group of overweight/obese participants experienced a significant decrease in triglyceride levels and an increase in HDL levels. The study demonstrated good compliance and acceptability, with over 90% of participants completing the intervention.
Article
Cardiac & Cardiovascular Systems
Ken Chen, Jilin Zheng, Chunli Shao, Qing Zhou, Jie Yang, Tao Huang, Yi-Da Tang
Summary: Our study using Mendelian randomization method found that T2DM causally influenced the levels of TG, HDL-C, and different particle sizes of lipoprotein subclasses, while no causal effect was observed on TC or LDL-C levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Bibiana Fabre, Nahuel Fernandez Machulsky, Carolina Olano, Dario Jacobsen, Maria Eugenia Gomez, Beatriz Perazzi, Valeria Zago, Damian Zopatti, Andres Ferrero, Laura Schreier, Gabriela Berg
Summary: Patients with severe complications of COVID-19, such as cardiovascular disease, hypertension, and type-2 diabetes, have metabolic alterations including insulin resistance and dyslipidemia. This study found that levels of remnant lipoprotein cholesterol were associated with the severity and death of COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Yaerim Kim, Soojin Lee, Yeonhee Lee, Min Woo Kang, Sehoon Park, Sanghyun Park, Kyungdo Han, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seugyeup Han, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: This study included 3,634,873 participants, with 404,298 (11.1%) and 66,805 (1.8%) having early and advanced CKD, respectively. TG/HDL-C levels showed a linear association with MACCEs and all-cause mortality, while LDL-C showed a different pattern of association. In the advanced CKD group, the significance of LDL-C levels with outcomes was attenuated, while the linear patterns with TG/HDL-C and outcomes were maintained.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Clare Stradling, G. Neil Thomas, Karla Hemming, Stephen Taylor, Shahrad Taheri
Summary: The study demonstrated the feasibility of adopting a Mediterranean Portfolio diet in people living with HIV, which may lead to short-term improvements in diet quality, blood pressure, and LDL-cholesterol.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Samantha Logan, Rajeevan Selvaratnam
Summary: A new estimation method for LDLc, known as NeLDLc, has been proposed to overcome the limitations of the commonly used Friedewald estimation. Through a retrospective analysis, NeLDLc was found to have better correlation and concordance with Non-HDLc. However, caution is needed when triglycerides are > 4.5 mmol/L and when NeLDLc results are < 0.5 mmol/L. The use of NeLDLc allows for flagging at triglyceride levels of 1.7 mmol/L, suggesting reliance on Non-HDLc and indicating hypertriglyceridemia.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Yanli Chen, Guangxiao Li, Xiaofan Guo, Nanxiang Ouyang, Zhao Li, Ning Ye, Shasha Yu, Hongmei Yang, Yingxian Sun
Summary: The study found a link between remnant cholesterol and cardiovascular diseases, with higher levels of remnant cholesterol increasing the risk of combined cardiovascular diseases, especially in specific subgroups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Peripheral Vascular Disease
Margaret Constanti, Rebecca Boffa, Christopher N. Floyd, Anthony S. Wierzbicki, Richard J. McManus, Mark Glover
Summary: The 2011 NICE hypertension guideline and the 2019 update both showed that Ambulatory BP remains the most cost-effective option for confirming a diagnosis of hypertension, with higher sensitivity and specificity than Clinic BP and Home BP. Despite improvements in accuracy for Clinic BP and Home BP, Ambulatory BP continues to be the preferred method in all subgroups evaluated.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Medicine, General & Internal
Tim M. Reynolds, Karen L. Tylee, Kathryn L. Booth, Anthony S. Wierzbicki
Summary: This study aimed to identify the prevalence of Fabry Disease in patients with abnormal renal function. Among 579 women, one subject was identified as a heterozygous carrier of a likely pathogenic variant for FD, with reduced alpha-galactosidase activity and increased Lyso-GL-3 concentration. This highlights the importance of utilizing pathology databases for identifying patients with inherited metabolic disorders.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
T. Barrett, A. Khwaja, C. Carmona, Y. Martinez, H. Nicholas, G. Rogers, A. S. Wierzbicki, A. J. P. Lewington
Summary: NICE has updated the guideline for Acute kidney injury, providing new recommendations on preventing AKI in adults receiving intravenous iodine-based contrast media. The association between contrast media and AKI is controversial, but the committee recommends oral hydration and volume expansion only for high-risk inpatients.
CLINICAL RADIOLOGY
(2021)
Article
Peripheral Vascular Disease
Margaret Constanti, Christopher N. Floyd, Mark Glover, Rebecca Boffa, Anthony S. Wierzbicki, Richard J. McManus
Summary: This study indicates that initiating antihypertensive drug treatment for adults with stage 1 hypertension at the age of 60 is cost-effective regardless of their 10-year cardiovascular disease risk level. The treatment is cost-effective for men of all ages and women over 60. For other age groups, treatment is also cost-effective regardless of risk, except for younger women.
Review
Cardiac & Cardiovascular Systems
Oluwayemisi Esan, Anthony S. Wierzbicki
Summary: Recent studies have shown a clear relationship between TG-containing lipoproteins and cardiovascular disease risk, particularly non-HDL-C. Genetic variation studies and intervention trials indicate that reducing TG levels can decrease CVD event rates, and high-dose omega-3 fatty acid formulations may improve CVD outcomes. Further research with newer agents such as pemafibrate and vupanorsen is needed.
CURRENT OPINION IN CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Anthony S. Wierzbicki, Dimitri P. Mikhailidis
CURRENT OPINION IN CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Alexandry Augustin, Louise Coutts, Lorenzo Zanisi, Anthony S. Wierzbicki, Francesco Shankar, Phil J. Chowienczyk, Christopher N. Floyd
Summary: The study found that measurement error can affect systolic blood pressure control, with therapeutic inertia potentially leading to some individuals failing to achieve their SBP target within a 10-year timeframe.
Editorial Material
Medicine, General & Internal
Yolanda Martinez, Ivan Benett, Andrew J. P. Lewington, Anthony S. Wierzbicki
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Editorial Material
Medicine, General & Internal
Eun Ji Kim, Anthony S. Wierzbicki
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Endocrinology & Metabolism
Eun Ji Kim, Radha Ramachandran, Anthony S. Wierzbicki
Summary: Multiple studies have shown a strong association between lipids and diabetes. Lipoprotein particles contain components such as phospholipids, ceramides, and sphingolipids, which may have a role in regulating cell metabolism and insulin resistance. Recent findings from lipidomics techniques suggest that ceramides and sphingolipids could be potential mediators of cellular dysfunction in diabetes.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Pharmacology & Pharmacy
Oluwayemisi Esan, Adie Viljoen, Anthony S. Wierzbicki
Summary: Low density Lipoprotein cholesterol (LDL-C) levels are associated with cardiovascular disease (CVD). Colesevelam HCl can be used to reduce LDL-C and HbA(1c) levels in patients with diabetes.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Alan Jones, Katherine Peers, Anthony S. Wierzbicki, Radha Ramachandran, Michael Mansfield, Charlotte Dawson, Antonio Ochoa-Ferraro, Handrean Soran, Fiona Jenkinson, Ian McDowell, Paul Downie, Paul Hamilton, Richard Jones
Summary: The VOL4002 study evaluated the efficacy and safety of volanesorsen in patients with familial chylomicronaemia syndrome (FCS). The results showed that volanesorsen can significantly reduce triglyceride levels and decrease the incidence of pancreatitis events in FCS patients. This study supports the effectiveness of volanesorsen in FCS patients and suggests that long-term use is safe.
Review
Biochemistry & Molecular Biology
Bilal Bashir, Jan H. Ho, Paul Downie, Paul Hamilton, Gordon Ferns, Dev Datta, Jaimini Cegla, Anthony S. Wierzbicki, Charlotte Dawson, Fiona Jenkinson, Hannah Delaney, Michael Mansfield, Yee Teoh, Zosia Miedzybrodzka, Haya Haso, Paul N. Durrington, Handrean Soran
Summary: This article reviews the genetic basis of chylomicronaemia, the difference between monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular, and microvascular complications, and current and potential future pharmacotherapies.
Article
Pathology
Anthony S. Wierzbicki, Eun Ji Kim, Oluwayemisi Esan, Radha Ramachandran
Summary: Triglycerides (TGs) are part of the standard lipid profile and elevated TGs are associated with increased cardiovascular disease risk. Primary hypertriglyceridaemia syndromes need to be identified as many TG elevations are secondary to other causes. Management includes diet optimization, reducing exacerbating factors, and using lipid-lowering medications. Extreme hypertriglyceridaemia syndromes, especially chylomicronaemia syndromes, are medical emergencies that require immediate admission and specialist management.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Anthony S. Wierzbicki
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)